Drug Information

Drug ID:  NPD8124
Drug Name:  Vaniprevir
Molecular Formula:  C38H53N5O9S
Canonical SMILES:  C=C[C@@H]1C[C@]1(N=C([C@@H]1C[C@@H]2CN1C(=O)[C@@H](N=C(O)OCC(C)(C)CCCCc1c3CN(C(=O)O2)Cc3ccc1)C(C)(C)C)O)C(=NS(=O)(=O)C1CC1)O
Standard InCHI:  InChI=1S/C38H53N5O9S/c1-7-25-18-38(25,33(46)41-53(49,50)27-14-15-27)40-31(44)29-17-26-20-43(29)32(45)30(36(2,3)4)39-34(47)51-22-37(5,6)16-9-8-11-23-12-10-13-24-19-42(21-28(23)24)35(48)52-26/h7,10,12-13,25-27,29-30H,1,8-9,11,14-22H2,2-6H3,(H,39,47)(H,40,44)(H,41,46)/t25-,26-,29+,30-,38-/m1/s1
Standard InCHIKey:  HPAPGONEMPZXMM-ONAXAZCASA-N
Max Developmental Stage:  Phase 3
Max Developmental Stage Source:  ChEMBL

  Structural Similarity Between NPASS Natural Products and NPD8124

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient
Tanimoto coefficient is calculated based on PubChem 881-bit substructure fingerprints.


  Similar Natural Products

High Similarity Level: Tc>=0.85; Intermediate Similarity Level: 0.7 <= Tc < 0.85; Remote Similarity Level: 0.65 <= Tc < 0.7

