Natural Product: NPC327652

Natural Product ID:  NPC327652
Common Name:   Pulvinatal
IUPAC Name:   9,10-dihydroxy-6,8-dimethoxy-1-oxo-3-[(E)-prop-1-enyl]-6H-pyrano[4,3-c]isochromene-7-carbaldehyde
Synonyms:   Pulvinatal
Molecular Formula:   C18H16O8
Standard InCHIKey:  LNBDQNHIHNAAHW-SNAWJCMRSA-N
Standard InCHI:  InChI=1S/C18H16O8/c1-4-5-8-6-10-12(17(22)25-8)13-11(18(24-3)26-10)9(7-19)16(23-2)15(21)14(13)20/h4-7,18,20-21H,1-3H3/b5-4+
Canonical SMILES:  C/C=C/c1cc2OC(OC)c3c(c2c(=O)o1)c(O)c(c(c3C=O)OC)O
First Find Year:  
Max Developmental Stage:  
Synthetic Gene Cluster:   ;

  Species Source

Organism ID Organism Name Taxonomy Level Family SuperKingdom Isolation Part Collection Location Collection Time Reference
NPO28590 Cyathus stercoreus Species Nidulariaceae Eukaryota PMID[17511503]
NPO31218 Nidularia pulvinata Species Nidulariaceae Eukaryota PMID[9232889]

  Biological Activity

Target ID Target Type Target Name Target Organism Activity Type Activity Relation Value Unit Reference
NPT1 Others Radical scavenging activity EC50 = 28590 nM 17511503
NPT2 Others Unspecified EC50 = 8360 nM 17511503

  Similar Natural Products in NPASS

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient

●  The left chart: Distribution of similarity level between NPC327652 and all remaining natural products in the NPASS database.
●  The right table: Most similar natural products (Tc>=0.56 or Top200).

