Natural Product: NPC273843

Natural Product ID:  NPC273843
Common Name:   Notabilisin C
IUPAC Name:   2-[2-[(2E)-3,7-dimethylocta-2,6-dienyl]-3,4-dihydroxyphenyl]-3,5,7-trihydroxy-8-(3-methylbut-2-enyl)chromen-4-one
Synonyms:   Notabilisin C
Molecular Formula:   C30H34O7
Standard InCHIKey:  MQNQGTVUMGNSEG-VCHYOVAHSA-N
Standard InCHI:  InChI=1S/C30H34O7/c1-16(2)7-6-8-18(5)10-12-19-20(13-14-22(31)26(19)34)30-28(36)27(35)25-24(33)15-23(32)21(29(25)37-30)11-9-17(3)4/h7,9-10,13-15,31-34,36H,6,8,11-12H2,1-5H3/b18-10+
Canonical SMILES:  C/C(=CCc1c(O)c(O)ccc1c1oc2c(CC=C(C)C)c(O)cc(c2c(=O)c1O)O)/CCC=C(C)C
First Find Year:  
Max Developmental Stage:  
Synthetic Gene Cluster:   ;

  Species Source

Organism ID Organism Name Taxonomy Level Family SuperKingdom Isolation Part Collection Location Collection Time Reference
NPO27320 Morus notabilis Species Moraceae Eukaryota PMID[21737271]

  Biological Activity

Target ID Target Type Target Name Target Organism Activity Type Activity Relation Value Unit Reference
NPT520 Cell Line 3T3-L1 Mus musculus Activity = 948.51 % 15646539
NPT520 Cell Line 3T3-L1 Mus musculus Activity = 312.24 % 15646539

  Similar Natural Products in NPASS

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient

●  The left chart: Distribution of similarity level between NPC273843 and all remaining natural products in the NPASS database.
●  The right table: Most similar natural products (Tc>=0.56 or Top200).

