Natural Product: NPC45270

Natural Product ID:  NPC45270
Common Name:   Menthone
IUPAC Name:   (2S,5R)-5-methyl-2-propan-2-ylcyclohexan-1-one
Synonyms:  
Molecular Formula:   C10H18O
Standard InCHIKey:  NFLGAXVYCFJBMK-BDAKNGLRSA-N
Standard InCHI:  InChI=1S/C10H18O/c1-7(2)9-5-4-8(3)6-10(9)11/h7-9H,4-6H2,1-3H3/t8-,9+/m1/s1
Canonical SMILES:  C[C@@H]1CC[C@H](C(=O)C1)C(C)C
First Find Year:  
Max Developmental Stage:  
Synthetic Gene Cluster:   ;

  Species Source

Organism ID Organism Name Taxonomy Level Family SuperKingdom Isolation Part Collection Location Collection Time Reference
NPO11492 Kopsia grandifolia Species Apocynaceae Eukaryota UNPD*
NPO13857 Mentha canadensis Species Lamiaceae Eukaryota TCMID*
NPO13766 Ceanothus velutinus Species Rhamnaceae Eukaryota UNPD*
NPO10492 Artemisia montana Species Asteraceae Eukaryota TM-MC*
NPO11329 Echinops grijsii Species Asteraceae Eukaryota TCMID*
NPO1795 Fragaria vesca Species Rosaceae Eukaryota UNPD*
NPO8650.1 Perilla frutescens var. arguta Varieties Lamiaceae Eukaryota TCMID*
NPO14162 Chlorophytum borivilianum Species Asparagaceae Eukaryota UNPD*
NPO10494 Alpinia katsumadai Species Staphylinidae Eukaryota TCMID*
NPO13014 Ipomoea cairica Species Convolvulaceae Eukaryota UNPD*
NPO3051 Mentha sp. Species Lamiaceae Eukaryota TCMID*
NPO11998 Ledebouria socialis Species Hyacinthaceae Eukaryota UNPD*
NPO6473.1 Perilla frutescens var. acuta Varieties Lamiaceae Eukaryota TCMID*
NPO11329 Echinops grijsii Species Asteraceae Eukaryota HerDing*
NPO8789 Schizonepeta tenuifolia Species Lamiaceae Eukaryota TCMID*
NPO23814 Elsholtzia splendens Species Lamiaceae Eukaryota HerDing*
NPO28696 Rhaponticum uniflorum Species Asteraceae Eukaryota HerDing*
NPO23814 Elsholtzia splendens Species Lamiaceae Eukaryota TCMID*
NPO30604 Mentha sp Species Lamiaceae Eukaryota HerDing*
NPO25094 Artemisia princeps Species Asteraceae Eukaryota TM-MC*
NPO28696 Rhaponticum uniflorum Species Asteraceae Eukaryota TCMID*
NPO31056 Mentha haplocalyx Species Lamiaceae Eukaryota HerDing*
NPO16087 Atractylodes lancea Species Asteraceae Eukaryota TM-MC*
NPO11230 Herba glechomae longitubae NA NA NA TCMID*
NPO6473.1 Perilla frutescens var. acuta Varieties Lamiaceae Eukaryota HerDing*
NPO20902 Atractylodes macrocephala Species Asteraceae Eukaryota TM-MC*
NPO5191 Penicillium cinerascens Species Aspergillaceae Eukaryota UNPD*
NPO8650.1 Perilla frutescens var. arguta Varieties Lamiaceae Eukaryota HerDing*
NPO25825 Saussurea costus Species Asteraceae Eukaryota TM-MC*
NPO8789 Schizonepeta tenuifolia Species Lamiaceae Eukaryota HerDing*
NPO28260 Senna alexandrina Species Fabaceae Eukaryota TM-MC*
NPO7016 Gardenia tubifera Species Rubiaceae Eukaryota UNPD*
NPO15373 Actaea dahurica Species Ranunculaceae Eukaryota TM-MC*
NPO29594 Herba taxilli NA NA NA TCMSP*
NPO15890 Actaea cimicifuga Species Ranunculaceae Eukaryota TM-MC*
NPO11144 Centella asiatica Species Apiaceae Eukaryota TCMSP*
