Collective Molecular Activities of the Plant: Coptis Chinensis
Country/Region:
ChinaTraditional Medicine System:
TCMMedicinal Functions:
Anaesthetic; Analgesic; Antibacterial; Antidote; Antipyretic; Antispasmodic; Bitter; Blood tonic; Carminative; Cholagogue; Digestive; Sedative; Skin; Stomachic; Tonic; Vasodilator
China
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
121 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
94 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
66 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC99572
Ingredient ID: NPC99480
Ingredient ID: NPC98356
Ingredient ID: NPC96405
Ingredient ID: NPC92828
Ingredient ID: NPC91382
Ingredient ID: NPC89402
Ingredient ID: NPC88864
Ingredient ID: NPC88566
Ingredient ID: NPC87125
Ingredient ID: NPC83975
Ingredient ID: NPC83511
Ingredient ID: NPC81775
Ingredient ID: NPC81218
Ingredient ID: NPC80167
Ingredient ID: NPC79977
Ingredient ID: NPC79549
Ingredient ID: NPC77572
Ingredient ID: NPC76468
Ingredient ID: NPC73020
Ingredient ID: NPC70744
Ingredient ID: NPC70741
Ingredient ID: NPC59567
Ingredient ID: NPC57512
Ingredient ID: NPC53069
Ingredient ID: NPC52230
Ingredient ID: NPC4669
Ingredient ID: NPC44740
Ingredient ID: NPC44101
Ingredient ID: NPC4071
Ingredient ID: NPC40432
Ingredient ID: NPC3855
Ingredient ID: NPC3780
Ingredient ID: NPC36229
Ingredient ID: NPC3295
Ingredient ID: NPC328725
Ingredient ID: NPC314267
Ingredient ID: NPC307312
Ingredient ID: NPC307050
Ingredient ID: NPC306669
Ingredient ID: NPC305327
Ingredient ID: NPC305016
Ingredient ID: NPC302857
Ingredient ID: NPC296482
Ingredient ID: NPC294100
Ingredient ID: NPC290613
Ingredient ID: NPC29
Ingredient ID: NPC269699
Ingredient ID: NPC26906
Ingredient ID: NPC268334
Ingredient ID: NPC266144
Ingredient ID: NPC259732
Ingredient ID: NPC25810
Ingredient ID: NPC257582
Ingredient ID: NPC257124
Ingredient ID: NPC252126
Ingredient ID: NPC251651
Ingredient ID: NPC246543
Ingredient ID: NPC243044
Ingredient ID: NPC23962
Ingredient ID: NPC236767
Ingredient ID: NPC230786
Ingredient ID: NPC230301
Ingredient ID: NPC228346
Ingredient ID: NPC215098
Ingredient ID: NPC214584
Ingredient ID: NPC214456
Ingredient ID: NPC212686
Ingredient ID: NPC210437
Ingredient ID: NPC209593
Ingredient ID: NPC20820
Ingredient ID: NPC207721
Ingredient ID: NPC202768
Ingredient ID: NPC202605
Ingredient ID: NPC200555
Ingredient ID: NPC196548
Ingredient ID: NPC196026
Ingredient ID: NPC193180
Ingredient ID: NPC192135
Ingredient ID: NPC189853
Ingredient ID: NPC187998
Ingredient ID: NPC184049
Ingredient ID: NPC183485
Ingredient ID: NPC179704
Ingredient ID: NPC171409
Ingredient ID: NPC170526
Ingredient ID: NPC167976
Ingredient ID: NPC16567
Ingredient ID: NPC16452
Ingredient ID: NPC164203
Ingredient ID: NPC161557
Ingredient ID: NPC161097
Ingredient ID: NPC16107
Ingredient ID: NPC158494
Ingredient ID: NPC158079
Ingredient ID: NPC1540
Ingredient ID: NPC14622
Ingredient ID: NPC143639
Ingredient ID: NPC138347
Ingredient ID: NPC13826
Ingredient ID: NPC138113
Ingredient ID: NPC136014
Ingredient ID: NPC132658
Ingredient ID: NPC131624
Ingredient ID: NPC126409
Ingredient ID: NPC124302
Ingredient ID: NPC121539
Ingredient ID: NPC12053
Ingredient ID: NPC120464
Ingredient ID: NPC119218
Ingredient ID: NPC116007
Ingredient ID: NPC115207
Ingredient ID: NPC115096
Ingredient ID: NPC114721
Ingredient ID: NPC112704
Ingredient ID: NPC111888
Ingredient ID: NPC109387
Ingredient ID: NPC106786
Ingredient ID: NPC106295
Ingredient ID: NPC102091
Ingredient ID: NPC101638