Similarity Score Similarity Level Natural Product ID
0.9933 High Similarity NPC13779
0.9933 High Similarity NPC475799
0.9732 High Similarity NPC37684
0.9732 High Similarity NPC63187
0.9732 High Similarity NPC157784
0.9669 High Similarity NPC3980
0.9664 High Similarity NPC304295
0.9664 High Similarity NPC59162
0.9664 High Similarity NPC205046
0.9605 High Similarity NPC237418
0.9603 High Similarity NPC80534
0.9603 High Similarity NPC133392
0.9603 High Similarity NPC56786
0.9597 High Similarity NPC88804
0.9597 High Similarity NPC3825
0.9542 High Similarity NPC210459
0.9484 High Similarity NPC211107
0.9481 High Similarity NPC321399
0.9477 High Similarity NPC236796
0.947 High Similarity NPC249570
0.9419 High Similarity NPC278427
0.9416 High Similarity NPC46736
0.9416 High Similarity NPC197856
0.9416 High Similarity NPC280680
0.9412 High Similarity NPC142339
0.9408 High Similarity NPC476631
0.9408 High Similarity NPC170492
0.9404 High Similarity NPC154345
0.94 High Similarity NPC270465
0.94 High Similarity NPC87125
0.9363 High Similarity NPC475888
0.9359 High Similarity NPC329760
0.9359 High Similarity NPC201800
0.9359 High Similarity NPC78332
0.9355 High Similarity NPC320359
0.9355 High Similarity NPC45146
0.9355 High Similarity NPC476280
0.9355 High Similarity NPC471973
0.9355 High Similarity NPC36217
0.9355 High Similarity NPC119224
0.9355 High Similarity NPC235018
0.9355 High Similarity NPC297212
0.9351 High Similarity NPC136674
0.9351 High Similarity NPC476630
0.9351 High Similarity NPC218871
0.9346 High Similarity NPC67396
0.9342 High Similarity NPC471982
0.9338 High Similarity NPC286342
0.9338 High Similarity NPC188871
0.9338 High Similarity NPC149127
0.9329 High Similarity NPC179271
0.9329 High Similarity NPC20791
0.9304 High Similarity NPC39091
0.9299 High Similarity NPC189473
0.9299 High Similarity NPC474240
0.9299 High Similarity NPC23298
0.9299 High Similarity NPC207690
0.9299 High Similarity NPC186686
0.9295 High Similarity NPC32694
0.9295 High Similarity NPC187354
0.9295 High Similarity NPC40491
0.9295 High Similarity NPC278052
0.929 High Similarity NPC235448
0.929 High Similarity NPC22192
0.929 High Similarity NPC100123
0.929 High Similarity NPC85121
0.9286 High Similarity NPC472907
0.9286 High Similarity NPC24640
0.9286 High Similarity NPC471985
0.9286 High Similarity NPC276444
0.9286 High Similarity NPC153512
0.9281 High Similarity NPC179126
0.9281 High Similarity NPC89474
0.9281 High Similarity NPC189130
0.9281 High Similarity NPC78326
0.9281 High Similarity NPC270620
0.9281 High Similarity NPC213896
0.9281 High Similarity NPC192083
0.9281 High Similarity NPC236223
0.9281 High Similarity NPC298692
0.9276 High Similarity NPC200740
0.9276 High Similarity NPC260895
0.9276 High Similarity NPC125062
0.9276 High Similarity NPC252933
0.9276 High Similarity NPC54394
0.9272 High Similarity NPC269420
0.9267 High Similarity NPC108406
0.9267 High Similarity NPC51443
0.9267 High Similarity NPC74881
0.9245 High Similarity NPC476306
0.9245 High Similarity NPC218226
0.9241 High Similarity NPC239752
0.9241 High Similarity NPC293319
0.9241 High Similarity NPC156432
0.9241 High Similarity NPC275780
0.9241 High Similarity NPC472450
0.9236 High Similarity NPC206605
0.9231 High Similarity NPC56085
0.9231 High Similarity NPC282009