NPO389 Actaea heracleifolia Species Ranunculaceae Eukaryota TM-MC*
NPO8650 Perilla frutescens Species Lamiaceae Eukaryota UNPD*
NPO24198 Radix cynanchi paniculati Species Lymnaeidae Eukaryota TCMSP*
NPO2727 Actaea simplex Species Ranunculaceae Eukaryota TM-MC*
NPO12357 Lycopus europaeus Species Lamiaceae Eukaryota UNPD*
NPO29697 Menthae herba NA NA NA TCMSP*
NPO4391 Hypericum perforatum Species Hypericaceae Eukaryota TM-MC*
NPO4004 Aquilegia ecalcarata Species Ranunculaceae Eukaryota UNPD*
NPO29545 Capsici fructus NA NA NA TCMSP*
NPO17755 Inula helenium Species Asteraceae Eukaryota TM-MC*
NPO14358 Rhodobacter sphaeroides Species Rhodobacteraceae Bacteria UNPD*
NPO3827 Violsse herba NA NA NA TCMSP*
NPO23548 Leonurus japonicus Species Lamiaceae Eukaryota TM-MC*
NPO205 Lasianthus fordii Species Rubiaceae Eukaryota UNPD*
NPO8455 Magnolia officinalis rehd et wils Species Magnoliaceae Eukaryota TCMSP*
NPO11474 Ligusticum jeholense Species Apiaceae Eukaryota TM-MC*
NPO4671 Persea mexicana Species Lauraceae Eukaryota UNPD*
NPO29667 Scutellariae radix NA NA NA TCMSP*
NPO18951 Ligusticum sinense Species Apiaceae Eukaryota TM-MC*
NPO8068 Blumea mollis Species Asteraceae Eukaryota UNPD*
NPO29650 Lysimachiae herba NA NA NA TCMSP*
NPO2154 Ligusticum tenuissimum Species Apiaceae Eukaryota TM-MC*
NPO8892 Sordaria araneosa Species Sordariaceae Eukaryota UNPD*
NPO29651 Sennae folium NA NA NA TCMSP*
NPO23256 Mentha arvensis Species Lamiaceae Eukaryota TM-MC*
NPO14057 Apollonias barbujana Species Lauraceae Eukaryota UNPD*
NPO28423 Apocyniveneti folium NA NA NA TCMSP*
NPO13857 Mentha canadensis Species Lamiaceae Eukaryota TM-MC*
NPO10550 Artemisia hanseniana Species Asteraceae Eukaryota UNPD*
NPO29653 Hippophae fructus Species Elaeagnaceae Eukaryota TCMSP*
NPO19048 Pinellia ternata Species Araceae Eukaryota TM-MC*
NPO13968 Garcinia scortechinii Species Clusiaceae Eukaryota UNPD*
NPO29414 Schizonepetae herba NA NA NA TCMSP*
NPO8789 Schizonepeta tenuifolia Species Lamiaceae Eukaryota TM-MC*
NPO3465 Aconitum leucostomum Species Ranunculaceae Eukaryota UNPD*
NPO29640 Schizonepetae spica NA NA NA TCMSP*
NPO1880 Schizonepeta tenuisfolia Species Lamiaceae Eukaryota TM-MC*
NPO12509 Dipterocarpus dyeri Species Dipterocarpaceae Eukaryota UNPD*
NPO28985 Radix bupleuri Species Lymnaeidae Eukaryota TCMSP*
NPO16039 Scutellaria barbata Species Lamiaceae Eukaryota TM-MC*
NPO13467 Anarsia lineatella Species Gelechiidae Eukaryota UNPD*
NPO19649 Akebia quinata Species Lardizabalaceae Eukaryota TM-MC*
NPO12935 Thymus quinquecostatus Species Lamiaceae Eukaryota TM-MC*
NPO16703 Isodon lophanthoides Species Lamiaceae Eukaryota UNPD*
NPO11170 Akebia trifoliata Species Lardizabalaceae Eukaryota TM-MC*
NPO19472 Thymus vulgaris Species Lamiaceae Eukaryota TM-MC*
NPO746 Panax innovans Species Araliaceae Eukaryota UNPD*
NPO28276 Artemisia argyi Species Asteraceae Eukaryota TM-MC*
NPO14602 Vitex negundo Species Lamiaceae Eukaryota TM-MC*

