NPASS Natural Product

Natural Product: NPC476297

Natural Product ID:	NPC476297
Common Name:	Tebernine B
IUPAC Name:
Synonyms:
Molecular Formula:	C16H17N3
Standard InCHIKey:	ZDRMIRKEMZHLHE-UHFFFAOYSA-N
Standard InCHI:	InChI=1S/C16H17N3/c1-10-9-13-12-5-3-4-6-15(12)19-11(2)17-8-7-14(18-10)16(13)19/h3-6,9,11,17H,7-8H2,1-2H3
Canonical SMILES:	Cc1nc2CCNC(n3c2c(c1)c1ccccc31)C
First Find Year:
Max Developmental Stage:
Synthetic Gene Cluster:	;

Species Source

Organism ID	Organism Name	Taxonomy Level	Family	SuperKingdom	Isolation Part	Collection Location	Collection Time	Reference
NPO32684	tabernaemontana elegans	Species	Apocynaceae	Eukaryota	Leaves			PMID[19473031]

Biological Activity

Activity Type	# Activity
Others	6

Activity Type	# Activity
Cell Line	2
Individual Protein	4

Target ID	Target Type	Target Name	Target Organism	Activity Type	Activity Relation	Value	Unit	Reference
NPT1864	Cell Line	L5178Y	Mus musculus	ID50	=	46.6	nM	PubChem BioAssay data set
NPT668	Individual Protein	P-glycoprotein 1	Homo sapiens	Ratio	=	0.78		PubChem BioAssay data set
NPT1864	Cell Line	L5178Y	Mus musculus	ID50	=	39.7	nM	PubChem BioAssay data set
NPT668	Individual Protein	P-glycoprotein 1	Homo sapiens	Activity	=	10.7		22435669
NPT668	Individual Protein	P-glycoprotein 1	Homo sapiens	Ratio	=	0.99		22435669
NPT668	Individual Protein	P-glycoprotein 1	Homo sapiens	Activity	=	8.9		8991944

Similar Natural Products in NPASS

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient

● The left chart: Distribution of similarity level between NPC476297 and all remaining natural products in the NPASS database.
● The right table: Most similar natural products (Tc>=0.56 or Top200).

range	Tanimoto Coefficient
0-0.1	738
0.1-0.2	9127
0.2-0.3	13854
0.3-0.4	3365
0.4-0.5	1609
0.5-0.6	1216
0.6-0.7	728
0.7-0.8	217
0.8-0.85	29
0.85-0.9	5
0.9-0.95	0
0.95-1	1

