Natural Product: NPC45934

Natural Product ID:  NPC45934
Common Name:   Dorsilurin C
IUPAC Name:   2-(2,2-dimethylchromen-7-yl)-3,5,7-trihydroxy-6,8-bis(3-methylbut-2-enyl)chromen-4-one
Synonyms:   Dorsilurin C
Molecular Formula:   C30H32O6
Standard InCHIKey:  GKELGBDDLUFHJZ-UHFFFAOYSA-N
Standard InCHI:  InChI=1S/C30H32O6/c1-16(2)7-11-20-24(31)21(12-8-17(3)4)29-23(25(20)32)26(33)27(34)28(35-29)19-10-9-18-13-14-30(5,6)36-22(18)15-19/h7-10,13-15,31-32,34H,11-12H2,1-6H3
Canonical SMILES:  CC(=CCc1c(O)c(CC=C(C)C)c(c2c1oc(c1ccc3c(c1)OC(C=C3)(C)C)c(c2=O)O)O)C
First Find Year:  
Max Developmental Stage:  
Synthetic Gene Cluster:   ;

  Species Source

Organism ID Organism Name Taxonomy Level Family SuperKingdom Isolation Part Collection Location Collection Time Reference
NPO4673 Dorstenia psilurus Species Moraceae Eukaryota PMID[19061390]

  Biological Activity

Target ID Target Type Target Name Target Organism Activity Type Activity Relation Value Unit Reference
NPT2 Others Unspecified IC50 = 358210 nM 12762798
NPT2 Others Unspecified IC50 = 422210 nM 12762798
NPT2 Others Unspecified IC50 = 11170 nM 16722644

  Similar Natural Products in NPASS

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient

●  The left chart: Distribution of similarity level between NPC45934 and all remaining natural products in the NPASS database.
●  The right table: Most similar natural products (Tc>=0.56 or Top200).

