CMAUP Plant Collective Molecular Activities

Collective Molecular Activities of the Plant: Diospyros Abyssinica

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PLANiTS DNA barcode

Click for details-----ITS2

Taxonomic Information

Plant ID: NPO13042
Plant Latin Name: Diospyros Abyssinica
Taxonomy Genus: Diospyros
Taxonomy Family: Ebenaceae

Plant External Links:

NCBI TaxonomyDB: 413718
Plant-of-the-World-Online: 322036-1

Used in Medicines

Country/Region:

Kenya; Tanzania; Rwanda

Traditional Medicine System:

Geographical Distribution

Cote d'Ivoire; Sudan; Guinea; Ethiopia; Rwanda; Nigeria; Cameroon; Burkina Faso; Benin; Ghana; Zambia; Malawi; Togo; Zimbabwe; Eritrea; Tanzania; Gabon; Mali; Angola; Chad; Mozambique; Uganda; Kenya

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Compounds Summary

Overview of Ingredients

40 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.

35 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Å² < TPSA < 130Å²
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)

18 Ingredients with experimental-derived Activity

Unique ingredients have activity data available.

Ingredient Structrual Cards

Ingredient ID: NPC96603

Ingredient ID: NPC9201

Ingredient ID: NPC88640

Ingredient ID: NPC83926

Ingredient ID: NPC76145

Ingredient ID: NPC76020

Ingredient ID: NPC66922

Ingredient ID: NPC48075

Ingredient ID: NPC45404

Ingredient ID: NPC42391

Ingredient ID: NPC34770

Ingredient ID: NPC305518

Ingredient ID: NPC300505

Ingredient ID: NPC296025

Ingredient ID: NPC276664

Ingredient ID: NPC27577

Ingredient ID: NPC271749

Ingredient ID: NPC271463

Ingredient ID: NPC267340

Ingredient ID: NPC264784

Ingredient ID: NPC255042

Ingredient ID: NPC241473

Ingredient ID: NPC239540

Ingredient ID: NPC237058

Ingredient ID: NPC236536

Ingredient ID: NPC22098

Ingredient ID: NPC216630

Ingredient ID: NPC210560

Ingredient ID: NPC210516

Ingredient ID: NPC198629

Ingredient ID: NPC184014

Ingredient ID: NPC152425

Ingredient ID: NPC142319

Ingredient ID: NPC13489

Ingredient ID: NPC132669

Ingredient ID: NPC131885

Ingredient ID: NPC13143

Ingredient ID: NPC131172

Ingredient ID: NPC123526

Ingredient ID: NPC101153

Classification of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM Target Type: Individual Protein of Homo sapiens

*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.

Detailed Information of Target Proteins

Target Type	Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450	Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Therapeutic Target	Fatty acid binding protein family	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083
Therapeutic Target	Methyl-lysine/arginine binding protein	SMN1	Survival motor neuron protein	Q16637	CHEMBL1293232
Therapeutic Target	Small molecule receptor (family A GPCR)	CNR1	Cannabinoid CB1 receptor	P21554	CHEMBL218
Therapeutic Target	Small molecule receptor (family A GPCR)	CNR2	Cannabinoid CB2 receptor	P34972	CHEMBL253

Clinical Trials Summary

Overview

Clinical trials associated with plant from natural product (NP) & plant level:

Clinical trials type	Number of clinical trials
NP level	3

Clinical trial details

NCT ID	Title	Condition	Form in clinical use	Associated by plant or compound
NCT04392622	d-Limonene +Radiation +Platinum Based Chemo for Xerostomia Prevention in Locally Advanced Head and Neck Squamous Cell Carcinoma	xerostomia	Limonene (NPC76145)	NP level
NCT04853082	Limonene on Regulating Metabolism-related Fatty Liver Disease (MAFLD) and Analysis of TCM Constitution	Hepatic steatosis	Limonene (NPC76145)	NP level
NCT00717652	Efficiency And Safety Of Association Arbutin, Triamcinolone And Tretinoin In Treatment Of Melasma	freckles	Arbutin (NPC142319)	NP level

❱❱❱ Associated Human Diseases and Detailed Association Evidence

How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.