Similarity Score	Similarity Level	Natural Product ID
0.9589	High Similarity	NPC476219
0.8836	High Similarity	NPC115611
0.8649	High Similarity	NPC63157
0.8649	High Similarity	NPC473868
0.8553	High Similarity	NPC321911
0.8535	High Similarity	NPC470203
0.8493	Intermediate Similarity	NPC198988
0.8487	Intermediate Similarity	NPC179787
0.8487	Intermediate Similarity	NPC469811
0.8487	Intermediate Similarity	NPC201380
0.8471	Intermediate Similarity	NPC470204
0.8435	Intermediate Similarity	NPC325252
0.8421	Intermediate Similarity	NPC63545
0.8387	Intermediate Similarity	NPC325903
0.8366	Intermediate Similarity	NPC21605
0.8355	Intermediate Similarity	NPC204141
0.8333	Intermediate Similarity	NPC59084
0.8267	Intermediate Similarity	NPC88097
0.8258	Intermediate Similarity	NPC40070
0.8239	Intermediate Similarity	NPC122141
0.8212	Intermediate Similarity	NPC284635
0.8212	Intermediate Similarity	NPC2949
0.8137	Intermediate Similarity	NPC317105
0.8129	Intermediate Similarity	NPC470111
0.8113	Intermediate Similarity	NPC236711
0.8105	Intermediate Similarity	NPC20144
0.8086	Intermediate Similarity	NPC195507
0.8086	Intermediate Similarity	NPC2165
0.8075	Intermediate Similarity	NPC225018
0.8067	Intermediate Similarity	NPC218268
0.8026	Intermediate Similarity	NPC73767
0.8026	Intermediate Similarity	NPC104483
0.8026	Intermediate Similarity	NPC110126
0.8	Intermediate Similarity	NPC82331
0.8	Intermediate Similarity	NPC470440
0.7974	Intermediate Similarity	NPC469768
0.7974	Intermediate Similarity	NPC469767
0.7974	Intermediate Similarity	NPC469779
0.7974	Intermediate Similarity	NPC469784
0.7974	Intermediate Similarity	NPC469783
0.7974	Intermediate Similarity	NPC469761
0.7974	Intermediate Similarity	NPC469780
0.7973	Intermediate Similarity	NPC22079
0.7964	Intermediate Similarity	NPC474958
0.795	Intermediate Similarity	NPC475990
0.795	Intermediate Similarity	NPC474880
0.795	Intermediate Similarity	NPC221786
0.7922	Intermediate Similarity	NPC469766
0.7919	Intermediate Similarity	NPC475450
0.7914	Intermediate Similarity	NPC478182
0.7914	Intermediate Similarity	NPC478184
0.7911	Intermediate Similarity	NPC53947
0.7904	Intermediate Similarity	NPC317054
0.7901	Intermediate Similarity	NPC229173
0.7895	Intermediate Similarity	NPC84911
0.7895	Intermediate Similarity	NPC105127
0.7882	Intermediate Similarity	NPC307191
0.7862	Intermediate Similarity	NPC470233
0.7857	Intermediate Similarity	NPC280852
0.784	Intermediate Similarity	NPC477591
0.7834	Intermediate Similarity	NPC288838
0.7834	Intermediate Similarity	NPC478186
0.7829	Intermediate Similarity	NPC261195
0.7829	Intermediate Similarity	NPC96102
0.7829	Intermediate Similarity	NPC29886
0.7823	Intermediate Similarity	NPC250361
0.7799	Intermediate Similarity	NPC33421
0.7791	Intermediate Similarity	NPC108011
0.7785	Intermediate Similarity	NPC473587
0.7778	Intermediate Similarity	NPC150259
0.7778	Intermediate Similarity	NPC251722
0.7778	Intermediate Similarity	NPC125746
0.7778	Intermediate Similarity	NPC314102
0.7758	Intermediate Similarity	NPC274229
0.7733	Intermediate Similarity	NPC475428
0.773	Intermediate Similarity	NPC56765
0.773	Intermediate Similarity	NPC293487
0.7722	Intermediate Similarity	NPC143872
0.7718	Intermediate Similarity	NPC473762
0.7697	Intermediate Similarity	NPC247987
0.7692	Intermediate Similarity	NPC81561
0.7682	Intermediate Similarity	NPC179365
0.7671	Intermediate Similarity	NPC41174
0.7658	Intermediate Similarity	NPC314372
0.7643	Intermediate Similarity	NPC190296
0.7632	Intermediate Similarity	NPC473930
0.7628	Intermediate Similarity	NPC279081
0.7622	Intermediate Similarity	NPC148140
0.7619	Intermediate Similarity	NPC474897
0.7619	Intermediate Similarity	NPC97343
0.7605	Intermediate Similarity	NPC478183
0.76	Intermediate Similarity	NPC141612
0.76	Intermediate Similarity	NPC17273
0.76	Intermediate Similarity	NPC135601
0.759	Intermediate Similarity	NPC271797
0.759	Intermediate Similarity	NPC21174
0.759	Intermediate Similarity	NPC90723
0.7588	Intermediate Similarity	NPC471579
0.7578	Intermediate Similarity	NPC105818
0.7578	Intermediate Similarity	NPC24678
