Collective Molecular Activities of the Plant: Galanthus Nivalis
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PLANiTS DNA barcode
Taxonomic Information
Used in Medicines
Country/Region:
ChinaTraditional Medicine System:
TCMMedicinal Functions:
Emmenagogue
Geographical Distribution
Canada; Turkey; Italy; France; Norway; Belarus; China; Belgium; Germany; Spain; Ukraine; Netherlands; Poland; United States; Sweden; Switzerland; Bulgaria; Romania; Albania; United Kingdom; Austria; Greece; Hungary
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Compounds Summary
Overview of Ingredients
24 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
22 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
17 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC83032
Ingredient ID: NPC40511
Ingredient ID: NPC321801
Ingredient ID: NPC320134
Ingredient ID: NPC315707
Ingredient ID: NPC314606
Ingredient ID: NPC309330
Ingredient ID: NPC29077
Ingredient ID: NPC265319
Ingredient ID: NPC246534
Ingredient ID: NPC243319
Ingredient ID: NPC237812
Ingredient ID: NPC226453
Ingredient ID: NPC226340
Ingredient ID: NPC20535
Ingredient ID: NPC174020
Ingredient ID: NPC166904
Ingredient ID: NPC163099
Ingredient ID: NPC15566
Ingredient ID: NPC148057
Ingredient ID: NPC139478
Ingredient ID: NPC13625
Ingredient ID: NPC112890
Ingredient ID: NPC111132
Classification of Human Proteins Collectively Targeted by the Plant
*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.
.
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Therapeutic Target | Enzyme | BLM | Bloom syndrome protein | P54132 | CHEMBL1293237 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | HRH1 | Histamine H1 receptor | P35367 | CHEMBL231 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | HRH4 | Histamine H4 receptor | Q9H3N8 | CHEMBL3759 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | HRH3 | Histamine H3 receptor | Q9Y5N1 | CHEMBL264 |
| Therapeutic Target | Structural protein | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
| Therapeutic Target | Transcription factor | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | P19838 | CHEMBL3251 |
Clinical Trials Summary
Overview
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 96 | |
Clinical trial details
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00387738 | Efficacy and Safety Study of TOLAMBA™ in Ragweed-Allergic Adults | seasonal allergic rhinitis | Histamine (NPC111132) | NP level |
| NCT02427581 | Safety and Immunogenicity of a Personalized Synthetic Long Peptide Breast Cancer Vaccine Strategy in Patients With Persistent Triple-Negative Breast Cancer Following Neoadjuvant Chemotherapy | triple-negative breast cancer | Lysine (NPC112890) | NP level |
| NCT00262730 | Radiation Therapy and Temozolomide Followed by Temozolomide and Poly ICLC in Treating Patients With Newly Diagnosed GBM | glioblastoma multiforme | Lysine (NPC112890) | NP level |
| NCT03121677 | Personalized Tumor Vaccine Strategy and PD-1 Blockade in Patients With Follicular Lymphoma | follicular lymphoma | Lysine (NPC112890) | NP level |
| NCT01783431 | Study of Vaccination With Poly-ICLC and Peptide-pulsed Dendritic Cells | melanoma | Lysine (NPC112890) | NP level |
| NCT00513617 | Effectiveness of Arginine as a Treatment for Sickle Cell Anemia | sickle cell anemia | Arginine (NPC226453) | NP level |
| NCT02756117 | The Effect of Acute Lysine Administration on α-aminoadipic Acid | prediabetes syndrome | Lysine (NPC112890) | NP level |
| NCT00134433 | Endothelial Modulation for Angiogenic Therapy | coronary artery disease | Arginine (NPC226453) | NP level |
| NCT03376620 | Role of Topical Putrescine (Fibrostat) for Prevention of Hypertrophic Scars in Mammoplasty Patients | severe cutaneous adverse reaction | Putrescine (NPC309330) | NP level |
| NCT00405665 | The Short Term Safety and Efficacy of Inhaled L-arginine in Patients With Cystic Fibrosis | cystic fibrosis | Arginine (NPC226453) | NP level |
