Natural Product Target: Rap guanine nucleotide exchange factor 4

Target ID:   NPT161
Target Name:   Rap guanine nucleotide exchange factor 4
Target Type:   Individual Protein
Organism of Target:   Homo sapiens
Target External ID:   Uniprot_ID:[ Q8WZA2]

  Biological Activities of Natural Products against the Target

Natural Product ID Natural Product Name # Activity Records
NPC212551 Cyclic Adenosine Monophosphate 4
NPC117445 Lanatoside C 2
NPC130193 (1E,4Z,6E)-5-Hydroxy-1,7-Bis(4-Hydroxyphenyl)Hepta-1,4,6-Trien-3-One 2
NPC161768 Butyl 2-(2,4-Dichlorophenoxy)Acetate 1
NPC48733 (2S,3R,5R,10R,13R,14S)-17-[(2R,3R)-2,3-Dihydroxy-6-Methylheptan-2-Yl]-2,3,14-Trihydroxy-10,13-Dimethyl-2,3,4,5,9,11,12,15,16,17-Decahydro-1H-Cyclopenta[A]Phenanthren-6-One 1
NPC210048 n.a. 1
NPC264178 2-Hydroxy-3-[(E)-16-(2-Hydroxy-5-Methoxy-3,6-Dioxocyclohexa-1,4-Dien-1-Yl)Hexadec-8-Enyl]-5-Methoxycyclohexa-2,5-Diene-1,4-Dione 1
NPC97577 Lovastatin 1
NPC314679 12-Methyltetradecanoic Acid 1
NPC168829 Honokiol 1
NPC17848 Candidin 1
NPC211551 N-(1-Hydroxy-3-Phenylpropan-2-Yl)Benzamide 1
NPC264317 Betulinic Acid 1
NPC10251 Dibutyl Phthalate 1
NPC315807 5,7-Dimethoxy-4-Phenylchromen-2-One 1
NPC169749 Myricetin 1
NPC163846 Amorfrutin A 1
NPC274356 Austrobailignan 6 1
NPC102683 (4As,6As,6Br,10S,12Ar)-10-Hydroxy-2,2,6A,6B,9,9,12A-Heptamethyl-1,3,4,5,6,6A,7,8,8A,10,11,12,13,14B-Tetradecahydropicene-4A-Carboxylic Acid 1
NPC316910 Celecoxib 1
NPC170018 (9R)-9-[(9R)-2-Carboxy-4-Hydroxy-10-Oxo-5-[(3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Oxan-2-Yl]Oxy-9H-Anthracen-9-Yl]-4-Hydroxy-10-Oxo-5-[(2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Oxan-2-Yl]Oxy-9H-Anthracene-2-Carboxylic Acid 1
NPC51700 Ursolic Acid 1
NPC214067 Bis(2-Methylpropyl) Benzene-1,2-Dicarboxylate 1
NPC275627 Butylated Hydroxyanisole 1
NPC103958 (1R,4As,4Br,7R,10As)-7-Ethenyl-1,4A,7-Trimethyl-3,4,4B,5,6,9,10,10A-Octahydro-2H-Phenanthrene-1-Carboxylic Acid 1
NPC318325 4-Octylphenol 1
NPC319933 2,4-Dibromo-1-(2,4-Dibromophenoxy)Benzene 1
NPC178134 Ellagic Acid 1
NPC53240 (E,7S)-N-[(E,2E)-2-(Chloromethylidene)-4-Methoxy-6-(3-Methoxy-5-Oxo-2H-Pyrrol-1-Yl)-6-Oxohex-4-Enyl]-7-Methoxy-N-Methyltetradec-4-Enamide 1
NPC216092 9-[(2E)-3,7-Dimethylocta-2,6-Dienoxy]Furo[3,2-G]Chromen-7-One 1
NPC288411 Magnolol 1
NPC107572 Sophoraflavanone B 1
NPC109083 Curcumin 1
NPC40818 Tangeretin 1
NPC181594 Kamebanin 1
NPC55149 Columbianadin 1
NPC220705 Sphaeropsidin A 1
NPC4669 Berberrubine 1
NPC290550 Emodic Acid 1
NPC328740 5,7-Dihydroxy-2-(4-Hydroxyphenyl)-6-[3,4,5-Trihydroxy-6-(Hydroxymethyl)Oxan-2-Yl]Chromen-4-One 1