  Biological Activity

Target ID Target Type Target Name Target Organism Activity Type Activity Relation Value Unit Reference
NPT73 Individual Protein Solute carrier organic anion transporter family member 1B1 Homo sapiens Inhibition = 96.98 % 23571415
NPT72 Individual Protein Solute carrier organic anion transporter family member 1B3 Homo sapiens Inhibition = 100.16 % 23571415
NPT2 Others Unspecified Potency 595.5 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency 123 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency 16785.5 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency 6007 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency 18832.2 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency 26832.5 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency 48966.2 nM PubChem BioAssay data set
NPT2 Others Unspecified AC50 12589.3 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency 68589.6 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency 61644.8 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency 54482.7 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency 298.5 nM PubChem BioAssay data set
NPT2 Others Unspecified AC50 4466.8 nM PubChem BioAssay data set
NPT2 Others Unspecified AC50 39810.7 nM PubChem BioAssay data set

  Similar Natural Products in NPASS

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient

●  The left chart: Distribution of similarity level between NPC45270 and all remaining natural products in the NPASS database.
●  The right table: Most similar natural products (Tc>=0.56 or Top200).

Similarity Score Similarity Level Natural Product ID
1.0 High Similarity NPC59570
1.0 High Similarity NPC135077
1.0 High Similarity NPC215118
0.8462 Intermediate Similarity NPC223315
0.8333 Intermediate Similarity NPC171783
0.8095 Intermediate Similarity NPC18397
0.7872 Intermediate Similarity NPC274182
0.7805 Intermediate Similarity NPC141634
0.7778 Intermediate Similarity NPC83187
0.7778 Intermediate Similarity NPC173996
0.7778 Intermediate Similarity NPC98246
0.7778 Intermediate Similarity NPC131981
0.7778 Intermediate Similarity NPC285814
0.7778 Intermediate Similarity NPC40249
0.7568 Intermediate Similarity NPC321646
0.75 Intermediate Similarity NPC236623
0.7447 Intermediate Similarity NPC293343
0.7447 Intermediate Similarity NPC258672
0.7447 Intermediate Similarity NPC247786
0.74 Intermediate Similarity NPC53245
0.74 Intermediate Similarity NPC288296
0.7317 Intermediate Similarity NPC69245
0.7297 Intermediate Similarity NPC153439
0.7297 Intermediate Similarity NPC79887
0.7297 Intermediate Similarity NPC196434
0.7297 Intermediate Similarity NPC29561
0.7297 Intermediate Similarity NPC221192
0.7297 Intermediate Similarity NPC42403
0.7297 Intermediate Similarity NPC4962
0.7297 Intermediate Similarity NPC222997
0.7255 Intermediate Similarity NPC200258
0.7255 Intermediate Similarity NPC184819
0.7255 Intermediate Similarity NPC307063
0.7234 Intermediate Similarity NPC294440
0.7234 Intermediate Similarity NPC20017
0.7115 Intermediate Similarity NPC151464
0.7115 Intermediate Similarity NPC474105
0.7115 Intermediate Similarity NPC143597
0.7105 Intermediate Similarity NPC168982
0.7027 Intermediate Similarity NPC38859
0.7027 Intermediate Similarity NPC295442
0.7027 Intermediate Similarity NPC198118
0.6981 Remote Similarity NPC115385
0.6923 Remote Similarity NPC149101
0.6923 Remote Similarity NPC225318
0.6923 Remote Similarity NPC268596
0.6923 Remote Similarity NPC76608
0.6923 Remote Similarity NPC16578
0.6852 Remote Similarity NPC127798
0.6829 Remote Similarity NPC218357
0.6757 Remote Similarity NPC100997
0.6727 Remote Similarity NPC472304
0.6727 Remote Similarity NPC276764
0.6667 Remote Similarity NPC192427
0.6667 Remote Similarity NPC14917
0.6667 Remote Similarity NPC4079
0.6667 Remote Similarity NPC236355
0.6607 Remote Similarity NPC270042
0.66 Remote Similarity NPC116906
0.6585 Remote Similarity NPC248190
0.6545 Remote Similarity NPC27610
0.6545 Remote Similarity NPC56905
0.6538 Remote Similarity NPC268564
0.6531 Remote Similarity NPC13105
0.6491 Remote Similarity NPC60565
0.6471 Remote Similarity NPC27438
0.6458 Remote Similarity NPC314679
0.6429 Remote Similarity NPC121215
0.6415 Remote Similarity NPC202850
0.6415 Remote Similarity NPC319589
0.6415 Remote Similarity NPC63396
0.641 Remote Similarity NPC158107
0.6379 Remote Similarity NPC472306
