Natural Product: NPC139044

Natural Product ID:  NPC139044
Common Name:   Hederacolchiside A
IUPAC Name:   (4aS,6aR,6aS,6bR,8aR,9R,10S,12aR,14bS)-9-(hydroxymethyl)-10-[(2S,3R,4S,5S)-4-hydroxy-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-2,2,6a,6b,9,12a-hexamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid
Synonyms:  
Molecular Formula:   C47H76O17
Standard InCHIKey:  SOLICHUQXFAOEP-YDIXZRNLSA-N
Standard InCHI:  InChI=1S/C47H76O17/c1-22-30(50)33(53)35(55)38(60-22)64-37-32(52)26(62-39-36(56)34(54)31(51)25(19-48)61-39)20-59-40(37)63-29-11-12-43(4)27(44(29,5)21-49)10-13-46(7)28(43)9-8-23-24-18-42(2,3)14-16-47(24,41(57)58)17-15-45(23,46)6/h8,22,24-40,48-56H,9-21H2,1-7H3,(H,57,58)/t22-,24-,25+,26-,27+,28+,29-,30-,31+,32-,33+,34-,35+,36+,37+,38-,39-,40-,43-,44-,45+,46+,47-/m0/s1
Canonical SMILES:  OC[C@H]1O[C@@H](O[C@H]2CO[C@H]([C@@H]([C@H]2O)O[C@@H]2O[C@@H](C)[C@@H]([C@H]([C@H]2O)O)O)O[C@H]2CC[C@]3([C@H]([C@]2(C)CO)CC[C@@]2([C@@H]3CC=C3[C@@]2(C)CC[C@@]2([C@H]3CC(C)(C)CC2)C(=O)O)C)C)[C@@H]([C@H]([C@@H]1O)O)O
First Find Year:  
Max Developmental Stage:  
Synthetic Gene Cluster:   ;

  Species Source

Organism ID Organism Name Taxonomy Level Family SuperKingdom Isolation Part Collection Location Collection Time Reference
NPO29856 Serjania salzmanniana Species Sapindaceae Eukaryota PMID[8699187]
NPO1373 Pulsatilla chinensis Species Ranunculaceae Eukaryota roots PMID[10514313]
NPO1373 Pulsatilla chinensis Species Ranunculaceae Eukaryota Root PMID[10514313]
NPO18782 Pulsatilla cernua Species Ranunculaceae Eukaryota DOI[10.1248/cpb.26.1666]
NPO31082 Pulsatilla koreana Species Ranunculaceae Eukaryota Root PMID[15473660]
NPO1373 Pulsatilla chinensis Species Ranunculaceae Eukaryota TM-MC*
NPO18782.1 Pulsatilla cernua var. koreana Varieties Ranunculaceae Eukaryota TM-MC*

  Biological Activity

Target ID Target Type Target Name Target Organism Activity Type Activity Relation Value Unit Reference
NPT4589 Organism Biomphalaria alexandrina Biomphalaria alexandrina Activity = 100 % 8699187
NPT4589 Organism Biomphalaria alexandrina Biomphalaria alexandrina Activity = 90 % 8699187
NPT20 Organism Candida albicans Candida albicans MIC <= 16 ug/ml 8699187
NPT85 Organism Filobasidiella neoformans Cryptococcus neoformans MIC <= 8 ug/ml 8699187
NPT87 Organism Aspergillus fumigatus Aspergillus fumigatus MIC >= 250 ug/ml 8699187
NPT116 Cell Line HL-60 Homo sapiens IC50 = 3.8 ug/ml 10514313
NPT81 Cell Line A549 Homo sapiens IC50 = 59000 nM 19200744
NPT579 Cell Line DLD-1 Homo sapiens IC50 = 62000 nM 19200744
NPT81 Cell Line A549 Homo sapiens IC50 = 110000 nM 19200744
NPT579 Cell Line DLD-1 Homo sapiens IC50 = 159000 nM 19200744
NPT81 Cell Line A549 Homo sapiens IC50 = 6300 nM 25958248
NPT2 Others Unspecified IC50 = 8900 nM 25958248
NPT659 Cell Line SMMC-7721 Homo sapiens IC50 = 7600 nM 25958248
NPT2 Others Unspecified IC50 = 12600 nM 25958248

  Similar Natural Products in NPASS

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient

●  The left chart: Distribution of similarity level between NPC139044 and all remaining natural products in the NPASS database.
●  The right table: Most similar natural products (Tc>=0.56 or Top200).

