Natural Product: NPC182570

Natural Product ID:  NPC182570
Common Name:   Nicotine
IUPAC Name:   3-[(2S)-1-methylpyrrolidin-2-yl]pyridine
Synonyms:   Habitrol; Nicabate; Nicoderm; Nicoderm CQ; Nicopass; Nicopatch; Nicorette Invisi; Nicotine; Nicotinell Classic; Nicotinell Support; Nicotinell TTS 10; Nicotinell TTS 20; Nicotinell TTS 30; Nicotrol; Nicotrol Inhaler; Nicotrol NS; Niquitin; NiQuitin Clr; NiQuitin Minis Cherry; NiQuitin Minis Mint; NiQuitin Minis Orange; NiQuitin Mint; NiQuitin Pre-Quit; NiQuitin Strips Mint; Prostep; Stoppers; Stubit
Molecular Formula:   C10H14N2
Standard InCHIKey:  SNICXCGAKADSCV-JTQLQIEISA-N
Standard InCHI:  InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m0/s1
Canonical SMILES:  CN1CCC[C@H]1c1cccnc1
First Find Year:  
Max Developmental Stage:  
Synthetic Gene Cluster:   ;

  Species Source

Organism ID Organism Name Taxonomy Level Family SuperKingdom Isolation Part Collection Location Collection Time Reference
NPO2842 Garcinia lucida Species Clusiaceae Eukaryota UNPD*
NPO19837 Euonymus latifolius Species Celastraceae Eukaryota UNPD*
NPO29303 Salvia multicaulis Species Lamiaceae Eukaryota UNPD*
NPO20233 Marchantia paleacea Species Marchantiaceae Eukaryota UNPD*
NPO20648 Streptomyces cellulosae Species Streptomycetaceae Bacteria UNPD*
NPO26309 Ahnfeltiopsis flabelliformis Species Phyllophoraceae Eukaryota UNPD*
NPO3468 Astragalus floccosifolius Species Fabaceae Eukaryota UNPD*
NPO24627 Chondromyces robustus Species Polyangiaceae Bacteria UNPD*
NPO20101 Eria acutifolia Species Orchidaceae Eukaryota UNPD*
NPO21382 Eutypa lata Species Diatrypaceae Eukaryota UNPD*
NPO20718 Hypericum elegans Species Hypericaceae Eukaryota UNPD*
NPO29212 Tanaecium jaroba Species Bignoniaceae Eukaryota UNPD*
NPO21251 Tabernaemontana odoratissima Species Apocynaceae Eukaryota UNPD*
NPO29050 Lemnalia nitida Species Nephtheidae Eukaryota UNPD*
NPO29323 Glaucium leiocarpum Species Papaveraceae Eukaryota UNPD*
NPO29515 Laurus nobilis Species Lauraceae Eukaryota UNPD*
NPO29118 Euonymus alatus Species Celastraceae Eukaryota UNPD*
NPO29391 Papaver bracteatum Species Papaveraceae Eukaryota UNPD*
NPO19559 Cetraria pseudocomplicata Species Parmeliaceae Eukaryota UNPD*
NPO17908 Rhododendron reticulatum Species Ericaceae Eukaryota UNPD*
NPO17115 Kielmeyera petiolaris Species Calophyllaceae Eukaryota UNPD*
NPO28876 Narcissus cyclamineus Species Amaryllidaceae Eukaryota UNPD*
NPO11034 Mnium pseudopunctatum Species Mniaceae Eukaryota UNPD*
NPO19272 Alcyonium fauri Species Alcyoniidae Eukaryota UNPD*
NPO14172 Rhopaloeides odorabile Species Spongiidae Eukaryota UNPD*
NPO19410 Clutia abyssinica Species Peraceae Eukaryota UNPD*
NPO20982 Morus lactea Species Sulidae Eukaryota UNPD*
NPO29105 Meconopsis punicea Species Papaveraceae Eukaryota UNPD*
NPO20431 Centaurea canariensis Species Asteraceae Eukaryota UNPD*
NPO22397 Equiseti hiemalis herba NA NA NA TCMSP*
NPO29633 Ecliptae herba NA NA NA TCMSP*
NPO18749 Corydalis vernyi Species Papaveraceae Eukaryota UNPD*
NPO7727 Momordicae fructus NA NA NA TCMSP*
NPO1797 Homo sapiens Species Hominidae Eukaryota blood PMID[16473381]
NPO22874 Bombyx mori Species Bombycidae Eukaryota TCMSP*
NPO1797 Homo sapiens Species Hominidae Eukaryota saliva PMID[6802384]
NPO28928 Piper nigrum Species Piperaceae Eukaryota TM-MC*
NPO1797 Homo sapiens Species Hominidae Eukaryota urine PMID[12194923]
NPO21507 Ephedra intermedia Species Ephedraceae Eukaryota UNPD*

