Collective Molecular Activities of the Plant: Centipeda Minima
Plant ID: NPO8881
Plant Latin Name: Centipeda Minima
Taxonomy Genus: Centipeda
Taxonomy Family: Asteraceae
Plant External Links:
NCBI TaxonomyDB:
397370
Plant-of-the-World-Online:
n.a.
Country/Region:
Thailand; South Korea; China; IndiaTraditional Medicine System:
Sowa-Rigpa; TCM; Unani; Ayurveda; SiddhaMedicinal Functions:
Anodyne; Antitussive; Depurative; Diuretic; Skin; Sternutatory
India; South Korea; China; Thailand
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
86 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
68 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
41 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC99170
Ingredient ID: NPC88573
Ingredient ID: NPC72924
Ingredient ID: NPC71540
Ingredient ID: NPC70744
Ingredient ID: NPC63391
Ingredient ID: NPC62045
Ingredient ID: NPC59506
Ingredient ID: NPC59108
Ingredient ID: NPC49561
Ingredient ID: NPC38072
Ingredient ID: NPC37802
Ingredient ID: NPC36168
Ingredient ID: NPC328788
Ingredient ID: NPC307518
Ingredient ID: NPC306990
Ingredient ID: NPC302857
Ingredient ID: NPC299856
Ingredient ID: NPC294902
Ingredient ID: NPC293628
Ingredient ID: NPC29128
Ingredient ID: NPC289574
Ingredient ID: NPC287823
Ingredient ID: NPC286342
Ingredient ID: NPC285635
Ingredient ID: NPC284185
Ingredient ID: NPC281259
Ingredient ID: NPC279989
Ingredient ID: NPC278102
Ingredient ID: NPC271638
Ingredient ID: NPC26960
Ingredient ID: NPC266573
Ingredient ID: NPC265800
Ingredient ID: NPC265024
Ingredient ID: NPC26211
Ingredient ID: NPC261178
Ingredient ID: NPC258773
Ingredient ID: NPC256280
Ingredient ID: NPC256268
Ingredient ID: NPC253144
Ingredient ID: NPC252931
Ingredient ID: NPC251949
Ingredient ID: NPC247986
Ingredient ID: NPC245027
Ingredient ID: NPC241498
Ingredient ID: NPC24146
Ingredient ID: NPC230301
Ingredient ID: NPC219848
Ingredient ID: NPC219357
Ingredient ID: NPC216630
Ingredient ID: NPC213345
Ingredient ID: NPC210040
Ingredient ID: NPC209217
Ingredient ID: NPC208450
Ingredient ID: NPC20791
Ingredient ID: NPC20742
Ingredient ID: NPC200903
Ingredient ID: NPC196776
Ingredient ID: NPC192698
Ingredient ID: NPC186994
Ingredient ID: NPC182102
Ingredient ID: NPC178218
Ingredient ID: NPC1777
Ingredient ID: NPC170656
Ingredient ID: NPC167976
Ingredient ID: NPC167647
Ingredient ID: NPC162620
Ingredient ID: NPC161557
Ingredient ID: NPC157925
Ingredient ID: NPC157288
Ingredient ID: NPC156654
Ingredient ID: NPC15336
Ingredient ID: NPC1527
Ingredient ID: NPC147398
Ingredient ID: NPC146394
Ingredient ID: NPC140751
Ingredient ID: NPC130306
Ingredient ID: NPC122493
Ingredient ID: NPC120464
Ingredient ID: NPC117493
Ingredient ID: NPC115049
Ingredient ID: NPC113733
Ingredient ID: NPC111888
Ingredient ID: NPC10781
Ingredient ID: NPC1075
Ingredient ID: NPC105363
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Therapeutic Target | Enzyme | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Therapeutic Target | Enzyme | NOX4 | NADPH oxidase 4 | Q9NPH5 | CHEMBL1250375 |
| Therapeutic Target | Enzyme | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
| Therapeutic Target | Enzyme | GFER | FAD-linked sulfhydryl oxidase ALR | P55789 | CHEMBL1741189 |
| Therapeutic Target | Fatty acid binding protein family | FABP4 | Fatty acid binding protein adipocyte | P15090 | CHEMBL2083 |
| Therapeutic Target | Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
| Therapeutic Target | Lyase | CA14 | Carbonic anhydrase XIV | Q9ULX7 | CHEMBL3510 |
| Therapeutic Target | Metallo protease | MMP1 | Matrix metalloproteinase-1 | P03956 | CHEMBL332 |
| Therapeutic Target | Metallo protease | MMP9 | Matrix metalloproteinase 9 | P14780 | CHEMBL321 |
| Therapeutic Target | Metallo protease | MMP2 | Matrix metalloproteinase-2 | P08253 | CHEMBL333 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 37 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00429416 | Research Study to Determine if an Experimental Agent, LLME Can Decrease the Incidence and Severity of Graft-Versus-Host-Disease (GVHD) Following Blood (Hematopoietic) Stem Cell Transplantation | cancer | Leucine (NPC245027) | NP level |
| NCT00455416 | Dietary Intervention in Follicular Lymphoma | follicular lymphoma | Quercetin (NPC20791) | NP level |
| NCT00643773 | The Effect of Leucine on Body Composition and Muscle Characteristics in Elderly, Type 2 Diabetes Patients | type 2 diabetes mellitus | Leucine (NPC245027) | NP level |
| NCT01233492 | Boron Phenylalanine With or Without Mannitol in Treating Patients With Glioblastoma Multiforme | Central Nervous System Neoplasm | L-Phenylalanine (NPC10781) | NP level |
| NCT01348204 | Nasal Potential Studies Utilizing Cystic Fibrosis Transmembrane Regulator (CFTR) Modulators | cystic fibrosis | Quercetin (NPC20791) | NP level |
| NCT01375101 | Therapeutic Effect of Quercetin and the Current Treatment of Erosive and Atrophic Oral Lichen Planus | oral lichen planus | Quercetin (NPC20791) | NP level |
| NCT01438320 | Q-Trial in Patients With Hepatitis C | chronic hepatitis C virus infection | Quercetin (NPC20791) | NP level |
| NCT01708278 | Beneficial Effects of Quercetin in Chronic Obstructive Pulmonary Disease (COPD) | chronic obstructive pulmonary disease | Quercetin (NPC20791) | NP level |
| NCT01720147 | Quercetin in Children With Fanconi Anemia; a Pilot Study | Fanconi anemia | Quercetin (NPC20791) | NP level |
| NCT01839344 | Effects of Quercetin on Blood Sugar and Blood Vessel Function in Type 2 Diabetes. | type 2 diabetes mellitus | Quercetin (NPC20791) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
MMP2
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
AKR1B1,AURKB,KDR
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
NFKB1,TP53,PIM1,SRC,AXL,AURKB,FLT3
|
Acute/subacute hepatic failureDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB91 |
NFKB1
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
CDK1,AURKB,MMP9,XDH,TSHR,MMP1,F2,NPSR1
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
CA14,RECQL,POLB,XDH,MMP2,OR51E2,MET,LMNA,AURKB,PIM1,CYP1B1,CA2,F2,MMP1,NPSR1,ALOX15,SNCA,ALOX5,AXL,ABCG2
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
FABP5,ALOX15,OR51E2,NOX4
NCT01912820 |
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
CDK1,AURKB,MMP9,F2,MMP1,NPSR1,ALOX15,CYP19A1,MET,NOX4
|
Ageing associated decline in intrinsic capacityDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG2A |
NCT04946383,NCT05422885
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
KDR,SNCA,FLT3,MET
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
