Browse Target by Protein Family

• Protein Targets (2946)
  • Enzymes (1831)
    • EC1 Oxidoreductases (313)
      • EC1.- Unclassified (2)
        • EC1.-.- Unclassified (2)
      • EC1.1 Acting on diphenols and related substances as donors (88)
        • EC1.1.- Unclassified (2)
        • EC1.1.1 With NAD(+) or NADP(+) as acceptor (84)
        • EC1.10.3 With oxygen as acceptor (1)
        • EC1.10.5 With a quinone or related compound as acceptor (1)
      • EC1.11 Acting on a peroxide as acceptor (7)
        • EC1.11.1 Peroxidases (5)
        • EC1.11.2 With H(2)O(2) as acceptor, one oxygen atom of which is incorporated into the product (2)
      • EC1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases) (28)
        • EC1.13.11 With incorporation of two atoms of oxygen (25)
        • EC1.13.12 With incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) (3)
      • EC1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen (104)
        • EC1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors (19)
        • EC1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen (28)
        • EC1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen (30)
        • EC1.14.15 With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen (12)
        • EC1.14.16 With reduced pteridine as one donor, and incorporation of one atom of oxygen (3)
        • EC1.14.17 With reduced ascorbate as one donor, and incorporation of one atom of oxygen (3)
        • EC1.14.18 With another compound as one donor, and incorporation of one atom of oxygen (4)
        • EC1.14.19 With oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water (1)
        • EC1.14.99 Miscellaneous (4)
      • EC1.15 Acting on superoxide as acceptor (1)
        • EC1.15.1 Acting on superoxide as acceptor (1)
      • EC1.17 Acting on CH or CH(2) groups (1)
        • EC1.17.7 With an iron-sulfur protein as acceptor (1)
      • EC1.2 Acting on phosphorus or arsenic in donors (11)
        • EC1.2.1 With NAD(+) or NADP(+) as acceptor (10)
        • EC1.2.4 With a disulfide as acceptor (1)
      • EC1.3 Acting on the CH-CH group of donors (16)
        • EC1.3.1 With NAD(+) or NADP(+) as acceptor (14)
        • EC1.3.5 With a quinone or related compound as acceptor (1)
        • EC1.3.98 With other, known, acceptors (1)
      • EC1.4 Acting on the CH-NH(2) group of donors (20)
        • EC1.4.1 With NAD(+) or NADP(+) as acceptor (1)
        • EC1.4.3 With oxygen as acceptor (19)
      • EC1.5 Acting on the CH-NH group of donors (12)
        • EC1.5.1 With NAD(+) or NADP(+) as acceptor (7)
        • EC1.5.3 With oxygen as acceptor (5)
      • EC1.6 Acting on NADH or NADPH (9)
        • EC1.6.2 With a heme protein as acceptor (2)
        • EC1.6.3 With oxygen as acceptor (1)
        • EC1.6.4 With a disulfide as acceptor (1)
        • EC1.6.5 With a quinone or similar compound as acceptor (5)
      • EC1.8 Acting on a sulfur group of donors (12)
        • EC1.8.1 With NAD(+) or NADP(+) as acceptor (10)
        • EC1.8.3 With oxygen as acceptor (1)
        • EC1.8.4 With a disulfide as acceptor (1)
      • EC1.9 Acting on a heme group of donors (1)
        • EC1.9.3 With oxygen as acceptor (1)
      • EC1.97 Other oxidoreductases (1)
        • EC1.97.1 Other oxidoreductases (1)
    • EC2 Transferases (826)
      • EC2.1 Transferring molybdenum- or tungsten-containing groups (51)
