CMAUP Plant Collective Molecular Activities

Collective Molecular Activities of the Plant: Eucalyptus Viminalis

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PLANiTS DNA barcode

Click for details-----ITS2

Taxonomic Information

Plant ID: NPO28778
Plant Latin Name: Eucalyptus Viminalis
Taxonomy Genus: Eucalyptus
Taxonomy Family: Myrtaceae

Plant External Links:

NCBI TaxonomyDB: 155764
Plant-of-the-World-Online: n.a.

Used in Medicines

Country/Region:

Australia; China

Traditional Medicine System:

TCM

Medicinal Functions:

Antiviral; Laxative

Geographical Distribution

Australia; China

Geographical Distribution

−

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Compounds Summary

Overview of Ingredients

81 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.

62 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Å² < TPSA < 130Å²
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)

30 Ingredients with experimental-derived Activity

Unique ingredients have activity data available.

Ingredient Structrual Cards

Ingredient ID: NPC95676

Ingredient ID: NPC94304

Ingredient ID: NPC94218

Ingredient ID: NPC94045

Ingredient ID: NPC93033

Ingredient ID: NPC90787

Ingredient ID: NPC85813

Ingredient ID: NPC85327

Ingredient ID: NPC84319

Ingredient ID: NPC82648

Ingredient ID: NPC82363

Ingredient ID: NPC79527

Ingredient ID: NPC78540

Ingredient ID: NPC76145

Ingredient ID: NPC76074

Ingredient ID: NPC68492

Ingredient ID: NPC62086

Ingredient ID: NPC5708

Ingredient ID: NPC4827

Ingredient ID: NPC4125

Ingredient ID: NPC3922

Ingredient ID: NPC3649

Ingredient ID: NPC327254

Ingredient ID: NPC3190

Ingredient ID: NPC312391

Ingredient ID: NPC306616

Ingredient ID: NPC299529

Ingredient ID: NPC289758

Ingredient ID: NPC281994

Ingredient ID: NPC270088

Ingredient ID: NPC270074

Ingredient ID: NPC269806

Ingredient ID: NPC268862

Ingredient ID: NPC266021

Ingredient ID: NPC26583

Ingredient ID: NPC265513

Ingredient ID: NPC261831

Ingredient ID: NPC261411

Ingredient ID: NPC258723

Ingredient ID: NPC258019

Ingredient ID: NPC257522

Ingredient ID: NPC249018

Ingredient ID: NPC243601

Ingredient ID: NPC229403

Ingredient ID: NPC225406

Ingredient ID: NPC225284

Ingredient ID: NPC223417

Ingredient ID: NPC219573

Ingredient ID: NPC217781

Ingredient ID: NPC215702

Ingredient ID: NPC213322

Ingredient ID: NPC20892

Ingredient ID: NPC207869

Ingredient ID: NPC206380

Ingredient ID: NPC202691

Ingredient ID: NPC200872

Ingredient ID: NPC197378

Ingredient ID: NPC194383

Ingredient ID: NPC181582

Ingredient ID: NPC180612

Ingredient ID: NPC178859

Ingredient ID: NPC176017

Ingredient ID: NPC17458

Ingredient ID: NPC173658

Ingredient ID: NPC170070

Ingredient ID: NPC166894

Ingredient ID: NPC163424

Ingredient ID: NPC162169

Ingredient ID: NPC157923

Ingredient ID: NPC15292

Ingredient ID: NPC149691

Ingredient ID: NPC149570

Ingredient ID: NPC149203

Ingredient ID: NPC148677

Ingredient ID: NPC142871

Ingredient ID: NPC127447

Ingredient ID: NPC125962

Ingredient ID: NPC121270

Ingredient ID: NPC114239

Ingredient ID: NPC105380

Ingredient ID: NPC100178

Classification of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM Target Type: Individual Protein of Homo sapiens

*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.