  Biological Activity

Target ID Target Type Target Name Target Organism Activity Type Activity Relation Value Unit Reference
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 1.05 nM 9435889
NPT414 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Rattus norvegicus Ki = 4000 nM 9435889
NPT3922 Protein Complex Acetylcholine receptor Torpedo californica Ki > 10000 nM 9435889
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus EC50 = 4000 nM 9435889
NPT414 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Rattus norvegicus EC50 = 54000 nM 9435889
NPT3922 Protein Complex Acetylcholine receptor Torpedo californica EC50 = 60000 nM 9435889
NPT2 Others Unspecified Ratio = 3810 9435889
NPT2 Others Unspecified Ratio = 13.5 9435889
NPT2 Others Unspecified Ratio < 6 9435889
NPT409 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Homo sapiens EC50 = 4000 nM 9435889
NPT410 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Homo sapiens EC50 = 83000 nM 9435889
NPT411 Protein Complex Neuronal acetylcholine receptor; alpha3/beta4 Homo sapiens EC50 = 21000 nM 9435889
NPT408 Individual Protein Acetylcholine receptor protein delta chain Torpedo californica EC50 = 160000 nM 9435889
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus EC50 = 590 nM 9435889
NPT413 Protein Complex Neuronal acetylcholine receptor Rattus norvegicus EC50 = 20000 nM 9435889
NPT29 Organism Rattus norvegicus Rattus norvegicus EC50 = 40 nM 9435889
NPT409 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Homo sapiens EC50 = 5000 nM 9871663
NPT5028 Protein Complex Nicotinic acetylcholine receptor alpha3/betaX Homo sapiens EC50 = 21000 nM 9871663
NPT413 Protein Complex Neuronal acetylcholine receptor Rattus norvegicus Ki = 8.4 nM 10.1016/S0960-894X(01)80157-8
NPT422 Protein Family Muscarinic acetylcholine receptor Rattus norvegicus Ki > 5000 nM 10.1016/S0960-894X(01)80157-8
NPT413 Protein Complex Neuronal acetylcholine receptor Rattus norvegicus Ki = 2.4 nM 14611857
NPT32 Organism Mus musculus Mus musculus ED50 = 1.5 mg/kg 14611857
NPT32 Organism Mus musculus Mus musculus ED50 = 12 ug mouse-1 14611857
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 0.94 nM 12190326
NPT413 Protein Complex Neuronal acetylcholine receptor Rattus norvegicus Ki = 1.15 nM 10.1016/0960-894X(95)00154-L
NPT413 Protein Complex Neuronal acetylcholine receptor Rattus norvegicus Ki = 1.1 nM 7799396
NPT413 Protein Complex Neuronal acetylcholine receptor Rattus norvegicus IC50 = 6.6 nM 10585207
NPT422 Protein Family Muscarinic acetylcholine receptor Rattus norvegicus IC50 = 32000 nM 10585207
NPT415 Protein Complex Neuronal acetylcholine receptor; alpha2/beta2 Rattus norvegicus Ki = 15 nM 15050613
NPT2 Others Unspecified Ki = 130 nM 15050613
NPT416 Protein Complex Neuronal acetylcholine receptor; alpha3/beta2 Rattus norvegicus Ki = 43 nM 15050613
NPT417 Protein Complex Neuronal acetylcholine receptor; alpha3/beta4 Rattus norvegicus Ki = 530 nM 15050613
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 12 nM 15050613
NPT418 Protein Complex Neuronal acetylcholine receptor; alpha4/beta4 Rattus norvegicus Ki = 46 nM 15050613
NPT413 Protein Complex Neuronal acetylcholine receptor Rattus norvegicus Ki = 13 nM 15050613
NPT2 Others Unspecified Ratio = 9 15050613
NPT2 Others Unspecified Ratio = 12 15050613
NPT2 Others Unspecified Ratio = 4 15050613
NPT2 Others Unspecified Ratio = 41 15050613
NPT32 Organism Mus musculus Mus musculus ED50 = 4.44 umol/kg 8230128
NPT32 Organism Mus musculus Mus musculus ED50 = 4.81 umol/kg 8230128
NPT32 Organism Mus musculus Mus musculus Kd = 1.41 nM 8230128
NPT413 Protein Complex Neuronal acetylcholine receptor Rattus norvegicus Ki = 27 nM 14684341
NPT409 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Homo sapiens Ki = 9.1 nM 14684341
NPT3921 Protein Complex Neuronal acetylcholine receptor; alpha2/beta4 Homo sapiens Ki = 103 nM 14684341
NPT411 Protein Complex Neuronal acetylcholine receptor; alpha3/beta4 Homo sapiens Ki = 320 nM 14684341
NPT3920 Protein Complex Neuronal acetylcholine receptor; alpha4/beta4 Homo sapiens Ki = 129 nM 14684341
NPT411 Protein Complex Neuronal acetylcholine receptor; alpha3/beta4 Homo sapiens EC50 = 4300 nM 14684341
NPT421 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Mus musculus Ki = 480 nM 11212100
NPT1783 Protein Complex Serotonin 3 (5-HT3) receptor Homo sapiens Ki = 71000 nM 11212100
NPT409 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Homo sapiens Ki = 2.3 nM 11212100
NPT424 Individual Protein Neuronal acetylcholine receptor subunit alpha-3 Homo sapiens Ki = 220 nM 11212100
NPT3919 Protein Complex Acetylcholine receptor; alpha1/beta1/delta/gamma Homo sapiens Ki = 5500 nM 11212100
NPT410 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Homo sapiens EC50 = 38000 nM 11212100
NPT2 Others Unspecified IC50 = 4 nM 9873508
NPT2 Others Unspecified Ki = 1.5 nM 11708907
NPT32 Organism Mus musculus Mus musculus ED50 = 0.006 mg/kg 11708907
NPT32 Organism Mus musculus Mus musculus ED50 = 0.004 mg/kg 11708907
NPT32 Organism Mus musculus Mus musculus ED50 = 0.001 mg/kg 11708907
NPT414 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Rattus norvegicus IC50 = 16 nM 10522693
NPT413 Protein Complex Neuronal acetylcholine receptor Rattus norvegicus Ki = 1.15 nM 7932582
NPT5029 Individual Protein Neuronal acetylcholine receptor protein alpha-9 subunit Rattus norvegicus Kd = 5 nM 9784094
NPT413 Protein Complex Neuronal acetylcholine receptor Rattus norvegicus Ki = 1.3 nM 12113825
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus IC50 = 3.8 nM 10377228
NPT413 Protein Complex Neuronal acetylcholine receptor Rattus norvegicus Ki = 1 nM 9022806
NPT410 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Homo sapiens Ki = 1610 nM 9022806
NPT744 Cell Line IMR-32 Homo sapiens EC50 = 21000 nM 9022806
NPT413 Protein Complex Neuronal acetylcholine receptor Rattus norvegicus Ki = 1 nM 8632405
NPT5030 Cell Line K177cell line EC50 = 5000 nM 8632405
NPT744 Cell Line IMR-32 Homo sapiens EC50 = 21000 nM 8632405
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 1.5 nM 11405659
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 1.01 nM 11405659
NPT32 Organism Mus musculus Mus musculus ED50 = 74 nM mouse-1 11405659
NPT413 Protein Complex Neuronal acetylcholine receptor Rattus norvegicus IC50 = 7 nM 3346870
NPT3922 Protein Complex Acetylcholine receptor Torpedo californica IC50 = 4 nM 3346870
NPT413 Protein Complex Neuronal acetylcholine receptor Rattus norvegicus IC50 = 3 nM 3346870
NPT3922 Protein Complex Acetylcholine receptor Torpedo californica IC50 = 1 nM 3346870
NPT29 Organism Rattus norvegicus Rattus norvegicus ED50 = 10 nM 3346870
NPT416 Protein Complex Neuronal acetylcholine receptor; alpha3/beta2 Rattus norvegicus Ki = 1 nM 11354387
NPT414 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Rattus norvegicus Ki = 770 nM 11354387
NPT3042 Protein Complex Neuronal nicotinic acetylcholine receptor Mus musculus IC50 = 4 nM 8765504
NPT422 Protein Family Muscarinic acetylcholine receptor Rattus norvegicus IC50 = 360000 nM 8765504
NPT5031 Protein Complex Nicotinic acetylcholine receptor alpha2/beta4 Homo sapiens EC50 = 10000 nM 8765504
NPT411 Protein Complex Neuronal acetylcholine receptor; alpha3/beta4 Homo sapiens EC50 = 51000 nM 8765504
NPT3920 Protein Complex Neuronal acetylcholine receptor; alpha4/beta4 Homo sapiens EC50 = 7100 nM 8765504
NPT409 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Homo sapiens EC50 = 2100 nM 8765504
NPT5032 Protein Complex Muscle-type nicotinic acetylcholine receptor Homo sapiens EC50 = 65000 nM 8765504
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 1 nM 15050621
NPT409 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Homo sapiens Ki = 1.2 nM 15203136
NPT32 Organism Mus musculus Mus musculus ED50 = 1.5 mg/kg 15203136
NPT32 Organism Mus musculus Mus musculus ED50 = 12 mg/kg 15203136
NPT32 Organism Mus musculus Mus musculus ED50 = 0.5 mg/kg 15203136
NPT409 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Homo sapiens Ki = 2 nM 15050612
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 1.4 nM 12372503
NPT414 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Rattus norvegicus Ki = 450 nM 12372503
NPT413 Protein Complex Neuronal acetylcholine receptor Rattus norvegicus Ki = 1 nM 10.1016/S0960-894X(97)10080-4
NPT2 Others Unspecified EC50 = 21000 nM 10.1016/S0960-894X(97)10080-4
NPT409 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Homo sapiens EC50 = 5000 nM 10.1016/S0960-894X(97)10080-4
NPT29 Organism Rattus norvegicus Rattus norvegicus EC50 = 40000 nM 10.1016/S0960-894X(97)10080-4
NPT5033 Individual Protein Acetylcholine receptor protein alpha chain Homo sapiens EC50 = 180000 nM 10.1016/S0960-894X(97)10080-4
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 1 nM 11741488
NPT414 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Rattus norvegicus Ki = 4000 nM 11741488
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 1 nM 12467625
NPT414 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Rattus norvegicus Ki = 340 nM 12467625
NPT413 Protein Complex Neuronal acetylcholine receptor Rattus norvegicus IC50 = 4 nM 10.1016/S0960-894X(97)00347-8
NPT422 Protein Family Muscarinic acetylcholine receptor Rattus norvegicus IC50 = 28000 nM 10.1016/S0960-894X(97)00347-8
NPT2 Others Unspecified IC50 = 4.2 nM 10.1016/S0960-894X(97)00347-8
NPT423 Protein Complex Neuronal acetylcholine receptor; alpha3/beta2 Homo sapiens IC50 = 3.8 nM 10.1016/S0960-894X(97)00347-8
NPT29 Organism Rattus norvegicus Rattus norvegicus Activity = 100 % 10.1016/S0960-894X(97)00347-8
NPT29 Organism Rattus norvegicus Rattus norvegicus Activity = 180 % 10.1016/S0960-894X(97)00347-8
NPT29 Organism Rattus norvegicus Rattus norvegicus Activity = 96 % 10.1016/S0960-894X(97)00347-8
NPT29 Organism Rattus norvegicus Rattus norvegicus ED50 = 0.04 mg/kg 10.1016/S0960-894X(97)00347-8
NPT32 Organism Mus musculus Mus musculus ED50 = 0.3 mg/kg 10.1016/S0960-894X(97)00347-8
NPT32 Organism Mus musculus Mus musculus ED50 > 9 mg/kg 10.1016/S0960-894X(97)00347-8
NPT415 Protein Complex Neuronal acetylcholine receptor; alpha2/beta2 Rattus norvegicus Ki = 12 nM 12620069
NPT3923 Protein Complex Neuronal acetylcholine receptor; alpha2/beta4 Rattus norvegicus Ki = 112 nM 12620069
NPT416 Protein Complex Neuronal acetylcholine receptor; alpha3/beta2 Rattus norvegicus Ki = 47 nM 12620069
NPT417 Protein Complex Neuronal acetylcholine receptor; alpha3/beta4 Rattus norvegicus Ki = 443 nM 12620069
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 10 nM 12620069
NPT418 Protein Complex Neuronal acetylcholine receptor; alpha4/beta4 Rattus norvegicus Ki = 40 nM 12620069
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 8 nM 12086489
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus EC50 = 7.3 nM 12086489
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 1.3 nM 12639569
NPT98 Individual Protein HERG Homo sapiens IC50 = 245470.89 nM 12873512
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 2.3 nM 11063601
NPT414 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Rattus norvegicus Ki = 480 nM 11063601
NPT414 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Rattus norvegicus EC50 = 43000000 nM 11063601
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 0.84 nM 11855986
NPT414 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Rattus norvegicus Ki = 130 nM 11855986