        • EC2.1.1 Methyltransferases (51)
      • EC2.2 Transferring aldehyde or ketonic groups (3)
        • EC2.2.1 Transketolases and transaldolases (3)
      • EC2.3 Acyltransferases (45)
        • EC2.3.1 Transferring groups other than amino-acyl groups (36)
        • EC2.3.2 Aminoacyltransferases (6)
        • EC2.3.3 Acyl groups converted into alkyl groups on transfer (3)
      • EC2.4 Glycosyltransferases (68)
        • EC2.4.1 Hexosyltransferases (38)
        • EC2.4.2 Pentosyltransferases (25)
        • EC2.4.99 Transferring other glycosyl groups (5)
      • EC2.5 Transferring alkyl or aryl groups, other than methyl groups (32)
        • EC2.5.1 Transferring alkyl or aryl groups, other than methyl groups (32)
      • EC2.6 Transferring nitrogenous groups (9)
        • EC2.6.1 Transaminases (9)
      • EC2.7 Transferring phosphorus-containing groups (616)
        • EC2.7.- Unclassified (3)
        • EC2.7.1 Phosphotransferases with an alcohol group as acceptor (54)
        • EC2.7.10 Protein-tyrosine kinases (102)
        • EC2.7.11 Protein-serine/threonine kinases (386)
        • EC2.7.12 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues) (28)
        • EC2.7.13 Protein-histidine kinases (2)
        • EC2.7.2 Phosphotransferases with a carboxy group as acceptor (4)
        • EC2.7.3 Phosphotransferases with a nitrogenous group as acceptor (1)
        • EC2.7.4 Phosphotransferases with a phosphate group as acceptor (7)
        • EC2.7.6 Diphosphotransferases (1)
        • EC2.7.7 Nucleotidyltransferases (24)
        • EC2.7.8 Transferases for other substituted phosphate groups (4)
      • EC2.8 Transferring sulfur-containing groups (2)
        • EC2.8.2 Sulfotransferases (2)
    • EC3 Hydrolases (625)
      • EC3.- Unclassified (2)
        • EC3.-.- Unclassified (2)
      • EC3.1 Acting on sulfur-nitrogen bonds (190)
        • EC3.1.- Unclassified (3)
        • EC3.1.1 Carboxylic ester hydrolases (53)
        • EC3.1.11 Exodeoxyribonucleases producing 5'-phosphomonoesters (1)
        • EC3.1.2 Thiolester hydrolases (1)
        • EC3.1.21 Endodeoxyribonucleases producing 5'-phosphomonoesters (7)
        • EC3.1.22 Endodeoxyribonucleases producing other than 5'-phosphomonoesters (2)
        • EC3.1.26 Endoribonucleases producing 5'-phosphomonoesters (1)
        • EC3.1.27 Endoribonucleases producing other than 5'-phosphomonoesters (5)
        • EC3.1.3 Phosphoric monoester hydrolases (68)
        • EC3.1.4 Phosphoric diester hydrolases (47)
        • EC3.1.6 Sulfuric ester hydrolases (2)
      • EC3.2 Glycosylases (109)
        • EC3.2.1 Glycosidases, i.e.enzymes hydrolyzing O- and S-glycosyl compounds (104)
        • EC3.2.2 Hydrolyzing N-glycosyl compounds (5)
      • EC3.3 Acting on ether bonds (5)
        • EC3.3.1 Thioether and trialkylsulfonium hydrolases (3)
        • EC3.3.2 Ether hydrolases (2)
      • EC3.4 Acting on peptide bonds (peptidases) (191)
        • EC3.4.- Unclassified (3)
        • EC3.4.11 Aminopeptidases (26)
        • EC3.4.13 Dipeptidases (3)
        • EC3.4.14 Dipeptidyl-peptidases and tripeptidyl-peptidases (8)
        • EC3.4.16 Serine-type carboxypeptidases (1)
        • EC3.4.17 Metallocarboxypeptidases (7)
        • EC3.4.18 Cysteine-type carboxypeptidases (1)
        • EC3.4.19 Omega peptidases (11)
        • EC3.4.21 Serine endopeptidases (50)
