Collective Molecular Activities of the Plant: Abies Webbiana
Plant ID: NPO13059
Plant Latin Name: Abies Webbiana
Taxonomy Genus: Abies
Taxonomy Family: Pinaceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Country/Region:
IndiaTraditional Medicine System:
Sowa-Rigpa; Indian Folk; Unani; AyurvedaIndia
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Overview of Ingredients
75 All known Ingredients in Total
Unique ingredients have been isolated from this plant.Plant-Ingredients Associations were manually curated from publications or collected from other databases.
35 Ingredients with Acceptable Bioavailablity
Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
☑ SIZE: 150g/mol < MW < 500g/mol
☑ POLAR(Polarity): 20Ų < TPSA < 130Ų
☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9
If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)
33 Ingredients with experimental-derived Activity
Unique ingredients have activity data available.Ingredient Structrual Cards
Ingredient ID: NPC99298
Ingredient ID: NPC99078
Ingredient ID: NPC99006
Ingredient ID: NPC94280
Ingredient ID: NPC90174
Ingredient ID: NPC84718
Ingredient ID: NPC81249
Ingredient ID: NPC76268
Ingredient ID: NPC73883
Ingredient ID: NPC7359
Ingredient ID: NPC71105
Ingredient ID: NPC53773
Ingredient ID: NPC51352
Ingredient ID: NPC48143
Ingredient ID: NPC41331
Ingredient ID: NPC3910
Ingredient ID: NPC38566
Ingredient ID: NPC308240
Ingredient ID: NPC306420
Ingredient ID: NPC306255
Ingredient ID: NPC305799
Ingredient ID: NPC305602
Ingredient ID: NPC303672
Ingredient ID: NPC302531
Ingredient ID: NPC302519
Ingredient ID: NPC295895
Ingredient ID: NPC291449
Ingredient ID: NPC285596
Ingredient ID: NPC277042
Ingredient ID: NPC273416
Ingredient ID: NPC273023
Ingredient ID: NPC268041
Ingredient ID: NPC267442
Ingredient ID: NPC261158
Ingredient ID: NPC256452
Ingredient ID: NPC255817
Ingredient ID: NPC252107
Ingredient ID: NPC24216
Ingredient ID: NPC23376
Ingredient ID: NPC230698
Ingredient ID: NPC23035
Ingredient ID: NPC225745
Ingredient ID: NPC220923
Ingredient ID: NPC214036
Ingredient ID: NPC207541
Ingredient ID: NPC199209
Ingredient ID: NPC19839
Ingredient ID: NPC196609
Ingredient ID: NPC195986
Ingredient ID: NPC194266
Ingredient ID: NPC190904
Ingredient ID: NPC171928
Ingredient ID: NPC171872
Ingredient ID: NPC170583
Ingredient ID: NPC167096
Ingredient ID: NPC166725
Ingredient ID: NPC16634
Ingredient ID: NPC159362
Ingredient ID: NPC157740
Ingredient ID: NPC156944
Ingredient ID: NPC155753
Ingredient ID: NPC152186
Ingredient ID: NPC150195
Ingredient ID: NPC145154
Ingredient ID: NPC140857
Ingredient ID: NPC136330
Ingredient ID: NPC135155
Ingredient ID: NPC124863
Ingredient ID: NPC120066
Ingredient ID: NPC118885
Ingredient ID: NPC115688
Ingredient ID: NPC110740
Ingredient ID: NPC105821
Ingredient ID: NPC105550
Ingredient ID: NPC100163
Classification of Human Proteins Collectively Targeted by the Plant
Detailed Information of Target Proteins
| Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|---|
| Cytochrome P450 | Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Therapeutic Target | Oxidoreductase | MAOB | Monoamine oxidase B | P27338 | CHEMBL2039 |
| Therapeutic Target | Small molecule receptor (family A GPCR) | CNR2 | Cannabinoid CB2 receptor | P34972 | CHEMBL253 |
| Therapeutic Target | Structural protein | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
| Therapeutic Target | Transient receptor potential channel | TRPV1 | Vanilloid receptor | Q8NER1 | CHEMBL4794 |
Clinical trials associated with plant from natural product (NP) & plant level:
| Clinical trials type | Number of clinical trials | |
|---|---|---|
 NP level | 3 | |
| NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
|---|---|---|---|---|
| NCT01383694 | Effect Of Piperine In Patients With Oropharyngeal Dysphagia | Dysphagia | Piperine (NPC136330) | NP level |
| NCT01893424 | Bioequivalence Assessment of Oral Administration Vs. Oral Spray of a Cannabinoids (Tetrahydrocannabinol and Cannabidiol) | pain | Piperine (NPC136330) | NP level |
| NCT05430087 | Vitamin D and Curcumin Piperine Attenuates Disease Activity and Cytokine Levels in Systemic Lupus Erythematosus Patients | systemic lupus erythematosus | Piperine (NPC136330) | NP level |
❱❱❱ Associated Human Diseases and Detailed Association Evidence
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant | Association Type & Detailed Evidence |
|---|---|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
MAOB
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
LMNA,CNR2,MAOB
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
MAOB
|
AnxietyDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MB24.3 |
CYP3A4
|
AsthmaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA23 |
TRPV1
|
Atopic eczemaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA80 |
CNR2,TRPV1,CYP3A4
|
Attention deficit hyperactivity disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A05 |
CNR2
|
Chikungunya virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D40 |
LMNA
|
Chronic painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG30 |
TRPV1
|
Crohn diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD70 |
CNR2
|
❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations
>> Targets derived from weak experimental activities