| NCT00037869 | High Dose I-131 Metaiodobenzylguanidine(MIBG) for Metastatic Neuroendocrine Tumors | metastasis;neuroendocrine neoplasm | Guanidine (NPC20535) | NP level |
| NCT00719472 | A Study of Rituximab Alternative Dosing Rate in Patients With Previously Untreated Diffuse Large B-cell or Follicular Non-Hodgkin's Lymphoma (RATE) | non-Hodgkins lymphoma | Histamine (NPC111132) | NP level |
| NCT02440061 | Ghrelin and Beta Cell Function in Diabetes | type 2 diabetes mellitus | Arginine (NPC226453) | NP level |
| NCT00280683 | Effects of L-arginine Supplementation in Adults With Moderate to Severe Asthma | asthma | Arginine (NPC226453) | NP level |
| NCT01989897 | Effect of HSA or Saline Diluent on Immunotherapy Extract Stability as Determined by Graded ID Skin Tests | allergic rhinitis | Histamine (NPC111132) | NP level |
| NCT05210504 | Determinants of Alpha-aminoadipic Acid (2-AAA) and Relationship to Diabetes: Study 3 | type 2 diabetes mellitus | Lysine (NPC112890) | NP level |
| NCT00986609 | MUC1 Vaccine for Triple-negative Breast Cancer | inflammatory breast carcinoma;triple-negative breast cancer | Lysine (NPC112890) | NP level |
| NCT00200746 | Treatment of Alcohol-Related Hepatitis With Arginine | Hepatitis, Alcoholic | Arginine (NPC226453) | NP level |
| NCT04616248 | In Situ Immunomodulation With CDX-301, Radiation Therapy, CDX-1140 and Poly-ICLC in Patients w/ Unresectable and Metastatic Solid Tumors | breast carcinoma | Lysine (NPC112890) | NP level |
| NCT00058123 | Poly-ICLC in Treating Patients With Recurrent or Progressive Anaplastic Glioma | Central Nervous System Neoplasm | Lysine (NPC112890) | NP level |
| NCT02744820 | Multiple Ascending Dose Study of GMC-252-L-Lys Salt in Healthy Subjects and Type 2 Diabetics | type 2 diabetes mellitus | Lysine (NPC112890) | NP level |
| NCT01607879 | Use of β-hydroxy-β-methylbutyrate to Counteract Muscle Loss in Men With Prostate Cancer on Androgen Ablation | prostate cancer | Arginine (NPC226453) | NP level |
| NCT00147368 | Arginine Malaria Trial: Study of Adjunctive Arginine in Falciparum Malaria | Plasmodium falciparum malaria | Arginine (NPC226453) | NP level |
| NCT00677339 | L-arginine and Vitamin D Adjunctive Therapy in Pulmonary Tuberculosis (TB) | pulmonary tuberculosis | Arginine (NPC226453) | NP level |
| NCT00537355 | An Evaluation of the Efficacy and Safety of TOLAMBA™ for Ragweed-Allergic Rhinitis in an Environmental Exposure Chamber | seasonal allergic rhinitis | Histamine (NPC111132) | NP level |
| NCT05025488 | Mutant CALR-peptide Based Vaccine in Patients With Mutated CALR Myeloproliferative Neoplasm | essential thrombocythemia;myelofibrosis | Lysine (NPC112890) | NP level |
| NCT05470998 | L-Arginine in Children Having Sickle Cell Disease With Increased Tricuspid Regurgitant Jet Velocity | sickle cell anemia | Arginine (NPC226453) | NP level |
| NCT02061449 | Poly ICLC, Radiation, and Romidepsin for Advanced Cutaneous T Cell Lymphoma | Cutaneous T-cell lymphoma | Lysine (NPC112890) | NP level |
| NCT03679780 | The Effect of Endothelin and L-Arginine on Racial Differences in Vasoconstriction | cardiovascular disease | Arginine (NPC226453) | NP level |
| NCT02618824 | Role of Terminal Warm Blood Cardioplegia as Myocardial Protection in the Use of Histidine-Tryptophan-Ketoglutarate Cardioplegia in Complex Congenital Heart Surgery | congenital heart disease | Histidine (NPC237812) | NP level |
| NCT02291458 | L-arginine and Brown Adipose Tissue | Glucose intolerance | Arginine (NPC226453) | NP level |
| NCT00005107 | Role of Nitric Oxide in Cirrhosis: Relationship With Systemic Hemodynamics, Renal Function, Vasoactive Systems and Endotoxemia | cirrhosis of liver | Arginine (NPC226453) | NP level |
| NCT01388764 | Safety, Tolerability and Effects of L-Arginine in Boys With Dystrophinopathy on Corticosteroids | Duchenne muscular dystrophy | Arginine (NPC226453) | NP level |