Similarity Score Similarity Level Natural Product ID
0.9863 High Similarity NPC142527
0.9793 High Similarity NPC269420
0.973 High Similarity NPC275575
0.9655 High Similarity NPC14001
0.9655 High Similarity NPC166757
0.96 High Similarity NPC281137
0.96 High Similarity NPC282390
0.9589 High Similarity NPC244407
0.9586 High Similarity NPC220418
0.953 High Similarity NPC193200
0.947 High Similarity NPC237418
0.9456 High Similarity NPC296869
0.9452 High Similarity NPC124729
0.9448 High Similarity NPC24821
0.9448 High Similarity NPC293053
0.9448 High Similarity NPC212932
0.9448 High Similarity NPC9117
0.9448 High Similarity NPC190637
0.9392 High Similarity NPC474052
0.9384 High Similarity NPC216538
0.9384 High Similarity NPC326500
0.9384 High Similarity NPC273538
0.9379 High Similarity NPC214236
0.9379 High Similarity NPC293852
0.9379 High Similarity NPC62840
0.9379 High Similarity NPC473042
0.9379 High Similarity NPC217083
0.9379 High Similarity NPC59739
0.9379 High Similarity NPC200694
0.9379 High Similarity NPC78803
0.9379 High Similarity NPC299080
0.9329 High Similarity NPC472633
0.932 High Similarity NPC5820
0.932 High Similarity NPC178343
0.932 High Similarity NPC306488
0.9315 High Similarity NPC219915
0.9272 High Similarity NPC329844
0.9272 High Similarity NPC210942
0.9272 High Similarity NPC169990
0.9272 High Similarity NPC170492
0.9262 High Similarity NPC5173
0.9257 High Similarity NPC237635
0.9257 High Similarity NPC104406
0.9257 High Similarity NPC97716
0.9257 High Similarity NPC201731
0.9257 High Similarity NPC79469
0.9257 High Similarity NPC24673
0.9216 High Similarity NPC218871
0.9216 High Similarity NPC476630
0.9205 High Similarity NPC63187
0.9205 High Similarity NPC157784
0.9205 High Similarity NPC37684
0.92 High Similarity NPC120105
0.92 High Similarity NPC61258
0.92 High Similarity NPC188403
0.92 High Similarity NPC101957
0.9195 High Similarity NPC6511
0.9195 High Similarity NPC266572
0.9189 High Similarity NPC329678
0.9189 High Similarity NPC196114
0.9184 High Similarity NPC38219
0.9184 High Similarity NPC158874
0.9178 High Similarity NPC64908
0.9178 High Similarity NPC156590
0.9178 High Similarity NPC118840
0.9178 High Similarity NPC205006
0.9178 High Similarity NPC147688
0.9172 High Similarity NPC55018
0.9172 High Similarity NPC301217
0.9172 High Similarity NPC96565
0.9172 High Similarity NPC216978
0.9172 High Similarity NPC303633
0.9172 High Similarity NPC220062
0.915 High Similarity NPC276444
0.915 High Similarity NPC471985
0.9145 High Similarity NPC280530
0.9145 High Similarity NPC236756
0.9145 High Similarity NPC95842
0.9145 High Similarity NPC311579
0.9145 High Similarity NPC178964
0.9139 High Similarity NPC205046
0.9139 High Similarity NPC59162
0.9139 High Similarity NPC304295
0.9139 High Similarity NPC478148
0.9133 High Similarity NPC10027
0.9133 High Similarity NPC97029
0.9133 High Similarity NPC65589
0.9133 High Similarity NPC288036
0.9133 High Similarity NPC470461
0.9133 High Similarity NPC469932
0.9133 High Similarity NPC158338
0.9133 High Similarity NPC100985
0.9133 High Similarity NPC97028
0.9133 High Similarity NPC65775
0.9133 High Similarity NPC223988
0.9128 High Similarity NPC296998
0.9128 High Similarity NPC473077
0.9128 High Similarity NPC283234
0.9122 High Similarity NPC319752