NPT5035 Individual Protein Neuronal acetylcholine receptor subunit beta-4 Rattus norvegicus Ki = 73 nM 11855986
NPT2 Others Unspecified Ki = 2.1 nM 11128647
NPT32 Organism Mus musculus Mus musculus ED50 = 12 ug mouse-1 11128647
NPT409 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Homo sapiens Ki = 2.1 nM 14698195
NPT409 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Homo sapiens Ki = 2 nM 12061885
NPT2 Others Unspecified Ki = 2000 nM 12061885
NPT296 Individual Protein Sigma opioid receptor Homo sapiens IC50 > 10000 nM 1469697
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 1 nM 9622546
NPT413 Protein Complex Neuronal acetylcholine receptor Rattus norvegicus Kd = 4.90E-06 nM 4032427
NPT413 Protein Complex Neuronal acetylcholine receptor Rattus norvegicus Kd = 0.01 nM 4032427
NPT413 Protein Complex Neuronal acetylcholine receptor Rattus norvegicus Kd = 430 nM 4032427
NPT413 Protein Complex Neuronal acetylcholine receptor Rattus norvegicus Kd = 11000 nM 4032427
NPT413 Protein Complex Neuronal acetylcholine receptor Rattus norvegicus Kd = 43000000 nM 4032427
NPT413 Protein Complex Neuronal acetylcholine receptor Rattus norvegicus Inhibition = 100 % 4032427
NPT413 Protein Complex Neuronal acetylcholine receptor Rattus norvegicus Kd = 0.022 nM 4032427
NPT413 Protein Complex Neuronal acetylcholine receptor Rattus norvegicus Kd = 10 nM 4032427
NPT413 Protein Complex Neuronal acetylcholine receptor Rattus norvegicus Kd = 5.2 nM 4032427
NPT413 Protein Complex Neuronal acetylcholine receptor Rattus norvegicus Kd = 45000 nM 4032427
NPT2 Others Unspecified Ki = 1.1 nM 7909335
NPT2 Others Unspecified Ki = 1.4 nM 7909335
NPT2 Others Unspecified Ki = 4000 nM 7909335
NPT2 Others Unspecified Ki > 20000 nM 7909335
NPT5029 Individual Protein Neuronal acetylcholine receptor protein alpha-9 subunit Rattus norvegicus IC50 = 2.4 nM 10346920
NPT29 Organism Rattus norvegicus Rattus norvegicus Activity = 1 10346920
NPT415 Protein Complex Neuronal acetylcholine receptor; alpha2/beta2 Rattus norvegicus Ki = 12 nM 15050615
NPT3923 Protein Complex Neuronal acetylcholine receptor; alpha2/beta4 Rattus norvegicus Ki = 112 nM 15050615
NPT416 Protein Complex Neuronal acetylcholine receptor; alpha3/beta2 Rattus norvegicus Ki = 47 nM 15050615
NPT417 Protein Complex Neuronal acetylcholine receptor; alpha3/beta4 Rattus norvegicus Ki = 443 nM 15050615
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 10 nM 15050615
NPT418 Protein Complex Neuronal acetylcholine receptor; alpha4/beta4 Rattus norvegicus Ki = 40 nM 15050615
NPT3042 Protein Complex Neuronal nicotinic acetylcholine receptor Mus musculus Ki = 1.2 nM 12270194
NPT32 Organism Mus musculus Mus musculus ED50 = 7.4 umol/kg 12270194
NPT32 Organism Mus musculus Mus musculus ED50 = 3.1 umol/kg 12270194
NPT29 Organism Rattus norvegicus Rattus norvegicus ED50 = 0.6 umol/kg 12270194
NPT409 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Homo sapiens Ki = 4 nM 10447950
NPT410 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Homo sapiens Ki = 620 nM 10447950
NPT2 Others Unspecified Ki = 12 nM 15771418
NPT2 Others Unspecified Ki = 112 nM 15771418
NPT423 Protein Complex Neuronal acetylcholine receptor; alpha3/beta2 Homo sapiens Ki = 47 nM 15771418
NPT417 Protein Complex Neuronal acetylcholine receptor; alpha3/beta4 Rattus norvegicus Ki = 443 nM 15771418
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 10 nM 15771418
NPT2 Others Unspecified Ki = 40 nM 15771418
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 1.5 nM 15715488
NPT32 Organism Mus musculus Mus musculus ED50 = 1.3 mg/kg 15715488
NPT32 Organism Mus musculus Mus musculus ED50 = 0.65 mg/kg 15715488
NPT32 Organism Mus musculus Mus musculus ED50 = 1 mg/kg 15715488
NPT32 Organism Mus musculus Mus musculus ED50 = 0.5 mg/kg 15715488
NPT240 Individual Protein Cytochrome P450 2A6 Homo sapiens Ki = 4400 nM 15634016
NPT2 Others Unspecified Ki = 2.5 nM 15686879
NPT2 Others Unspecified Kd = 3.08 nM 15686879
NPT410 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Homo sapiens Ki = 7200 nM 15686879
NPT410 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Homo sapiens Kd = 1.06 nM 15686879
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 1 nM 16005216
NPT414 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Rattus norvegicus Ki = 770 nM 16005216
NPT414 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Rattus norvegicus EC50 = 13000 nM 16005216
NPT417 Protein Complex Neuronal acetylcholine receptor; alpha3/beta4 Rattus norvegicus EC50 = 86000 nM 16005216
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus EC50 = 1000 nM 16005216
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 1.5 nM 15317468
NPT32 Organism Mus musculus Mus musculus ED50 = 1.3 mg/kg 15317468
NPT32 Organism Mus musculus Mus musculus ED50 = 0.65 mg/kg 15317468
NPT32 Organism Mus musculus Mus musculus ED50 = 1 mg/kg 15317468
NPT32 Organism Mus musculus Mus musculus ED50 = 0.5 mg/kg 15317468
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 2 nM 15501049
NPT414 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Rattus norvegicus Ki = 460 nM 15501049
NPT409 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Homo sapiens Ki = 1.6 nM 15908213
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 0.95 nM 15908213
NPT411 Protein Complex Neuronal acetylcholine receptor; alpha3/beta4 Homo sapiens Ki = 530 nM 15908213
NPT2 Others Unspecified Ki = 6300 nM 15908213
NPT410 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Homo sapiens Ki = 6300 nM 15908213
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 35 nM 15925512
NPT423 Protein Complex Neuronal acetylcholine receptor; alpha3/beta2 Homo sapiens EC50 = 132000 nM 16033252
NPT2 Others Unspecified EC50 = 80000 nM 16033252
NPT2 Others Unspecified EC50 = 5000 nM 16033252
NPT410 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Homo sapiens EC50 = 113000 nM 16033252
NPT2 Others Unspecified EC50 = 5500 nM 16033252
NPT2 Others Unspecified EC50 = 21000 nM 16033252
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 0.95 nM 15887955
NPT411 Protein Complex Neuronal acetylcholine receptor; alpha3/beta4 Homo sapiens Ki = 530 nM 15887955
NPT3922 Protein Complex Acetylcholine receptor Torpedo californica Ki = 6270 nM 15887955
NPT414 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Rattus norvegicus Ki = 6290 nM 15887955
NPT208 Individual Protein Cytochrome P450 1A2 Homo sapiens IC50 = 4100000 nM 15916432
NPT414 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Rattus norvegicus Ki = 1748 nM 15808471
NPT409 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Homo sapiens Ki > 10000 nM 15808471
NPT98 Individual Protein HERG Homo sapiens IC50 = 245470.89 nM 15911273
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 1.8 nM 16039854
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 10 nM 16039849
NPT418 Protein Complex Neuronal acetylcholine receptor; alpha4/beta4 Rattus norvegicus Ki = 40 nM 16039849
NPT415 Protein Complex Neuronal acetylcholine receptor; alpha2/beta2 Rattus norvegicus Ki = 12 nM 16039849
NPT3923 Protein Complex Neuronal acetylcholine receptor; alpha2/beta4 Rattus norvegicus Ki = 110 nM 16039849
NPT416 Protein Complex Neuronal acetylcholine receptor; alpha3/beta2 Rattus norvegicus Ki = 47 nM 16039849
NPT417 Protein Complex Neuronal acetylcholine receptor; alpha3/beta4 Rattus norvegicus Ki = 440 nM 16039849
NPT409 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Homo sapiens Ki = 1.6 nM 16171993
NPT411 Protein Complex Neuronal acetylcholine receptor; alpha3/beta4 Homo sapiens Ki = 530 nM 16171993
NPT3919 Protein Complex Acetylcholine receptor; alpha1/beta1/delta/gamma Homo sapiens Ki = 6270 nM 16171993
NPT410 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Homo sapiens Ki = 630 nM 16171993
NPT32 Organism Mus musculus Mus musculus Inhibition = 100 % 16412637
NPT32 Organism Mus musculus Mus musculus Inhibition = 88 % 16412637
NPT29 Organism Rattus norvegicus Rattus norvegicus Activity = 100 % 16412637
NPT29 Organism Rattus norvegicus Rattus norvegicus Activity = 50 % 16412637
NPT29 Organism Rattus norvegicus Rattus norvegicus Activity = 25 % 16412637
NPT417 Protein Complex Neuronal acetylcholine receptor; alpha3/beta4 Rattus norvegicus EC50 = 35000 nM 16640326
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus EC50 = 10000 nM 16640326
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 1.5 nM 16722642
NPT32 Organism Mus musculus Mus musculus ED50 = 1.3 mg/kg 16722642
NPT32 Organism Mus musculus Mus musculus ED50 = 0.65 mg/kg 16722642
NPT32 Organism Mus musculus Mus musculus ED50 = 1 mg/kg 16722642
NPT32 Organism Mus musculus Mus musculus ED50 = 0.5 mg/kg 16722642
NPT29 Organism Rattus norvegicus Rattus norvegicus Activity = 98.3 % 16722642
NPT414 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Rattus norvegicus Ki = 750 nM 16765047
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 4 nM 16942873
NPT414 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Rattus norvegicus Ki = 234 nM 16942873
NPT411 Protein Complex Neuronal acetylcholine receptor; alpha3/beta4 Homo sapiens EC50 = 19830 nM 15615518
NPT411 Protein Complex Neuronal acetylcholine receptor; alpha3/beta4 Homo sapiens Activity = 100 % 15615518
NPT409 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Homo sapiens Activity = 0.26 ml 15615518
NPT411 Protein Complex Neuronal acetylcholine receptor; alpha3/beta4 Homo sapiens Activity = 0.16 ml 15615518
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 0.9333 nM 17585748
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 0.94 nM 17585748
NPT409 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Homo sapiens EC50 = 9332.54 nM 17585748
NPT409 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Homo sapiens EC50 = 9400 nM 17585748
NPT2 Others Unspecified EC50 = 199.53 nM 17585748
NPT2 Others Unspecified EC50 = 200 nM 17585748
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 6.2 nM 17722904
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 6.31 nM 17722904
NPT418 Protein Complex Neuronal acetylcholine receptor; alpha4/beta4 Rattus norvegicus Ki = 33 nM 17722904
NPT417 Protein Complex Neuronal acetylcholine receptor; alpha3/beta4 Rattus norvegicus Ki = 220 nM 17722904
NPT417 Protein Complex Neuronal acetylcholine receptor; alpha3/beta4 Rattus norvegicus Ki = 199.53 nM 17722904
NPT418 Protein Complex Neuronal acetylcholine receptor; alpha4/beta4 Rattus norvegicus Ki = 31.62 nM 17722904
NPT410 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Homo sapiens Ki = 24000 nM 17722904
NPT410 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Homo sapiens Ki = 25118.86 nM 17722904
NPT410 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Homo sapiens Ki = 12000 nM 17722904
NPT410 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Homo sapiens Ki = 10000 nM 17722904
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 6.8 nM 17850058
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 3 nM 17850058
NPT414 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Rattus norvegicus Ki = 450 nM 17850058
NPT2 Others Unspecified Ki = 1 nM 17929796
NPT2 Others Unspecified Ki = 0.9333 nM 17929796
NPT409 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Homo sapiens EC50 = 6600 nM 17929796
NPT409 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Homo sapiens EC50 = 6606.93 nM 17929796