Detailed Information of Target Proteins

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Search:

Target Type	Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450	Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450	Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450	Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450	Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Cytochrome P450	Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Therapeutic Target	Enzyme	AKR1C3	Aldo-keto-reductase family 1 member C3	P42330	CHEMBL4681
Therapeutic Target	Fatty acid binding protein family	FABP5	Fatty acid binding protein epidermal	Q01469	CHEMBL3674
Therapeutic Target	Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Therapeutic Target	Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Therapeutic Target	Nuclear hormone receptor subfamily 1	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239

Showing 1 to 10 of 18 entries

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Clinical Trials Summary

Overview

Clinical trials associated with plant from natural product (NP) & plant level:

Clinical trials type	Number of clinical trials
NP level	84

Clinical trial details

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Search:

NCT ID	Title	Condition	Form in clinical use	Associated by plant or compound
NCT00029679	Borage Oil and Ginkgo Biloba (EGb 761) in Asthma	asthma	Linoleic Acid (NPC85813)	NP level
NCT00062972	Improving Memory in Patients With Multiple Sclerosis	multiple sclerosis	Glucose, Liquid (NPC289758)	NP level
NCT00091507	IMMEDIATE Trial - Out of Hospital Administration of Glucose, Insulin and Potassium.	congestive heart failure;intermediate coronary syndrome;myocardial infarction	Glucose, Liquid (NPC289758)	NP level
NCT00204932	Effects of CLA Supplements on Body Weight and Fat Oxidation	obesity	Linoleic Acid (NPC85813)	NP level
NCT00213759	Prevention Trial of Nosocomial Infections in Neutropenic Prematures With G-CSF	neutropenia	Glucose, Liquid (NPC289758)	NP level
NCT00337597	Continuous Regional Analgesia After Total Knee Arthroplasty	pain	Glucose, Liquid (NPC289758)	NP level
NCT00552786	Antioxidation Medication for Noise-induced Hearing Loss	hearing loss	Glucose, Liquid (NPC289758)	NP level
NCT00607945	Dietary Fatty Acids as Complementary Therapy in Type 2 Diabetes Mellitus	type 2 diabetes mellitus	Linoleic Acid (NPC85813)	NP level
NCT00612014	Safety and Efficacy of IV Infusion of Investigational Agent (TZP-101) in Patients With Severe Diabetic Gastroparesis	gastroparesis	Glucose, Liquid (NPC289758)	NP level
NCT00617552	Safety and Efficacy of IV Infusion of TZP-101 for POI After Major Open Abdominal Surgery	ileus	Glucose, Liquid (NPC289758)	NP level

Showing 1 to 10 of 84 entries

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❱❱❱ Associated Human Diseases and Detailed Association Evidence

How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.

Show entries

Search:

Associated Disease of the Plant	Association Type & Detailed Evidence
Acute diabete complication Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A2Y	PPARA,FFAR1
Adenocarcinoma of bronchus or lung Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25.0	AKR1B10,AKR1C3,XDH,CA7,CBR1
Adenocarcinoma of pancreas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10.0	AKR1B10,LMNA,F10,AKR1C3,XDH,FFAR4,CYP1B1,FABP3,CA7,ALOX15,CYP2C19,CBR1
Adenocarcinoma of prostate Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C82.0	FABP5,ALOX15
Adenocarcinoma of stomach Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B72.0	ALOX15,CYP19A1
Amyotrophic lateral sclerosis Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8B60.0	NCT03039673
Asthma Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CA23	CBR1,CA4 NCT00029679
Atrial fibrillation Disease Category: 11.Diseases of the circulatory system Disease ICD-11 Code: BC81.3	CA7
Attention deficit hyperactivity disorder Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6A05	F10
Bacterial infection Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1A00-1C4Z	CA4

Showing 1 to 10 of 143 entries

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❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

Plant-Targeted Human Disease Network

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Plant Ingredients
3. Collective Molecular Proteins
4. Collective Enriched Activities
5. Plant molecular targets overlapping with DEGs
6. Associated clinical trials
7. Associated Human Diseases

Collective Molecular Activities of the Plant: Eucalyptus Viminalis

Click for details-----ITS

Click for details-----ITS1

Click for details-----ITS2

Plant External Links:

Country/Region:

Traditional Medicine System:

Medicinal Functions:

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Overview of Ingredients

81 All known Ingredients in Total

62 Ingredients with Acceptable Bioavailablity

30 Ingredients with experimental-derived Activity

Ingredient Structrual Cards

Classification of Human Proteins Collectively Targeted by the Plant

Detailed Information of Target Proteins

❱❱❱ Associated Human Diseases and Detailed Association Evidence

Associated Disease of the Plant

Association Type & Detailed Evidence

Acute diabete complication

Adenocarcinoma of bronchus or lung

Adenocarcinoma of pancreas

Adenocarcinoma of prostate

Adenocarcinoma of stomach

Amyotrophic lateral sclerosis

Asthma

Atrial fibrillation

Attention deficit hyperactivity disorder

Bacterial infection

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

>> Targets derived from weak experimental activities