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 | Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Therapeutic Target | Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
| Therapeutic Target | Membrane receptor | SIGMAR1 | Sigma opioid receptor | Q99720 | CHEMBL287 |
| Therapeutic Target | Protein Kinase | MAPK1 | MAP kinase ERK2 | P28482 | CHEMBL4040 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | DRD5 | Dopamine D5 receptor | P21918 | CHEMBL1850 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | DRD2 | Dopamine D2 receptor | P14416 | CHEMBL217 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | ADRA2B | Alpha-2b adrenergic receptor | P18089 | CHEMBL1942 |
| Therapeutic Target | Structural protein | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
| Therapeutic Target | Surface antigen | F3 | Coagulation factor III | P13726 | CHEMBL4081 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 21 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00425009 | Therapeutic Effects of Berberine in Patients With Type 2 Diabetes | type 2 diabetes mellitus | Berberine (NPC53069) | NP level |
| NCT00633282 | Role of Pioglitazone and Berberine in Treatment of Non-Alcoholic Fatty Liver Disease | non-alcoholic fatty liver disease | Berberine (NPC53069) | NP level |
| NCT01631383 | Pharmacokinetic and Safety Evaluation of L-tetrahydropalmatine (l-THP) With Cocaine Exposure in People With a History of Cocaine Use | cocaine dependence | Tetrahydropalmatine (NPC210437) | NP level |
| NCT02082756 | Effects of Berberine Hydrochloride and Bifidobacterium in Prediabetes Prevention and Treatment | prediabetes syndrome | Berberine (NPC53069) | NP level |
| NCT02084004 | Effects of Berberine Hydrochloride and Bifidobacterium in Diabetes Mellitus Prevention and Treatment | type 2 diabetes mellitus | Berberine (NPC53069) | NP level |
| NCT02136342 | Phase 1 Trial of Chlorogenic Acid in Patients With Advanced Cancer | cancer | Chlorogenic Acid (NPC302857) | NP level |
| NCT02139761 | L-tetrahydropalmatine (l-THP) Treatment for Cocaine Use Disorder | cocaine dependence | Tetrahydropalmatine (NPC210437) | NP level |
| NCT02226185 | Study of Berberine Hydrochloride in Prevention of Colorectal Adenomas Recurrence | colorectal adenoma | Berberine (NPC53069) | NP level |
| NCT02245204 | Phase I Studies of Chlorogenic Acid for Injection for Tolerance and Pharmacokinetic of Advanced Cancers | cancer | Chlorogenic Acid (NPC302857) | NP level |
| NCT02365480 | Berberine Chloride in Preventing Colorectal Cancer in Patients With Ulcerative Colitis in Remission | ulcerative colitis | Berberine Chloride (NPC296482) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Abdominal pelvic painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MD81 |
CHRM1
|
Abnormal micturitionDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MF50 |
CHRM1
|
AbortionDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JA00 |
DRD1
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
AKR1B1
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
CDK9
|
Acute respiratory distress syndromeDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB00 |
F3
|
Acute upper respiratory infectionDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA07 |
DRD2
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
F2,ACHE
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
ACHE,SNCA,CYP1B1,DRD2,F2,DRD1,LMNA
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
F2,DRD1
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