0.9122 High Similarity NPC234629
0.9122 High Similarity NPC311741
0.9116 High Similarity NPC11561
0.9116 High Similarity NPC226636
0.9116 High Similarity NPC144499
0.9116 High Similarity NPC1534
0.911 High Similarity NPC159275
0.911 High Similarity NPC261227
0.911 High Similarity NPC241100
0.911 High Similarity NPC235239
0.911 High Similarity NPC475680
0.911 High Similarity NPC172986
0.911 High Similarity NPC150522
0.911 High Similarity NPC270883
0.911 High Similarity NPC305355
0.9103 High Similarity NPC201395
0.9103 High Similarity NPC78332
0.9091 High Similarity NPC273843
0.9085 High Similarity NPC259710
0.9085 High Similarity NPC476169
0.9085 High Similarity NPC133392
0.9085 High Similarity NPC304207
0.9085 High Similarity NPC217706
0.9085 High Similarity NPC55662
0.9085 High Similarity NPC207809
0.9085 High Similarity NPC166054
0.9085 High Similarity NPC48579
0.9073 High Similarity NPC88804
0.9073 High Similarity NPC37348
0.9073 High Similarity NPC29777
0.9073 High Similarity NPC3825
0.9073 High Similarity NPC471984
0.9073 High Similarity NPC471115
0.9067 High Similarity NPC161864
0.9067 High Similarity NPC470460
0.9067 High Similarity NPC186397
0.9067 High Similarity NPC321623
0.9067 High Similarity NPC469933
0.9067 High Similarity NPC189087
0.9067 High Similarity NPC27221
0.9067 High Similarity NPC208303
0.9067 High Similarity NPC256672
0.9067 High Similarity NPC132592
0.9067 High Similarity NPC7025
0.9067 High Similarity NPC37135
0.9067 High Similarity NPC160821
0.9067 High Similarity NPC161191
0.906 High Similarity NPC57470
0.906 High Similarity NPC111786
0.906 High Similarity NPC476088
0.906 High Similarity NPC83357
0.906 High Similarity NPC142405
0.906 High Similarity NPC54577
0.906 High Similarity NPC246948
0.906 High Similarity NPC301276
0.906 High Similarity NPC312973
0.906 High Similarity NPC470647
0.906 High Similarity NPC20488
0.906 High Similarity NPC67805
0.906 High Similarity NPC214774
0.906 High Similarity NPC195621
0.906 High Similarity NPC24136
0.906 High Similarity NPC470458
0.906 High Similarity NPC88964
0.906 High Similarity NPC290133
0.906 High Similarity NPC267375
0.906 High Similarity NPC176229
0.906 High Similarity NPC475052
0.906 High Similarity NPC187282
0.906 High Similarity NPC474161
0.9054 High Similarity NPC11700
0.9054 High Similarity NPC106985
0.9054 High Similarity NPC166138
0.9054 High Similarity NPC18585
0.9048 High Similarity NPC282300
0.9048 High Similarity NPC14871
0.9048 High Similarity NPC110969
0.9048 High Similarity NPC103362
0.9048 High Similarity NPC262094
0.9048 High Similarity NPC90582
0.9041 High Similarity NPC152042
0.9041 High Similarity NPC217186
0.9041 High Similarity NPC241838
0.9041 High Similarity NPC78913
0.9041 High Similarity NPC143799
0.9041 High Similarity NPC18260
0.9041 High Similarity NPC53181
0.9032 High Similarity NPC177650
0.9026 High Similarity NPC470354
0.9026 High Similarity NPC192587
0.9026 High Similarity NPC470352
0.9026 High Similarity NPC282307
0.9026 High Similarity NPC170026
0.9026 High Similarity NPC3980
0.9026 High Similarity NPC13779
0.9026 High Similarity NPC475799
0.902 High Similarity NPC100134
0.902 High Similarity NPC209760
0.902 High Similarity NPC248793
0.902 High Similarity NPC180301
0.902 High Similarity NPC472462

  Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

●  The left chart: Distribution of similarity level between NPC45934 and all drugs/candidates.
●  The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).

Similarity Score Similarity Level Drug ID Developmental Stage
0.9384 High Similarity NPD4378 Clinical (unspecified phase)
0.8993 High Similarity NPD7410 Clinical (unspecified phase)
0.8808 High Similarity NPD1512 Approved
0.8774 High Similarity NPD2393 Clinical (unspecified phase)
0.8675 High Similarity NPD1511 Approved
0.8608 High Similarity NPD7075 Discontinued
0.8599 High Similarity NPD8443 Clinical (unspecified phase)
0.8581 High Similarity NPD4380 Phase 2
0.8562 High Similarity NPD6959 Discontinued
0.8535 High Similarity NPD2801 Approved
0.8535 High Similarity NPD7819 Suspended
0.8535 High Similarity NPD7096 Clinical (unspecified phase)
0.8523 High Similarity NPD1550 Clinical (unspecified phase)
0.8523 High Similarity NPD1552 Clinical (unspecified phase)
0.8514 High Similarity NPD1510 Phase 2
0.8503 High Similarity NPD1607 Approved
0.8476 Intermediate Similarity NPD7804 Clinical (unspecified phase)
0.8471 Intermediate Similarity NPD1934 Approved
0.8467 Intermediate Similarity NPD1549 Phase 2
0.8456 Intermediate Similarity NPD2796 Approved
0.8408 Intermediate Similarity NPD7411 Suspended
0.8405 Intermediate Similarity NPD6167 Clinical (unspecified phase)
0.8405 Intermediate Similarity NPD6166 Phase 2
0.8405 Intermediate Similarity NPD6168 Clinical (unspecified phase)
0.8367 Intermediate Similarity NPD1240 Approved
0.8365 Intermediate Similarity NPD3817 Phase 2
0.8354 Intermediate Similarity NPD6801 Discontinued
0.8313 Intermediate Similarity NPD3882 Suspended
0.8261 Intermediate Similarity NPD4381 Clinical (unspecified phase)
0.8242 Intermediate Similarity NPD7473 Discontinued
0.8235 Intermediate Similarity NPD3750 Approved
0.8228 Intermediate Similarity NPD6599 Discontinued
0.8214 Intermediate Similarity NPD7251 Discontinued
0.8212 Intermediate Similarity NPD6099 Approved
0.8212 Intermediate Similarity NPD6100 Approved
0.8199 Intermediate Similarity NPD7768 Phase 2
0.8194 Intermediate Similarity NPD6799 Approved
0.8171 Intermediate Similarity NPD6232 Discontinued
0.817 Intermediate Similarity NPD2800 Approved
0.8166 Intermediate Similarity NPD7808 Phase 3
0.8155 Intermediate Similarity NPD6797 Phase 2
0.8144 Intermediate Similarity NPD7054 Approved
0.8141 Intermediate Similarity NPD2532 Approved
0.8141 Intermediate Similarity NPD2534 Approved
0.8141 Intermediate Similarity NPD2533 Approved
0.8137 Intermediate Similarity NPD5402 Approved
0.8105 Intermediate Similarity NPD970 Clinical (unspecified phase)
0.8095 Intermediate Similarity NPD7074 Phase 3
0.8095 Intermediate Similarity NPD7472 Approved
0.8092 Intermediate Similarity NPD2935 Discontinued
0.8077 Intermediate Similarity NPD7390 Discontinued
0.8072 Intermediate Similarity NPD7852 Clinical (unspecified phase)
0.805 Intermediate Similarity NPD3226 Approved
0.8049 Intermediate Similarity NPD5494 Approved
0.8038 Intermediate Similarity NPD5403 Approved
0.8037 Intermediate Similarity NPD3749 Approved
0.8026 Intermediate Similarity NPD1509 Clinical (unspecified phase)
0.8 Intermediate Similarity NPD6559 Discontinued
0.8 Intermediate Similarity NPD6398 Clinical (unspecified phase)
0.7976 Intermediate Similarity NPD3818 Discontinued
0.7974 Intermediate Similarity NPD1551 Phase 2
0.7953 Intermediate Similarity NPD4338 Clinical (unspecified phase)
0.7935 Intermediate Similarity NPD1243 Approved
0.7935 Intermediate Similarity NPD7421 Clinical (unspecified phase)
0.7929 Intermediate Similarity NPD5844 Phase 1
0.7922 Intermediate Similarity NPD2346 Discontinued
0.7911 Intermediate Similarity NPD5401 Approved