0.9231 High Similarity NPC299436
0.9231 High Similarity NPC287328
0.9231 High Similarity NPC80375
0.9231 High Similarity NPC476283
0.9231 High Similarity NPC14353
0.9231 High Similarity NPC228785
0.9231 High Similarity NPC246478
0.9231 High Similarity NPC470183
0.9226 High Similarity NPC472963
0.9221 High Similarity NPC472280
0.9221 High Similarity NPC321779
0.9221 High Similarity NPC234255
0.9216 High Similarity NPC237994
0.9216 High Similarity NPC82325
0.9216 High Similarity NPC55205
0.9216 High Similarity NPC106976
0.9216 High Similarity NPC279989
0.9211 High Similarity NPC50728
0.9211 High Similarity NPC85131
0.9211 High Similarity NPC166753
0.92 High Similarity NPC169749
0.9195 High Similarity NPC190637
0.9195 High Similarity NPC9117
0.9195 High Similarity NPC212932
0.9195 High Similarity NPC24821
0.9195 High Similarity NPC293053
0.9195 High Similarity NPC279121
0.9182 High Similarity NPC43319
0.9182 High Similarity NPC37870
0.9182 High Similarity NPC472449
0.9177 High Similarity NPC7483
0.9177 High Similarity NPC270837
0.9177 High Similarity NPC476295
0.9177 High Similarity NPC12461
0.9177 High Similarity NPC236132
0.9177 High Similarity NPC220313
0.9177 High Similarity NPC472625
0.9172 High Similarity NPC61010
0.9172 High Similarity NPC471499
0.9172 High Similarity NPC474239
0.9172 High Similarity NPC289771
0.9172 High Similarity NPC474187
0.9167 High Similarity NPC469658
0.9167 High Similarity NPC172770
0.9167 High Similarity NPC185258
0.9161 High Similarity NPC274730
0.9161 High Similarity NPC209614
0.9161 High Similarity NPC68093
0.9161 High Similarity NPC291878
0.9161 High Similarity NPC265511
0.9161 High Similarity NPC472626
0.9161 High Similarity NPC49824
0.9161 High Similarity NPC282307
0.9161 High Similarity NPC170026
0.9161 High Similarity NPC470328
0.9161 High Similarity NPC195796
0.9161 High Similarity NPC472455
0.9161 High Similarity NPC471500
0.9161 High Similarity NPC191146
0.9161 High Similarity NPC278778
0.9161 High Similarity NPC35038
0.9156 High Similarity NPC473664
0.9156 High Similarity NPC33051
0.9156 High Similarity NPC472905
0.9156 High Similarity NPC58382
0.9156 High Similarity NPC227337
0.9156 High Similarity NPC74924
0.9156 High Similarity NPC162351
0.9156 High Similarity NPC273462
0.9156 High Similarity NPC49402
0.9156 High Similarity NPC93552
0.9156 High Similarity NPC70433
0.915 High Similarity NPC236769
0.915 High Similarity NPC133953
0.915 High Similarity NPC202157
0.915 High Similarity NPC50403
0.915 High Similarity NPC28274
0.9145 High Similarity NPC183950
0.9145 High Similarity NPC52005
0.9145 High Similarity NPC137062
0.9145 High Similarity NPC65775
0.9145 High Similarity NPC177298
0.9145 High Similarity NPC48479
0.9145 High Similarity NPC287101
0.9145 High Similarity NPC195351
0.9145 High Similarity NPC38545
0.9145 High Similarity NPC171916
0.9145 High Similarity NPC10027
0.9145 High Similarity NPC223579
0.9145 High Similarity NPC159103
0.9139 High Similarity NPC259632
0.9133 High Similarity NPC216538
0.9133 High Similarity NPC326500
0.9133 High Similarity NPC70136
0.9133 High Similarity NPC273538
0.9128 High Similarity NPC473042
0.9128 High Similarity NPC175013
0.9128 High Similarity NPC200694
0.9125 High Similarity NPC126204
0.9119 High Similarity NPC303174
0.9119 High Similarity NPC62261

  Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

●  The left chart: Distribution of similarity level between NPC273843 and all drugs/candidates.
●  The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).

Similarity Score Similarity Level Drug ID Developmental Stage
0.9329 High Similarity NPD1512 Approved
0.9281 High Similarity NPD2393 Clinical (unspecified phase)
0.9195 High Similarity NPD1511 Approved
0.9133 High Similarity NPD4378 Clinical (unspecified phase)
0.9032 High Similarity NPD2801 Approved
0.8968 High Similarity NPD1934 Approved
0.8797 High Similarity NPD3882 Suspended
0.8765 High Similarity NPD6166 Phase 2
0.8765 High Similarity NPD6168 Clinical (unspecified phase)
0.8765 High Similarity NPD6167 Clinical (unspecified phase)
0.8734 High Similarity NPD3817 Phase 2
0.8671 High Similarity NPD7819 Suspended
0.8625 High Similarity NPD7075 Discontinued
0.8598 High Similarity NPD7473 Discontinued
0.8563 High Similarity NPD7251 Discontinued
0.8553 High Similarity NPD7096 Clinical (unspecified phase)
0.8528 High Similarity NPD6232 Discontinued
0.8516 High Similarity NPD7410 Clinical (unspecified phase)
0.8503 High Similarity NPD6797 Phase 2
0.8494 Intermediate Similarity NPD7054 Approved
0.8481 Intermediate Similarity NPD4380 Phase 2
0.8443 Intermediate Similarity NPD7472 Approved
0.8443 Intermediate Similarity NPD7074 Phase 3
0.8434 Intermediate Similarity NPD3818 Discontinued
0.8402 Intermediate Similarity NPD7808 Phase 3
0.8385 Intermediate Similarity NPD8443 Clinical (unspecified phase)
0.8383 Intermediate Similarity NPD7804 Clinical (unspecified phase)
0.8375 Intermediate Similarity NPD6801 Discontinued
0.8354 Intermediate Similarity NPD6959 Discontinued
0.8301 Intermediate Similarity NPD1552 Clinical (unspecified phase)
0.8301 Intermediate Similarity NPD1550 Clinical (unspecified phase)
0.8294 Intermediate Similarity NPD4338 Clinical (unspecified phase)
0.8293 Intermediate Similarity NPD5494 Approved
0.8289 Intermediate Similarity NPD1510 Phase 2
0.8258 Intermediate Similarity NPD3750 Approved
0.8247 Intermediate Similarity NPD970 Clinical (unspecified phase)
0.8247 Intermediate Similarity NPD1549 Phase 2
0.8235 Intermediate Similarity NPD2796 Approved
0.8221 Intermediate Similarity NPD4868 Clinical (unspecified phase)
0.8217 Intermediate Similarity NPD6799 Approved
0.821 Intermediate Similarity NPD1465 Phase 2
0.8171 Intermediate Similarity NPD4381 Clinical (unspecified phase)
0.817 Intermediate Similarity NPD651 Clinical (unspecified phase)
0.8166 Intermediate Similarity NPD5844 Phase 1
0.8146 Intermediate Similarity NPD1240 Approved
0.8146 Intermediate Similarity NPD943 Approved
0.8137 Intermediate Similarity NPD6599 Discontinued
0.8086 Intermediate Similarity NPD7411 Suspended
0.8077 Intermediate Similarity NPD2800 Approved
0.805 Intermediate Similarity NPD2534 Approved
0.805 Intermediate Similarity NPD2533 Approved
0.805 Intermediate Similarity NPD2532 Approved
0.8039 Intermediate Similarity NPD1607 Approved
0.8024 Intermediate Similarity NPD1247 Approved
0.8012 Intermediate Similarity NPD919 Approved
0.8 Intermediate Similarity NPD7768 Phase 2
0.7965 Intermediate Similarity NPD7993 Clinical (unspecified phase)
0.7963 Intermediate Similarity NPD3226 Approved
0.7952 Intermediate Similarity NPD3749 Approved
0.7939 Intermediate Similarity NPD5402 Approved
0.7935 Intermediate Similarity NPD1509 Clinical (unspecified phase)
0.7935 Intermediate Similarity NPD3748 Approved
0.7929 Intermediate Similarity NPD3926 Phase 2
0.7885 Intermediate Similarity NPD2935 Discontinued
0.7885 Intermediate Similarity NPD6100 Approved
0.7885 Intermediate Similarity NPD6099 Approved
0.7882 Intermediate Similarity NPD7852 Clinical (unspecified phase)