NPT409 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Homo sapiens Activity = 101 % 17929796
NPT411 Protein Complex Neuronal acetylcholine receptor; alpha3/beta4 Homo sapiens EC50 = 8000 nM 17929796
NPT411 Protein Complex Neuronal acetylcholine receptor; alpha3/beta4 Homo sapiens EC50 = 7943.28 nM 17929796
NPT411 Protein Complex Neuronal acetylcholine receptor; alpha3/beta4 Homo sapiens Activity = 89 % 17929796
NPT409 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Homo sapiens Ki = 1.5 nM 17994682
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 7 nM 18006307
NPT414 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Rattus norvegicus EC50 = 1500 nM 18078760
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 4 nM 18262785
NPT414 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Rattus norvegicus Ki = 1500 nM 18262785
NPT2 Others Unspecified Ki > 10000 nM 18262785
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 1.5 nM 17964169
NPT414 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Rattus norvegicus Ki = 670 nM 17964169
NPT32 Organism Mus musculus Mus musculus ED50 = 1.3 mg/kg 17964169
NPT32 Organism Mus musculus Mus musculus ED50 = 0.65 mg/kg 17964169
NPT32 Organism Mus musculus Mus musculus ED50 = 1 mg/kg 17964169
NPT32 Organism Mus musculus Mus musculus ED50 = 0.5 mg/kg 17964169
NPT2 Others Unspecified Ki = 415 nM 17485662
NPT2 Others Unspecified Ki = 260 nM 17485662
NPT410 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Homo sapiens EC50 = 1584.89 nM 19208472
NPT3924 Individual Protein Neuronal acetylcholine receptor protein alpha-4 subunit Rattus norvegicus Ki = 0.94 nM 19232492
NPT429 Individual Protein Neuronal acetylcholine receptor protein alpha-4 subunit Homo sapiens EC50 = 4700 nM 19232492
NPT424 Individual Protein Neuronal acetylcholine receptor subunit alpha-3 Homo sapiens EC50 = 9400 nM 19232492
NPT98 Individual Protein HERG Homo sapiens IC50 = 244300 nM 19534531
NPT98 Individual Protein HERG Homo sapiens IC50 = 244299.74 nM 19534531
NPT3924 Individual Protein Neuronal acetylcholine receptor protein alpha-4 subunit Rattus norvegicus Ki = 0.94 nM 19552432
NPT414 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Rattus norvegicus Ki = 176 nM 19552432
NPT2 Others Unspecified Ratio Ki = 190 19552432
NPT429 Individual Protein Neuronal acetylcholine receptor protein alpha-4 subunit Homo sapiens EC50 = 6600 nM 19552432
NPT410 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Homo sapiens EC50 = 91000 nM 19552432
NPT612 Individual Protein Canalicular multispecific organic anion transporter 1 Homo sapiens Activity = 101 % 18457386
NPT98 Individual Protein HERG Homo sapiens IC50 = 245470.89 nM 18448342
NPT613 Individual Protein Solute carrier family 22 member 1 Homo sapiens Inhibition = -3.7 % 18788725
NPT3924 Individual Protein Neuronal acetylcholine receptor protein alpha-4 subunit Rattus norvegicus Ki = 22 nM 18989912
NPT3924 Individual Protein Neuronal acetylcholine receptor protein alpha-4 subunit Rattus norvegicus Ki = 19.95 nM 18989912
NPT428 Individual Protein Neuronal acetylcholine receptor subunit alpha-3 Rattus norvegicus Ki = 600 nM 18989912
NPT428 Individual Protein Neuronal acetylcholine receptor subunit alpha-3 Rattus norvegicus Ki = 630.96 nM 18989912
NPT3924 Individual Protein Neuronal acetylcholine receptor protein alpha-4 subunit Rattus norvegicus Ki = 150 nM 18989912
NPT3924 Individual Protein Neuronal acetylcholine receptor protein alpha-4 subunit Rattus norvegicus Ki = 158.49 nM 18989912
NPT414 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Rattus norvegicus Ki = 16000 nM 18989912
NPT414 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Rattus norvegicus Ki = 15848.93 nM 18989912
NPT430 Individual Protein Acetylcholine-binding protein Lymnaea stagnalis Ki = 63.1 nM 19331415
NPT410 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Homo sapiens Ki = 1000 nM 19331415
NPT2 Others Unspecified Ki = 398.11 nM 19331415
NPT2 Others Unspecified Ki = 0.9 nM 8496700
NPT2 Others Unspecified Activity = 75 % 8496700
NPT414 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Rattus norvegicus Ki = 234 nM 19097783
NPT3924 Individual Protein Neuronal acetylcholine receptor protein alpha-4 subunit Rattus norvegicus Ki = 4 nM 19097783
NPT98 Individual Protein HERG Homo sapiens IC50 = 245470.89 nM 18262683
NPT1420 Individual Protein Cytochrome P450 2A5 Mus musculus IC50 = 159955.8 nM 19110342
NPT240 Individual Protein Cytochrome P450 2A6 Homo sapiens IC50 = 579428.7 nM 19110342
NPT5036 Individual Protein Neuronal acetylcholine receptor protein alpha-2 subunit Rattus norvegicus Ki = 12 nM 19481945
NPT5036 Individual Protein Neuronal acetylcholine receptor protein alpha-2 subunit Rattus norvegicus Ki = 110 nM 19481945
NPT428 Individual Protein Neuronal acetylcholine receptor subunit alpha-3 Rattus norvegicus Ki = 47 nM 19481945
NPT428 Individual Protein Neuronal acetylcholine receptor subunit alpha-3 Rattus norvegicus Ki = 440 nM 19481945
NPT3924 Individual Protein Neuronal acetylcholine receptor protein alpha-4 subunit Rattus norvegicus Ki = 10 nM 19481945
NPT3924 Individual Protein Neuronal acetylcholine receptor protein alpha-4 subunit Rattus norvegicus Ki = 40 nM 19481945
NPT2 Others Unspecified Ratio Ki = 44 19481945
NPT3924 Individual Protein Neuronal acetylcholine receptor protein alpha-4 subunit Rattus norvegicus IC50 = 1.65 nM 19576766
NPT2 Others Unspecified Ki = 330 nM 20036131
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 1.4 nM 20036131
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 1.5 nM 20038125
NPT32 Organism Mus musculus Mus musculus ED50 = 1.3 mg/kg 20038125
NPT32 Organism Mus musculus Mus musculus ED50 = 0.65 mg/kg 20038125
NPT32 Organism Mus musculus Mus musculus ED50 = 1 mg/kg 20038125
NPT32 Organism Mus musculus Mus musculus ED50 = 0.5 mg/kg 20038125
NPT346 Individual Protein Transient receptor potential cation channel subfamily A member 1 Homo sapiens EC50 = 17000 nM 20356305
NPT411 Protein Complex Neuronal acetylcholine receptor; alpha3/beta4 Homo sapiens Ki = 394 nM 20663668
NPT409 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Homo sapiens Ki = 9.46 nM 20663668
NPT2 Others Unspecified Ki = 168 nM 20663668
NPT410 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Homo sapiens Ki = 2110 nM 20663668
NPT3919 Protein Complex Acetylcholine receptor; alpha1/beta1/delta/gamma Homo sapiens Ki = 1480 nM 20663668
NPT32 Organism Mus musculus Mus musculus ED50 = 22.7 mg/kg 20356304
NPT409 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Homo sapiens EC50 = 300 nM 20822184
NPT409 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Homo sapiens IC50 = 430 nM 20822184
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 4.9 nM 20822184
NPT415 Protein Complex Neuronal acetylcholine receptor; alpha2/beta2 Rattus norvegicus Ki = 5.5 nM 20822184
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 9.8 nM 20822184
NPT418 Protein Complex Neuronal acetylcholine receptor; alpha4/beta4 Rattus norvegicus Ki = 23 nM 20822184
NPT416 Protein Complex Neuronal acetylcholine receptor; alpha3/beta2 Rattus norvegicus Ki = 29 nM 20822184
NPT3923 Protein Complex Neuronal acetylcholine receptor; alpha2/beta4 Rattus norvegicus Ki = 70 nM 20822184
NPT417 Protein Complex Neuronal acetylcholine receptor; alpha3/beta4 Rattus norvegicus Ki = 260 nM 20822184
NPT430 Individual Protein Acetylcholine-binding protein Lymnaea stagnalis Kd = 478.63 nM 20828128
NPT2 Others Unspecified Kd = 2884.03 nM 20828128
NPT430 Individual Protein Acetylcholine-binding protein Lymnaea stagnalis Ki = 331.13 nM 20828128
NPT410 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Homo sapiens Ki = 1023.29 nM 20828128
NPT417 Protein Complex Neuronal acetylcholine receptor; alpha3/beta4 Rattus norvegicus Ki = 481 nM 20979364
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 11.1 nM 20979364
NPT51 Individual Protein Microtubule-associated protein tau Homo sapiens Potency = 22387.2 nM PubChem BioAssay data set
NPT94 Individual Protein Aldehyde dehydrogenase 1A1 Homo sapiens Potency = 15848.9 nM PubChem BioAssay data set
NPT94 Individual Protein Aldehyde dehydrogenase 1A1 Homo sapiens Potency = 39810.7 nM PubChem BioAssay data set
NPT94 Individual Protein Aldehyde dehydrogenase 1A1 Homo sapiens Potency = 28183.8 nM PubChem BioAssay data set
NPT583 Individual Protein Inositol monophosphatase 1 Rattus norvegicus Potency = 28183.8 nM PubChem BioAssay data set
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 2 nM 20932609
NPT414 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Rattus norvegicus Ki = 469 nM 20932609
NPT2 Others Unspecified IC50 = 10 nM 20875743
NPT2 Others Unspecified EC50 = 941600 nM 18710918
NPT2 Others Unspecified EC50 = 1963000 nM 18710918
NPT2 Others Unspecified Ratio EC50 = 2.1 18710918
NPT2 Others Unspecified IC50 = 5800 nM 18710918
NPT2 Others Unspecified IC50 = 6200 nM 18710918
NPT2 Others Unspecified Ratio IC50 = 1.07 18710918
NPT2 Others Unspecified IC50 = 3700 nM 18710918
NPT2 Others Unspecified IC50 = 3600 nM 18710918
NPT2 Others Unspecified Ratio IC50 = 0.95 18710918
NPT242 Individual Protein Dopamine D1 receptor Homo sapiens Potency 145.8 nM PubChem BioAssay data set
NPT5 Individual Protein Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Homo sapiens Potency 26679.5 nM PubChem BioAssay data set
NPT135 Individual Protein Chromobox protein homolog 1 Homo sapiens Potency 79432.8 nM PubChem BioAssay data set
NPT533 Protein-Protein Interaction Runt-related transcription factor 1/Core-binding factor subunit beta Homo sapiens Potency 10000 nM PubChem BioAssay data set
NPT2 Others Unspecified IC50 = 4.7 nM 21824774
NPT430 Individual Protein Acetylcholine-binding protein Lymnaea stagnalis Ki = 316.23 nM 21920761
NPT410 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Homo sapiens Ki = 1000 nM 21920761
NPT415 Protein Complex Neuronal acetylcholine receptor; alpha2/beta2 Rattus norvegicus Ki = 5.5 nM 21905669
NPT3923 Protein Complex Neuronal acetylcholine receptor; alpha2/beta4 Rattus norvegicus Ki = 70 nM 21905669
NPT416 Protein Complex Neuronal acetylcholine receptor; alpha3/beta2 Rattus norvegicus Ki = 29 nM 21905669
NPT417 Protein Complex Neuronal acetylcholine receptor; alpha3/beta4 Rattus norvegicus Ki = 260 nM 21905669
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 4.9 nM 21905669
NPT418 Protein Complex Neuronal acetylcholine receptor; alpha4/beta4 Rattus norvegicus Ki = 23 nM 21905669
NPT409 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Homo sapiens EC50 = 290 nM 21905669
NPT409 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Homo sapiens IC50 = 430 nM 21905669
NPT7 Individual Protein Thioredoxin reductase 1, cytoplasmic Rattus norvegicus Potency 44668.4 nM PubChem BioAssay data set
NPT698 Individual Protein Regulator of G-protein signaling 4 Homo sapiens Potency 422.8 nM PubChem BioAssay data set
NPT698 Individual Protein Regulator of G-protein signaling 4 Homo sapiens Potency 2667.9 nM PubChem BioAssay data set
NPT698 Individual Protein Regulator of G-protein signaling 4 Homo sapiens Potency 94.7 nM PubChem BioAssay data set
NPT154 Individual Protein Mothers against decapentaplegic homolog 3 Homo sapiens Potency 3162.3 nM PubChem BioAssay data set
NPT71 Cell Line HEK293 Homo sapiens Potency 4.1 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency 3548.1 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency 20587.8 nM PubChem BioAssay data set