Similarity Score Similarity Level Natural Product ID
1.0 High Similarity NPC475516
1.0 High Similarity NPC102439
1.0 High Similarity NPC292677
1.0 High Similarity NPC469946
1.0 High Similarity NPC109079
1.0 High Similarity NPC324875
1.0 High Similarity NPC473373
1.0 High Similarity NPC79718
1.0 High Similarity NPC475504
1.0 High Similarity NPC101744
1.0 High Similarity NPC104071
1.0 High Similarity NPC104400
1.0 High Similarity NPC10320
1.0 High Similarity NPC276093
1.0 High Similarity NPC471383
1.0 High Similarity NPC257468
0.9904 High Similarity NPC166422
0.9904 High Similarity NPC475467
0.9904 High Similarity NPC309714
0.9904 High Similarity NPC219180
0.9904 High Similarity NPC134835
0.9904 High Similarity NPC155410
0.9904 High Similarity NPC473343
0.9904 High Similarity NPC46665
0.9904 High Similarity NPC475287
0.9904 High Similarity NPC163183
0.9904 High Similarity NPC174720
0.9904 High Similarity NPC258885
0.9904 High Similarity NPC96641
0.9904 High Similarity NPC241909
0.9904 High Similarity NPC150400
0.9904 High Similarity NPC295823
0.9904 High Similarity NPC114304
0.9904 High Similarity NPC133818
0.9904 High Similarity NPC192600
0.9904 High Similarity NPC473826
0.9904 High Similarity NPC151543
0.9904 High Similarity NPC124296
0.9904 High Similarity NPC73318
0.9904 High Similarity NPC251263
0.9904 High Similarity NPC323341
0.9904 High Similarity NPC114287
0.9903 High Similarity NPC164419
0.981 High Similarity NPC70809
0.981 High Similarity NPC161717
0.981 High Similarity NPC261506
0.981 High Similarity NPC67857
0.981 High Similarity NPC471550
0.981 High Similarity NPC471385
0.981 High Similarity NPC469782
0.981 High Similarity NPC294453
0.981 High Similarity NPC100639
0.981 High Similarity NPC204414
0.981 High Similarity NPC473714
0.981 High Similarity NPC79643
0.981 High Similarity NPC76972
0.981 High Similarity NPC305981
0.981 High Similarity NPC250247
0.981 High Similarity NPC54636
0.981 High Similarity NPC65105
0.981 High Similarity NPC119592
0.981 High Similarity NPC476068
0.981 High Similarity NPC298034
0.981 High Similarity NPC57484
0.981 High Similarity NPC224381
0.981 High Similarity NPC202828
0.981 High Similarity NPC60557
0.981 High Similarity NPC227551
0.981 High Similarity NPC309907
0.981 High Similarity NPC4328
0.981 High Similarity NPC123199
0.981 High Similarity NPC43550
0.981 High Similarity NPC475140
0.981 High Similarity NPC236638
0.981 High Similarity NPC475160
0.981 High Similarity NPC475486
0.981 High Similarity NPC293330
0.981 High Similarity NPC41061
0.981 High Similarity NPC164389
0.981 High Similarity NPC71065
0.9808 High Similarity NPC139894
0.9808 High Similarity NPC473383
0.9806 High Similarity NPC279554
0.9806 High Similarity NPC174679
0.9806 High Similarity NPC90856
0.9806 High Similarity NPC474589
0.9806 High Similarity NPC59804
0.9806 High Similarity NPC270667
0.9806 High Similarity NPC127056
0.9806 High Similarity NPC475296
0.9806 High Similarity NPC136877
0.9806 High Similarity NPC29069
0.9806 High Similarity NPC56713
0.9806 High Similarity NPC164194
0.9717 High Similarity NPC51465
0.9717 High Similarity NPC476992
0.9717 High Similarity NPC161674
0.9717 High Similarity NPC160415
0.9717 High Similarity NPC75287
0.9717 High Similarity NPC288205