0.7908 Intermediate Similarity NPD3748 Approved
0.7895 Intermediate Similarity NPD6651 Approved
0.7867 Intermediate Similarity NPD2313 Discontinued
0.7867 Intermediate Similarity NPD6859 Clinical (unspecified phase)
0.7866 Intermediate Similarity NPD4868 Clinical (unspecified phase)
0.7812 Intermediate Similarity NPD920 Approved
0.78 Intermediate Similarity NPD4625 Phase 3
0.7797 Intermediate Similarity NPD7879 Clinical (unspecified phase)
0.7792 Intermediate Similarity NPD2799 Discontinued
0.7784 Intermediate Similarity NPD1247 Approved
0.7771 Intermediate Similarity NPD919 Approved
0.7746 Intermediate Similarity NPD4419 Clinical (unspecified phase)
0.7719 Intermediate Similarity NPD7286 Phase 2
0.7692 Intermediate Similarity NPD2344 Approved
0.7688 Intermediate Similarity NPD642 Clinical (unspecified phase)
0.7677 Intermediate Similarity NPD4308 Phase 3
0.7673 Intermediate Similarity NPD643 Clinical (unspecified phase)
0.7647 Intermediate Similarity NPD943 Approved
0.7632 Intermediate Similarity NPD4907 Clinical (unspecified phase)
0.763 Intermediate Similarity NPD7993 Clinical (unspecified phase)
0.763 Intermediate Similarity NPD5953 Discontinued
0.7588 Intermediate Similarity NPD3926 Phase 2
0.7547 Intermediate Similarity NPD1878 Clinical (unspecified phase)
0.7547 Intermediate Similarity NPD4628 Phase 3
0.7533 Intermediate Similarity NPD1203 Approved
0.753 Intermediate Similarity NPD1465 Phase 2
0.7529 Intermediate Similarity NPD5711 Approved
0.7529 Intermediate Similarity NPD5710 Approved
0.7527 Intermediate Similarity NPD8090 Clinical (unspecified phase)
0.7517 Intermediate Similarity NPD4749 Approved
0.7516 Intermediate Similarity NPD3268 Approved
0.7516 Intermediate Similarity NPD5406 Approved
0.7516 Intermediate Similarity NPD5408 Approved
0.7516 Intermediate Similarity NPD5404 Approved
0.7516 Intermediate Similarity NPD5405 Approved
0.7514 Intermediate Similarity NPD4363 Phase 3
0.7514 Intermediate Similarity NPD4360 Phase 2
0.75 Intermediate Similarity NPD2309 Approved
0.75 Intermediate Similarity NPD4908 Phase 1
0.7484 Intermediate Similarity NPD5124 Phase 1
0.7484 Intermediate Similarity NPD5123 Clinical (unspecified phase)
0.7483 Intermediate Similarity NPD2798 Approved
0.7469 Intermediate Similarity NPD7004 Clinical (unspecified phase)
0.7467 Intermediate Similarity NPD3225 Approved
0.7452 Intermediate Similarity NPD7033 Discontinued
0.7419 Intermediate Similarity NPD4307 Phase 2
0.7417 Intermediate Similarity NPD2797 Approved
0.7405 Intermediate Similarity NPD6780 Approved
0.7405 Intermediate Similarity NPD6778 Approved
0.7405 Intermediate Similarity NPD6776 Approved
0.7405 Intermediate Similarity NPD6781 Approved
0.7405 Intermediate Similarity NPD6777 Approved
0.7405 Intermediate Similarity NPD6782 Approved
0.7405 Intermediate Similarity NPD6779 Approved
0.7403 Intermediate Similarity NPD6410 Clinical (unspecified phase)
0.7403 Intermediate Similarity NPD411 Approved
0.7401 Intermediate Similarity NPD8312 Approved
0.7401 Intermediate Similarity NPD8313 Approved
0.7394 Intermediate Similarity NPD7458 Discontinued
0.7394 Intermediate Similarity NPD5808 Clinical (unspecified phase)
0.7386 Intermediate Similarity NPD1529 Clinical (unspecified phase)
0.7386 Intermediate Similarity NPD6832 Phase 2
0.7383 Intermediate Similarity NPD1201 Approved
0.7383 Intermediate Similarity NPD422 Phase 1
0.738 Intermediate Similarity NPD7435 Discontinued
0.738 Intermediate Similarity NPD7696 Phase 3
0.738 Intermediate Similarity NPD7697 Approved
0.738 Intermediate Similarity NPD7698 Approved
0.7374 Intermediate Similarity NPD8150 Discontinued
0.7358 Intermediate Similarity NPD1471 Phase 3
0.7356 Intermediate Similarity NPD3751 Discontinued