NPT2 Others Unspecified IC50 = 12 nM DrugMatrix in vitro pharmacology data
NPT2 Others Unspecified Ki = 4.123 nM DrugMatrix in vitro pharmacology data
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus EC50 = 67 nM 21942635
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus EC50 = 67.61 nM 21942635
NPT430 Individual Protein Acetylcholine-binding protein Lymnaea stagnalis Ki = 316.23 nM 22243960
NPT1862 Individual Protein Soluble acetylcholine receptor Aplysia californica Ki = 2511.89 nM 22243960
NPT410 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Homo sapiens Ki = 1000 nM 22243960
NPT409 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Homo sapiens Ki = 12.59 nM 22243960
NPT414 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Rattus norvegicus Ki = 1400 nM 22281189
NPT415 Protein Complex Neuronal acetylcholine receptor; alpha2/beta2 Rattus norvegicus Ki = 5.5 nM 22171543
NPT3923 Protein Complex Neuronal acetylcholine receptor; alpha2/beta4 Rattus norvegicus Ki = 70 nM 22171543
NPT416 Protein Complex Neuronal acetylcholine receptor; alpha3/beta2 Rattus norvegicus Ki = 29 nM 22171543
NPT417 Protein Complex Neuronal acetylcholine receptor; alpha3/beta4 Rattus norvegicus Ki = 260 nM 22171543
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 4.9 nM 22171543
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 9.8 nM 22171543
NPT418 Protein Complex Neuronal acetylcholine receptor; alpha4/beta4 Rattus norvegicus Ki = 23 nM 22171543
NPT2 Others Unspecified Ratio Ki = 53 22171543
NPT409 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Homo sapiens EC50 = 290 nM 22171543
NPT409 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Homo sapiens IC50 = 430 nM 22171543
NPT2 Others Unspecified Ki = 0.85 nM 22609074
NPT2 Others Unspecified Ki = 75.3 nM 22609074
NPT2 Others Unspecified Ki = 129 nM 22609074
NPT409 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Homo sapiens EC50 = 1 nM 22591063
NPT1542 Individual Protein Solute carrier family 22 member 3 Rattus norvegicus Activity = 52 % 9632645
NPT1543 Individual Protein Solute carrier family 22 member 4 Homo sapiens Activity = 71.6 % 10215651
NPT705 Individual Protein Solute carrier family 22 member 5 Homo sapiens Activity = 82.6 % 10525100
NPT2851 Individual Protein Solute carrier family 22 member 4 Rattus norvegicus Activity = 29 % 10825452
NPT705 Individual Protein Solute carrier family 22 member 5 Homo sapiens Activity = 44 % 9618255
NPT613 Individual Protein Solute carrier family 22 member 1 Homo sapiens Activity = 53.2 nM 12606755
NPT1544 Individual Protein Solute carrier family 22 member 2 Rattus norvegicus Ki = 50500 nM 9808712
NPT435 Individual Protein Solute carrier family 22 member 1 Rattus norvegicus Ki = 64300 nM 9808712
NPT152 Individual Protein Nuclear factor erythroid 2-related factor 2 Homo sapiens Potency 47307.9 nM PubChem BioAssay data set
NPT10 Individual Protein Geminin Homo sapiens Potency 891.3 nM PubChem BioAssay data set
NPT102 Individual Protein Interleukin-8 Homo sapiens Potency 47307.9 nM PubChem BioAssay data set
NPT103 Individual Protein Nuclear receptor ROR-gamma Homo sapiens Potency 33491.5 nM PubChem BioAssay data set
NPT418 Protein Complex Neuronal acetylcholine receptor; alpha4/beta4 Rattus norvegicus Ki = 23 nM 22148173
NPT2 Others Unspecified Ki = 9.8 nM 22148173
NPT418 Protein Complex Neuronal acetylcholine receptor; alpha4/beta4 Rattus norvegicus Ki = 5.5 nM 22148173
NPT3923 Protein Complex Neuronal acetylcholine receptor; alpha2/beta4 Rattus norvegicus Ki = 70 nM 22148173
NPT411 Protein Complex Neuronal acetylcholine receptor; alpha3/beta4 Homo sapiens IC50 = 430 nM 22148173
NPT5037 Protein Complex Neuronal acetylcholine receptors; alpha-3/beta-4, alpha-5, beta-2 Homo sapiens EC50 = 30000 nM 22148173
NPT411 Protein Complex Neuronal acetylcholine receptor; alpha3/beta4 Homo sapiens EC50 = 290 nM 22148173
NPT417 Protein Complex Neuronal acetylcholine receptor; alpha3/beta4 Rattus norvegicus Ki = 260 nM 22148173
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 4.9 nM 22148173
NPT416 Protein Complex Neuronal acetylcholine receptor; alpha3/beta2 Rattus norvegicus Ki = 29 nM 22148173
NPT622 Individual Protein Solute carrier organic anion transporter family member 2B1 Homo sapiens Inhibition = -16.5 % 22541068
NPT72 Individual Protein Solute carrier organic anion transporter family member 1B3 Homo sapiens Inhibition = 11 % 22541068
NPT73 Individual Protein Solute carrier organic anion transporter family member 1B1 Homo sapiens Inhibition = 6.9 % 22541068
NPT66 Individual Protein Acetylcholinesterase Electrophorus electricus Inhibition = 15.6 % 23062825
NPT67 Individual Protein Cholinesterase Equus caballus Inhibition = 1.2 % 23062825
NPT1862 Individual Protein Soluble acetylcholine receptor Aplysia californica Ki = 598 nM 22928944
NPT430 Individual Protein Acetylcholine-binding protein Lymnaea stagnalis Ki = 496 nM 22928944
NPT414 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Rattus norvegicus EC50 = 1071.52 nM 23083093
NPT411 Protein Complex Neuronal acetylcholine receptor; alpha3/beta4 Homo sapiens EC50 = 7000 nM 22793665
NPT409 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Homo sapiens EC50 = 3000 nM 22793665
NPT410 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Homo sapiens Ki = 3000 nM 22793665
NPT411 Protein Complex Neuronal acetylcholine receptor; alpha3/beta4 Homo sapiens Ki = 400 nM 22793665
NPT2 Others Unspecified Ki = 3.5 nM 23025891
NPT421 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Mus musculus Ki = 244 nM 23025891
NPT2 Others Unspecified Ki = 167 nM 23025891
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 2 nM 22793665
NPT409 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Homo sapiens Ki = 2 nM 22793665
NPT409 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Homo sapiens IC50 = 426.58 nM 23092294
NPT409 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Homo sapiens EC50 = 295.12 nM 23092294
NPT3919 Protein Complex Acetylcholine receptor; alpha1/beta1/delta/gamma Homo sapiens IC50 > 1000 nM 23092294
NPT3919 Protein Complex Acetylcholine receptor; alpha1/beta1/delta/gamma Homo sapiens EC50 > 1000 nM 23092294
NPT411 Protein Complex Neuronal acetylcholine receptor; alpha3/beta4 Homo sapiens IC50 > 1000 nM 23092294
NPT411 Protein Complex Neuronal acetylcholine receptor; alpha3/beta4 Homo sapiens EC50 > 1000 nM 23092294
NPT409 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Homo sapiens Ki = 2 nM 23126648
NPT409 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Homo sapiens IC50 = 427 nM 23092294
NPT409 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Homo sapiens EC50 = 295 nM 23092294
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 9.8 nM 23092294
NPT3920 Protein Complex Neuronal acetylcholine receptor; alpha4/beta4 Homo sapiens Ki = 23 nM 23092294
NPT409 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Homo sapiens Ki = 4.9 nM 23092294
NPT411 Protein Complex Neuronal acetylcholine receptor; alpha3/beta4 Homo sapiens Ki = 260 nM 23092294
NPT423 Protein Complex Neuronal acetylcholine receptor; alpha3/beta2 Homo sapiens Ki = 29 nM 23092294
NPT3920 Protein Complex Neuronal acetylcholine receptor; alpha4/beta4 Homo sapiens Ki = 70 nM 23092294
NPT409 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Homo sapiens Ki = 5.5 nM 23092294
NPT414 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Rattus norvegicus EC50 = 23000 nM 23126648
NPT410 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Homo sapiens Ki = 3000 nM 23126648
NPT411 Protein Complex Neuronal acetylcholine receptor; alpha3/beta4 Homo sapiens Ki = 260 nM 23641311
NPT3921 Protein Complex Neuronal acetylcholine receptor; alpha2/beta4 Homo sapiens Ki = 70 nM 23641311
NPT423 Protein Complex Neuronal acetylcholine receptor; alpha3/beta2 Homo sapiens Ki = 29 nM 23641311
NPT3920 Protein Complex Neuronal acetylcholine receptor; alpha4/beta4 Homo sapiens Ki = 23 nM 23641311
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 9.8 nM 23641311
NPT5038 Protein Complex Neuronal acetylcholine receptor; alpha2/beta2 Homo sapiens Ki = 5.5 nM 23641311
NPT409 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Homo sapiens Ki = 4.9 nM 23641311
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Activity > 80 % 23116890
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Activity = 24 % 23116890
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 2.83 nM 23116890
NPT430 Individual Protein Acetylcholine-binding protein Lymnaea stagnalis Ki = 100 nM 21341671
NPT1862 Individual Protein Soluble acetylcholine receptor Aplysia californica Ki = 30 nM 21341671
NPT427 Individual Protein Neuronal acetylcholine receptor subunit alpha-4 Gallus gallus Ki = 1.9 nM 21341671
NPT4533 Individual Protein Acetylcholine receptor subunit beta-like 2 Drosophila melanogaster Ki = 2700 nM 21341671
NPT409 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Homo sapiens Ki = 1.05 nM 10.1007/s00044-005-0137-8
NPT1304 Individual Protein Nicotinic acetylcholine receptor alpha 5 subunit Musca domestica IC50 = 11900 nM 12834274
NPT5039 Individual Protein Neuronal acetylcholine receptor protein alpha-4 subunit Mus musculus IC50 = 7 nM 11312774
NPT424 Individual Protein Neuronal acetylcholine receptor subunit alpha-3 Homo sapiens IC50 = 45 nM 11312774
NPT410 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Homo sapiens IC50 = 21000 nM 11312774
NPT5033 Individual Protein Acetylcholine receptor protein alpha chain Homo sapiens IC50 = 21000 nM 11312774
NPT4533 Individual Protein Acetylcholine receptor subunit beta-like 2 Drosophila melanogaster IC50 = 4000 nM 11312774
NPT32 Organism Mus musculus Mus musculus LD50 = 6 mg/kg 11312774
NPT734 Organism Musca domestica Musca domestica LD50 > 50 mg/kg 11312774
NPT734 Organism Musca domestica Musca domestica Activity = 38.3 % 10.1584/jpestics.29.43
NPT1304 Individual Protein Nicotinic acetylcholine receptor alpha 5 subunit Musca domestica Activity = 11.9 nM 10.1584/jpestics.29.43
NPT2 Others Unspecified Ki = 146 nM 23112103
NPT2 Others Unspecified Ki = 800 nM 23112103
NPT2 Others Unspecified Ki = 1480 nM 10.1584/jpestics.17.4_231
NPT1304 Individual Protein Nicotinic acetylcholine receptor alpha 5 subunit Musca domestica Ki = 2480 nM 10.1584/jpestics.17.4_231
NPT3044 Individual Protein Acetylcholinesterase Musca domestica IC50 = 2600000 nM 10.1584/jpestics.17.4_231
NPT734 Organism Musca domestica Musca domestica FC = 1 10.1584/jpestics.17.4_231
NPT2 Others Unspecified IC50 = 9.6 nM 10.1584/jpestics.20.33
NPT3925 Individual Protein Acetylcholine receptor protein alpha chain Torpedo californica IC50 = 23100 nM 10.1584/jpestics.20.33
NPT2 Others Unspecified IC50 = 1250 nM 10.1584/jpestics.20.33
NPT3925 Individual Protein Acetylcholine receptor protein alpha chain Torpedo californica IC50 = 23100 nM 10.1584/jpestics.20.49
NPT734 Organism Musca domestica Musca domestica LD50 = 14.8 ug 10.1584/jpestics.20.57
NPT2 Others Unspecified IC50 = 1550 nM 10.1584/jpestics.20.57
NPT2 Others Unspecified IC50 = 1140 nM 10.1584/jpestics.20.57
NPT3837 Individual Protein Lycopene cyclase Pantoea ananas Activity = 64 % 10.1584/jpestics.23.113
NPT3837 Individual Protein Lycopene cyclase Pantoea ananas IC50 = 4800 nM 10.1584/jpestics.23.113
NPT2 Others Unspecified Ratio Ki = 18 23256554
NPT2 Others Unspecified Ratio Ki = 33 23256554