| NCT00571766 | Effects of Oral L-Arginine on Chronic Hypertension in Pregnancy | preeclampsia | Arginine (NPC226453) | NP level |
| NCT03359239 | Atezolizumab Given in Combination With a Personalized Vaccine in Patients With Urothelial Cancer | urinary bladder cancer | Lysine (NPC112890) | NP level |
| NCT01263041 | Effect of L-arginine and Glutamine on Preterm | Sepsis | Arginine (NPC226453) | NP level |
| NCT01292070 | Safety Evaluation of an Experimental Treatment, Intradermal Human Fcγ1-Fel d1 Fusion Protein (GFD), for Cat Allergy | allergic disease | Histamine (NPC111132) | NP level |
| NCT02129075 | A Vaccine (CDX-1401) With or Without a Biologic Drug (CDX-301) for the Treatment of Patients With Stage IIB-IV Melanoma | cutaneous melanoma | Lysine (NPC112890) | NP level |
| NCT01324115 | NG-Nitro-L-Arginine in Treating Patients With Advanced Solid Tumors | neoplasm | Arginine (NPC226453) | NP level |
| NCT00345150 | Effects of Inhibition of NO-Synthesis on Renal Hemodynamics and Sodium Excretion in Patients With Essential Hypertension and Healthy Controls | hypertension | Arginine (NPC226453) | NP level |
| NCT04345705 | Poly-ICLC (Hiltonol®) Vaccine In Malignant Pleural Mesothelioma | mesothelioma | Lysine (NPC112890) | NP level |
| NCT04535427 | Role of L-Arginine Supplementation in the Treatment of Rheumatoid Arthritis | rheumatoid arthritis | Arginine (NPC226453) | NP level |
| NCT01266018 | Study of ADI-PEG 20 in Patients With Relapsed Sensitive or Refractory Small Cell Lung Cancer | small cell lung carcinoma | Arginine (NPC226453) | NP level |
| NCT02929888 | Study of Platelet Function After Administration of Aspirin Versus Lysine Acetylsalicylate in STEMI Patients | acute myocardial infarction | Lysine (NPC112890) | NP level |
| NCT01287585 | Ph 3 ADI-PEG 20 Versus Placebo in Subjects With Advanced Hepatocellular Carcinoma Who Have Failed Prior Systemic Therapy | hepatocellular carcinoma | Arginine (NPC226453) | NP level |
| NCT01920191 | Phase I/II Trial of IMA950 Multi-peptide Vaccine Plus Poly-ICLC in Glioblastoma | neoplasm | Lysine (NPC112890) | NP level |
| NCT04249336 | Clinical Efficacy Of BioMin F, Colgate Sensitive Pro-Relief And Sensodyne Rapid Action Dentifrices In DH | allergic disease | Arginine (NPC226453) | NP level |
| NCT00157521 | L-Arginine in Pre-Eclampsia | preeclampsia | Arginine (NPC226453) | NP level |
| NCT01842139 | Vaccine Therapy and Basiliximab in Treating Patients With Acute Myeloid Leukemia in Complete Remission | acute myeloid leukemia | Lysine (NPC112890) | NP level |
| NCT00344916 | Phase 1 Study of L-NMMA in Patients With Liver Cirrhosis | cirrhosis of liver | Arginine (NPC226453) | NP level |
| NCT01142219 | L-Arginine and Sickle Cell Disease | sickle cell anemia | Arginine (NPC226453) | NP level |
| NCT00047983 | Omega-3 Fatty Acids That Affect the Immune System in Kidney Transplant Patients | kidney disease | Arginine (NPC226453) | NP level |
| NCT04201873 | Pembrolizumab and a Vaccine (ATL-DC) for the Treatment of Surgically Accessible Recurrent Glioblastoma | glioblastoma multiforme | Lysine (NPC112890) | NP level |
| NCT04054973 | L-arginine Study for Persistent Symptoms of Schizophrenia | schizophrenia | Arginine (NPC226453) | NP level |
| NCT03606967 | Testing the Addition of an Individualized Vaccine to Nab-Paclitaxel, Durvalumab and Tremelimumab and Chemotherapy in Patients With Metastatic Triple Negative Breast Cancer | breast carcinoma | Lysine (NPC112890) | NP level |
| NCT01439555 | Endothelial Facilitation in Alzheimer's Disease | Alzheimer disease | Arginine (NPC226453) | NP level |
| NCT04631536 | Managing Endothelial Dysfunction in COVID-19 : A Randomized Controlled Trial at LAUMC | COVID-19 | Arginine (NPC226453) | NP level |