Similarity Score Similarity Level Natural Product ID
0.9936 High Similarity NPC329119
0.9871 High Similarity NPC474763
0.9808 High Similarity NPC317781
0.9679 High Similarity NPC474779
0.9548 High Similarity NPC197751
0.9484 High Similarity NPC16286
0.9182 High Similarity NPC315157
0.8902 High Similarity NPC470773
0.8889 High Similarity NPC470358
0.8855 High Similarity NPC471287
0.8841 High Similarity NPC327809
0.8788 High Similarity NPC191930
0.8758 High Similarity NPC16082
0.8758 High Similarity NPC82592
0.875 High Similarity NPC471181
0.8727 High Similarity NPC470772
0.8727 High Similarity NPC249181
0.872 High Similarity NPC65746
0.872 High Similarity NPC470756
0.8704 High Similarity NPC227062
0.8704 High Similarity NPC150227
0.8696 High Similarity NPC281477
0.8683 High Similarity NPC283041
0.8683 High Similarity NPC116745
0.8683 High Similarity NPC471288
0.8683 High Similarity NPC298847
0.8662 High Similarity NPC471689
0.865 High Similarity NPC84935
0.865 High Similarity NPC77679
0.865 High Similarity NPC190020
0.8647 High Similarity NPC108202
0.8642 High Similarity NPC79998
0.8642 High Similarity NPC199926
0.8639 High Similarity NPC172807
0.8639 High Similarity NPC254540
0.8639 High Similarity NPC260263
0.8639 High Similarity NPC256760
0.8639 High Similarity NPC211594
0.8639 High Similarity NPC471688
0.8623 High Similarity NPC20237
0.8614 High Similarity NPC94777
0.8606 High Similarity NPC471290
0.8605 High Similarity NPC212290
0.8596 High Similarity NPC196771
0.8589 High Similarity NPC54928
0.8588 High Similarity NPC208668
0.8588 High Similarity NPC4390
0.858 High Similarity NPC150767
0.858 High Similarity NPC78734
0.858 High Similarity NPC109827
0.858 High Similarity NPC124470
0.8571 High Similarity NPC471180
0.8571 High Similarity NPC215921
0.8571 High Similarity NPC229729
0.8571 High Similarity NPC105591
0.8571 High Similarity NPC70016
0.8571 High Similarity NPC250488
0.8571 High Similarity NPC477502
0.8563 High Similarity NPC165720
0.8563 High Similarity NPC22832
0.8563 High Similarity NPC311830
0.8554 High Similarity NPC127782
0.8554 High Similarity NPC300537
0.8547 High Similarity NPC168584
0.8545 High Similarity NPC36217
0.8538 High Similarity NPC139350
0.8538 High Similarity NPC472607
0.8538 High Similarity NPC199533
0.8538 High Similarity NPC477848
0.8538 High Similarity NPC470454
0.8537 High Similarity NPC222689
0.8537 High Similarity NPC35598
0.8537 High Similarity NPC472860
0.8529 High Similarity NPC307518
0.8529 High Similarity NPC153755
0.8529 High Similarity NPC48773
0.8529 High Similarity NPC190003
0.8529 High Similarity NPC472386
0.8529 High Similarity NPC175107
0.8529 High Similarity NPC205076
0.8521 High Similarity NPC475942
0.8521 High Similarity NPC93337
0.8521 High Similarity NPC469931
0.8521 High Similarity NPC45638
0.8521 High Similarity NPC186807
0.8521 High Similarity NPC328321
0.8521 High Similarity NPC105025
0.8521 High Similarity NPC58053
0.8521 High Similarity NPC201292
0.8521 High Similarity NPC226294
0.8521 High Similarity NPC229687
0.8521 High Similarity NPC117911
0.8519 High Similarity NPC295646
0.8519 High Similarity NPC199773
0.8512 High Similarity NPC236934
0.8512 High Similarity NPC5778
0.8512 High Similarity NPC99957
0.8512 High Similarity NPC181616
0.8509 High Similarity NPC31132
0.8509 High Similarity NPC96501
0.8509 High Similarity NPC38775
0.8503 High Similarity NPC309025
0.8503 High Similarity NPC222936
0.8503 High Similarity NPC186686
0.8503 High Similarity NPC19709
0.8503 High Similarity NPC284960
0.8503 High Similarity NPC243930
0.8503 High Similarity NPC191306
0.8503 High Similarity NPC474350
0.8503 High Similarity NPC88023