NPT430 Individual Protein Acetylcholine-binding protein Lymnaea stagnalis Ki = 83.18 nM 23256554
NPT430 Individual Protein Acetylcholine-binding protein Lymnaea stagnalis Ki = 83 nM 23256554
NPT418 Protein Complex Neuronal acetylcholine receptor; alpha4/beta4 Rattus norvegicus Ki = 141.25 nM 23256554
NPT417 Protein Complex Neuronal acetylcholine receptor; alpha3/beta4 Rattus norvegicus Ki = 251.19 nM 23256554
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 7.586 nM 23256554
NPT418 Protein Complex Neuronal acetylcholine receptor; alpha4/beta4 Rattus norvegicus Ki = 140 nM 23256554
NPT417 Protein Complex Neuronal acetylcholine receptor; alpha3/beta4 Rattus norvegicus Ki = 250 nM 23256554
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 7.6 nM 23256554
NPT417 Protein Complex Neuronal acetylcholine receptor; alpha3/beta4 Rattus norvegicus IC50 > 10000 nM 23540678
NPT417 Protein Complex Neuronal acetylcholine receptor; alpha3/beta4 Rattus norvegicus EC50 = 23000 nM 23540678
NPT409 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Homo sapiens EC50 = 2400 nM 23540678
NPT2 Others Unspecified Ratio Ki = 520 23540678
NPT414 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Rattus norvegicus Ki = 517 nM 23540678
NPT417 Protein Complex Neuronal acetylcholine receptor; alpha3/beta4 Rattus norvegicus Ki = 440 nM 23540678
NPT409 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Homo sapiens IC50 = 370 nM 23540678
NPT3923 Protein Complex Neuronal acetylcholine receptor; alpha2/beta4 Rattus norvegicus Ki = 110 nM 23540678
NPT416 Protein Complex Neuronal acetylcholine receptor; alpha3/beta2 Rattus norvegicus Ki = 47 nM 23540678
NPT2 Others Unspecified Ratio Ki = 44 23540678
NPT418 Protein Complex Neuronal acetylcholine receptor; alpha4/beta4 Rattus norvegicus Ki = 40 nM 23540678
NPT2 Others Unspecified Ratio Ki = 12 23540678
NPT415 Protein Complex Neuronal acetylcholine receptor; alpha2/beta2 Rattus norvegicus Ki = 12 nM 23540678
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 10 nM 23540678
NPT411 Protein Complex Neuronal acetylcholine receptor; alpha3/beta4 Homo sapiens Ki = 260 nM 23461628
NPT414 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Rattus norvegicus Ki = 230 nM 23461628
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus EC50 = 220 nM 23461628
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 10 nM 23461628
NPT2 Others Unspecified Potency 4109.5 nM PubChem BioAssay data set
NPT160 Individual Protein TAR DNA-binding protein 43 Homo sapiens Potency 39810.7 nM PubChem BioAssay data set
NPT410 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Homo sapiens Ki = 3800 nM 23561269
NPT409 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Homo sapiens Ki = 0.6 nM 23561269
NPT410 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Homo sapiens IC50 = 7600 nM 23561269
NPT409 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Homo sapiens IC50 = 1.2 nM 23561269
NPT411 Protein Complex Neuronal acetylcholine receptor; alpha3/beta4 Homo sapiens EC50 = 7000 nM 23692872
NPT409 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Homo sapiens EC50 = 3000 nM 23692872
NPT410 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Homo sapiens Ki = 3000 nM 23692872
NPT411 Protein Complex Neuronal acetylcholine receptor; alpha3/beta4 Homo sapiens Ki = 400 nM 23692872
NPT409 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Homo sapiens Ki = 2 nM 23692872
NPT409 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Homo sapiens IC50 = 430 nM 23734673
NPT409 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Homo sapiens EC50 = 290 nM 23734673
NPT417 Protein Complex Neuronal acetylcholine receptor; alpha3/beta4 Rattus norvegicus Ki = 260 nM 23734673
NPT5040 Protein Complex Neuronal acetylcholine receptor; alpha3/alpha6/beta2/beta3 Homo sapiens EC50 = 127 nM 23734673
NPT5040 Protein Complex Neuronal acetylcholine receptor; alpha3/alpha6/beta2/beta3 Homo sapiens IC50 = 84.8 nM 23734673
NPT3923 Protein Complex Neuronal acetylcholine receptor; alpha2/beta4 Rattus norvegicus Ki = 70 nM 23734673
NPT416 Protein Complex Neuronal acetylcholine receptor; alpha3/beta2 Rattus norvegicus Ki = 29 nM 23734673
NPT418 Protein Complex Neuronal acetylcholine receptor; alpha4/beta4 Rattus norvegicus Ki = 23 nM 23734673
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 9.8 nM 23734673
NPT415 Protein Complex Neuronal acetylcholine receptor; alpha2/beta2 Rattus norvegicus Ki = 5.5 nM 23734673
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 4.9 nM 23734673
NPT414 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Rattus norvegicus Ki = 234 nM 24128660
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 4 nM 24128660
NPT417 Protein Complex Neuronal acetylcholine receptor; alpha3/beta4 Rattus norvegicus IC50 > 10000 nM 24047231
NPT417 Protein Complex Neuronal acetylcholine receptor; alpha3/beta4 Rattus norvegicus EC50 = 24000 nM 24047231
NPT409 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Homo sapiens IC50 = 370 nM 24047231
NPT409 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Homo sapiens EC50 = 2400 nM 24047231
NPT2 Others Unspecified Ratio Ki = 44 24047231
NPT2 Others Unspecified Ki = 12 nM 24047231
NPT414 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Rattus norvegicus Ki = 520 nM 24047231
NPT418 Protein Complex Neuronal acetylcholine receptor; alpha4/beta4 Rattus norvegicus Ki = 40 nM 24047231
NPT409 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Homo sapiens Ki = 10 nM 24047231
NPT417 Protein Complex Neuronal acetylcholine receptor; alpha3/beta4 Rattus norvegicus Ki = 440 nM 24047231
NPT416 Protein Complex Neuronal acetylcholine receptor; alpha3/beta2 Rattus norvegicus Ki = 47 nM 24047231
NPT3923 Protein Complex Neuronal acetylcholine receptor; alpha2/beta4 Rattus norvegicus Ki = 110 nM 24047231
NPT415 Protein Complex Neuronal acetylcholine receptor; alpha2/beta2 Rattus norvegicus Ki = 12 nM 24047231
NPT2 Others Unspecified Ki = 1.5 nM 24428686
NPT32 Organism Mus musculus Mus musculus ED50 = 1.3 mg/kg 24428686
NPT32 Organism Mus musculus Mus musculus ED50 = 1 mg/kg 24428686
NPT32 Organism Mus musculus Mus musculus ED50 = 0.65 mg/kg 24428686
NPT32 Organism Mus musculus Mus musculus ED50 = 0.5 mg/kg 24428686
NPT2 Others Unspecified Activity = 85.8 % 24581918
NPT2 Others Unspecified Activity = 72 % 24581918
NPT2 Others Unspecified Activity = 73.3 % 24581918
NPT2 Others Unspecified Activity = 76.4 % 24581918
NPT2 Others Unspecified Activity = 75.3 % 24581918
NPT2 Others Unspecified Activity = 80 % 24581918
NPT2 Others Unspecified Activity = 67 % 24581918
NPT2 Others Unspecified Activity = 63.6 % 24581918
NPT2 Others Unspecified Activity = 65.2 % 24581918
NPT2 Others Unspecified Activity = 70.5 % 24581918
NPT153 Individual Protein Androgen Receptor Homo sapiens Potency 24541.2 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency 54443.9 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency 24336.5 nM PubChem BioAssay data set
NPT104 Individual Protein Cerebroside-sulfatase Homo sapiens Potency 2393.4 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency 61130.6 nM PubChem BioAssay data set
NPT2 Others Unspecified Potency 22387.2 nM PubChem BioAssay data set
NPT414 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Rattus norvegicus Ki = 610 nM 24050653
NPT29 Organism Rattus norvegicus Rattus norvegicus Activity = 30 % 24942641
NPT2 Others Unspecified Ki = 5.5 nM 25408831
NPT2 Others Unspecified Ki = 70 nM 25408831
NPT2 Others Unspecified Ki = 29 nM 25408831
NPT2 Others Unspecified Ki = 260 nM 25408831
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 4.9 nM 25408831
NPT2 Others Unspecified Ki = 9.8 nM 25408831
NPT2 Others Unspecified Ki = 23 nM 25408831
NPT2 Others Unspecified Ratio Ki = 53 25408831
NPT409 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Homo sapiens EC50 = 300 nM 25408831
NPT409 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Homo sapiens IC50 = 430 nM 25408831
NPT409 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Homo sapiens EC50 = 316.23 nM 25408831
NPT409 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Homo sapiens IC50 = 398.11 nM 25408831
NPT4296 Individual Protein Equilibrative nucleoside transporter 4 Homo sapiens Activity = -6.3 nanoampere 22396231
NPT4296 Individual Protein Equilibrative nucleoside transporter 4 Homo sapiens Activity = -75.7 nanoampere 22396231
NPT240 Individual Protein Cytochrome P450 2A6 Homo sapiens Ki = 130000 nM 22696418
NPT2599 Individual Protein Cytochrome P450 2A13 Homo sapiens Ki = 72000 nM 22696418
NPT240 Individual Protein Cytochrome P450 2A6 Homo sapiens Kd = 470000 nM 22696418
NPT2599 Individual Protein Cytochrome P450 2A13 Homo sapiens Kd = 54000 nM 22696418
NPT2 Others Unspecified Ki = 230 nM 25941557
NPT2 Others Unspecified Ki = 51 nM 25941557
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 11 nM 25941557
NPT414 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Rattus norvegicus Ki = 15000 nM 25941557
NPT414 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Rattus norvegicus Ratio = 0.93 26087938
NPT414 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Rattus norvegicus EC50 = 109647.82 nM 26087938
NPT414 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Rattus norvegicus EC50 = 108700 nM 26087938
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 4 nM 26225816
NPT414 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Rattus norvegicus Ki = 234 nM 26225816
NPT411 Protein Complex Neuronal acetylcholine receptor; alpha3/beta4 Homo sapiens Ki = 261 nM 26225816
NPT32 Organism Mus musculus Mus musculus ED50 = 0.65 mg/kg 26233800
NPT32 Organism Mus musculus Mus musculus ED50 = 1.3 mg/kg 26233800
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 1.5 nM 26233800
NPT32 Organism Mus musculus Mus musculus ED50 = 1 mg/kg 26233800
NPT32 Organism Mus musculus Mus musculus ED50 = 0.5 mg/kg 26233800
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Activity = 40 % 26233800
NPT2 Others Unspecified Activity = 37 % 26233800
NPT414 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Rattus norvegicus Activity = 43 % 26233800
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 2.1 nM 26164842
NPT2 Others Unspecified Ki = 3.3 nM 26164842
NPT414 Individual Protein Neuronal acetylcholine receptor protein alpha-7 subunit Rattus norvegicus Ki = 250 nM 26164842
NPT430 Individual Protein Acetylcholine-binding protein Lymnaea stagnalis Kd = 320 nM 26301559
NPT430 Individual Protein Acetylcholine-binding protein Lymnaea stagnalis Kd = 316.23 nM 26301559
NPT2 Others Unspecified Kd = 3160 nM 26301559
NPT2 Others Unspecified Kd = 3162.28 nM 26301559
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 13 nM 26298493
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus Ki = 14.13 nM 26298493
NPT2 Others Unspecified Ki = 72 nM 26298493
NPT2 Others Unspecified Ki = 72.44 nM 26298493
NPT2 Others Unspecified Ki = 290 nM 26298493
NPT2 Others Unspecified Ki = 288.4 nM 26298493
NPT2 Others Unspecified EC50 = 720 nM 26298493
NPT2 Others Unspecified EC50 = 724.44 nM 26298493
NPT2 Others Unspecified EC50 = 1500 nM 26298493
NPT2 Others Unspecified EC50 = 1513.56 nM 26298493
NPT412 Protein Complex Neuronal acetylcholine receptor; alpha4/beta2 Rattus norvegicus EC50 = 210 nM 26383127
NPT240 Individual Protein Cytochrome P450 2A6 Homo sapiens IC50 > 400000 nM Patent: US8609708 B2
NPT2 Others Unspecified Ki = 2.3 nM 26840365