| NCT05457959 | Peptide-Pulsed Dendritic Cell Vaccination in Combination With Nivolumab and Ipilimumab for the Treatment of Recurrent and/or Progressive Diffuse Hemispheric Glioma, H3 G34-mutant | glioma | Lysine (NPC112890) | NP level |
| NCT00630383 | Immunoregulation by Controlled Parasite Exposure in Multiple Sclerosis. | multiple sclerosis | Histamine (NPC111132) | NP level |
| NCT00056433 | Evaluation of Hydroxyurea Plus L-arginine or Sildenafil to Treat Sickle Cell Anemia | sickle cell anemia | Arginine (NPC226453) | NP level |
| NCT00137124 | L-Arginine Metabolism in Essential Hypertension | essential hypertension | Arginine (NPC226453) | NP level |
| NCT02882217 | Study to Assess Pharmacokinetics, Safety, and Tolerability of XC-8 | asthma | Histamine (NPC111132) | NP level |
| NCT03861416 | "Unifuzol®" in Patients With Peripheral Arterial Disease | peripheral arterial disease | Arginine (NPC226453) | NP level |
| NCT05042024 | Supplementation With L-ornithine But Not L-arginine Increases Density of CD68+ and CD163+ Macrophages in Periodontitis | periodontitis | Arginine (NPC226453) | NP level |
| NCT03580122 | The Effect of Arginine on Classic Galactosemia | classic galactosemia | Arginine (NPC226453) | NP level |
| NCT04750902 | A Clinical Trial to Assess the Safety and the Anti-caries Efficacy of COL 101 (Arginine) Non-fluoride Dentifrices in Comparison With 0.24% Sodium Fluoride (1100 Ppm F) Dentifrice Control in 10 to 14-year-old Children | dental caries | Arginine (NPC226453) | NP level |
| NCT01603446 | L-arginine Therapy on Endothelium-dependent Vasodilation & Mitochondrial Metabolism in MELAS Syndrome | MELAS | Arginine (NPC226453) | NP level |
| NCT03088345 | Early Use of Vasopressin in Post-Fontan Management | congenital heart disease | Arginine (NPC226453) | NP level |
| NCT02388178 | To Determine the Ability of a New Product Formulation to Remineralize an Early Caries Lesion by an In-situ Study | dental caries | Arginine (NPC226453) | NP level |
| NCT03446456 | Vasopressin and Pain Perception in the Brain | pain | Arginine (NPC226453) | NP level |
| NCT01380678 | Intralesional Bevacizumab Injection on Primary Pterygium | inflammation;pterygium | Histamine (NPC111132) | NP level |
| NCT02447874 | Arginine Therapy for the Treatment of Pain in Children With Sickle Cell Disease | sickle cell anemia | Arginine (NPC226453) | NP level |
| NCT03266965 | Histaminergic Basis of Central Fatigue in Multiple Sclerosis - A Novel Approach | multiple sclerosis | Histidine (NPC237812) | NP level |
| NCT00223717 | Treatment of Supine Hypertension in Autonomic Failure | hypertension | Arginine (NPC226453) | NP level |
| NCT03166254 | Personalized Therapeutic Anti-tumor Vaccine With Pembrolizumab and Standard of Care Chemotherapy in Squamous Non-Small Cell Lung Cancer and Extensive Stage Small Cell Lung Cancer | non-small cell lung carcinoma | Lysine (NPC112890) | NP level |
| NCT00052715 | Biological Therapy and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme | Central Nervous System Neoplasm | Lysine (NPC112890) | NP level |
| NCT03956056 | Neoantigen Peptide Vaccine Strategy in Pancreatic Cancer Patients Following Surgical Resection and Adjuvant Chemotherapy | pancreatic carcinoma | Lysine (NPC112890) | NP level |
| NCT00006136 | Phase II Study of Arginine Butyrate With or Without Epoetin Alfa in Patients With Thalassemia Intermedia | Beta-thalassemia | Arginine (NPC226453) | NP level |
| NCT00344734 | Effects of Acute L-NMMA Treatment on Renal Hemodynamics and Vasoactive Hormones in Patients With Congestive Heart Failure | congestive heart failure | Arginine (NPC226453) | NP level |
| NCT01719133 | Skin Prick Tests With AllerT in Subjects Allergic to Birch Pollen | allergic rhinitis | Histamine (NPC111132) | NP level |
| NCT00974714 | L-arginine Effects on Chronic Hypertension in Pregnancy | preeclampsia | Arginine (NPC226453) | NP level |
| NCT01188096 | A Trial of Poly-ICLC in the Management of Recurrent Pediatric Low Grade Gliomas | brain neoplasm | Lysine (NPC112890) | NP level |