        • EC3.4.22 Cysteine endopeptidases (33)
        • EC3.4.23 Aspartic endopeptidases (8)
        • EC3.4.24 Metalloendopeptidases (33)
        • EC3.4.25 Threonine endopeptidases (7)
      • EC3.5 Acting on carbon-nitrogen bonds, other than peptide bonds (101)
        • EC3.5.1 In linear amides (43)
        • EC3.5.2 In cyclic amides (42)
        • EC3.5.3 In linear amidines (8)
        • EC3.5.4 In cyclic amidines (8)
      • EC3.6 Acting on acid anhydrides (26)
        • EC3.6.1 In phosphorus-containing anhydrides (5)
        • EC3.6.3 Acting on acid anhydrides; catalyzing transmembrane movement of substances (13)
        • EC3.6.4 Acting on ATP; involved in cellular and subcellular movement (7)
        • EC3.6.5 Acting on GTP; involved in cellular and subcellular movement (1)
      • EC3.7 Acting on carbon-carbon bonds (1)
        • EC3.7.1 In ketonic substances (1)
    • EC4 Lyases (80)
      • EC4.- Unclassified (1)
        • EC4.-.- Unclassified (1)
      • EC4.1 Carbon-carbon lyases (24)
        • EC4.1.1 Carboxy-lyases (11)
        • EC4.1.2 Aldehyde-lyases (7)
        • EC4.1.3 Oxo-acid-lyases (6)
      • EC4.2 Carbon-oxygen lyases (39)
        • EC4.2.1 Hydro-lyases (36)
        • EC4.2.2 Acting on polysaccharides (1)
        • EC4.2.3 Acting on phosphates (2)
      • EC4.3 Carbon-nitrogen lyases (3)
        • EC4.3.3 Amine-lyases (3)
      • EC4.4 Carbon-sulfur lyases (3)
        • EC4.4.1 Carbon-sulfur lyases (3)
      • EC4.6 Phosphorus-oxygen lyases (10)
        • EC4.6.1 Phosphorus-oxygen lyases (10)
    • EC5 Isomerases (65)
      • EC5.- Unclassified (1)
        • EC5.-.- Unclassified (1)
      • EC5.1 Racemases and epimerases (8)
        • EC5.1.1 Acting on amino acids and derivatives (5)
        • EC5.1.2 Acting on hydroxy acids and derivatives (1)
        • EC5.1.3 Acting on carbohydrates and derivatives (2)
      • EC5.2 Cis-trans-isomerases (10)
        • EC5.2.1 Cis-trans isomerases (10)
      • EC5.3 Intramolecular oxidoreductases (16)
        • EC5.3.1 Interconverting aldoses and ketoses (4)
        • EC5.3.2 Interconverting keto- and enol-groups (1)
        • EC5.3.3 Transposing C=C bonds (4)
        • EC5.3.4 Transposing S-S bonds (1)
        • EC5.3.99 Other intramolecular oxidoreductases (6)
      • EC5.4 Intramolecular transferases (2)
        • EC5.4.2 Phosphotransferases (phosphomutases) (1)
        • EC5.4.99 Transferring other groups (1)
      • EC5.99 Other isomerases (28)
        • EC5.99.1 Other isomerases (28)
    • EC6 Ligases (25)
      • EC6.1 Forming carbon-oxygen bonds (7)
        • EC6.1.1 Ligases forming aminoacyl-tRNA and related compounds (7)
      • EC6.2 Forming carbon-sulfur bonds (2)
        • EC6.2.1 Acid--thiol ligases (2)
      • EC6.3 Forming carbon-nitrogen bonds (15)
        • EC6.3.1 Acid--ammonia (or amine) ligases (amide synthases) (5)
        • EC6.3.2 Acid--amino-acid ligases (peptide synthases) (8)
        • EC6.3.4 Other carbon--nitrogen ligases (1)
        • EC6.3.5 Carbon--nitrogen ligases with glutamine as amido-N-donor (1)
      • EC6.5 Forming phosphoric ester bonds (1)
        • EC6.5.1 Forming phosphoric ester bonds (1)
  • Membrane receptor (397)
    • Family A G protein-coupled receptor (345)
      • Small molecule receptor (family A GPCR) (228)
        • Monoamine receptor (133)
          • Acetylcholine receptor (23)
          • Adrenergic receptor (40)