0.9717 High Similarity NPC58448
0.9717 High Similarity NPC26626
0.9717 High Similarity NPC305267
0.9717 High Similarity NPC37134
0.9717 High Similarity NPC471384
0.9717 High Similarity NPC291903
0.9712 High Similarity NPC108748
0.9712 High Similarity NPC473481
0.9712 High Similarity NPC235841
0.9712 High Similarity NPC211798
0.9712 High Similarity NPC179434
0.9712 High Similarity NPC297208
0.9712 High Similarity NPC30397
0.9709 High Similarity NPC204407
0.9709 High Similarity NPC306746
0.9709 High Similarity NPC237503
0.9709 High Similarity NPC57362
0.9709 High Similarity NPC167383
0.9626 High Similarity NPC104137
0.9626 High Similarity NPC300419
0.9626 High Similarity NPC110633
0.9626 High Similarity NPC69811
0.9626 High Similarity NPC136768
0.9626 High Similarity NPC191827
0.9626 High Similarity NPC323359
0.9626 High Similarity NPC148417
0.9626 High Similarity NPC475119
0.9626 High Similarity NPC123522
0.9626 High Similarity NPC473452
0.9626 High Similarity NPC475514
0.9626 High Similarity NPC8524
0.9626 High Similarity NPC68175
0.9626 High Similarity NPC309223
0.9626 High Similarity NPC102505
0.9626 High Similarity NPC470876
0.9626 High Similarity NPC33012
0.9626 High Similarity NPC473824
0.9626 High Similarity NPC475209
0.9626 High Similarity NPC286457
0.9626 High Similarity NPC220160
0.9626 High Similarity NPC185466
0.9626 High Similarity NPC471547
0.9626 High Similarity NPC85154
0.9619 High Similarity NPC128925
0.9619 High Similarity NPC80843
0.9619 High Similarity NPC1046
0.9619 High Similarity NPC256798
0.9615 High Similarity NPC476884
0.9615 High Similarity NPC274507
0.9615 High Similarity NPC199457
0.9615 High Similarity NPC476882
0.9615 High Similarity NPC68419
0.9615 High Similarity NPC102914
0.9615 High Similarity NPC476887
0.9615 High Similarity NPC108709
0.9615 High Similarity NPC78046
0.9615 High Similarity NPC476886
0.9615 High Similarity NPC476880
0.9615 High Similarity NPC7870
0.9615 High Similarity NPC476881
0.9615 High Similarity NPC269095
0.9615 High Similarity NPC476885
0.9615 High Similarity NPC110139
0.9615 High Similarity NPC476883
0.9615 High Similarity NPC75747
0.9612 High Similarity NPC284807
0.9612 High Similarity NPC177246
0.9612 High Similarity NPC28198
0.9612 High Similarity NPC476123
0.9537 High Similarity NPC471548
0.9537 High Similarity NPC475899
0.9537 High Similarity NPC109588
0.9537 High Similarity NPC105800
0.9537 High Similarity NPC237191
0.9537 High Similarity NPC232237
0.9537 High Similarity NPC36831
0.9537 High Similarity NPC473459
0.9528 High Similarity NPC475208
0.9528 High Similarity NPC238935
0.9528 High Similarity NPC189884
0.9528 High Similarity NPC138334
0.9528 High Similarity NPC204458
0.9528 High Similarity NPC47063
0.9524 High Similarity NPC31839
0.9524 High Similarity NPC191763
0.9519 High Similarity NPC127853
0.9519 High Similarity NPC137917
0.9515 High Similarity NPC283849
0.9515 High Similarity NPC473538
0.945 High Similarity NPC471577
0.945 High Similarity NPC207738
0.945 High Similarity NPC477464
0.945 High Similarity NPC473401
0.945 High Similarity NPC473386
0.945 High Similarity NPC51564
0.945 High Similarity NPC135849
0.945 High Similarity NPC192791
0.945 High Similarity NPC25663
0.9444 High Similarity NPC473405
0.9444 High Similarity NPC471580

  Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

●  The left chart: Distribution of similarity level between NPC139044 and all drugs/candidates.
●  The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).

Similarity Score Similarity Level Drug ID Developmental Stage
0.8947 High Similarity NPD8328 Phase 3
0.8796 High Similarity NPD8132 Clinical (unspecified phase)
0.875 High Similarity NPD8295 Clinical (unspecified phase)
0.8649 High Similarity NPD8133 Approved
0.8108 Intermediate Similarity NPD6412 Phase 2
0.8051 Intermediate Similarity NPD8294 Approved
0.8051 Intermediate Similarity NPD8377 Approved
0.8036 Intermediate Similarity NPD6686 Approved
0.7983 Intermediate Similarity NPD8335 Approved
0.7983 Intermediate Similarity NPD8380 Approved
0.7983 Intermediate Similarity NPD8379 Approved
0.7983 Intermediate Similarity NPD8296 Approved
0.7983 Intermediate Similarity NPD8378 Approved
0.7925 Intermediate Similarity NPD7748 Approved
0.787 Intermediate Similarity NPD7902 Approved
0.7869 Intermediate Similarity NPD7507 Approved
0.7833 Intermediate Similarity NPD8033 Approved
0.7736 Intermediate Similarity NPD7515 Phase 2
0.7686 Intermediate Similarity NPD8516 Approved
0.7686 Intermediate Similarity NPD8513 Phase 3
0.7686 Intermediate Similarity NPD8517 Approved
0.7686 Intermediate Similarity NPD8515 Approved
0.768 Intermediate Similarity NPD7319 Approved
0.76 Intermediate Similarity NPD7736 Approved
0.7593 Intermediate Similarity NPD7900 Approved
0.7593 Intermediate Similarity NPD7901 Clinical (unspecified phase)
0.7583 Intermediate Similarity NPD7328 Approved
0.7583 Intermediate Similarity NPD7327 Approved
0.7521 Intermediate Similarity NPD7516 Approved
0.7456 Intermediate Similarity NPD8170 Clinical (unspecified phase)
0.7398 Intermediate Similarity NPD7503 Approved
0.7381 Intermediate Similarity NPD8293 Discontinued
0.7248 Intermediate Similarity NPD8034 Phase 2
0.7248 Intermediate Similarity NPD8035 Phase 2
0.7227 Intermediate Similarity NPD8413 Clinical (unspecified phase)
0.72 Intermediate Similarity NPD6370 Approved
0.7168 Intermediate Similarity NPD7638 Approved
0.7167 Intermediate Similarity NPD6882 Approved
0.7167 Intermediate Similarity NPD8297 Approved
0.7105 Intermediate Similarity NPD7639 Approved
0.7105 Intermediate Similarity NPD7640 Approved
0.7087 Intermediate Similarity NPD7492 Approved
0.7087 Intermediate Similarity NPD7645 Phase 2
0.7073 Intermediate Similarity NPD6009 Approved
0.7059 Intermediate Similarity NPD4061 Clinical (unspecified phase)
0.704 Intermediate Similarity NPD6059 Approved
0.704 Intermediate Similarity NPD6054 Approved
0.704 Intermediate Similarity NPD6319 Approved
0.7031 Intermediate Similarity NPD6616 Approved
0.7027 Intermediate Similarity NPD6399 Phase 3
0.7027 Intermediate Similarity NPD8171 Discontinued
0.7009 Intermediate Similarity NPD7520 Clinical (unspecified phase)
0.7008 Intermediate Similarity NPD6067 Discontinued
0.6977 Remote Similarity NPD7078 Approved
0.6975 Remote Similarity NPD5345 Clinical (unspecified phase)
0.6967 Remote Similarity NPD4632 Approved
0.6949 Remote Similarity NPD6402 Approved
0.6949 Remote Similarity NPD5739 Approved
0.6949 Remote Similarity NPD6675 Approved
0.6949 Remote Similarity NPD7128 Approved
0.6917 Remote Similarity NPD6373 Approved