0.8503 High Similarity NPC270335
0.8503 High Similarity NPC88043
0.8497 Intermediate Similarity NPC240887
0.8497 Intermediate Similarity NPC470091
0.8497 Intermediate Similarity NPC113446
0.8497 Intermediate Similarity NPC329161
0.8494 Intermediate Similarity NPC295009
0.8494 Intermediate Similarity NPC260640
0.8488 Intermediate Similarity NPC472385
0.8488 Intermediate Similarity NPC233994
0.8488 Intermediate Similarity NPC79736
0.8488 Intermediate Similarity NPC198324
0.8488 Intermediate Similarity NPC211532
0.8488 Intermediate Similarity NPC67629
0.848 Intermediate Similarity NPC181523
0.848 Intermediate Similarity NPC88560
0.848 Intermediate Similarity NPC175230
0.848 Intermediate Similarity NPC472993
0.848 Intermediate Similarity NPC172033
0.8476 Intermediate Similarity NPC301897
0.8471 Intermediate Similarity NPC116864
0.8471 Intermediate Similarity NPC244776
0.8471 Intermediate Similarity NPC218488
0.8471 Intermediate Similarity NPC246716
0.8471 Intermediate Similarity NPC21190
0.8471 Intermediate Similarity NPC298778
0.8471 Intermediate Similarity NPC155763
0.8471 Intermediate Similarity NPC149011
0.8471 Intermediate Similarity NPC105511
0.8471 Intermediate Similarity NPC235260
0.8471 Intermediate Similarity NPC204937
0.8471 Intermediate Similarity NPC212748
0.8471 Intermediate Similarity NPC231194
0.8471 Intermediate Similarity NPC224462
0.8471 Intermediate Similarity NPC20505
0.8471 Intermediate Similarity NPC22195
0.8471 Intermediate Similarity NPC51326
0.8471 Intermediate Similarity NPC183357
0.8466 Intermediate Similarity NPC291510
0.8466 Intermediate Similarity NPC43872
0.8466 Intermediate Similarity NPC238672
0.8466 Intermediate Similarity NPC73703
0.8466 Intermediate Similarity NPC144801
0.8466 Intermediate Similarity NPC116850
0.8466 Intermediate Similarity NPC197188
0.8462 Intermediate Similarity NPC45400
0.8462 Intermediate Similarity NPC146792
0.8462 Intermediate Similarity NPC45618
0.8462 Intermediate Similarity NPC58716
0.8457 Intermediate Similarity NPC240768
0.8457 Intermediate Similarity NPC200773
0.8457 Intermediate Similarity NPC256406
0.8452 Intermediate Similarity NPC472450
0.8452 Intermediate Similarity NPC275780
0.8452 Intermediate Similarity NPC7752
0.8452 Intermediate Similarity NPC471788
0.8452 Intermediate Similarity NPC88243
0.8452 Intermediate Similarity NPC303174
0.8452 Intermediate Similarity NPC239752
0.8443 Intermediate Similarity NPC77660
0.8443 Intermediate Similarity NPC474150
0.8443 Intermediate Similarity NPC22324
0.8443 Intermediate Similarity NPC215612
0.8443 Intermediate Similarity NPC189142
0.8443 Intermediate Similarity NPC474162
0.8443 Intermediate Similarity NPC201800
0.8443 Intermediate Similarity NPC473043
0.8439 Intermediate Similarity NPC469600
0.8439 Intermediate Similarity NPC267549
0.8438 Intermediate Similarity NPC137296
0.8438 Intermediate Similarity NPC251188
0.8434 Intermediate Similarity NPC285973
0.8434 Intermediate Similarity NPC292415
0.8434 Intermediate Similarity NPC228785
0.8434 Intermediate Similarity NPC24627
0.8434 Intermediate Similarity NPC56085
0.8434 Intermediate Similarity NPC225624
0.8434 Intermediate Similarity NPC203020
0.8434 Intermediate Similarity NPC14353
0.8434 Intermediate Similarity NPC471973
0.8434 Intermediate Similarity NPC472055
0.8434 Intermediate Similarity NPC239966
0.843 Intermediate Similarity NPC264735
0.843 Intermediate Similarity NPC68381
0.843 Intermediate Similarity NPC49344
0.843 Intermediate Similarity NPC101191
0.843 Intermediate Similarity NPC469354
0.843 Intermediate Similarity NPC146803
0.843 Intermediate Similarity NPC237435
0.843 Intermediate Similarity NPC135277

  Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

●  The left chart: Distribution of similarity level between NPC327652 and all drugs/candidates.
●  The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).

Similarity Score Similarity Level Drug ID Developmental Stage
0.8571 High Similarity NPD3818 Discontinued
0.8554 High Similarity NPD6232 Discontinued
0.843 Intermediate Similarity NPD4338 Clinical (unspecified phase)
0.8428 Intermediate Similarity NPD2533 Approved
0.8428 Intermediate Similarity NPD2532 Approved
0.8428 Intermediate Similarity NPD2534 Approved
0.8412 Intermediate Similarity NPD7054 Approved
0.8402 Intermediate Similarity NPD7473 Discontinued
0.8363 Intermediate Similarity NPD7074 Phase 3
0.8363 Intermediate Similarity NPD7472 Approved
0.8242 Intermediate Similarity NPD2801 Approved
0.8242 Intermediate Similarity NPD2393 Clinical (unspecified phase)
0.8208 Intermediate Similarity NPD6797 Phase 2
0.8193 Intermediate Similarity NPD3817 Phase 2
0.8182 Intermediate Similarity NPD1934 Approved
0.8161 Intermediate Similarity NPD7251 Discontinued
0.8155 Intermediate Similarity NPD6234 Discontinued
0.8114 Intermediate Similarity NPD7808 Phase 3
0.8095 Intermediate Similarity NPD4381 Clinical (unspecified phase)
0.8057 Intermediate Similarity NPD6559 Discontinued
0.805 Intermediate Similarity NPD970 Clinical (unspecified phase)
0.8036 Intermediate Similarity NPD4868 Clinical (unspecified phase)
0.8024 Intermediate Similarity NPD7819 Suspended
0.7989 Intermediate Similarity NPD7804 Clinical (unspecified phase)
0.7964 Intermediate Similarity NPD37 Approved
0.7952 Intermediate Similarity NPD4380 Phase 2
0.7944 Intermediate Similarity NPD8397 Clinical (unspecified phase)
0.7931 Intermediate Similarity NPD7228 Approved
0.7929 Intermediate Similarity NPD4966 Approved
0.7929 Intermediate Similarity NPD3882 Suspended
0.7929 Intermediate Similarity NPD4967 Phase 2
0.7929 Intermediate Similarity NPD4965 Approved
0.7919 Intermediate Similarity NPD6166 Phase 2
0.7919 Intermediate Similarity NPD6168 Clinical (unspecified phase)
0.7919 Intermediate Similarity NPD6167 Clinical (unspecified phase)
0.7917 Intermediate Similarity NPD1465 Phase 2
0.7914 Intermediate Similarity NPD1511 Approved
0.7886 Intermediate Similarity NPD5844 Phase 1
0.7882 Intermediate Similarity NPD7075 Discontinued
0.7857 Intermediate Similarity NPD7879 Clinical (unspecified phase)
0.7849 Intermediate Similarity NPD7199 Phase 2
0.7818 Intermediate Similarity NPD1512 Approved
0.7803 Intermediate Similarity NPD5711 Approved
0.7803 Intermediate Similarity NPD5710 Approved
0.7771 Intermediate Similarity NPD6980 Clinical (unspecified phase)
0.7759 Intermediate Similarity NPD7184 Clinical (unspecified phase)
0.7758 Intermediate Similarity NPD4378 Clinical (unspecified phase)
0.7751 Intermediate Similarity NPD6801 Discontinued
0.7733 Intermediate Similarity NPD919 Approved
0.7725 Intermediate Similarity NPD1653 Approved
0.7706 Intermediate Similarity NPD7096 Clinical (unspecified phase)
0.7688 Intermediate Similarity NPD5494 Approved
0.7673 Intermediate Similarity NPD230 Phase 1
0.7654 Intermediate Similarity NPD7685 Pre-registration
0.7622 Intermediate Similarity NPD1878 Clinical (unspecified phase)
0.759 Intermediate Similarity NPD6143 Clinical (unspecified phase)
0.7588 Intermediate Similarity NPD7411 Suspended
0.7582 Intermediate Similarity NPD8055 Clinical (unspecified phase)
0.7569 Intermediate Similarity NPD8313 Approved
0.7569 Intermediate Similarity NPD8312 Approved
0.7561 Intermediate Similarity NPD2800 Approved
0.7558 Intermediate Similarity NPD5402 Approved
0.7545 Intermediate Similarity NPD7410 Clinical (unspecified phase)
0.7543 Intermediate Similarity NPD1247 Approved
