CMAUP Plant Collective Molecular Activities

Collective Molecular Activities of the Plant: Lycopodium Japonicum

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PLANiTS DNA barcode

Click for details-----ITS2

Taxonomic Information

Plant ID: NPO24671
Plant Latin Name: Lycopodium Japonicum
Taxonomy Genus: Lycopodium
Taxonomy Family: Lycopodiaceae

Plant External Links:

NCBI TaxonomyDB: 672196
Plant-of-the-World-Online: n.a.

Used in Medicines

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution

China

Geographical Distribution

−

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Compounds Summary

Overview of Ingredients

90 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.

42 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Å² < TPSA < 130Å²
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)

23 Ingredients with experimental-derived Activity

Unique ingredients have activity data available.

Ingredient Structrual Cards

Ingredient ID: NPC98150

Ingredient ID: NPC92837

Ingredient ID: NPC86150

Ingredient ID: NPC77249

Ingredient ID: NPC74393

Ingredient ID: NPC71446

Ingredient ID: NPC69314

Ingredient ID: NPC68360

Ingredient ID: NPC67342

Ingredient ID: NPC66411

Ingredient ID: NPC65786

Ingredient ID: NPC65079

Ingredient ID: NPC64828

Ingredient ID: NPC61983

Ingredient ID: NPC51862

Ingredient ID: NPC45865

Ingredient ID: NPC43094

Ingredient ID: NPC39543

Ingredient ID: NPC39269

Ingredient ID: NPC38756

Ingredient ID: NPC3780

Ingredient ID: NPC311830

Ingredient ID: NPC311440

Ingredient ID: NPC311099

Ingredient ID: NPC30936

Ingredient ID: NPC306806

Ingredient ID: NPC304810

Ingredient ID: NPC299856

Ingredient ID: NPC299787

Ingredient ID: NPC296770

Ingredient ID: NPC293662

Ingredient ID: NPC29353

Ingredient ID: NPC291158

Ingredient ID: NPC286988

Ingredient ID: NPC286667

Ingredient ID: NPC279928

Ingredient ID: NPC278680

Ingredient ID: NPC274237

Ingredient ID: NPC270675

Ingredient ID: NPC265442

Ingredient ID: NPC262519

Ingredient ID: NPC261894

Ingredient ID: NPC256879

Ingredient ID: NPC252918

Ingredient ID: NPC247586

Ingredient ID: NPC245853

Ingredient ID: NPC243728

Ingredient ID: NPC243083

Ingredient ID: NPC235391

Ingredient ID: NPC231772

Ingredient ID: NPC230789

Ingredient ID: NPC225800

Ingredient ID: NPC218249

Ingredient ID: NPC216996

Ingredient ID: NPC21519

Ingredient ID: NPC214585

Ingredient ID: NPC214168

Ingredient ID: NPC210003

Ingredient ID: NPC207734

Ingredient ID: NPC201806

Ingredient ID: NPC196776

Ingredient ID: NPC195685

Ingredient ID: NPC180407

Ingredient ID: NPC173592

Ingredient ID: NPC158998

Ingredient ID: NPC157972

Ingredient ID: NPC157935

Ingredient ID: NPC157699

Ingredient ID: NPC156869

Ingredient ID: NPC156851

Ingredient ID: NPC150419

Ingredient ID: NPC147364

Ingredient ID: NPC146713

Ingredient ID: NPC146091

Ingredient ID: NPC145952

Ingredient ID: NPC142319

Ingredient ID: NPC140154

Ingredient ID: NPC137062

Ingredient ID: NPC136263

Ingredient ID: NPC130683

Ingredient ID: NPC126813

Ingredient ID: NPC12618

Ingredient ID: NPC124285

Ingredient ID: NPC123965

Ingredient ID: NPC118514

Ingredient ID: NPC118027

Ingredient ID: NPC115289

Ingredient ID: NPC113101

Ingredient ID: NPC109037

Ingredient ID: NPC1021

Classification of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM Target Type: Individual Protein of Homo sapiens

*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.