  Similar Natural Products in NPASS

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient

●  The left chart: Distribution of similarity level between NPC182570 and all remaining natural products in the NPASS database.
●  The right table: Most similar natural products (Tc>=0.56 or Top200).

Similarity Score Similarity Level Natural Product ID
1.0 High Similarity NPC48564
1.0 High Similarity NPC265605
0.9412 High Similarity NPC27740
0.9035 High Similarity NPC27802
0.8983 High Similarity NPC297486
0.8983 High Similarity NPC471402
0.8983 High Similarity NPC240136
0.8862 High Similarity NPC166424
0.8862 High Similarity NPC146373
0.8862 High Similarity NPC245244
0.8837 High Similarity NPC65408
0.8772 High Similarity NPC76540
0.875 High Similarity NPC91958
0.8699 High Similarity NPC290094
0.8629 High Similarity NPC476322
0.8595 High Similarity NPC143603
0.8594 High Similarity NPC324611
0.8492 Intermediate Similarity NPC169625
0.8492 Intermediate Similarity NPC202957
0.8425 Intermediate Similarity NPC471311
0.8425 Intermediate Similarity NPC471313
0.8403 Intermediate Similarity NPC235843
0.84 Intermediate Similarity NPC46358
0.8359 Intermediate Similarity NPC89490
0.832 Intermediate Similarity NPC329825
0.8295 Intermediate Similarity NPC475090
0.8295 Intermediate Similarity NPC475105
0.8295 Intermediate Similarity NPC329896
0.8295 Intermediate Similarity NPC476131
0.8291 Intermediate Similarity NPC231655
0.8284 Intermediate Similarity NPC110126
0.8271 Intermediate Similarity NPC150259
0.8246 Intermediate Similarity NPC83987
0.8231 Intermediate Similarity NPC282398
0.8231 Intermediate Similarity NPC69914
0.8168 Intermediate Similarity NPC101165
0.8168 Intermediate Similarity NPC471322
0.8162 Intermediate Similarity NPC476454
0.8148 Intermediate Similarity NPC73767
0.8143 Intermediate Similarity NPC40070
0.8134 Intermediate Similarity NPC84911
0.8134 Intermediate Similarity NPC105127
0.8134 Intermediate Similarity NPC251722
0.8134 Intermediate Similarity NPC314102
0.813 Intermediate Similarity NPC476566
0.806 Intermediate Similarity NPC29886
0.806 Intermediate Similarity NPC261195
0.806 Intermediate Similarity NPC96102
0.803 Intermediate Similarity NPC256893
0.803 Intermediate Similarity NPC82295
0.8015 Intermediate Similarity NPC316811
0.8015 Intermediate Similarity NPC32002
0.8015 Intermediate Similarity NPC315348
0.7956 Intermediate Similarity NPC469784
0.7956 Intermediate Similarity NPC469761
0.7956 Intermediate Similarity NPC469768
0.7956 Intermediate Similarity NPC469767
0.7956 Intermediate Similarity NPC469783
0.7956 Intermediate Similarity NPC469779
0.7956 Intermediate Similarity NPC469780
0.7899 Intermediate Similarity NPC469766
0.7872 Intermediate Similarity NPC470111
0.7872 Intermediate Similarity NPC201380
0.7872 Intermediate Similarity NPC179787
0.7868 Intermediate Similarity NPC471312
0.7857 Intermediate Similarity NPC285731
0.7842 Intermediate Similarity NPC190296
0.7832 Intermediate Similarity NPC470233
0.7826 Intermediate Similarity NPC279081
0.7817 Intermediate Similarity NPC321911
0.7801 Intermediate Similarity NPC63545
0.7746 Intermediate Similarity NPC469811
0.773 Intermediate Similarity NPC314372
0.773 Intermediate Similarity NPC86288
0.7727 Intermediate Similarity NPC212125
0.7721 Intermediate Similarity NPC198988
0.7714 Intermediate Similarity NPC20144
0.7698 Intermediate Similarity NPC148140
0.7698 Intermediate Similarity NPC230002
0.7687 Intermediate Similarity NPC56765
0.7681 Intermediate Similarity NPC169433
0.7664 Intermediate Similarity NPC325252
0.7643 Intermediate Similarity NPC473868
0.7643 Intermediate Similarity NPC63157
0.7638 Intermediate Similarity NPC81561
0.7626 Intermediate Similarity NPC104483
0.7622 Intermediate Similarity NPC471957
0.7619 Intermediate Similarity NPC129721
0.7607 Intermediate Similarity NPC213774
0.7606 Intermediate Similarity NPC159856
0.76 Intermediate Similarity NPC473901
0.7571 Intermediate Similarity NPC59084
0.7568 Intermediate Similarity NPC477591
0.7556 Intermediate Similarity NPC315320
0.7552 Intermediate Similarity NPC288838
0.7552 Intermediate Similarity NPC143872
0.7551 Intermediate Similarity NPC51054
0.7551 Intermediate Similarity NPC476464
0.7534 Intermediate Similarity NPC200214
0.7534 Intermediate Similarity NPC325903
0.7517 Intermediate Similarity NPC53947
0.7517 Intermediate Similarity NPC24678
0.7517 Intermediate Similarity NPC105818
0.75 Intermediate Similarity NPC88097
0.75 Intermediate Similarity NPC236711
0.7483 Intermediate Similarity NPC34844
0.7481 Intermediate Similarity NPC41174
0.748 Intermediate Similarity NPC84268
0.7466 Intermediate Similarity NPC470823
0.7463 Intermediate Similarity NPC306397
0.7462 Intermediate Similarity NPC215519
0.745 Intermediate Similarity NPC206819
0.745 Intermediate Similarity NPC293487
0.745 Intermediate Similarity NPC318065
0.7447 Intermediate Similarity NPC2949
0.7442 Intermediate Similarity NPC162689
0.7442 Intermediate Similarity NPC54102
0.7426 Intermediate Similarity NPC22079
0.7417 Intermediate Similarity NPC478184
0.7417 Intermediate Similarity NPC90723
0.7417 Intermediate Similarity NPC478182
0.7415 Intermediate Similarity NPC138842
0.7415 Intermediate Similarity NPC469763
0.7415 Intermediate Similarity NPC141926
0.7415 Intermediate Similarity NPC25008
0.7415 Intermediate Similarity NPC73952
0.7415 Intermediate Similarity NPC259644
0.7415 Intermediate Similarity NPC469765
0.7415 Intermediate Similarity NPC469786
0.7415 Intermediate Similarity NPC469760
0.7413 Intermediate Similarity NPC471323
0.74 Intermediate Similarity NPC215584
0.74 Intermediate Similarity NPC44773
0.7397 Intermediate Similarity NPC473878
0.7379 Intermediate Similarity NPC477974
0.7379 Intermediate Similarity NPC21605
0.7365 Intermediate Similarity NPC75540
0.7365 Intermediate Similarity NPC211572
0.7365 Intermediate Similarity NPC80597
0.7365 Intermediate Similarity NPC212376
0.7365 Intermediate Similarity NPC70922
0.7347 Intermediate Similarity NPC216713
0.7333 Intermediate Similarity NPC41257
0.7333 Intermediate Similarity NPC165370
0.7324 Intermediate Similarity NPC115611
0.7319 Intermediate Similarity NPC322488
0.731 Intermediate Similarity NPC316069
0.7303 Intermediate Similarity NPC317105
0.729 Intermediate Similarity NPC82331
0.7286 Intermediate Similarity NPC29702
0.7286 Intermediate Similarity NPC218268
0.7285 Intermediate Similarity NPC470204
0.7285 Intermediate Similarity NPC122141
0.7279 Intermediate Similarity NPC471589
0.7267 Intermediate Similarity NPC286427
0.7267 Intermediate Similarity NPC469897
0.7252 Intermediate Similarity NPC11863
0.7241 Intermediate Similarity NPC467188
0.7241 Intermediate Similarity NPC470440
0.7239 Intermediate Similarity NPC122718
0.7237 Intermediate Similarity NPC470203
0.7237 Intermediate Similarity NPC124542
0.7237 Intermediate Similarity NPC282231
0.7237 Intermediate Similarity NPC59779
0.7237 Intermediate Similarity NPC478185
0.7237 Intermediate Similarity NPC471177
0.7237 Intermediate Similarity NPC225018
0.7234 Intermediate Similarity NPC125746
0.723 Intermediate Similarity NPC470679
0.723 Intermediate Similarity NPC472260
0.723 Intermediate Similarity NPC217021
0.7226 Intermediate Similarity NPC91895
0.7218 Intermediate Similarity NPC56856
0.7208 Intermediate Similarity NPC98187
0.7208 Intermediate Similarity NPC478183
0.7208 Intermediate Similarity NPC56233
0.72 Intermediate Similarity NPC469785
0.7194 Intermediate Similarity NPC330326
0.719 Intermediate Similarity NPC78375
0.719 Intermediate Similarity NPC469813
0.719 Intermediate Similarity NPC476446
0.7171 Intermediate Similarity NPC279918
0.7162 Intermediate Similarity NPC33421
0.7152 Intermediate Similarity NPC474958
0.7152 Intermediate Similarity NPC216643
0.7152 Intermediate Similarity NPC469762
0.7152 Intermediate Similarity NPC280852
0.7143 Intermediate Similarity NPC105811
0.7143 Intermediate Similarity NPC274229
0.7143 Intermediate Similarity NPC100726
0.7133 Intermediate Similarity NPC476219
0.7133 Intermediate Similarity NPC476297
0.7133 Intermediate Similarity NPC477815
0.7132 Intermediate Similarity NPC250361
0.7132 Intermediate Similarity NPC135488
0.7132 Intermediate Similarity NPC476140
0.7123 Intermediate Similarity NPC204141
0.7123 Intermediate Similarity NPC469525
0.7115 Intermediate Similarity NPC32534
0.7115 Intermediate Similarity NPC194411

  Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

●  The left chart: Distribution of similarity level between NPC182570 and all drugs/candidates.
●  The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).