0.7543 Intermediate Similarity NPD6959 Discontinued
0.7531 Intermediate Similarity NPD1510 Phase 2
0.7526 Intermediate Similarity NPD8151 Discontinued
0.75 Intermediate Similarity NPD7993 Clinical (unspecified phase)
0.7485 Intermediate Similarity NPD6799 Approved
0.7485 Intermediate Similarity NPD2935 Discontinued
0.7459 Intermediate Similarity NPD7240 Approved
0.7457 Intermediate Similarity NPD8443 Clinical (unspecified phase)
0.7456 Intermediate Similarity NPD920 Approved
0.7448 Intermediate Similarity NPD7435 Discontinued
0.744 Intermediate Similarity NPD7422 Clinical (unspecified phase)
0.7427 Intermediate Similarity NPD6599 Discontinued
0.7416 Intermediate Similarity NPD7852 Clinical (unspecified phase)
0.7414 Intermediate Similarity NPD7768 Phase 2
0.741 Intermediate Similarity NPD3750 Approved
0.7407 Intermediate Similarity NPD6651 Approved
0.7382 Intermediate Similarity NPD6781 Approved
0.7382 Intermediate Similarity NPD6778 Approved
0.7382 Intermediate Similarity NPD6779 Approved
0.7382 Intermediate Similarity NPD6776 Approved
0.7382 Intermediate Similarity NPD6780 Approved
0.7382 Intermediate Similarity NPD6777 Approved
0.7382 Intermediate Similarity NPD6782 Approved
0.7368 Intermediate Similarity NPD3226 Approved
0.7353 Intermediate Similarity NPD5403 Approved
0.7346 Intermediate Similarity NPD447 Suspended
0.7337 Intermediate Similarity NPD642 Clinical (unspecified phase)
0.7333 Intermediate Similarity NPD1550 Clinical (unspecified phase)
0.7333 Intermediate Similarity NPD1552 Clinical (unspecified phase)
0.7317 Intermediate Similarity NPD651 Clinical (unspecified phase)
0.7296 Intermediate Similarity NPD9494 Approved
0.7289 Intermediate Similarity NPD1549 Phase 2
0.7284 Intermediate Similarity NPD943 Approved
0.7284 Intermediate Similarity NPD1240 Approved
0.7273 Intermediate Similarity NPD2796 Approved
0.7273 Intermediate Similarity NPD7782 Clinical (unspecified phase)
0.7273 Intermediate Similarity NPD1551 Phase 2
0.7273 Intermediate Similarity NPD3749 Approved
0.7273 Intermediate Similarity NPD7783 Phase 2
0.7246 Intermediate Similarity NPD6674 Discontinued
0.7243 Intermediate Similarity NPD7090 Clinical (unspecified phase)
0.7235 Intermediate Similarity NPD5401 Approved
0.7229 Intermediate Similarity NPD2346 Discontinued
0.7222 Intermediate Similarity NPD7874 Approved
0.7222 Intermediate Similarity NPD7875 Clinical (unspecified phase)
0.7219 Intermediate Similarity NPD643 Clinical (unspecified phase)
0.7211 Intermediate Similarity NPD6535 Approved
0.7211 Intermediate Similarity NPD6534 Approved
0.7202 Intermediate Similarity NPD7501 Clinical (unspecified phase)
0.7195 Intermediate Similarity NPD1607 Approved
0.7179 Intermediate Similarity NPD7697 Approved
0.7179 Intermediate Similarity NPD7696 Phase 3
0.7179 Intermediate Similarity NPD7698 Approved
0.7168 Intermediate Similarity NPD7458 Discontinued
0.7167 Intermediate Similarity NPD3926 Phase 2
0.716 Intermediate Similarity NPD6190 Approved
0.715 Intermediate Similarity NPD7237 Clinical (unspecified phase)
0.7143 Intermediate Similarity NPD7421 Clinical (unspecified phase)
0.7143 Intermediate Similarity NPD7871 Phase 2
0.7143 Intermediate Similarity NPD7870 Phase 2
0.7143 Intermediate Similarity NPD3751 Discontinued
0.7134 Intermediate Similarity NPD5123 Clinical (unspecified phase)
0.7134 Intermediate Similarity NPD5124 Phase 1
0.7134 Intermediate Similarity NPD1933 Approved
0.7128 Intermediate Similarity NPD6823 Phase 2
0.7126 Intermediate Similarity NPD7266 Discontinued
0.7121 Intermediate Similarity NPD7701 Phase 2
0.712 Intermediate Similarity NPD5953 Discontinued
0.7111 Intermediate Similarity NPD3787 Discontinued
0.7108 Intermediate Similarity NPD3748 Approved