Detailed Information of Target Proteins

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Search:

Target Type	Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450	Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450	Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450	Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450	Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Therapeutic Target	Oxidoreductase	MAOB	Monoamine oxidase B	P27338	CHEMBL2039
Therapeutic Target	Oxidoreductase	MAOA	Monoamine oxidase A	P21397	CHEMBL1951
Therapeutic Target	Protein Kinase	CDK8	Cell division protein kinase 8	P49336	CHEMBL5719
Therapeutic Target	Structural protein	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Therapeutic Target	Transcription factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261

Showing 1 to 9 of 9 entries

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Clinical Trials Summary

Overview

Clinical trials associated with plant from natural product (NP) & plant level:

Clinical trials type	Number of clinical trials
NP level	20

Clinical trial details

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Search:

NCT ID	Title	Condition	Form in clinical use	Associated by plant or compound
NCT00218946	Nasogastric Tube in Premature Babies - Pain and Treatment	premature birth	Sucrose (NPC130683)	NP level
NCT00482560	Analgesic Effect of Breast Feeding vs Sucrose in Neonatal Screening	pain	Sucrose (NPC130683)	NP level
NCT00519207	Evaluation of Topical Liposomal Lidocaine and Oral Sucrose for Treatment of Pain in Newborns Undergoing Venipuncture	pain	Sucrose (NPC130683)	NP level
NCT00717652	Efficiency And Safety Of Association Arbutin, Triamcinolone And Tretinoin In Treatment Of Melasma	freckles	Arbutin (NPC142319)	NP level
NCT00787059	AC6 Gene Transfer for CHF	congestive heart failure	Sucrose (NPC130683)	NP level
NCT00949104	Role of Oral Sucrose in Reducing the Pain to Orogastric Tube Insertion in Preterm Neonates	pain	Sucrose (NPC130683)	NP level
NCT01190995	Role of Repeated Painful Procedures in Preterm Neonates on Short Term Neurobehavioural Outcome	pain	Sucrose (NPC130683)	NP level
NCT01201954	Pain Relief of Newborn Preterm Infants During Endotracheal Suctioning	pain	Sucrose (NPC130683)	NP level
NCT01238471	Oral Propranolol Versus Placebo for Early Stages of Retinopathy of Prematurity: A Randomized and Prospective Study	retinopathy of prematurity	Sucrose (NPC130683)	NP level
NCT01503060	Effectiveness of Parent-Led Interventions in Reducing Infant Hypersensitivity to Pain	pain	Sucrose (NPC130683)	NP level

Showing 1 to 10 of 20 entries

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❱❱❱ Associated Human Diseases and Detailed Association Evidence

How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.

Show entries

Search:

Associated Disease of the Plant	Association Type & Detailed Evidence
Acquired hypomelanotic disorder Disease Category: 14.Diseases of the skin Disease ICD-11 Code: ED63	MAOA,MAOB
Acute myeloid leukaemia Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A60	CDK8
Acute respiratory distress syndrome Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CB00	NCT03718507
Adenocarcinoma of pancreas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10.0	CYP1B1,MAOB,HIF1A,CYP2C19,LMNA
Adenocarcinoma of stomach Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B72.0	CYP19A1
Adrenomedullary hyperfunction Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A75	HIF1A
Alzheimer disease Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A20	MAOA,MAOB
Attention deficit hyperactivity disorder Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6A05	NCT02086864
Brain cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00	HIF1A
Breast cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C60-2C6Y	CYP19A1

Showing 1 to 10 of 68 entries

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❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

Plant-Targeted Human Disease Network

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Plant Ingredients
3. Collective Molecular Proteins
4. Collective Enriched Activities
5. Plant molecular targets overlapping with DEGs
6. Associated clinical trials
7. Associated Human Diseases

Collective Molecular Activities of the Plant: Lycopodium Japonicum

Click for details-----ITS

Click for details-----ITS1

Click for details-----ITS2

Plant External Links:

Country/Region:

Traditional Medicine System:

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Overview of Ingredients

90 All known Ingredients in Total

42 Ingredients with Acceptable Bioavailablity

23 Ingredients with experimental-derived Activity

Ingredient Structrual Cards

Classification of Human Proteins Collectively Targeted by the Plant

Detailed Information of Target Proteins

❱❱❱ Associated Human Diseases and Detailed Association Evidence

Associated Disease of the Plant

Association Type & Detailed Evidence

Acquired hypomelanotic disorder

Acute myeloid leukaemia

Acute respiratory distress syndrome

Adenocarcinoma of pancreas

Adenocarcinoma of stomach

Adrenomedullary hyperfunction

Alzheimer disease

Attention deficit hyperactivity disorder

Brain cancer

Breast cancer

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

>> Targets derived from weak experimental activities