Collective Molecular Activities of the Plant: Lactuca Serriola
Plant ID: NPO7731
Plant Latin Name: Lactuca Serriola
Taxonomy Genus: Lactuca
Taxonomy Family: Asteraceae
Plant External Links:
NCBI TaxonomyDB:
75943
Plant-of-the-World-Online:
n.a.
Country/Region:
China; Italy; IndiaTraditional Medicine System:
Indian Folk; TCM; Unani; AyurvedaMedicinal Functions:
Anodyne; Antipyretic; Diuretic; Homeopathy; Hypnotic; Narcotic; Sedative
India; Italy; China
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
64 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
25 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
25 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC9874
Ingredient ID: NPC9356
Ingredient ID: NPC91949
Ingredient ID: NPC88023
Ingredient ID: NPC79483
Ingredient ID: NPC74404
Ingredient ID: NPC68517
Ingredient ID: NPC65426
Ingredient ID: NPC45826
Ingredient ID: NPC42731
Ingredient ID: NPC39834
Ingredient ID: NPC37468
Ingredient ID: NPC312368
Ingredient ID: NPC302857
Ingredient ID: NPC294815
Ingredient ID: NPC287570
Ingredient ID: NPC282348
Ingredient ID: NPC281461
Ingredient ID: NPC268298
Ingredient ID: NPC258236
Ingredient ID: NPC254696
Ingredient ID: NPC251102
Ingredient ID: NPC246683
Ingredient ID: NPC246380
Ingredient ID: NPC240053
Ingredient ID: NPC238943
Ingredient ID: NPC222834
Ingredient ID: NPC215435
Ingredient ID: NPC214669
Ingredient ID: NPC213157
Ingredient ID: NPC212679
Ingredient ID: NPC210298
Ingredient ID: NPC209528
Ingredient ID: NPC20791
Ingredient ID: NPC206250
Ingredient ID: NPC203468
Ingredient ID: NPC202340
Ingredient ID: NPC200819
Ingredient ID: NPC199909
Ingredient ID: NPC195305
Ingredient ID: NPC1940
Ingredient ID: NPC19174
Ingredient ID: NPC188093
Ingredient ID: NPC186444
Ingredient ID: NPC184649
Ingredient ID: NPC184248
Ingredient ID: NPC181465
Ingredient ID: NPC176740
Ingredient ID: NPC171620
Ingredient ID: NPC1712
Ingredient ID: NPC157778
Ingredient ID: NPC14316
Ingredient ID: NPC142319
Ingredient ID: NPC140191
Ingredient ID: NPC135694
Ingredient ID: NPC13486
Ingredient ID: NPC130683
Ingredient ID: NPC12323
Ingredient ID: NPC118700
Ingredient ID: NPC116775
Ingredient ID: NPC114268
Ingredient ID: NPC112654
Ingredient ID: NPC110249
Ingredient ID: NPC107091
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Therapeutic Target | Enzyme | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
| Therapeutic Target | Enzyme | NOX4 | NADPH oxidase 4 | Q9NPH5 | CHEMBL1250375 |
| Therapeutic Target | Enzyme | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Therapeutic Target | Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
| Therapeutic Target | Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Therapeutic Target | Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
| Therapeutic Target | Nuclear hormone receptor subfamily 3 | ESR2 | Estrogen receptor beta | Q92731 | CHEMBL242 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 54 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00000324 | Tryptophan and Behavior Therapy for Cocaine Abuse - 1 | cocaine dependence | Tryptophan (NPC203468) | NP level |
| NCT00218946 | Nasogastric Tube in Premature Babies - Pain and Treatment | premature birth | Sucrose (NPC130683) | NP level |
| NCT00455416 | Dietary Intervention in Follicular Lymphoma | follicular lymphoma | Quercetin (NPC20791) | NP level |
| NCT00482560 | Analgesic Effect of Breast Feeding vs Sucrose in Neonatal Screening | pain | Sucrose (NPC130683) | NP level |
| NCT00519207 | Evaluation of Topical Liposomal Lidocaine and Oral Sucrose for Treatment of Pain in Newborns Undergoing Venipuncture | pain | Sucrose (NPC130683) | NP level |
| NCT00567931 | 1-Methyl-D-Tryptophan in Treating Patients With Metastatic or Refractory Solid Tumors That Cannot Be Removed By Surgery | neoplasm | Tryptophan (NPC203468) | NP level |
| NCT00717652 | Efficiency And Safety Of Association Arbutin, Triamcinolone And Tretinoin In Treatment Of Melasma | freckles | Arbutin (NPC142319) | NP level |
| NCT00787059 | AC6 Gene Transfer for CHF | congestive heart failure | Sucrose (NPC130683) | NP level |
| NCT00949104 | Role of Oral Sucrose in Reducing the Pain to Orogastric Tube Insertion in Preterm Neonates | pain | Sucrose (NPC130683) | NP level |
| NCT01042535 | Vaccine Therapy and 1-MT in Treating Patients With Metastatic Breast Cancer | male breast carcinoma | Tryptophan (NPC203468) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acquired hypermelanosisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED60 |
TYR
|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
TYR
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
AKR1B1,KDR,DPP4,AURKB
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
AURKB,SRC,PIM1,FLT3,AXL,TP53
|
Acute respiratory distress syndromeDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB00 |
NCT03718507
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
AURKB,ACHE,CA7,CA12,NPSR1,CDK1,CYP2C9,XDH
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
ACHE,AURKB,CA7,CISD1,CYP1B1,AXL,MET,NPSR1,ALOX5,POLB,DPP4,CYP2C9,ALOX15,XDH,PIM1,ABCG2,HSD17B2,RECQL
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
NOX4,ALOX15
NCT01912820 |
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
AURKB,NOX4,MET,NPSR1,CDK1,CYP19A1,ALOX15
|
Ageing associated decline in intrinsic capacityDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG2A |
NCT04946383,NCT05422885
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
