Natural Product: NPC319279

Natural Product ID:  NPC319279
Common Name:   Tranexamic Acid
IUPAC Name:  
Synonyms:   CL-65336; Cyklo-f Heavy Period Relief; Cyklokapron; Exacyl; Lysteda; Menstralite; Tranexamic Acid; Trans AMCHA
Molecular Formula:   C8H15NO2
Standard InCHIKey:  GYDJEQRTZSCIOI-LJGSYFOKSA-N
Standard InCHI:  InChI=1S/C8H15NO2/c9-5-6-1-3-7(4-2-6)8(10)11/h6-7H,1-5,9H2,(H,10,11)/t6-,7-
Canonical SMILES:  NC[C@@H]1CC[C@H](CC1)C(=O)O
First Find Year:  
Max Developmental Stage:  
Synthetic Gene Cluster:   ;

  Species Source

Organism ID Organism Name Taxonomy Level Family SuperKingdom Isolation Part Collection Location Collection Time Reference
NPO1797 Homo sapiens Species Hominidae Eukaryota urine PMID[21059682]
NPO1797 Homo sapiens Species Hominidae Eukaryota blood PMID[21059682]

  Biological Activity

Target ID Target Type Target Name Target Organism Activity Type Activity Relation Value Unit Reference
NPT605 Organism Homo sapiens Homo sapiens Activity = 0.55 % 20022146
NPT2689 Individual Protein Indoleamine 2,3-dioxygenase 2 Mus musculus Inhibition >= 55 % 23122865
NPT1720 Individual Protein Plasminogen Homo sapiens IC50 = 3100 nM 23521080
NPT1720 Individual Protein Plasminogen Homo sapiens IC50 = 11500 nM 23521080
NPT73 Individual Protein Solute carrier organic anion transporter family member 1B1 Homo sapiens Inhibition = 81.79 % 23571415
NPT72 Individual Protein Solute carrier organic anion transporter family member 1B3 Homo sapiens Inhibition = 102.32 % 23571415
NPT1720 Individual Protein Plasminogen Homo sapiens Kd = 1100 nM 24900876
NPT1720 Individual Protein Plasminogen Homo sapiens Kd = 2200 nM 24900876
NPT1720 Individual Protein Plasminogen Homo sapiens Kd = 36000 nM 24900876
NPT1720 Individual Protein Plasminogen Homo sapiens Kd = 750000 nM 24900876
NPT1720 Individual Protein Plasminogen Homo sapiens IC50 = 12000 nM 24900876
NPT1720 Individual Protein Plasminogen Homo sapiens IC50 = 3100 nM 24900876
NPT2 Others Unspecified IC50 = 1600000 nM 24900876
NPT29 Organism Rattus norvegicus Rattus norvegicus ED50 = 15.9 umol/kg.min 24900876
NPT29 Organism Rattus norvegicus Rattus norvegicus EC50 = 19200 nM 24900876
NPT1720 Individual Protein Plasminogen Homo sapiens Inhibition = 9.5 % 25987378
NPT1720 Individual Protein Plasminogen Homo sapiens IC50 = 2000000 nM 25987378
NPT1720 Individual Protein Plasminogen Homo sapiens Ki = 40000000 nM 26732532
NPT1720 Individual Protein Plasminogen Homo sapiens IC50 = 10000000 nM 26732532
NPT1720 Individual Protein Plasminogen Homo sapiens IC50 = 50000 nM 26732532

  Similar Natural Products in NPASS

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient

●  The left chart: Distribution of similarity level between NPC319279 and all remaining natural products in the NPASS database.
●  The right table: Most similar natural products (Tc>=0.56 or Top200).