Similarity Level Similarity Score Natural Product ID
Intermediate Similarity 0.7778 NPC322878
Intermediate Similarity 0.7607 NPC476978
Intermediate Similarity 0.7547 NPC287401
Intermediate Similarity 0.7455 NPC5620
Intermediate Similarity 0.7407 NPC471264
Intermediate Similarity 0.7407 NPC471265
Intermediate Similarity 0.7358 NPC300315
Intermediate Similarity 0.7353 NPC286551
Intermediate Similarity 0.7349 NPC316008
Intermediate Similarity 0.7349 NPC313867
Intermediate Similarity 0.7312 NPC130309
Intermediate Similarity 0.7305 NPC314358
Intermediate Similarity 0.7289 NPC315283
Intermediate Similarity 0.7289 NPC314388
Intermediate Similarity 0.7278 NPC129666
Intermediate Similarity 0.7229 NPC161069
Intermediate Similarity 0.7219 NPC240848
Intermediate Similarity 0.7197 NPC46427
Intermediate Similarity 0.7169 NPC269398
Intermediate Similarity 0.7169 NPC263493
Intermediate Similarity 0.7152 NPC92784
Intermediate Similarity 0.7152 NPC476133
Intermediate Similarity 0.7152 NPC470884
Intermediate Similarity 0.7152 NPC98424
Intermediate Similarity 0.7152 NPC178662
Intermediate Similarity 0.7143 NPC315266
Intermediate Similarity 0.7143 NPC209509
Intermediate Similarity 0.7134 NPC252878
Intermediate Similarity 0.7118 NPC105717
Intermediate Similarity 0.7101 NPC262077
Intermediate Similarity 0.7089 NPC6975
Intermediate Similarity 0.7076 NPC283783
Intermediate Similarity 0.7076 NPC2501
Intermediate Similarity 0.707 NPC202521
Intermediate Similarity 0.7059 NPC138775
Intermediate Similarity 0.7048 NPC89489
Intermediate Similarity 0.7006 NPC476990
Intermediate Similarity 0.7006 NPC163392
Intermediate Similarity 0.7006 NPC239762
Remote Similarity 0.6994 NPC162104
Remote Similarity 0.6989 NPC297145
Remote Similarity 0.6989 NPC197743
Remote Similarity 0.6982 NPC52748
Remote Similarity 0.697 NPC248283
Remote Similarity 0.697 NPC141050
Remote Similarity 0.6964 NPC168113
Remote Similarity 0.6954 NPC122590
Remote Similarity 0.6936 NPC475168
Remote Similarity 0.6936 NPC7817
Remote Similarity 0.6923 NPC139326
Remote Similarity 0.6923 NPC176226
Remote Similarity 0.6923 NPC197682
Remote Similarity 0.6914 NPC319766
Remote Similarity 0.6905 NPC476259
Remote Similarity 0.6899 NPC200964
Remote Similarity 0.6864 NPC469427
Remote Similarity 0.6864 NPC469426
Remote Similarity 0.686 NPC145113
Remote Similarity 0.686 NPC225648
Remote Similarity 0.686 NPC329761
Remote Similarity 0.6854 NPC469898
Remote Similarity 0.6829 NPC200589
Remote Similarity 0.6824 NPC77905
Remote Similarity 0.6821 NPC471820
Remote Similarity 0.6821 NPC471821
Remote Similarity 0.6818 NPC470902
Remote Similarity 0.6816 NPC469901
Remote Similarity 0.6811 NPC318930
Remote Similarity 0.6811 NPC477462
Remote Similarity 0.6811 NPC317362
Remote Similarity 0.6788 NPC255447
Remote Similarity 0.6786 NPC127741
Remote Similarity 0.6786 NPC68865
Remote Similarity 0.6776 NPC473000
Remote Similarity 0.6751 NPC477527
Remote Similarity 0.6747 NPC246079
Remote Similarity 0.6725 NPC468984
Remote Similarity 0.672 NPC326407
Remote Similarity 0.672 NPC317725
Remote Similarity 0.6667 NPC474082
Remote Similarity 0.6667 NPC262166
Remote Similarity 0.6667 NPC175726
Remote Similarity 0.6667 NPC470546
Remote Similarity 0.6646 NPC470544
Remote Similarity 0.6632 NPC329731
Remote Similarity 0.6632 NPC4910
Remote Similarity 0.6612 NPC472923
Remote Similarity 0.6611 NPC326349
Remote Similarity 0.6611 NPC323336
Remote Similarity 0.6608 NPC307357
Remote Similarity 0.6608 NPC268841
Remote Similarity 0.6608 NPC46098
Remote Similarity 0.6604 NPC470545
Remote Similarity 0.6599 NPC184933
Remote Similarity 0.6599 NPC59827
Remote Similarity 0.6596 NPC469900
Remote Similarity 0.6592 NPC469903
Remote Similarity 0.6573 NPC56685
Remote Similarity 0.6573 NPC473341
Remote Similarity 0.6571 NPC135121