0.7576	Intermediate Similarity	NPC44773
0.7576	Intermediate Similarity	NPC215584
0.7566	Intermediate Similarity	NPC82295
0.7561	Intermediate Similarity	NPC216643
0.753	Intermediate Similarity	NPC478185
0.7517	Intermediate Similarity	NPC54102
0.7517	Intermediate Similarity	NPC162689
0.7516	Intermediate Similarity	NPC230002
0.7516	Intermediate Similarity	NPC2272
0.7515	Intermediate Similarity	NPC91895
0.7515	Intermediate Similarity	NPC318065
0.7515	Intermediate Similarity	NPC135141
0.7515	Intermediate Similarity	NPC92796
0.7515	Intermediate Similarity	NPC206819
0.75	Intermediate Similarity	NPC56233
0.75	Intermediate Similarity	NPC476566
0.7485	Intermediate Similarity	NPC469760
0.7485	Intermediate Similarity	NPC200214
0.7485	Intermediate Similarity	NPC469763
0.7485	Intermediate Similarity	NPC73952
0.7485	Intermediate Similarity	NPC469765
0.7485	Intermediate Similarity	NPC469786
0.7485	Intermediate Similarity	NPC329688
0.7485	Intermediate Similarity	NPC189812
0.7485	Intermediate Similarity	NPC25008
0.7485	Intermediate Similarity	NPC259644
0.7472	Intermediate Similarity	NPC231536
0.747	Intermediate Similarity	NPC255229
0.747	Intermediate Similarity	NPC81229
0.7455	Intermediate Similarity	NPC286427
0.7453	Intermediate Similarity	NPC114209
0.7453	Intermediate Similarity	NPC471957
0.745	Intermediate Similarity	NPC122718
0.7439	Intermediate Similarity	NPC212376
0.7439	Intermediate Similarity	NPC70922
0.7439	Intermediate Similarity	NPC211572
0.7439	Intermediate Similarity	NPC80597
0.7439	Intermediate Similarity	NPC75540
0.7438	Intermediate Similarity	NPC159856
0.7415	Intermediate Similarity	NPC215519
0.7414	Intermediate Similarity	NPC16659
0.7412	Intermediate Similarity	NPC32534
0.741	Intermediate Similarity	NPC41257
0.7407	Intermediate Similarity	NPC37548
0.7394	Intermediate Similarity	NPC476464
0.7383	Intermediate Similarity	NPC46358
0.7375	Intermediate Similarity	NPC242556
0.7371	Intermediate Similarity	NPC191415
0.7356	Intermediate Similarity	NPC265710
0.7353	Intermediate Similarity	NPC317430
0.7342	Intermediate Similarity	NPC312092
0.7341	Intermediate Similarity	NPC121903
0.7333	Intermediate Similarity	NPC34844
0.7333	Intermediate Similarity	NPC27740
0.733	Intermediate Similarity	NPC472110
0.733	Intermediate Similarity	NPC472109
0.7329	Intermediate Similarity	NPC469525
0.7326	Intermediate Similarity	NPC472123
0.7326	Intermediate Similarity	NPC161861
0.7321	Intermediate Similarity	NPC194881
0.7317	Intermediate Similarity	NPC470823
0.7305	Intermediate Similarity	NPC300238
0.7299	Intermediate Similarity	NPC240088
0.7299	Intermediate Similarity	NPC473380
0.7299	Intermediate Similarity	NPC234987
0.7294	Intermediate Similarity	NPC49217
0.7289	Intermediate Similarity	NPC469785
0.7288	Intermediate Similarity	NPC284678
0.7278	Intermediate Similarity	NPC324091
0.7273	Intermediate Similarity	NPC141926
0.7257	Intermediate Similarity	NPC12649
0.7256	Intermediate Similarity	NPC148592
0.7247	Intermediate Similarity	NPC133003
0.7246	Intermediate Similarity	NPC469762
0.7246	Intermediate Similarity	NPC129721
0.7239	Intermediate Similarity	NPC477134
0.7232	Intermediate Similarity	NPC48938
0.7232	Intermediate Similarity	NPC102755
0.7229	Intermediate Similarity	NPC470507
0.7229	Intermediate Similarity	NPC38736
0.7225	Intermediate Similarity	NPC477611
0.7216	Intermediate Similarity	NPC314919
0.7212	Intermediate Similarity	NPC216713
0.7209	Intermediate Similarity	NPC194411
0.7195	Intermediate Similarity	NPC124005
0.7195	Intermediate Similarity	NPC187951
0.7193	Intermediate Similarity	NPC49954
0.7193	Intermediate Similarity	NPC474561
0.7191	Intermediate Similarity	NPC472294
0.7189	Intermediate Similarity	NPC265576
0.7186	Intermediate Similarity	NPC285469
0.7176	Intermediate Similarity	NPC311276
0.7175	Intermediate Similarity	NPC113626
0.7171	Intermediate Similarity	NPC245244
0.7171	Intermediate Similarity	NPC146373
0.7171	Intermediate Similarity	NPC166424
0.717	Intermediate Similarity	NPC169433
0.7169	Intermediate Similarity	NPC232798
0.7169	Intermediate Similarity	NPC281094
0.7161	Intermediate Similarity	NPC282398

Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

● The left chart: Distribution of similarity level between NPC476297 and all drugs/candidates.
● The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).

range	Tanimoto Coefficient
0-0.1	337
0.1-0.2	853
0.2-0.3	1149
0.3-0.4	1653
0.4-0.5	2178
0.5-0.6	1833
0.6-0.7	910
0.7-0.8	233
0.8-0.85	13
0.85-0.9	2
0.9-0.95	0
0.95-1	0

Similarity Score	Similarity Level	Drug ID	Developmental Stage
0.8973	High Similarity	NPD4637	Clinical (unspecified phase)
0.8552	High Similarity	NPD3385	Approved
0.8421	Intermediate Similarity	NPD1683	Approved
0.8397	Intermediate Similarity	NPD2150	Discontinued
0.828	Intermediate Similarity	NPD2927	Phase 3
0.8276	Intermediate Similarity	NPD3654	Approved
0.8199	Intermediate Similarity	NPD1313	Approved
0.8193	Intermediate Similarity	NPD3341	Clinical (unspecified phase)
0.8092	Intermediate Similarity	NPD3943	Clinical (unspecified phase)
0.8086	Intermediate Similarity	NPD509	Phase 3
0.8039	Intermediate Similarity	NPD1722	Approved
0.8038	Intermediate Similarity	NPD2837	Discontinued
0.8013	Intermediate Similarity	NPD4547	Phase 3
0.8013	Intermediate Similarity	NPD45	Approved
0.8013	Intermediate Similarity	NPD6554	Approved
0.7947	Intermediate Similarity	NPD1256	Approved
0.7947	Intermediate Similarity	NPD1255	Approved
0.7947	Intermediate Similarity	NPD1254	Approved
0.7947	Intermediate Similarity	NPD1253	Approved
0.7939	Intermediate Similarity	NPD2875	Clinical (unspecified phase)
0.7935	Intermediate Similarity	NPD5254	Discontinued
0.7929	Intermediate Similarity	NPD5962	Phase 2
0.7908	Intermediate Similarity	NPD786	Approved
0.7907	Intermediate Similarity	NPD3378	Clinical (unspecified phase)
0.7892	Intermediate Similarity	NPD6828	Phase 2
0.7892	Intermediate Similarity	NPD6827	Clinical (unspecified phase)
0.7853	Intermediate Similarity	NPD2149	Clinical (unspecified phase)
0.7848	Intermediate Similarity	NPD3100	Discontinued
0.7829	Intermediate Similarity	NPD198	Clinical (unspecified phase)
0.7778	Intermediate Similarity	NPD1895	Discontinued
0.7778	Intermediate Similarity	NPD4649	Clinical (unspecified phase)
0.7771	Intermediate Similarity	NPD2333	Discontinued
0.7756	Intermediate Similarity	NPD2006	Phase 2
0.7756	Intermediate Similarity	NPD4047	Discontinued
0.774	Intermediate Similarity	NPD3485	Clinical (unspecified phase)
0.7736	Intermediate Similarity	NPD2430	Phase 2
0.7736	Intermediate Similarity	NPD4374	Clinical (unspecified phase)
0.7727	Intermediate Similarity	NPD6761	Discontinued
0.7711	Intermediate Similarity	NPD1215	Discontinued
0.7711	Intermediate Similarity	NPD6794	Approved
0.7709	Intermediate Similarity	NPD2880	Discontinued
0.7706	Intermediate Similarity	NPD7111	Discontinued
0.7701	Intermediate Similarity	NPD2591	Phase 2
0.7697	Intermediate Similarity	NPD3323	Discontinued
0.7688	Intermediate Similarity	NPD4462	Approved
0.7688	Intermediate Similarity	NPD4463	Approved