| NCT00616304 | Safety and Preliminary Efficacy of L-arginine in Severe Falciparum Malaria | Plasmodium falciparum malaria | Arginine (NPC226453) | NP level |
| NCT04364750 | Biomarkers of Diet-microbiota Interactions in Irritable Bowel Syndrome | irritable bowel syndrome | Histidine (NPC237812) | NP level |
| NCT03162562 | The Safety and Antitumor Activity of the Combination of Oregovomab and Hiltonol in Recurrent Advanced Ovarian Cancer | ovarian carcinoma | Lysine (NPC112890) | NP level |
| NCT02017249 | Efficacy Study of Oral Arginine to Improve Immune Function in Glioblastoma Multiforme | glioblastoma multiforme | Arginine (NPC226453) | NP level |
| NCT04764383 | Histaminergic Basis of Fatigue in Multiple Sclerosis | multiple sclerosis | Histidine (NPC237812) | NP level |
| NCT05281926 | A Phase I, Open-label Study to Assess the Safety and Efficacy of Poly-ICLC Plus Nivolumab in Unresectable Hepatocellular Carcinoma Patients | hepatocellular carcinoma | Lysine (NPC112890) | NP level |
| NCT00917826 | Study of Arginine Butyrate and Ganciclovir/Valganciclovir in EBV(+) Lymphoid Malignancies | lymphoma | Arginine (NPC226453) | NP level |
| NCT02516085 | Improved Muscle Function in Duchenne Muscular Dystrophy Through L-Arginine and Metformin | Duchenne muscular dystrophy | Arginine (NPC226453) | NP level |
| NCT00408577 | Prevention of Cardiac and Vascular Events in Patients With NGT/IGT. | cardiovascular disease | Arginine (NPC226453) | NP level |
| NCT01796678 | Arginine Therapy in Sickle Cell Disease-VOC Clinical Trial | pain | Arginine (NPC226453) | NP level |
| NCT03640949 | Vasopressin and Methylprednisolone for In-Hospital Cardiac Arrest | sudden cardiac arrest | Arginine (NPC226453) | NP level |
| NCT00345605 | Arginine and Buphenyl in Patients With Argininosuccinic Aciduria (ASA), a Urea Cycle Disorder | argininosuccinic aciduria | Arginine (NPC226453) | NP level |
| NCT01112722 | Apitox, Honeybee Toxin for Pain and Inflammation of Osteoarthritis | osteoarthritis, knee | Histamine (NPC111132) | NP level |
| NCT03068832 | Neoepitope-based Personalized Vaccine Approach in Pediatric Patients With Recurrent Brain Tumors | brain neoplasm | Lysine (NPC112890) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
|---|---|
Vasomotor/allergic rhinitisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA08 |
HRH1,HRH4,HRH3
NCT00537355,NCT01719133,NCT01989897,NCT00387738 |
Multiple sclerosisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A40 |
NFKB1
HRH4 NCT04764383,NCT00630383,NCT03266965 |
Sickle-cell disorderDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3A51 |
NCT00513617,NCT00056433,NCT02447874,NCT05470998,NCT01142219
|
Type 2 diabetes mellitusDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A11 |
NFKB1
NCT05210504,NCT02744820,NCT02440061 |
AsthmaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA23 |
HRH4,HRH1
NCT02882217,NCT00280683 |
Rheumatoid arthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA20 |
NFKB1,HRH1,HRH4
NCT04535427 |
Atopic eczemaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA80 |
HRH4,CYP3A4,NFKB1
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
HRH3,HRH1
NCT01439555 |
Allergic/hypersensitivity disorderDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A80-4A8Z |
HRH1
NCT04249336,NCT01292070 |
SchizophreniaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A20 |
HRH3,HRH1
NCT04054973 |
Glioblastoma, primary, NOSDisease Category: X.Extension CodesDisease ICD-11 Code: XH0MB1 |
NCT00262730,NCT04201873,NCT02017249
|
Pre-eclampsiaDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JA24 |
NCT00157521,NCT00571766,NCT00974714
|
PheochromocytomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH3854 |
HRH3,BLM,HRH1
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
LMNA,BLM,HRH1
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