0.6316 Remote Similarity NPC127582
0.6279 Remote Similarity NPC301919
0.6271 Remote Similarity NPC128608
0.6271 Remote Similarity NPC469662
0.6271 Remote Similarity NPC285371
0.6271 Remote Similarity NPC475124
0.625 Remote Similarity NPC55023
0.6226 Remote Similarity NPC474141
0.6216 Remote Similarity NPC307594
0.6216 Remote Similarity NPC227197
0.6216 Remote Similarity NPC66624
0.6216 Remote Similarity NPC129976
0.62 Remote Similarity NPC91962
0.62 Remote Similarity NPC324793
0.62 Remote Similarity NPC477878
0.6182 Remote Similarity NPC20603
0.6167 Remote Similarity NPC469791
0.6102 Remote Similarity NPC197238
0.6102 Remote Similarity NPC202118
0.6102 Remote Similarity NPC165695
0.6098 Remote Similarity NPC49151
0.6098 Remote Similarity NPC179831
0.6098 Remote Similarity NPC254713
0.6098 Remote Similarity NPC262505
0.6098 Remote Similarity NPC261991
0.6071 Remote Similarity NPC193695
0.6071 Remote Similarity NPC55004
0.6071 Remote Similarity NPC49575
0.6071 Remote Similarity NPC230823
0.6071 Remote Similarity NPC267626
0.6066 Remote Similarity NPC189917
0.6066 Remote Similarity NPC96812
0.6066 Remote Similarity NPC103734
0.6066 Remote Similarity NPC168824
0.6066 Remote Similarity NPC107704
0.6066 Remote Similarity NPC43300
0.6066 Remote Similarity NPC323005
0.6066 Remote Similarity NPC39462
0.6053 Remote Similarity NPC79591
0.6034 Remote Similarity NPC478126
0.6 Remote Similarity NPC6697
0.6 Remote Similarity NPC275472
0.6 Remote Similarity NPC21844
0.5968 Remote Similarity NPC220210
0.5968 Remote Similarity NPC20181
0.5965 Remote Similarity NPC30215
0.5965 Remote Similarity NPC266295
0.5965 Remote Similarity NPC94991
0.5962 Remote Similarity NPC305182
0.5962 Remote Similarity NPC32351
0.5957 Remote Similarity NPC248763
0.5957 Remote Similarity NPC325452
0.5946 Remote Similarity NPC14312
0.5946 Remote Similarity NPC91093
0.5946 Remote Similarity NPC27501
0.5932 Remote Similarity NPC213152
0.5932 Remote Similarity NPC306750
0.5926 Remote Similarity NPC72722
0.5902 Remote Similarity NPC230047
0.5902 Remote Similarity NPC19311
0.5902 Remote Similarity NPC251118
0.5897 Remote Similarity NPC7777
0.5873 Remote Similarity NPC180777
0.5873 Remote Similarity NPC82477
0.5873 Remote Similarity NPC310992
0.5873 Remote Similarity NPC281203
0.5873 Remote Similarity NPC296697
0.5873 Remote Similarity NPC260319
0.5873 Remote Similarity NPC469724
0.5873 Remote Similarity NPC260474
0.5873 Remote Similarity NPC20610
0.5873 Remote Similarity NPC39157
0.5873 Remote Similarity NPC100917
0.5873 Remote Similarity NPC473225
0.5873 Remote Similarity NPC31187
0.5873 Remote Similarity NPC103647
0.5873 Remote Similarity NPC188292
0.5873 Remote Similarity NPC474954
0.5873 Remote Similarity NPC470956
0.5873 Remote Similarity NPC475977
0.5873 Remote Similarity NPC142754
0.5873 Remote Similarity NPC2568
0.587 Remote Similarity NPC3531
0.5862 Remote Similarity NPC285594
0.5862 Remote Similarity NPC96551
0.5862 Remote Similarity NPC259261
0.5862 Remote Similarity NPC143834
0.5849 Remote Similarity NPC291724
0.5849 Remote Similarity NPC274261
0.5849 Remote Similarity NPC314084
0.5814 Remote Similarity NPC49615
0.5806 Remote Similarity NPC84562
0.58 Remote Similarity NPC77550
0.58 Remote Similarity NPC108441
0.5781 Remote Similarity NPC6120
0.5781 Remote Similarity NPC182815
0.5781 Remote Similarity NPC213178
0.5781 Remote Similarity NPC474962
0.5781 Remote Similarity NPC139397
0.5781 Remote Similarity NPC477857
0.5781 Remote Similarity NPC327728
0.5781 Remote Similarity NPC286814
0.5781 Remote Similarity NPC131892
0.5781 Remote Similarity NPC324607
0.5781 Remote Similarity NPC321732
0.5763 Remote Similarity NPC25853
0.5763 Remote Similarity NPC40206
0.5741 Remote Similarity NPC22182
0.5738 Remote Similarity NPC212210
0.5714 Remote Similarity NPC287331
0.5714 Remote Similarity NPC144891
0.5714 Remote Similarity NPC302939
0.5714 Remote Similarity NPC41542
0.5714 Remote Similarity NPC263161
0.5714 Remote Similarity NPC472984
0.5692 Remote Similarity NPC108131
0.5692 Remote Similarity NPC282593
0.5692 Remote Similarity NPC307176
0.5692 Remote Similarity NPC260040
0.5692 Remote Similarity NPC214770
0.5692 Remote Similarity NPC477856
0.5692 Remote Similarity NPC163020
0.5692 Remote Similarity NPC251929
0.5692 Remote Similarity NPC2634
0.5692 Remote Similarity NPC40574
0.5692 Remote Similarity NPC476731
0.5692 Remote Similarity NPC265782

  Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

●  The left chart: Distribution of similarity level between NPC45270 and all drugs/candidates.
●  The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).

Similarity Score Similarity Level Drug ID Developmental Stage
0.7778 Intermediate Similarity NPD345 Approved
0.7778 Intermediate Similarity NPD344 Approved
0.7778 Intermediate Similarity NPD343 Approved
0.7059 Intermediate Similarity NPD615 Clinical (unspecified phase)
0.6458 Remote Similarity NPD634 Phase 3
0.617 Remote Similarity NPD387 Clinical (unspecified phase)
0.6167 Remote Similarity NPD3171 Clinical (unspecified phase)
0.6136 Remote Similarity NPD9449 Clinical (unspecified phase)
0.6066 Remote Similarity NPD4224 Phase 2
0.6047 Remote Similarity NPD9447 Approved
0.5873 Remote Similarity NPD3621 Clinical (unspecified phase)
0.5873 Remote Similarity NPD5360 Phase 3
0.5873 Remote Similarity NPD5361 Clinical (unspecified phase)
0.587 Remote Similarity NPD9450 Approved
0.587 Remote Similarity NPD77 Approved
0.58 Remote Similarity NPD386 Approved
0.58 Remote Similarity NPD388 Approved
0.5781 Remote Similarity NPD4137 Phase 3
0.5781 Remote Similarity NPD3700 Clinical (unspecified phase)
0.5781 Remote Similarity NPD3699 Clinical (unspecified phase)
0.5781 Remote Similarity NPD3698 Phase 2
0.5741 Remote Similarity NPD3186 Phase 1
0.5714 Remote Similarity NPD367 Approved
0.5692 Remote Similarity NPD4747 Approved
0.5692 Remote Similarity NPD4691 Approved
0.5692 Remote Similarity NPD4244 Approved
0.5692 Remote Similarity NPD4245 Approved
0.5692 Remote Similarity NPD4789 Approved
0.569 Remote Similarity NPD287 Approved
0.5686 Remote Similarity NPD384 Approved
0.5686 Remote Similarity NPD385 Approved
0.5606 Remote Similarity NPD4758 Discontinued
0.5606 Remote Similarity NPD4808 Clinical (unspecified phase)
0.5606 Remote Similarity NPD6081 Approved
0.5606 Remote Similarity NPD5777 Approved
0.5606 Remote Similarity NPD4809 Clinical (unspecified phase)

Structure

External Identifiers

PubChem CID   26447
ChEMBL   CHEMBL276311
ZINC  

Physicochemical Properties

Molecular Weight:  154.14
ALogP:  0.8438
MLogP:  2.45
XLogP:  2.798
# Rotatable Bonds:  4
Polar Surface Area:  17.07
# H-Bond Aceptor:  1
# H-Bond Donor:  0
# Rings:  1
# Heavy Atoms:  11

Download Data

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General Info & Identifiers & Properties  
Structure MOL file  
Source Organisms  
Biological Activities  
Similar NPs/Drugs