0.7347 Intermediate Similarity NPD1548 Phase 1
0.7342 Intermediate Similarity NPD651 Clinical (unspecified phase)
0.734 Intermediate Similarity NPD7870 Phase 2
0.734 Intermediate Similarity NPD7871 Phase 2
0.7333 Intermediate Similarity NPD9717 Approved
0.7333 Intermediate Similarity NPD1608 Approved
0.7326 Intermediate Similarity NPD3787 Discontinued
0.7326 Intermediate Similarity NPD7229 Phase 3
0.732 Intermediate Similarity NPD1530 Clinical (unspecified phase)
0.7305 Intermediate Similarity NPD7615 Clinical (unspecified phase)
0.7303 Intermediate Similarity NPD1470 Approved
0.7293 Intermediate Similarity NPD8397 Clinical (unspecified phase)
0.7283 Intermediate Similarity NPD4361 Phase 2
0.7283 Intermediate Similarity NPD4362 Clinical (unspecified phase)
0.7278 Intermediate Similarity NPD4288 Approved
0.7278 Intermediate Similarity NPD8434 Phase 2
0.7273 Intermediate Similarity NPD6980 Clinical (unspecified phase)
0.7267 Intermediate Similarity NPD1610 Phase 2
0.7267 Intermediate Similarity NPD1547 Clinical (unspecified phase)
0.7263 Intermediate Similarity NPD7584 Approved
0.7262 Intermediate Similarity NPD6844 Discontinued
0.7261 Intermediate Similarity NPD1899 Clinical (unspecified phase)
0.7261 Intermediate Similarity NPD447 Suspended
0.7241 Intermediate Similarity NPD7784 Clinical (unspecified phase)
0.7225 Intermediate Similarity NPD7701 Phase 2
0.7222 Intermediate Similarity NPD8055 Clinical (unspecified phase)
0.7222 Intermediate Similarity NPD7003 Approved
0.7219 Intermediate Similarity NPD3972 Approved
0.7219 Intermediate Similarity NPD7501 Clinical (unspecified phase)
0.7197 Intermediate Similarity NPD1613 Approved
0.7197 Intermediate Similarity NPD1612 Clinical (unspecified phase)
0.719 Intermediate Similarity NPD3266 Approved
0.719 Intermediate Similarity NPD3267 Approved
0.716 Intermediate Similarity NPD2654 Approved
0.7159 Intermediate Similarity NPD5940 Clinical (unspecified phase)
0.7159 Intermediate Similarity NPD7177 Discontinued
0.7152 Intermediate Similarity NPD230 Phase 1
0.715 Intermediate Similarity NPD7875 Clinical (unspecified phase)
0.715 Intermediate Similarity NPD7874 Approved
0.7143 Intermediate Similarity NPD2403 Approved
0.7143 Intermediate Similarity NPD6585 Discontinued
0.7135 Intermediate Similarity NPD6535 Approved
0.7135 Intermediate Similarity NPD6534 Approved
0.7134 Intermediate Similarity NPD3300 Phase 2
0.7133 Intermediate Similarity NPD17 Approved
0.7118 Intermediate Similarity NPD5761 Phase 2
0.7118 Intermediate Similarity NPD5760 Phase 2
0.7115 Intermediate Similarity NPD7095 Approved
0.7113 Intermediate Similarity NPD7801 Approved
0.7113 Intermediate Similarity NPD7782 Clinical (unspecified phase)
0.7113 Intermediate Similarity NPD7783 Phase 2
0.7112 Intermediate Similarity NPD7699 Phase 2
0.7112 Intermediate Similarity NPD7700 Phase 2
0.7108 Intermediate Similarity NPD5049 Phase 3
0.7104 Intermediate Similarity NPD4287 Approved
0.7098 Intermediate Similarity NPD8151 Discontinued
0.7091 Intermediate Similarity NPD6143 Clinical (unspecified phase)
0.7089 Intermediate Similarity NPD4060 Phase 1
0.7086 Intermediate Similarity NPD7184 Clinical (unspecified phase)
0.7079 Intermediate Similarity NPD1729 Discontinued
0.7073 Intermediate Similarity NPD2354 Approved
0.707 Intermediate Similarity NPD1296 Phase 2

Structure

External Identifiers

PubChem CID   15478904
ChEMBL   CHEMBL455687
ZINC  

Physicochemical Properties

Molecular Weight:  488.22
ALogP:  2.782
MLogP:  4.1
XLogP:  6.255
# Rotatable Bonds:  14
Polar Surface Area:  96.22
# H-Bond Aceptor:  2
# H-Bond Donor:  3
# Rings:  4
# Heavy Atoms:  36

Download Data

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Biological Activities  
Similar NPs/Drugs