LMNA,HRH1,BLM
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
HRH2,LMNA,BLM
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
NFKB1,CYP3A4,HRH2
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
LMNA,BLM,HRH1
|
Malignant neoplasms of adrenal glandDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
HRH3,CYP3A4,BLM
|
Solid tumour/cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00-2F9Z |
NFKB1,CYP3A4
|
Attention deficit hyperactivity disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A05 |
HRH1,HRH3
|
AnxietyDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MB24.3 |
HRH1,CYP3A4
|
Sleep-wake disorderDisease Category: 07.Sleep-wake disordersDisease ICD-11 Code: 7A00-7B2Z |
HRH3,HRH1
|
PsoriasisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA90 |
NFKB1,HRH4
|
Irritable bowel syndromeDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD91 |
NFKB1
NCT04364750 |
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
NFKB1
NCT01842139 |
Central nervous system diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A04-8D87 |
NCT00058123,NCT00052715
|
Primary neoplasms of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00 |
NCT03068832,NCT01188096
|
Pulmonary hypertensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BB01 |
NCT00223717,NCT00345150
|
Hepatocellular carcinoma, NOSDisease Category: X.Extension CodesDisease ICD-11 Code: XH4W48 |
NCT01287585,NCT05281926
|
Dental cariesDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA08.0 |
NCT02388178,NCT04750902
|
Cardiovascular diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA00-BE2Z |
NCT03679780,NCT00408577
|
NeoplasmsDisease Category: 02.NeoplasmsDisease ICD-11 Code: 02 |
NCT01324115,NCT01920191
|
Pain, unspecifiedDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG3Z |
NCT01796678,NCT03446456
|
Breast in situ carcinomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2E65 |
NCT03606967,NCT04616248
|
MalariaDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F40-1F45 |
NCT00147368,NCT00616304
|
Duchenne muscular dystrophyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C70.1 |
NCT02516085,NCT01388764
|
Structural developmental anomaly of heart or great vessels, unspecifiedDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LA8Z |
NCT03088345,NCT02618824
|
Hepatic fibrosis/cirrhosisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB93 |
NCT00005107,NCT00344916
|
Breast cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C60-2C6Y |
NCT00986609,NCT02427581
|
Inflammatory bowel diseases, unspecifiedDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD7Z |
HRH4,HRH2
|
LeishmaniasisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F54 |
HRH2,BLM
|
Other specified malignant neoplasms of kidney, except renal pelvisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90.Y |
HRH1,HRH2
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
LMNA,HRH1
|
Urothelial carcinoma of bladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94.2 |
CYP3A4,BLM
|
Cytomegaloviral diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D82 |
HRH3,HRH2
|
Malignant neoplasms of corpus uteri, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.Z |
HRH3,BLM
|
Invasive carcinoma of breastDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C61 |
HRH3,BLM
|
Renal cell carcinoma, chromophobe typeDisease Category: X.Extension CodesDisease ICD-11 Code: XH6153 |
CYP3A4,HRH2
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
HRH2,BLM
|
Gliomas of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.0 |
BLM,HRH1
|
Breathing abnormalityDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MD11 |
HRH1
|
Diabetes mellitus, type unspecifiedDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A14 |
NFKB1
|
DementiaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6D80-6D8Z |
HRH3
|
PruritusDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EC90 |