Similarity Score Similarity Level Drug ID Developmental Stage
1.0 High Similarity NPD270 Clinical (unspecified phase)
1.0 High Similarity NPD271 Approved
1.0 High Similarity NPD268 Approved
0.9244 High Similarity NPD748 Clinical (unspecified phase)
0.896 High Similarity NPD3475 Approved
0.896 High Similarity NPD3476 Approved
0.8837 High Similarity NPD201 Phase 2
0.8837 High Similarity NPD200 Phase 2
0.872 High Similarity NPD2119 Approved
0.872 High Similarity NPD2118 Approved
0.872 High Similarity NPD992 Clinical (unspecified phase)
0.872 High Similarity NPD991 Phase 2
0.8655 High Similarity NPD269 Clinical (unspecified phase)
0.864 High Similarity NPD9583 Approved
0.8629 High Similarity NPD9357 Approved
0.8559 High Similarity NPD4824 Approved
0.8559 High Similarity NPD4823 Approved
0.8462 Intermediate Similarity NPD4030 Approved
0.8462 Intermediate Similarity NPD4028 Approved
0.8462 Intermediate Similarity NPD4029 Approved
0.8425 Intermediate Similarity NPD1598 Discontinued
0.8387 Intermediate Similarity NPD9598 Discontinued
0.8361 Intermediate Similarity NPD9392 Approved
0.8361 Intermediate Similarity NPD9396 Approved
0.8321 Intermediate Similarity NPD3942 Approved
0.8321 Intermediate Similarity NPD3944 Approved
0.8308 Intermediate Similarity NPD803 Phase 1
0.8291 Intermediate Similarity NPD9099 Clinical (unspecified phase)
0.8291 Intermediate Similarity NPD9098 Phase 3
0.8284 Intermediate Similarity NPD768 Clinical (unspecified phase)
0.8244 Intermediate Similarity NPD1995 Approved
0.8244 Intermediate Similarity NPD1994 Approved
0.8244 Intermediate Similarity NPD1993 Approved
0.8235 Intermediate Similarity NPD2006 Phase 2
0.8231 Intermediate Similarity NPD715 Phase 3
0.8148 Intermediate Similarity NPD786 Approved
0.8129 Intermediate Similarity NPD4547 Phase 3
0.806 Intermediate Similarity NPD198 Clinical (unspecified phase)
0.806 Intermediate Similarity NPD206 Clinical (unspecified phase)
0.8045 Intermediate Similarity NPD3385 Approved
0.8029 Intermediate Similarity NPD1722 Approved
0.8015 Intermediate Similarity NPD2070 Approved
0.8015 Intermediate Similarity NPD2073 Approved
0.8015 Intermediate Similarity NPD2068 Approved
0.8015 Intermediate Similarity NPD2072 Approved
0.8015 Intermediate Similarity NPD2071 Approved
0.8015 Intermediate Similarity NPD3654 Approved
0.8015 Intermediate Similarity NPD2069 Approved
0.8015 Intermediate Similarity NPD2074 Approved
0.8015 Intermediate Similarity NPD2075 Approved
0.7985 Intermediate Similarity NPD2142 Approved
0.7985 Intermediate Similarity NPD2140 Approved
0.7985 Intermediate Similarity NPD2141 Approved
0.797 Intermediate Similarity NPD1627 Clinical (unspecified phase)
0.7943 Intermediate Similarity NPD2430 Phase 2
0.7926 Intermediate Similarity NPD792 Discontinued
0.7926 Intermediate Similarity NPD490 Clinical (unspecified phase)
0.7801 Intermediate Similarity NPD7469 Discontinued
0.7778 Intermediate Similarity NPD2837 Discontinued
0.7746 Intermediate Similarity NPD4703 Approved
0.7746 Intermediate Similarity NPD4702 Approved
0.7727 Intermediate Similarity NPD9284 Approved
0.7721 Intermediate Similarity NPD272 Approved
0.7714 Intermediate Similarity NPD2007 Clinical (unspecified phase)
0.7714 Intermediate Similarity NPD4637 Clinical (unspecified phase)
0.7714 Intermediate Similarity NPD3717 Discontinued
0.7692 Intermediate Similarity NPD3100 Discontinued
0.766 Intermediate Similarity NPD1918 Clinical (unspecified phase)
0.766 Intermediate Similarity NPD3813 Approved
0.7639 Intermediate Similarity NPD2465 Approved
0.7639 Intermediate Similarity NPD2466 Phase 3
0.7639 Intermediate Similarity NPD2462 Phase 3
0.763 Intermediate Similarity NPD9726 Discontinued
0.7626 Intermediate Similarity NPD945 Clinical (unspecified phase)
0.7609 Intermediate Similarity NPD6554 Approved
0.7609 Intermediate Similarity NPD45 Approved
0.7589 Intermediate Similarity NPD4510 Discontinued
0.7584 Intermediate Similarity NPD5315 Discontinued
0.7571 Intermediate Similarity NPD1395 Clinical (unspecified phase)
0.7556 Intermediate Similarity NPD9206 Approved
0.7556 Intermediate Similarity NPD9207 Approved
0.7554 Intermediate Similarity NPD2896 Discontinued
0.7552 Intermediate Similarity NPD6148 Clinical (unspecified phase)
0.7551 Intermediate Similarity NPD3113 Approved
0.7551 Intermediate Similarity NPD473 Clinical (unspecified phase)
0.7551 Intermediate Similarity NPD3112 Approved
0.7551 Intermediate Similarity NPD3114 Approved
0.7551 Intermediate Similarity NPD3115 Approved
0.7551 Intermediate Similarity NPD2580 Discontinued
0.7537 Intermediate Similarity NPD1095 Clinical (unspecified phase)
0.7535 Intermediate Similarity NPD649 Clinical (unspecified phase)
0.7533 Intermediate Similarity NPD3323 Discontinued
0.7517 Intermediate Similarity NPD2172 Phase 1
0.75 Intermediate Similarity NPD2865 Clinical (unspecified phase)
0.75 Intermediate Similarity NPD1192 Clinical (unspecified phase)
0.75 Intermediate Similarity NPD2089 Clinical (unspecified phase)
0.7483 Intermediate Similarity NPD2165 Phase 1
0.7483 Intermediate Similarity NPD175 Clinical (unspecified phase)
0.7467 Intermediate Similarity NPD2385 Clinical (unspecified phase)
0.7463 Intermediate Similarity NPD9080 Approved
0.7448 Intermediate Similarity NPD4374 Clinical (unspecified phase)
0.7447 Intermediate Similarity NPD1649 Discontinued
0.7447 Intermediate Similarity NPD9599 Approved
0.7431 Intermediate Similarity NPD1683 Approved
0.7415 Intermediate Similarity NPD2012 Clinical (unspecified phase)
0.7413 Intermediate Similarity NPD751 Clinical (unspecified phase)
0.741 Intermediate Similarity NPD1254 Approved
0.741 Intermediate Similarity NPD1256 Approved
0.741 Intermediate Similarity NPD1255 Approved
0.741 Intermediate Similarity NPD1253 Approved
0.7403 Intermediate Similarity NPD5934 Clinical (unspecified phase)
0.74 Intermediate Similarity NPD6454 Clinical (unspecified phase)
0.7394 Intermediate Similarity NPD5020 Approved
0.7386 Intermediate Similarity NPD4779 Clinical (unspecified phase)
0.7383 Intermediate Similarity NPD6497 Approved
0.7379 Intermediate Similarity NPD1270 Approved
0.7379 Intermediate Similarity NPD2110 Approved
0.7379 Intermediate Similarity NPD1661 Suspended
0.7376 Intermediate Similarity NPD174 Discontinued
0.7372 Intermediate Similarity NPD809 Discontinued
0.7351 Intermediate Similarity NPD6771 Discontinued
0.7351 Intermediate Similarity NPD1853 Clinical (unspecified phase)
0.7344 Intermediate Similarity NPD60 Approved
0.7343 Intermediate Similarity NPD4047 Discontinued
0.7333 Intermediate Similarity NPD5255 Approved
0.7329 Intermediate Similarity NPD1183 Approved
0.7324 Intermediate Similarity NPD165 Phase 2
0.732 Intermediate Similarity NPD4174 Clinical (unspecified phase)
0.7305 Intermediate Similarity NPD1380 Discovery
0.7292 Intermediate Similarity NPD1352 Discontinued
0.729 Intermediate Similarity NPD3610 Approved
0.729 Intermediate Similarity NPD3609 Approved
0.7285 Intermediate Similarity NPD1404 Approved
0.7285 Intermediate Similarity NPD1403 Approved
0.7279 Intermediate Similarity NPD1031 Discontinued
0.7273 Intermediate Similarity NPD2641 Approved
0.7273 Intermediate Similarity NPD1343 Approved
0.7273 Intermediate Similarity NPD2390 Clinical (unspecified phase)
0.7273 Intermediate Similarity NPD2640 Approved
0.7267 Intermediate Similarity NPD2581 Approved
0.7267 Intermediate Similarity NPD2582 Approved
0.7261 Intermediate Similarity NPD6044 Discontinued
0.7248 Intermediate Similarity NPD977 Approved
0.7248 Intermediate Similarity NPD975 Approved
0.7248 Intermediate Similarity NPD976 Approved
0.7234 Intermediate Similarity NPD9506 Approved
0.7231 Intermediate Similarity NPD8840 Approved
0.723 Intermediate Similarity NPD4641 Discontinued
0.723 Intermediate Similarity NPD1257 Approved
0.7226 Intermediate Similarity NPD5436 Phase 1
0.7222 Intermediate Similarity NPD1427 Clinical (unspecified phase)
0.7219 Intermediate Similarity NPD704 Clinical (unspecified phase)
0.7218 Intermediate Similarity NPD5787 Discontinued
0.7218 Intermediate Similarity NPD1561 Phase 2
0.7211 Intermediate Similarity NPD5538 Clinical (unspecified phase)
0.7203 Intermediate Similarity NPD3943 Clinical (unspecified phase)
0.72 Intermediate Similarity NPD2150 Discontinued
0.7197 Intermediate Similarity NPD5065 Approved
0.7194 Intermediate Similarity NPD9100 Approved
0.719 Intermediate Similarity NPD8129 Discovery
0.7183 Intermediate Similarity NPD203 Clinical (unspecified phase)
0.7181 Intermediate Similarity NPD3339 Approved
0.7181 Intermediate Similarity NPD1917 Discontinued
0.7179 Intermediate Similarity NPD1078 Clinical (unspecified phase)
0.7161 Intermediate Similarity NPD2185 Clinical (unspecified phase)
0.7161 Intermediate Similarity NPD4640 Approved
0.7161 Intermediate Similarity NPD2333 Discontinued
0.7161 Intermediate Similarity NPD4639 Approved
0.7161 Intermediate Similarity NPD4638 Approved
0.7153 Intermediate Similarity NPD1383 Phase 3
0.7153 Intermediate Similarity NPD1382 Phase 2
0.7152 Intermediate Similarity NPD6375 Clinical (unspecified phase)
0.7133 Intermediate Similarity NPD1328 Approved
0.7133 Intermediate Similarity NPD2809 Approved
0.7133 Intermediate Similarity NPD4804 Approved
0.7124 Intermediate Similarity NPD8026 Phase 1
0.7124 Intermediate Similarity NPD4384 Clinical (unspecified phase)
0.7114 Intermediate Similarity NPD3262 Approved
0.7114 Intermediate Similarity NPD5965 Clinical (unspecified phase)
0.7107 Intermediate Similarity NPD4181 Approved
0.7105 Intermediate Similarity NPD5418 Discontinued
0.7101 Intermediate Similarity NPD9305 Clinical (unspecified phase)
0.7101 Intermediate Similarity NPD947 Approved
0.7097 Intermediate Similarity NPD2639 Approved
0.7097 Intermediate Similarity NPD3929 Clinical (unspecified phase)
0.7097 Intermediate Similarity NPD2642 Approved
0.7086 Intermediate Similarity NPD6026 Approved
0.7086 Intermediate Similarity NPD2748 Clinical (unspecified phase)
0.7078 Intermediate Similarity NPD3583 Phase 2
0.707 Intermediate Similarity NPD3117 Approved
0.707 Intermediate Similarity NPD3116 Approved
0.707 Intermediate Similarity NPD1567 Clinical (unspecified phase)
0.7068 Intermediate Similarity NPD4811 Discontinued
0.7063 Intermediate Similarity NPD2323 Clinical (unspecified phase)
0.7063 Intermediate Similarity NPD3341 Clinical (unspecified phase)
0.7059 Intermediate Similarity NPD2511 Approved
0.7055 Intermediate Similarity NPD5254 Discontinued
0.7051 Intermediate Similarity NPD7287 Clinical (unspecified phase)
0.7044 Intermediate Similarity NPD4075 Phase 2
0.7039 Intermediate Similarity NPD5300 Clinical (unspecified phase)

Structure

External Identifiers

PubChem CID   89594
ChEMBL   CHEMBL3
ZINC  

Physicochemical Properties

Molecular Weight:  162.12
ALogP:  -0.4993
MLogP:  2.34
XLogP:  1.485
# Rotatable Bonds:  2
Polar Surface Area:  16.13
# H-Bond Aceptor:  2
# H-Bond Donor:  0
# Rings:  2
# Heavy Atoms:  12

Download Data

Data Type Select
General Info & Identifiers & Properties  
Structure MOL file  
Source Organisms  
Biological Activities  
Similar NPs/Drugs