Similarity Score Similarity Level Natural Product ID
0.8167 Intermediate Similarity NPC302188
0.8 Intermediate Similarity NPC50457
0.7547 Intermediate Similarity NPC323974
0.6949 Remote Similarity NPC155512
0.6897 Remote Similarity NPC324825
0.6897 Remote Similarity NPC62045
0.6897 Remote Similarity NPC43204
0.6897 Remote Similarity NPC84636
0.6897 Remote Similarity NPC316231
0.6897 Remote Similarity NPC226027
0.6897 Remote Similarity NPC112890
0.6897 Remote Similarity NPC162620
0.6897 Remote Similarity NPC245027
0.6897 Remote Similarity NPC174246
0.6727 Remote Similarity NPC276294
0.6667 Remote Similarity NPC314679
0.6545 Remote Similarity NPC248763
0.6545 Remote Similarity NPC325452
0.6522 Remote Similarity NPC188231
0.6522 Remote Similarity NPC222327
0.6491 Remote Similarity NPC55023
0.6452 Remote Similarity NPC279661
0.6452 Remote Similarity NPC183845
0.6441 Remote Similarity NPC324793
0.6441 Remote Similarity NPC477878
0.6406 Remote Similarity NPC278209
0.6364 Remote Similarity NPC329564
0.6364 Remote Similarity NPC327170
0.6338 Remote Similarity NPC15864
0.6308 Remote Similarity NPC176164
0.6308 Remote Similarity NPC189301
0.6271 Remote Similarity NPC21844
0.6212 Remote Similarity NPC276928
0.6212 Remote Similarity NPC317143
0.6212 Remote Similarity NPC321468
0.6212 Remote Similarity NPC316826
0.6212 Remote Similarity NPC64250
0.6212 Remote Similarity NPC327748
0.6212 Remote Similarity NPC254541
0.6212 Remote Similarity NPC268927
0.6212 Remote Similarity NPC320598
0.6207 Remote Similarity NPC118459
0.6207 Remote Similarity NPC327698
0.6182 Remote Similarity NPC3531
0.6167 Remote Similarity NPC140872
0.6167 Remote Similarity NPC93081
0.6154 Remote Similarity NPC317147
0.6154 Remote Similarity NPC318260
0.6111 Remote Similarity NPC252843
0.6066 Remote Similarity NPC476469
0.6061 Remote Similarity NPC190385
0.6056 Remote Similarity NPC314221
0.6056 Remote Similarity NPC60424
0.6034 Remote Similarity NPC126925
0.6034 Remote Similarity NPC132307
0.6034 Remote Similarity NPC325097
0.6 Remote Similarity NPC268826
0.6 Remote Similarity NPC234767
0.6 Remote Similarity NPC101249
0.6 Remote Similarity NPC18188
0.5952 Remote Similarity NPC304454
0.5938 Remote Similarity NPC72722
0.5926 Remote Similarity NPC134782
0.5926 Remote Similarity NPC155263
0.5915 Remote Similarity NPC230047
0.5915 Remote Similarity NPC19311
0.5915 Remote Similarity NPC469791
0.5893 Remote Similarity NPC154186
0.5893 Remote Similarity NPC214610
0.5893 Remote Similarity NPC279026
0.5893 Remote Similarity NPC261080
0.5893 Remote Similarity NPC301585
0.5893 Remote Similarity NPC118968
0.5893 Remote Similarity NPC201844
0.5893 Remote Similarity NPC301696
0.5893 Remote Similarity NPC14227
0.5893 Remote Similarity NPC294085
0.5893 Remote Similarity NPC183424
0.5893 Remote Similarity NPC113928
0.5882 Remote Similarity NPC68974
0.5873 Remote Similarity NPC322946
0.5867 Remote Similarity NPC315897
0.5833 Remote Similarity NPC477931
0.5833 Remote Similarity NPC268736
0.5833 Remote Similarity NPC42060
0.5814 Remote Similarity NPC135005
0.5753 Remote Similarity NPC41542
0.5753 Remote Similarity NPC130459
0.5753 Remote Similarity NPC478180
0.5753 Remote Similarity NPC474221
0.5714 Remote Similarity NPC137958
0.5714 Remote Similarity NPC273330
0.5694 Remote Similarity NPC470108
0.569 Remote Similarity NPC196924
0.569 Remote Similarity NPC307783
0.569 Remote Similarity NPC171736
0.569 Remote Similarity NPC216630
0.569 Remote Similarity NPC209970
0.569 Remote Similarity NPC149184
0.5676 Remote Similarity NPC470956
0.5676 Remote Similarity NPC100917
0.5676 Remote Similarity NPC281203
0.5676 Remote Similarity NPC469724
0.5676 Remote Similarity NPC31187
0.5663 Remote Similarity NPC320936
0.5652 Remote Similarity NPC475821
0.5652 Remote Similarity NPC469924
0.5645 Remote Similarity NPC193872
0.5634 Remote Similarity NPC474552
0.5616 Remote Similarity NPC322035
0.5616 Remote Similarity NPC166791
0.5616 Remote Similarity NPC100719
0.5616 Remote Similarity NPC470109
0.56 Remote Similarity NPC252032
0.56 Remote Similarity NPC319671
0.56 Remote Similarity NPC469941
0.56 Remote Similarity NPC476734
0.56 Remote Similarity NPC196197
0.56 Remote Similarity NPC64466

  Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

●  The left chart: Distribution of similarity level between NPC319279 and all drugs/candidates.
●  The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).