0.7679	Intermediate Similarity	NPD1567	Clinical (unspecified phase)
0.7667	Intermediate Similarity	NPD6469	Phase 3
0.7667	Intermediate Similarity	NPD6468	Clinical (unspecified phase)
0.7665	Intermediate Similarity	NPD4779	Clinical (unspecified phase)
0.7665	Intermediate Similarity	NPD2390	Clinical (unspecified phase)
0.7643	Intermediate Similarity	NPD2007	Clinical (unspecified phase)
0.7625	Intermediate Similarity	NPD5538	Clinical (unspecified phase)
0.7616	Intermediate Similarity	NPD3475	Approved
0.7616	Intermediate Similarity	NPD715	Phase 3
0.7616	Intermediate Similarity	NPD3476	Approved
0.7588	Intermediate Similarity	NPD7006	Approved
0.7584	Intermediate Similarity	NPD4615	Phase 2
0.7578	Intermediate Similarity	NPD2172	Phase 1
0.7576	Intermediate Similarity	NPD6074	Clinical (unspecified phase)
0.7561	Intermediate Similarity	NPD4326	Phase 2
0.7558	Intermediate Similarity	NPD2930	Clinical (unspecified phase)
0.7557	Intermediate Similarity	NPD7394	Phase 2
0.755	Intermediate Similarity	NPD947	Approved
0.7548	Intermediate Similarity	NPD1262	Discovery
0.7545	Intermediate Similarity	NPD1333	Phase 3
0.7545	Intermediate Similarity	NPD5744	Clinical (unspecified phase)
0.7533	Intermediate Similarity	NPD2119	Approved
0.7533	Intermediate Similarity	NPD991	Phase 2
0.7533	Intermediate Similarity	NPD992	Clinical (unspecified phase)
0.7533	Intermediate Similarity	NPD2118	Approved
0.753	Intermediate Similarity	NPD1016	Phase 2
0.753	Intermediate Similarity	NPD1015	Phase 2
0.753	Intermediate Similarity	NPD1853	Clinical (unspecified phase)
0.75	Intermediate Similarity	NPD2580	Discontinued
0.75	Intermediate Similarity	NPD4181	Approved
0.75	Intermediate Similarity	NPD4902	Discontinued
0.7487	Intermediate Similarity	NPD2443	Approved
0.7487	Intermediate Similarity	NPD2442	Approved
0.7485	Intermediate Similarity	NPD3799	Suspended
0.7484	Intermediate Similarity	NPD1918	Clinical (unspecified phase)
0.7484	Intermediate Similarity	NPD5671	Approved
0.7472	Intermediate Similarity	NPD5145	Clinical (unspecified phase)
0.7457	Intermediate Similarity	NPD40	Phase 2
0.7457	Intermediate Similarity	NPD5730	Phase 2
0.7456	Intermediate Similarity	NPD5021	Discontinued
0.7456	Intermediate Similarity	NPD2640	Approved
0.7456	Intermediate Similarity	NPD2641	Approved
0.7455	Intermediate Similarity	NPD2865	Clinical (unspecified phase)
0.7451	Intermediate Similarity	NPD803	Phase 1
0.7442	Intermediate Similarity	NPD2406	Clinical (unspecified phase)
0.744	Intermediate Similarity	NPD3889	Approved
0.7439	Intermediate Similarity	NPD975	Approved
0.7439	Intermediate Similarity	NPD976	Approved
0.7439	Intermediate Similarity	NPD977	Approved
0.7439	Intermediate Similarity	NPD2165	Phase 1
0.7425	Intermediate Similarity	NPD2385	Clinical (unspecified phase)
0.7423	Intermediate Similarity	NPD2524	Discontinued
0.7418	Intermediate Similarity	NPD5462	Discontinued
0.7414	Intermediate Similarity	NPD1873	Clinical (unspecified phase)