0.7881 Intermediate Similarity NPD1529 Clinical (unspecified phase)
0.7875 Intermediate Similarity NPD7390 Discontinued
0.784 Intermediate Similarity NPD5403 Approved
0.7834 Intermediate Similarity NPD2346 Discontinued
0.7816 Intermediate Similarity NPD6559 Discontinued
0.7815 Intermediate Similarity NPD1530 Clinical (unspecified phase)
0.7736 Intermediate Similarity NPD7421 Clinical (unspecified phase)
0.7736 Intermediate Similarity NPD1243 Approved
0.7722 Intermediate Similarity NPD7879 Clinical (unspecified phase)
0.7719 Intermediate Similarity NPD7184 Clinical (unspecified phase)
0.7717 Intermediate Similarity NPD7501 Clinical (unspecified phase)
0.7716 Intermediate Similarity NPD5401 Approved
0.7709 Intermediate Similarity NPD8397 Clinical (unspecified phase)
0.7707 Intermediate Similarity NPD2799 Discontinued
0.7692 Intermediate Similarity NPD6651 Approved
0.7677 Intermediate Similarity NPD1612 Clinical (unspecified phase)
0.7677 Intermediate Similarity NPD1613 Approved
0.767 Intermediate Similarity NPD4419 Clinical (unspecified phase)
0.7662 Intermediate Similarity NPD6859 Clinical (unspecified phase)
0.7662 Intermediate Similarity NPD2313 Discontinued
0.7628 Intermediate Similarity NPD230 Phase 1
0.7622 Intermediate Similarity NPD920 Approved
0.761 Intermediate Similarity NPD2344 Approved
0.7602 Intermediate Similarity NPD7199 Phase 2
0.7597 Intermediate Similarity NPD4625 Phase 3
0.7588 Intermediate Similarity NPD6234 Discontinued
0.7586 Intermediate Similarity NPD3751 Discontinued
0.7578 Intermediate Similarity NPD6398 Clinical (unspecified phase)
0.7558 Intermediate Similarity NPD3787 Discontinued
0.7547 Intermediate Similarity NPD1551 Phase 2
0.7543 Intermediate Similarity NPD7286 Phase 2
0.7542 Intermediate Similarity NPD8055 Clinical (unspecified phase)
0.7516 Intermediate Similarity NPD447 Suspended
0.7515 Intermediate Similarity NPD6980 Clinical (unspecified phase)
0.75 Intermediate Similarity NPD7422 Clinical (unspecified phase)
0.75 Intermediate Similarity NPD642 Clinical (unspecified phase)
0.7485 Intermediate Similarity NPD643 Clinical (unspecified phase)
0.7484 Intermediate Similarity NPD3027 Phase 3
0.7469 Intermediate Similarity NPD4628 Phase 3
0.7459 Intermediate Similarity NPD8090 Clinical (unspecified phase)
0.7458 Intermediate Similarity NPD5953 Discontinued
0.7457 Intermediate Similarity NPD7229 Phase 3
0.7457 Intermediate Similarity NPD5710 Approved
0.7457 Intermediate Similarity NPD5711 Approved
0.7452 Intermediate Similarity NPD4060 Phase 1
0.7436 Intermediate Similarity NPD3268 Approved
0.7436 Intermediate Similarity NPD4907 Clinical (unspecified phase)
0.743 Intermediate Similarity NPD8312 Approved
0.743 Intermediate Similarity NPD8313 Approved
0.7423 Intermediate Similarity NPD2309 Approved
0.7417 Intermediate Similarity NPD1201 Approved
0.7403 Intermediate Similarity NPD8434 Phase 2
0.7403 Intermediate Similarity NPD2798 Approved
0.7403 Intermediate Similarity NPD8150 Discontinued
0.7396 Intermediate Similarity NPD37 Approved
0.7391 Intermediate Similarity NPD1471 Phase 3
0.7386 Intermediate Similarity NPD7228 Approved
0.7368 Intermediate Similarity NPD4966 Approved
0.7368 Intermediate Similarity NPD4965 Approved
0.7368 Intermediate Similarity NPD4967 Phase 2
0.7362 Intermediate Similarity NPD1878 Clinical (unspecified phase)
0.7351 Intermediate Similarity NPD4360 Phase 2
0.7351 Intermediate Similarity NPD4363 Phase 3
0.734 Intermediate Similarity NPD6776 Approved
0.734 Intermediate Similarity NPD6779 Approved
0.734 Intermediate Similarity NPD6781 Approved
0.734 Intermediate Similarity NPD6780 Approved
0.734 Intermediate Similarity NPD6777 Approved
0.734 Intermediate Similarity NPD6778 Approved
0.734 Intermediate Similarity NPD6782 Approved