Similarity Score Similarity Level Drug ID Developmental Stage
1.0 High Similarity NPD9439 Approved
1.0 High Similarity NPD9438 Approved
0.8333 Intermediate Similarity NPD9676 Phase 3
0.8246 Intermediate Similarity NPD9454 Approved
0.8167 Intermediate Similarity NPD9656 Approved
0.7547 Intermediate Similarity NPD9019 Approved
0.7538 Intermediate Similarity NPD375 Phase 2
0.7538 Intermediate Similarity NPD9421 Phase 1
0.7536 Intermediate Similarity NPD632 Discontinued
0.7123 Intermediate Similarity NPD617 Approved
0.6897 Remote Similarity NPD9018 Approved
0.6897 Remote Similarity NPD9017 Approved
0.6897 Remote Similarity NPD9016 Clinical (unspecified phase)
0.6897 Remote Similarity NPD9044 Approved
0.6885 Remote Similarity NPD615 Clinical (unspecified phase)
0.6667 Remote Similarity NPD634 Phase 3
0.6618 Remote Similarity NPD9201 Clinical (unspecified phase)
0.6543 Remote Similarity NPD621 Discontinued
0.6301 Remote Similarity NPD1147 Phase 2
0.6267 Remote Similarity NPD2257 Approved
0.625 Remote Similarity NPD8979 Approved
0.625 Remote Similarity NPD8980 Approved
0.625 Remote Similarity NPD8981 Clinical (unspecified phase)
0.6216 Remote Similarity NPD9217 Clinical (unspecified phase)
0.6203 Remote Similarity NPD857 Phase 3
0.6182 Remote Similarity NPD9450 Approved
0.6182 Remote Similarity NPD77 Approved
0.6167 Remote Similarity NPD8809 Approved
0.6167 Remote Similarity NPD8808 Approved
0.6111 Remote Similarity NPD9449 Clinical (unspecified phase)
0.6061 Remote Similarity NPD9023 Clinical (unspecified phase)
0.6034 Remote Similarity NPD8798 Approved
0.6032 Remote Similarity NPD3186 Phase 1
0.6 Remote Similarity NPD8866 Approved
0.6 Remote Similarity NPD8867 Approved
0.6 Remote Similarity NPD8623 Phase 1
0.593 Remote Similarity NPD2682 Approved
0.5893 Remote Similarity NPD9655 Approved
0.5893 Remote Similarity NPD633 Phase 3
0.5893 Remote Similarity NPD9448 Phase 2
0.5875 Remote Similarity NPD612 Discontinued
0.5875 Remote Similarity NPD9385 Clinical (unspecified phase)
0.5873 Remote Similarity NPD9441 Phase 2
0.5867 Remote Similarity NPD6944 Clinical (unspecified phase)
0.5867 Remote Similarity NPD1825 Clinical (unspecified phase)
0.5862 Remote Similarity NPD6699 Clinical (unspecified phase)
0.5833 Remote Similarity NPD4224 Phase 2
0.5806 Remote Similarity NPD8946 Approved
0.5806 Remote Similarity NPD8947 Approved
0.5789 Remote Similarity NPD9635 Discontinued
0.5741 Remote Similarity NPD9447 Approved
0.5738 Remote Similarity NPD8850 Approved
0.5714 Remote Similarity NPD8872 Phase 3
0.5714 Remote Similarity NPD8871 Approved
0.569 Remote Similarity NPD2270 Approved
0.5625 Remote Similarity NPD9638 Phase 2
0.56 Remote Similarity NPD3726 Approved
0.56 Remote Similarity NPD3725 Approved

Structure

External Identifiers

PubChem CID  
ChEMBL   CHEMBL877
ZINC  

Physicochemical Properties

Molecular Weight:  157.11
ALogP:  -0.4065
MLogP:  2.01
XLogP:  0.298
# Rotatable Bonds:  4
Polar Surface Area:  63.32
# H-Bond Aceptor:  3
# H-Bond Donor:  2
# Rings:  1
# Heavy Atoms:  11

Download Data

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General Info & Identifiers & Properties  
Structure MOL file  
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Biological Activities  
Similar NPs/Drugs