0.7414	Intermediate Similarity	NPD6277	Clinical (unspecified phase)
0.7414	Intermediate Similarity	NPD702	Clinical (unspecified phase)
0.7412	Intermediate Similarity	NPD5436	Phase 1
0.7401	Intermediate Similarity	NPD2793	Discontinued
0.7394	Intermediate Similarity	NPD3112	Approved
0.7394	Intermediate Similarity	NPD3115	Approved
0.7394	Intermediate Similarity	NPD3113	Approved
0.7394	Intermediate Similarity	NPD3114	Approved
0.7384	Intermediate Similarity	NPD4128	Approved
0.7384	Intermediate Similarity	NPD5065	Approved
0.7375	Intermediate Similarity	NPD3401	Clinical (unspecified phase)
0.7368	Intermediate Similarity	NPD3609	Approved
0.7368	Intermediate Similarity	NPD3610	Approved
0.7363	Intermediate Similarity	NPD6278	Clinical (unspecified phase)
0.7362	Intermediate Similarity	NPD2465	Approved
0.7362	Intermediate Similarity	NPD2462	Phase 3
0.7362	Intermediate Similarity	NPD2466	Phase 3
0.7355	Intermediate Similarity	NPD3944	Approved
0.7355	Intermediate Similarity	NPD4029	Approved
0.7355	Intermediate Similarity	NPD3942	Approved
0.7355	Intermediate Similarity	NPD4030	Approved
0.7355	Intermediate Similarity	NPD4028	Approved
0.7337	Intermediate Similarity	NPD4550	Clinical (unspecified phase)
0.7337	Intermediate Similarity	NPD1002	Clinical (unspecified phase)
0.7333	Intermediate Similarity	NPD6285	Phase 2
0.733	Intermediate Similarity	NPD1332	Clinical (unspecified phase)
0.733	Intermediate Similarity	NPD4441	Phase 2
0.7326	Intermediate Similarity	NPD4112	Clinical (unspecified phase)
0.7321	Intermediate Similarity	NPD2480	Clinical (unspecified phase)
0.7315	Intermediate Similarity	NPD1561	Phase 2
0.7315	Intermediate Similarity	NPD5787	Discontinued
0.7303	Intermediate Similarity	NPD6721	Phase 1
0.7297	Intermediate Similarity	NPD6816	Phase 3
0.7293	Intermediate Similarity	NPD7722	Suspended
0.7293	Intermediate Similarity	NPD3431	Approved
0.7293	Intermediate Similarity	NPD3430	Approved
0.7289	Intermediate Similarity	NPD473	Clinical (unspecified phase)
0.7288	Intermediate Similarity	NPD5463	Clinical (unspecified phase)
0.7285	Intermediate Similarity	NPD1950	Approved
0.7285	Intermediate Similarity	NPD1949	Approved
0.7278	Intermediate Similarity	NPD2818	Discontinued
0.7273	Intermediate Similarity	NPD1707	Approved
0.7273	Intermediate Similarity	NPD1708	Approved
0.7268	Intermediate Similarity	NPD2960	Clinical (unspecified phase)
0.7267	Intermediate Similarity	NPD4509	Discontinued
0.7263	Intermediate Similarity	NPD2408	Discontinued
0.7263	Intermediate Similarity	NPD3486	Clinical (unspecified phase)
0.7262	Intermediate Similarity	NPD1404	Approved
0.7262	Intermediate Similarity	NPD1403	Approved
0.7251	Intermediate Similarity	NPD5069	Clinical (unspecified phase)
0.7247	Intermediate Similarity	NPD6610	Clinical (unspecified phase)
0.7246	Intermediate Similarity	NPD1192	Clinical (unspecified phase)
0.7238	Intermediate Similarity	NPD3419	Clinical (unspecified phase)