0.7108 Intermediate Similarity NPD1509 Clinical (unspecified phase)
0.7102 Intermediate Similarity NPD8455 Phase 2
0.7101 Intermediate Similarity NPD4628 Phase 3
0.7099 Intermediate Similarity NPD3027 Phase 3
0.7098 Intermediate Similarity NPD7700 Phase 2
0.7098 Intermediate Similarity NPD7699 Phase 2
0.7092 Intermediate Similarity NPD7680 Approved
0.7076 Intermediate Similarity NPD7390 Discontinued
0.7074 Intermediate Similarity NPD8150 Discontinued
0.7074 Intermediate Similarity NPD8434 Phase 2
0.7072 Intermediate Similarity NPD5242 Approved
0.7056 Intermediate Similarity NPD8320 Phase 1
0.7056 Intermediate Similarity NPD8319 Approved
0.7055 Intermediate Similarity NPD6859 Clinical (unspecified phase)
0.7055 Intermediate Similarity NPD2313 Discontinued
0.7041 Intermediate Similarity NPD5006 Approved
0.7041 Intermediate Similarity NPD5005 Approved
0.7041 Intermediate Similarity NPD1243 Approved
0.7017 Intermediate Similarity NPD7229 Phase 3
0.7015 Intermediate Similarity NPD7801 Approved
0.7011 Intermediate Similarity NPD7286 Phase 2
0.7006 Intermediate Similarity NPD2799 Discontinued
0.7 Intermediate Similarity NPD6398 Clinical (unspecified phase)
0.6995 Remote Similarity NPD7930 Approved
0.6985 Remote Similarity NPD7584 Approved
0.6981 Remote Similarity NPD9269 Phase 2
0.6979 Remote Similarity NPD6214 Clinical (unspecified phase)
0.6979 Remote Similarity NPD6213 Phase 3
0.6979 Remote Similarity NPD6212 Phase 3
0.6971 Remote Similarity NPD5619 Clinical (unspecified phase)
0.697 Remote Similarity NPD1612 Clinical (unspecified phase)
0.697 Remote Similarity NPD1613 Approved
0.6966 Remote Similarity NPD5353 Approved
0.6964 Remote Similarity NPD5408 Approved
0.6964 Remote Similarity NPD5404 Approved
0.6964 Remote Similarity NPD5406 Approved
0.6964 Remote Similarity NPD5405 Approved
0.6933 Remote Similarity NPD1529 Clinical (unspecified phase)
0.6923 Remote Similarity NPD4420 Approved
0.6875 Remote Similarity NPD8155 Clinical (unspecified phase)
0.6872 Remote Similarity NPD8090 Clinical (unspecified phase)
0.6871 Remote Similarity NPD1530 Clinical (unspecified phase)
0.6867 Remote Similarity NPD4060 Phase 1
0.6866 Remote Similarity NPD7585 Approved
0.6862 Remote Similarity NPD4419 Clinical (unspecified phase)
0.6848 Remote Similarity NPD1699 Clinical (unspecified phase)
0.6816 Remote Similarity NPD7583 Approved
0.6813 Remote Similarity NPD3705 Approved
0.681 Remote Similarity NPD2798 Approved
0.6798 Remote Similarity NPD6386 Approved
0.6798 Remote Similarity NPD6385 Approved
0.678 Remote Similarity NPD5808 Clinical (unspecified phase)
0.6776 Remote Similarity NPD8127 Discontinued
0.6766 Remote Similarity NPD7211 Clinical (unspecified phase)
0.6765 Remote Similarity NPD6099 Approved
0.6765 Remote Similarity NPD6100 Approved
0.6758 Remote Similarity NPD5537 Clinical (unspecified phase)
0.6747 Remote Similarity NPD3764 Approved
0.673 Remote Similarity NPD9268 Approved
0.6727 Remote Similarity NPD6832 Phase 2
0.6725 Remote Similarity NPD2343 Clinical (unspecified phase)
0.6714 Remote Similarity NPD8366 Approved
0.6708 Remote Similarity NPD422 Phase 1
0.6706 Remote Similarity NPD7033 Discontinued
0.6705 Remote Similarity NPD7003 Approved
0.6705 Remote Similarity NPD8166 Discontinued

Structure

External Identifiers

PubChem CID   44424646
ChEMBL   CHEMBL375926
ZINC  

Physicochemical Properties

Molecular Weight:  360.08
ALogP:  -0.5759
MLogP:  2.56
XLogP:  1.177
# Rotatable Bonds:  9
Polar Surface Area:  111.52
# H-Bond Aceptor:  5
# H-Bond Donor:  2
# Rings:  3
# Heavy Atoms:  26

Download Data

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General Info & Identifiers & Properties  
Structure MOL file  
Source Organisms  
Biological Activities  
Similar NPs/Drugs