0.7338 Intermediate Similarity NPD1470 Approved
0.7338 Intermediate Similarity NPD2797 Approved
0.7338 Intermediate Similarity NPD1203 Approved
0.7333 Intermediate Similarity NPD6143 Clinical (unspecified phase)
0.7329 Intermediate Similarity NPD5408 Approved
0.7329 Intermediate Similarity NPD5405 Approved
0.7329 Intermediate Similarity NPD5404 Approved
0.7329 Intermediate Similarity NPD5406 Approved
0.7317 Intermediate Similarity NPD6190 Approved
0.7316 Intermediate Similarity NPD7435 Discontinued
0.731 Intermediate Similarity NPD4288 Approved
0.7308 Intermediate Similarity NPD4908 Phase 1
0.7273 Intermediate Similarity NPD3300 Phase 2
0.7255 Intermediate Similarity NPD1608 Approved
0.7225 Intermediate Similarity NPD7698 Approved
0.7225 Intermediate Similarity NPD7697 Approved
0.7225 Intermediate Similarity NPD7696 Phase 3
0.7219 Intermediate Similarity NPD4361 Phase 2
0.7219 Intermediate Similarity NPD4362 Clinical (unspecified phase)
0.7219 Intermediate Similarity NPD5808 Clinical (unspecified phase)
0.7216 Intermediate Similarity NPD8151 Discontinued
0.7208 Intermediate Similarity NPD4379 Clinical (unspecified phase)
0.7197 Intermediate Similarity NPD6832 Phase 2
0.719 Intermediate Similarity NPD422 Phase 1
0.719 Intermediate Similarity NPD1610 Phase 2
0.7188 Intermediate Similarity NPD7871 Phase 2
0.7188 Intermediate Similarity NPD6355 Discontinued
0.7188 Intermediate Similarity NPD7870 Phase 2
0.7188 Intermediate Similarity NPD1933 Approved
0.7175 Intermediate Similarity NPD2403 Approved
0.7165 Intermediate Similarity NPD7701 Phase 2
0.716 Intermediate Similarity NPD4308 Phase 3
0.716 Intermediate Similarity NPD7033 Discontinued
0.716 Intermediate Similarity NPD1653 Approved
0.7152 Intermediate Similarity NPD1548 Phase 1
0.7152 Intermediate Similarity NPD7095 Approved
0.7143 Intermediate Similarity NPD9717 Approved
0.7143 Intermediate Similarity NPD9269 Phase 2
0.7135 Intermediate Similarity NPD7615 Clinical (unspecified phase)
0.7134 Intermediate Similarity NPD9494 Approved
0.7127 Intermediate Similarity NPD7685 Pre-registration
0.7118 Intermediate Similarity NPD7458 Discontinued
0.7115 Intermediate Similarity NPD3267 Approved
0.7115 Intermediate Similarity NPD3266 Approved
0.7113 Intermediate Similarity NPD7584 Approved
0.7107 Intermediate Similarity NPD6798 Discontinued
0.7107 Intermediate Similarity NPD3764 Approved
0.7097 Intermediate Similarity NPD4749 Approved
0.7092 Intermediate Similarity NPD7874 Approved
0.7092 Intermediate Similarity NPD7875 Clinical (unspecified phase)
0.7091 Intermediate Similarity NPD5698 Clinical (unspecified phase)
0.7083 Intermediate Similarity NPD7004 Clinical (unspecified phase)
0.7081 Intermediate Similarity NPD1899 Clinical (unspecified phase)
0.7078 Intermediate Similarity NPD1547 Clinical (unspecified phase)
0.7074 Intermediate Similarity NPD6535 Approved
0.7074 Intermediate Similarity NPD6534 Approved
0.7059 Intermediate Similarity NPD17 Approved
0.7056 Intermediate Similarity NPD7801 Approved
0.7056 Intermediate Similarity NPD7782 Clinical (unspecified phase)
0.7056 Intermediate Similarity NPD7783 Phase 2
0.7053 Intermediate Similarity NPD7700 Phase 2
0.7053 Intermediate Similarity NPD7699 Phase 2
0.7051 Intermediate Similarity NPD3225 Approved

Structure

External Identifiers

PubChem CID   53363479
ChEMBL   CHEMBL1808154
ZINC  

Physicochemical Properties

Molecular Weight:  506.23
ALogP:  2.1858
MLogP:  3.99
XLogP:  6.143
# Rotatable Bonds:  18
Polar Surface Area:  127.45
# H-Bond Aceptor:  2
# H-Bond Donor:  5
# Rings:  3
# Heavy Atoms:  37

Download Data

Data Type Select
General Info & Identifiers & Properties  
Structure MOL file  
Source Organisms  
Biological Activities  
Similar NPs/Drugs