Remote Similarity 0.6566 NPC473322
Remote Similarity 0.6552 NPC471680
Remote Similarity 0.6538 NPC471527
Remote Similarity 0.6519 NPC324850
Remote Similarity 0.6517 NPC300443
Remote Similarity 0.65 NPC254088
Remote Similarity 0.6492 NPC472999
Remote Similarity 0.6485 NPC101719
Remote Similarity 0.648 NPC5194
Remote Similarity 0.648 NPC202198
Remote Similarity 0.648 NPC261934
Remote Similarity 0.6471 NPC475123
Remote Similarity 0.6471 NPC475204
Remote Similarity 0.6467 NPC471053
Remote Similarity 0.6467 NPC471052
Remote Similarity 0.6467 NPC471051
Remote Similarity 0.6461 NPC473491
Remote Similarity 0.646 NPC310467
Remote Similarity 0.6457 NPC477217
Remote Similarity 0.6457 NPC201244
Remote Similarity 0.6455 NPC471165
Remote Similarity 0.6448 NPC469902
Remote Similarity 0.6438 NPC239357
Remote Similarity 0.6436 NPC328494
Remote Similarity 0.6432 NPC477632
Remote Similarity 0.6432 NPC5719
Remote Similarity 0.6432 NPC477638
Remote Similarity 0.6432 NPC22883
Remote Similarity 0.6432 NPC210377
Remote Similarity 0.6432 NPC217804
Remote Similarity 0.6424 NPC22746
Remote Similarity 0.6424 NPC222466
Remote Similarity 0.6413 NPC241794
Remote Similarity 0.6413 NPC68650
Remote Similarity 0.6398 NPC169328
Remote Similarity 0.6398 NPC15068
Remote Similarity 0.6393 NPC24617
Remote Similarity 0.6393 NPC1390
Remote Similarity 0.6393 NPC62104
Remote Similarity 0.6373 NPC477637
Remote Similarity 0.6369 NPC111428
Remote Similarity 0.6368 NPC26108
Remote Similarity 0.6364 NPC302597
Remote Similarity 0.6364 NPC63040
Remote Similarity 0.6359 NPC114806
Remote Similarity 0.6358 NPC237420
Remote Similarity 0.635 NPC239660
Remote Similarity 0.635 NPC106235
Remote Similarity 0.6335 NPC285926
Remote Similarity 0.6335 NPC14672
Remote Similarity 0.6335 NPC315276
Remote Similarity 0.6332 NPC477631
Remote Similarity 0.6328 NPC81026
Remote Similarity 0.6324 NPC73655
Remote Similarity 0.6324 NPC73644
Remote Similarity 0.6319 NPC244509
Remote Similarity 0.6316 NPC137627
Remote Similarity 0.6313 NPC477636
Remote Similarity 0.631 NPC254700
Remote Similarity 0.6296 NPC40234
Remote Similarity 0.6292 NPC16188
Remote Similarity 0.6286 NPC476989
Remote Similarity 0.6283 NPC158277
Remote Similarity 0.6283 NPC136797
Remote Similarity 0.6281 NPC477526
Remote Similarity 0.628 NPC477061
Remote Similarity 0.628 NPC45777
Remote Similarity 0.6271 NPC266741
Remote Similarity 0.627 NPC473003
Remote Similarity 0.6264 NPC132636
Remote Similarity 0.6264 NPC473002
Remote Similarity 0.6256 NPC470112
Remote Similarity 0.6256 NPC470903
Remote Similarity 0.6256 NPC167763
Remote Similarity 0.625 NPC475427
Remote Similarity 0.6243 NPC469904
Remote Similarity 0.6242 NPC71684
Remote Similarity 0.6223 NPC61004
Remote Similarity 0.6218 NPC473001
Remote Similarity 0.6216 NPC244336
Remote Similarity 0.6216 NPC104345
Remote Similarity 0.6211 NPC33742
Remote Similarity 0.6201 NPC311658
Remote Similarity 0.6198 NPC476227
Remote Similarity 0.6193 NPC307396
Remote Similarity 0.619 NPC47667
Remote Similarity 0.619 NPC294516
Remote Similarity 0.619 NPC107938
Remote Similarity 0.6182 NPC478015
Remote Similarity 0.6182 NPC478014
Remote Similarity 0.6182 NPC478016
Remote Similarity 0.6178 NPC89831
Remote Similarity 0.6175 NPC39431
Remote Similarity 0.6166 NPC50016
Remote Similarity 0.6163 NPC246913
Remote Similarity 0.6158 NPC477639
Remote Similarity 0.6158 NPC329295
Remote Similarity 0.6158 NPC186617
Remote Similarity 0.6154 NPC470274
Remote Similarity 0.615 NPC329961

Drug Structure

External Identifiers

TTD  
DrugBank  
ChEMBL  
IUPHAR/BPS  
PharmaGKB  
KEGG Drug  
PubChem CID  
ChEBI  
CAS Number  

Drug Properties

Molecular Weight  755.36
ALogP  -0.5187
MLogP  3.99
XLogP  6.035
HDA  14
HBD  3
Rotatable Bonds  15
TPSA  199.37
RO5 Violation  2