HRH1
|
Acute/subacute hepatic failureDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB91 |
NFKB1
|
Episodic vestibular syndromeDisease Category: 10.Diseases of the ear or mastoid processDisease ICD-11 Code: AB31 |
HRH1
|
InsomniaDisease Category: 07.Sleep-wake disordersDisease ICD-11 Code: 7A00-7A0Z |
HRH1
|
SomnolenceDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG42 |
HRH3
|
Gastro-oesophageal reflux diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA22 |
HRH2
|
Substance abuseDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C40 |
HRH3
|
Corneal diseaseDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9A76-9A78 |
HRH1
|
Tension-type headacheDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A81 |
HRH1
|
Nausea/vomitingDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MD90 |
HRH1
|
NeuropathyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C0Z |
HRH3
|
ObesityDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B80-5B81 |
HRH1
|
NasopharyngitisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA00 |
HRH1
|
Lupus erythematosusDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A40 |
NFKB1
|
Conjunctiva disorderDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9A60 |
HRH1
|
Choreiform disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A01 |
NFKB1
|
Respiratory system diseaseDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB40-CB7Z |
HRH1
|
Skin and skin-structure infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F28-1G0Z |
NFKB1
|
Oesophageal/gastroduodenal disorderDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD90 |
HRH2
|
NarcolepsyDisease Category: 07.Sleep-wake disordersDisease ICD-11 Code: 7A20 |
HRH3
|
ParkinsonismDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A00 |
HRH1
|
Chronic painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG30 |
HRH3
|
DepressionDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A70-6A7Z |
HRH1
|
Mild neurocognitive disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6D71 |
HRH3
|
Muscular dystrophyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C70 |
NFKB1
|
Bipolar disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A60 |
HRH1
|
Indeterminate colitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD72 |
NFKB1
|
Morning sickness disorderDisease Category: 26.Supplementary Chapter Traditional Medicine Conditions - Module IDisease ICD-11 Code: SC00 |
HRH1
|
Peptic ulcerDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA61 |
HRH2
|
CoughDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MD12 |
HRH1
|
Fungal infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F29-1F2F |
NFKB1
|
Carcinomas of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.0 |
NCT03162562
|
Other specified disorders of carbohydrate absorption or transportDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C61.Y |
NCT02291458
|
Galactose-1-phosphate uridyltransferase deficiencyDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C51.40 |
NCT03580122
|
Chronic kidney diseaseDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GB61 |
NCT00047983
|
Malignant neoplasm metastasis, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2E2Z |
NCT00037869
|
coronary artery diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA8Y-BA8Z |
NCT00134433
|
Congestive heart failureDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD10 |
NCT00344734
|
Inflammatory carcinoma of breastDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C62 |
NCT00986609
|
Chronic arterial occlusive disease, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD4Z |
NCT03861416
|
Malignant neoplasm of pancreas, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.Z |
NCT03956056
|
Malignant lymphoma, not elsewhere classifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B33.5 |
NCT00719472
|
Glioma, malignantDisease Category: X.Extension CodesDisease ICD-11 Code: XH4RQ3 |