NPC183503 (1R,4Ar,7R)-7-Ethenyl-1,4A,7-Trimethyl-3,4,4B,5,6,9,10,10A-Octahydro-2H-Phenanthrene-1-Carboxylic Acid 1
NPC56493 Dipropyl Benzene-1,2-Dicarboxylate 1
NPC224270 Sclerotiorin 1
NPC5167 Graveoline 1
NPC297358 Guaiazulene 1
NPC125416 Chlorhexidine 1
NPC41719 Karanjin 1
NPC184641 n.a. 1
NPC63479 Pentachlorophenol 1
NPC23837 1,4-Dimethoxybenzene 1
NPC71074 Corosolic Acid 1
NPC34864 Piceatannol 1
NPC129784 (6Ar,11Ar)-1-Methoxy-10-(3-Methylbut-2-Enyl)-6A,11A-Dihydro-6H-[1]Benzofuro[3,2-C]Chromene-3,9-Diol 1
NPC329003 Oleoylethanolamide 1
NPC187145 3-(1H-Benzimidazol-2-Yl)-7-(Diethylamino)Chromen-2-One 1
NPC227850 N-Acetylaspartic Acid 1
NPC74178 5,7-Dihydroxy-3-(8-Hydroxy-2,2-Dimethylchromen-6-Yl)Chromen-4-One 1
NPC434 N-Phenylnaphthalen-2-Amine 1
NPC329416 Isotretinoin 1
NPC187616 Licarin A 1
NPC232316 Mesodihydroguaiaretic Acid 1
NPC79618 N-Phenylnaphthalen-1-Amine 1
NPC300984 Lobaric Acid 1
NPC132858 n.a. 1
NPC257025 Thunberginol B 1
NPC189588 Digoxigenin 1
NPC232969 (6As)-5-Chloro-9-[(2R,3R)-3-Hydroxy-2-Methylbutanoyl]-6A-Methyl-3-[(E,3S)-3-Methylpent-1-Enyl]Furo[2,3-H]Isochromene-6,8-Dione 1
NPC83409 (2R)-6-(2-Hydroxyethyl)-2,5,7-Trimethyl-2,3-Dihydroinden-1-One 1
NPC302857 Chlorogenic Acid 1
NPC133856 4-(3-Carboxy-2-Hydroxy-4-Methoxy-6-Methylbenzoyl)Oxy-2-Hydroxy-3,6-Dimethylbenzoic Acid 1
NPC186507 Sid85272548 1
NPC199023 Nelumol A 1
NPC233267 Diffractaic Acid 1
NPC84894 [8,8-Dimethyl-9-[(Z)-2-Methylbut-2-Enoyl]Oxy-2-Oxo-9,10-Dihydropyrano[2,3-F]Chromen-10-Yl] (Z)-2-Methylbut-2-Enoate 1
NPC306095 (1S,2R,4As,9As)-1-[(Z)-5-Hydroxy-3-(Hydroxymethyl)Pent-3-Enyl]-6-(Hydroxymethyl)-1,2-Dimethyl-3,4A,5,8,9,9A-Hexahydro-2H-Benzo[7]Annulen-4-One 1
NPC141782 Totarol 1
NPC44830 12-Phenyldodecanoic Acid 1
NPC201731 Osajin 1
NPC26244 Dienestrol 1
NPC92403 Sennoside B 1
NPC307176 Progesterone 1
NPC142415 Oleanolic_Acid 1
NPC470091 Stictic Acid 1
NPC201844 Dodecanoate 1
NPC238176 (2S)-2,8-Dimethyl-2-[(4S,8S)-4,8,12-Trimethyltridecyl]-3,4-Dihydrochromen-6-Ol 1
NPC93739 Physodic Acid 1
NPC312870 n.a. 1
NPC155144 Moracin M 1
NPC470089 Sid85272349 1
NPC202768 n.a. 1
NPC252281 n.a. 1
NPC95123 Evernic Acid 1
NPC314152 Cladribine 1
NPC161571 Resveratrol 1
NPC242945 Kolavenic Acid 1
NPC207702 Schisandrin A 1
NPC261831 Oleic Acid 1
NPC96286 Osthole 1
NPC314329 Flavanone 1

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4. Species Source: species sources that all natural products that have available activity against this target derived from.

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