0.7235	Intermediate Similarity	NPD2915	Discontinued
0.7232	Intermediate Similarity	NPD3512	Clinical (unspecified phase)
0.7228	Intermediate Similarity	NPD3830	Phase 1
0.7226	Intermediate Similarity	NPD1251	Discontinued
0.7225	Intermediate Similarity	NPD5996	Clinical (unspecified phase)
0.7222	Intermediate Similarity	NPD2729	Approved
0.7222	Intermediate Similarity	NPD2728	Approved
0.7222	Intermediate Similarity	NPD2730	Approved
0.7219	Intermediate Similarity	NPD5315	Discontinued
0.7212	Intermediate Similarity	NPD2660	Approved
0.7212	Intermediate Similarity	NPD2128	Phase 1
0.7212	Intermediate Similarity	NPD2662	Approved
0.7212	Intermediate Similarity	NPD2882	Phase 1
0.7197	Intermediate Similarity	NPD2142	Approved
0.7197	Intermediate Similarity	NPD2140	Approved
0.7197	Intermediate Similarity	NPD2141	Approved
0.7196	Intermediate Similarity	NPD2008	Discontinued
0.7196	Intermediate Similarity	NPD4023	Clinical (unspecified phase)
0.7196	Intermediate Similarity	NPD6271	Approved
0.7193	Intermediate Similarity	NPD2639	Approved
0.7193	Intermediate Similarity	NPD2392	Clinical (unspecified phase)
0.7193	Intermediate Similarity	NPD2478	Clinical (unspecified phase)
0.7193	Intermediate Similarity	NPD2642	Approved
0.7193	Intermediate Similarity	NPD3361	Phase 1
0.7181	Intermediate Similarity	NPD4811	Discontinued
0.7175	Intermediate Similarity	NPD5806	Clinical (unspecified phase)
0.7174	Intermediate Similarity	NPD7023	Clinical (unspecified phase)
0.7159	Intermediate Similarity	NPD1893	Phase 2
0.7159	Intermediate Similarity	NPD1892	Phase 2
0.7151	Intermediate Similarity	NPD2185	Clinical (unspecified phase)
0.7143	Intermediate Similarity	NPD4075	Phase 2
0.7135	Intermediate Similarity	NPD2111	Clinical (unspecified phase)
0.7134	Intermediate Similarity	NPD1661	Suspended
0.7133	Intermediate Similarity	NPD9598	Discontinued
0.7133	Intermediate Similarity	NPD270	Clinical (unspecified phase)
0.7133	Intermediate Similarity	NPD271	Approved
0.7133	Intermediate Similarity	NPD268	Approved
0.7128	Intermediate Similarity	NPD3015	Discontinued
0.7125	Intermediate Similarity	NPD174	Discontinued
0.7119	Intermediate Similarity	NPD6595	Phase 3
0.7115	Intermediate Similarity	NPD809	Discontinued
0.7111	Intermediate Similarity	NPD5820	Clinical (unspecified phase)
0.7108	Intermediate Similarity	NPD1257	Approved
0.7104	Intermediate Similarity	NPD6577	Clinical (unspecified phase)
0.7102	Intermediate Similarity	NPD6203	Clinical (unspecified phase)
0.7102	Intermediate Similarity	NPD2731	Phase 2
0.7101	Intermediate Similarity	NPD5418	Discontinued

Structure

External Identifiers

PubChem CID	44179504
ChEMBL	CHEMBL562793
ZINC

Physicochemical Properties

Molecular Weight:	251.14
ALogP:	0.2292
MLogP:	2.89
XLogP:	3.64
# Rotatable Bonds:	2
Polar Surface Area:	29.85
# H-Bond Aceptor:	3
# H-Bond Donor:	1
# Rings:	4
# Heavy Atoms:	19

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