Collective Molecular Activities of the Plant: Begonia Glabra
Country/Region:
ChinaTraditional Medicine System:
TCMBrazil; Jamaica; Belize; Honduras; Peru; Suriname; Cuba; Venezuela; Mexico; Costa Rica; Trinidad and Tobago; Guatemala; China; Colombia; French Guiana; Bolivia; Nicaragua; Ecuador
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
20 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
6 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
11 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC78326
Ingredient ID: NPC74259
Ingredient ID: NPC72455
Ingredient ID: NPC72260
Ingredient ID: NPC60056
Ingredient ID: NPC5785
Ingredient ID: NPC41586
Ingredient ID: NPC308492
Ingredient ID: NPC288816
Ingredient ID: NPC255569
Ingredient ID: NPC237067
Ingredient ID: NPC231518
Ingredient ID: NPC208193
Ingredient ID: NPC193893
Ingredient ID: NPC173555
Ingredient ID: NPC152166
Ingredient ID: NPC147543
Ingredient ID: NPC146787
Ingredient ID: NPC138125
Ingredient ID: NPC117445
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Drug Transporter | SLC superfamily of solute carriers | SLCO4C1 | Solute carrier organic anion transporter family member 4C1 | Q6ZQN7 | CHEMBL2073690 |
| Therapeutic Target | Hydrolase | RAB9A | Ras-related protein Rab-9A | P51151 | CHEMBL1293294 |
| Therapeutic Target | Other cytosolic protein | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
| Therapeutic Target | P-type ATPase | ATP1A1 | Sodium/potassium-transporting ATPase alpha-1 chain | P05023 | CHEMBL1807 |
| Therapeutic Target | Structural protein | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
| Therapeutic Target | Transcription factor | STAT3 | Signal transducer and activator of transcription 3 | P40763 | CHEMBL4026 |
| Therapeutic Target | Transcription factor | PAX8 | Paired box protein Pax-8 | Q06710 | CHEMBL2362980 |
| Therapeutic Target | Transcription factor | TP53 | Cellular tumor antigen p53 | P04637 | CHEMBL4096 |
| Therapeutic Target | Transporter | NPC1 | Niemann-Pick C1 protein | O15118 | CHEMBL1293277 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 69 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT00000556 | Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) | atrial fibrillation | Digoxin (NPC173555) | NP level |
| NCT00281021 | Second Line Erlotinib (Tarceva) Plus Digoxin in Non-Small Cell Lung Cancer | non-small cell lung carcinoma | Digoxin (NPC173555) | NP level |
| NCT00390546 | Multicenter Study of Antiarrhythmic Medications for Treatment of Infants With Supraventricular Tachycardia | Supraventricular tachycardia | Digoxin (NPC173555) | NP level |
| NCT00504413 | Role of CYP2B6, CYP3A4, and MDR1 in the Metabolic Clearance of Methadone | drug dependence | Digoxin (NPC173555) | NP level |
| NCT00650910 | Study To Examine The Effects Of Lapatinib On The Pharmacokinetics Of Digoxin In Subjects w/ ErbB2 Positive Breast Cancer | breast neoplasm | Digoxin (NPC173555) | NP level |
| NCT00712465 | An Interaction Study With Digoxin and AZD1305 | atrial fibrillation | Digoxin (NPC173555) | NP level |
| NCT00782288 | Phase II Study of Digitoxin to Treat Cystic Fibrosis | cystic fibrosis | Digitoxin (NPC72260) | NP level |
| NCT00904176 | Study of the Effect of Dapagliflozin on the Pharmacokinetics of Warfarin or Digoxin in Healthy Subjects | type 2 diabetes mellitus | Digoxin (NPC173555) | NP level |
| NCT00991783 | A Study to Evaluate the Effect of Fimasartan on Pharmacokinetics, and the Safety of Digoxin in Healthy Male Volunteers | essential hypertension | Digoxin (NPC173555) | NP level |
| NCT01005602 | Digoxin Dosing in Heart Failure: A Simplified Nomogram Versus Standard Care | heart failure | Digoxin (NPC173555) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Actinic keratosisDisease Category: X.Extension CodesDisease ICD-11 Code: XH36H6 |
NCT03684772
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
TP53,MAPT
NCT03113071 |
Acute upper respiratory infectionDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA07 |
STAT3
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
NPC1,PAX8,LMNA
|
Adrenomedullary hyperfunctionDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A75 |
NCT03433833
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
MAPT
|
AnxietyDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MB24.3 |
CYP3A4
|
Atopic eczemaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA80 |
CYP3A4
|
Atrial fibrillationDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC81.3 |
NCT00000556,NCT02489786,NCT03718273,NCT05287191,NCT01047566,NCT00712465,NCT02391337
|
Bladder cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94 |
TP53
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