0.6917 Remote Similarity NPD6372 Approved
0.686 Remote Similarity NPD5955 Clinical (unspecified phase)
0.685 Remote Similarity NPD6016 Approved
0.685 Remote Similarity NPD6015 Approved
0.6833 Remote Similarity NPD6899 Approved
0.6833 Remote Similarity NPD7320 Approved
0.6833 Remote Similarity NPD6881 Approved
0.6803 Remote Similarity NPD6649 Approved
0.6803 Remote Similarity NPD8130 Phase 1
0.6803 Remote Similarity NPD6650 Approved
0.68 Remote Similarity NPD7115 Discovery
0.6797 Remote Similarity NPD5988 Approved
0.6786 Remote Similarity NPD6411 Approved
0.675 Remote Similarity NPD5697 Approved
0.675 Remote Similarity NPD5701 Approved
0.6721 Remote Similarity NPD7290 Approved
0.6721 Remote Similarity NPD6883 Approved
0.6721 Remote Similarity NPD7102 Approved
0.6718 Remote Similarity NPD8074 Phase 3
0.6696 Remote Similarity NPD6698 Approved
0.6696 Remote Similarity NPD46 Approved
0.6667 Remote Similarity NPD7513 Clinical (unspecified phase)
0.6667 Remote Similarity NPD6617 Approved
0.6667 Remote Similarity NPD6847 Approved
0.6667 Remote Similarity NPD8450 Suspended
0.6667 Remote Similarity NPD6869 Approved
0.6639 Remote Similarity NPD6012 Approved
0.6639 Remote Similarity NPD6013 Approved
0.6639 Remote Similarity NPD6014 Approved
0.6638 Remote Similarity NPD6084 Phase 2
0.6638 Remote Similarity NPD6083 Phase 2
0.6636 Remote Similarity NPD3618 Phase 1
0.6615 Remote Similarity NPD7604 Phase 2
0.6612 Remote Similarity NPD5954 Clinical (unspecified phase)
0.6607 Remote Similarity NPD5764 Clinical (unspecified phase)
0.6607 Remote Similarity NPD6101 Approved
0.6607 Remote Similarity NPD5328 Approved
0.6606 Remote Similarity NPD4786 Approved
0.6593 Remote Similarity NPD8449 Approved
0.6589 Remote Similarity NPD5983 Phase 2
0.6581 Remote Similarity NPD4225 Approved
0.6577 Remote Similarity NPD3573 Approved
0.6574 Remote Similarity NPD3667 Approved
0.6557 Remote Similarity NPD6011 Approved
0.6555 Remote Similarity NPD7632 Discontinued
0.6541 Remote Similarity NPD6033 Approved
0.6532 Remote Similarity NPD6401 Clinical (unspecified phase)
0.6529 Remote Similarity NPD6008 Approved
0.6515 Remote Similarity NPD6336 Discontinued
0.6514 Remote Similarity NPD3670 Clinical (unspecified phase)
0.6514 Remote Similarity NPD3669 Approved
0.6496 Remote Similarity NPD4755 Approved
0.6491 Remote Similarity NPD7983 Approved
0.6491 Remote Similarity NPD6079 Approved
0.6486 Remote Similarity NPD7521 Approved
0.6486 Remote Similarity NPD6409 Approved
0.6486 Remote Similarity NPD7334 Approved
0.6486 Remote Similarity NPD6684 Approved
0.6486 Remote Similarity NPD7146 Approved
0.6486 Remote Similarity NPD5330 Approved
0.6462 Remote Similarity NPD6921 Approved
0.646 Remote Similarity NPD7285 Clinical (unspecified phase)
0.6457 Remote Similarity NPD6940 Discontinued
0.6452 Remote Similarity NPD4634 Approved
0.6441 Remote Similarity NPD8029 Clinical (unspecified phase)
0.6435 Remote Similarity NPD4202 Approved
0.6435 Remote Similarity NPD5779 Approved
0.6435 Remote Similarity NPD5778 Approved
0.6389 Remote Similarity NPD7525 Registered
0.6387 Remote Similarity NPD5285 Approved
0.6387 Remote Similarity NPD4696 Approved
0.6387 Remote Similarity NPD5286 Approved
0.6387 Remote Similarity NPD4700 Approved
0.6372 Remote Similarity NPD6672 Approved
0.6372 Remote Similarity NPD6903 Approved