NCT05457959
|
Essential hypertensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA00 |
NCT00137124
|
MyelofibrosisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A22 |
NCT05025488
|
Tuberculosis of the respiratory systemDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1B10 |
NCT00677339
|
MelasmaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED60.1 |
NCT01603446
|
Non-small cell lung cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25 |
NCT03166254
|
ThrombocytopeniaDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3B64 |
NCT05025488
|
Follicular lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A80 |
NCT03121677
|
PterygiumDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9A61.1 |
NCT01380678
|
Small cell carcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.1 |
NCT01266018
|
Mature T-cell lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A90 |
NCT00917826
|
NADisease Category: NADisease ICD-11 Code: NA |
NCT01380678
|
Intermediate hyperglycaemia, unspecifiedDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A40.Z |
NCT02756117
|
SepsisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1G40-1G41 |
NCT01263041
|
Osteoarthritis of kneeDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA01 |
NCT01112722
|
Unspecified adverse cutaneous reactions to medicationDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EH7Z |
NCT03376620
|
Melanoma of skin, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30.Z |
NCT02129075
|
Prostate cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82 |
NCT01607879
|
MelanomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30 |
NCT01783431
|
Neuroendocrine carcinomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C34 |
NCT00037869
|
Alcoholic hepatitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB94.1 |
NCT00200746
|
COVID-19Disease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D6Y |
NCT04631536
|
Beta thalassaemiaDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3A50.2 |
NCT00006136
|
Acute myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41 |
NCT02929888
|
Argininosuccinic aciduriaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C50.A0 |
NCT00345605
|
Cutaneous T-cell lymphoma, NOSDisease Category: X.Extension CodesDisease ICD-11 Code: XH1951 |
NCT02061449
|
Cystic fibrosisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA25 |
NCT00405665
|
Periodontal diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA0C |
NCT05042024
|
Cardiac arrestDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MC82 |
NCT03640949
|
Malignant neoplasms of bladder, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94.Z |
NCT03359239
|
Pleural mesotheliomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26 |
NCT04345705
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
HRH3
|
HepatoblastomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.01 |
BLM
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
BLM
|
Squamous cell carcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.2 |
BLM
|
West Nile virus infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D46 |
NFKB1
|
Hepatocellular carcinoma of liverDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.02 |
BLM
|
Superficial ovarian endometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10.B4 |
LMNA
|
Malignant neoplasms of oesophagusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B70 |
BLM
|
Malignant neoplasms of thyroid gland, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D10.Z |
HRH1
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
BLM
|
Chikungunya virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D40 |
LMNA
|
Carpal tunnel syndromeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C10.0 |
HRH2
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
Plant-Targeted Human Disease Network
>> Targets derived from weak experimental activities