          • Dopamine receptor (17)
          • Histamine receptor (15)
          • Serotonin receptor (34)
          • Trace amine receptor (4)
        • Lipid-like ligand receptor (family A GPCR) (48)
          • Cannabinoid receptor (9)
          • EDG receptor (5)
          • Free fatty acid receptor (4)
          • Leukotriene receptor (5)
          • Lysophosphatidylinositol receptor (1)
          • PAF receptor (2)
          • Prostanoid receptor (17)
          • Steroid-like ligand receptor (3)
          • Unclassified (2)
        • Nucleotide-like receptor (family A GPCR) (34)
          • Adenosine receptor (20)
          • Purine receptor (14)
        • Monoamine-derivative receptor (family A GPCR) (6)
        • Carboxylic acid receptor (7)
      • Peptide receptor (family A GPCR) (110)
        • Chemokine receptor (9)
        • Glycohormone receptor (2)
        • N-formyl methionyl peptide receptor (1)
        • Protease-activated receptor (1)
        • Relaxin-like peptide receptor (family A GPCR) (3)
        • Short peptide receptor (family A GPCR) (94)
      • Opsin (1)
      • Unclassified (6)
    • Family B G protein-coupled receptor (4)
    • Family C G protein-coupled receptor (23)
    • Frizzled family G protein-coupled receptor (2)
    • Taste family G protein-coupled receptor (1)
    • Toll-like and Il-1 receptors (4)
    • Unclassified (18)
  • Ion channel (224)
    • Ligand-gated ion channel (146)
      • 5HT3 receptor (7)
      • Epithelial sodium channel (1)
      • GABA-A receptor (38)
      • Glycine receptor (4)
      • Ionotropic glutamate receptor (33)
      • IP3 receptor (6)
      • Nicotinic acetylcholine receptor (41)
      • P2X receptor (12)
      • Ryanodine receptor (4)
    • Voltage-gated ion channel (68)
      • Transient receptor potential channel (15)
      • Potassium channels (25)
      • Voltage-gated calcium channel (14)
      • Voltage-gated sodium channel (14)
    • Other ion channel (10)
  • Transporter (141)
    • Electrochemical transporter (118)
      • SLC superfamily of solute carriers (118)
        • SLC01 family of amino acid transporters (3)
        • SLC02 family of hexose and sugar alcohol transporters (3)
        • SLC03 and SLC07 families of heteromeric amino acid transporters (HATs) (3)
        • SLC05 family of sodium-dependent glucose transporters (7)
        • SLC06 neurotransmitter transporter family (32)
        • SLC10 family of sodium-bile acid co-transporters (3)
        • SLC15 family of peptide transporters (3)
        • SLC16 family of monocarboxylate transporters (2)
        • SLC17 phosphate and organic anion transporter family (2)
        • SLC18 family of vesicular amine transporters (3)
        • SLC19 family of vitamin transporters (1)
        • SLC21/SLCO family of organic anion transporting polypeptides (16)
        • SLC22 family of organic cation and anion transporters (29)
        • SLC28 and SLC29 families of nucleoside transporters (7)
        • SLC36 family of proton-coupled amino acid transporters (1)
        • SLC37 family of phosphosugar/phosphate exchangers (1)
        • SLC47 family of multidrug and toxin extrusion transporters (2)
    • Group translocator (1)
    • Primary active transporter (21)
    • Transmembrane 1-electron transfer carriers (1)
  • Nuclear receptor (77)
  • Transcription factor (26)
  • Unclassified Protein Targets (571)