0.6372 Remote Similarity NPD5737 Approved
0.6355 Remote Similarity NPD6114 Approved
0.6355 Remote Similarity NPD6697 Approved
0.6355 Remote Similarity NPD6115 Approved
0.6355 Remote Similarity NPD6118 Approved
0.6345 Remote Similarity NPD7625 Phase 1
0.633 Remote Similarity NPD1779 Approved
0.633 Remote Similarity NPD1780 Approved
0.6328 Remote Similarity NPD6274 Approved
0.6325 Remote Similarity NPD5695 Phase 3
0.6308 Remote Similarity NPD7101 Approved
0.6308 Remote Similarity NPD7100 Approved
0.6306 Remote Similarity NPD3665 Phase 1
0.6306 Remote Similarity NPD3666 Approved
0.6306 Remote Similarity NPD3133 Approved
0.6303 Remote Similarity NPD5696 Approved
0.6296 Remote Similarity NPD8336 Approved
0.6296 Remote Similarity NPD8337 Approved
0.6281 Remote Similarity NPD5225 Approved
0.6281 Remote Similarity NPD5226 Approved
0.6281 Remote Similarity NPD4633 Approved
0.6281 Remote Similarity NPD5211 Phase 2
0.6281 Remote Similarity NPD5224 Approved
0.6279 Remote Similarity NPD8137 Clinical (unspecified phase)
0.6271 Remote Similarity NPD5220 Clinical (unspecified phase)
0.6271 Remote Similarity NPD4697 Phase 3
0.6271 Remote Similarity NPD5221 Approved
0.6271 Remote Similarity NPD5222 Approved
0.6262 Remote Similarity NPD6116 Phase 1
0.626 Remote Similarity NPD4768 Approved
0.626 Remote Similarity NPD4767 Approved
0.6231 Remote Similarity NPD6335 Approved
0.623 Remote Similarity NPD5174 Approved
0.623 Remote Similarity NPD5175 Approved
0.6222 Remote Similarity NPD8448 Approved
0.6218 Remote Similarity NPD5173 Approved
0.6212 Remote Similarity NPD6909 Approved
0.6212 Remote Similarity NPD6908 Approved
0.6204 Remote Similarity NPD8391 Approved
0.6204 Remote Similarity NPD8392 Approved
0.6204 Remote Similarity NPD8390 Approved
0.6202 Remote Similarity NPD6868 Approved
0.6198 Remote Similarity NPD5223 Approved
0.6198 Remote Similarity NPD5344 Discontinued
0.6194 Remote Similarity NPD8342 Approved
0.6194 Remote Similarity NPD8341 Approved
0.6194 Remote Similarity NPD8299 Approved
0.6194 Remote Similarity NPD8340 Approved
0.6186 Remote Similarity NPD6356 Clinical (unspecified phase)
0.6179 Remote Similarity NPD5141 Approved
0.6174 Remote Similarity NPD4753 Phase 2
0.6168 Remote Similarity NPD6117 Approved
0.6161 Remote Similarity NPD3668 Phase 3
0.616 Remote Similarity NPD4729 Approved
0.616 Remote Similarity NPD4730 Approved
0.6154 Remote Similarity NPD6317 Approved
0.6148 Remote Similarity NPD8451 Approved
0.6134 Remote Similarity NPD7614 Phase 1
0.6134 Remote Similarity NPD7732 Phase 3
0.6134 Remote Similarity NPD7839 Suspended
0.6121 Remote Similarity NPD7838 Discovery
0.6119 Remote Similarity NPD7830 Approved
0.6119 Remote Similarity NPD7829 Approved
0.6115 Remote Similarity NPD8338 Approved

Structure

External Identifiers

PubChem CID   11650910
ChEMBL   CHEMBL479310
ZINC  

Physicochemical Properties

Molecular Weight:  912.51
ALogP:  -3.1909
MLogP:  4.76
XLogP:  4.684
# Rotatable Bonds:  26
Polar Surface Area:  274.75
# H-Bond Aceptor:  17
# H-Bond Donor:  10
# Rings:  8
# Heavy Atoms:  64

Download Data

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General Info & Identifiers & Properties  
Structure MOL file  
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Biological Activities  
Similar NPs/Drugs