Associated Disease of the Plant	Association Type & Detailed Evidence
Diffuse large B-cell lymphomas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A81	CNR1,OR51E2,FABP5,FABP4,SMN1,CNR2
Other specified malignant neoplasms of kidney, except renal pelvis Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C90.Y	FABP5,CNR1,FABP5,CNR1,OR51E2
Hepatoblastoma Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C12.01	CNR1,OR51E2,FABP5,FABP4
Mesothelioma of pleura Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C26.0	CNR2,SMN1,CNR1,OR51E2
Hepatocellular carcinoma of liver Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C12.02	CNR1,OR51E2,FABP5,FABP4
Malignant neoplasms of biliary tract, distal bile duct Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C15	FABP5,CNR1,OR51E2
Germ cell tumour of testis Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C80.2	CNR2,FABP5,SMN1
Pain, unspecified Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MG3Z	CNR1,CNR2
Muscular atrophy Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8B61	SMN2,SMN1
Inborn lipid metabolism error Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5C52	CNR2,CNR1
Insomnia Disease Category: 07.Sleep-wake disorders Disease ICD-11 Code: 7A00-7A0Z	CNR1,CNR2
Serous cystadenoma,borderline malignancy of ovary Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C73.4	CYP1A2,FABP5
Pheochromocytoma Disease Category: X.Extension Codes Disease ICD-11 Code: XH3854	FABP5,OR51E2
Adenocarcinoma of pancreas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10.0	CNR2,OR51E2
Cytomegaloviral disease Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1D82	CNR2,CNR1
Adenocarcinoma of prostate Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C82.0	FABP5,OR51E2
Malignant neoplasms of stomach Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B72	FABP4,CNR1
Malignant neoplasms of thymus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C27	FABP5,CNR2
Human immunodeficiency virus disease without mention of tuberculosis or malaria Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1C62	CNR2,CNR1
Renal cell carcinoma, chromophobe type Disease Category: X.Extension Codes Disease ICD-11 Code: XH6153	CYP1A2,CNR1
Malignant neoplasms of adrenal gland Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D11	FABP5,OR51E2
Type 2 diabetes mellitus Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A11	CNR1
Chronic kidney disease Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GB61	CNR1
Urinary tract infection Disease Category: 16.Diseases of the genitourinary system Disease ICD-11 Code: GC08	CNR1
Metabolic disorder Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5C50-5D2Z	CNR1
Acute diabete complication Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5A2Y	CNR1
Atopic eczema Disease Category: 14.Diseases of the skin Disease ICD-11 Code: EA80	CNR2
Anorexia nervosa Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6B80	CNR1
Obesity Disease Category: 05.Endocrine, nutritional or metabolic diseases Disease ICD-11 Code: 5B80-5B81	CNR1
General pain disorder Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8E43	CNR2
Nausea/vomiting Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MD90	CNR1
Nicotine use disorder Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6C4A	CNR1
Attention deficit hyperactivity disorder Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6A05	CNR2
Colorectal cancer Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B91	CNR1
Crohn disease Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DD70	CNR2
Cannabis use disorder Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6C41	CNR1
Xerostomia Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DA02.1	NCT04392622
Other specified non-alcoholic fatty liver disease Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DB92.Y	NCT04853082
Freckles Disease Category: 14.Diseases of the skin Disease ICD-11 Code: ED61.0	NCT00717652
Carcinosarcoma of uterus Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C76.43	FABP5
Psoriasis Disease Category: 14.Diseases of the skin Disease ICD-11 Code: EA90	FABP5
Leishmaniasis Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1F54	CNR2
Malignant neoplasm metastasis in lymph nodes of head, face or neck Disease Category: 02.Neoplasms Disease ICD-11 Code: 2D60.0	FABP4
Non-alcoholic fatty liver disease Disease Category: 13.Diseases of the digestive system Disease ICD-11 Code: DB92	FABP4
Malignant neoplasms of bladder Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C94	FABP4
Squamous cell carcinoma of bronchus or lung Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25.2	OR51E2
Urothelial carcinoma of bladder Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C94.2	CYP1A2
Systemic sclerosis Disease Category: 04.Diseases of the immune system Disease ICD-11 Code: 4A42	FABP4
Invasive carcinoma of breast Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C61	CNR2
Glioblastoma of brain Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A00.00	FABP5
Carpal tunnel syndrome Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8C10.0	OR51E2
Malignant neoplasm of pancreas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10	FABP4

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

Plant-Targeted Human Disease Network

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Plant Ingredients
3. Collective Molecular Proteins
4. Collective Enriched Activities
5. Plant molecular targets overlapping with DEGs
6. Associated clinical trials
7. Associated Human Diseases

Collective Molecular Activities of the Plant: Diospyros Abyssinica

Click for details-----ITS

Click for details-----ITS1

Click for details-----ITS2

Plant External Links:

Country/Region:

Traditional Medicine System:

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Overview of Ingredients

40 All known Ingredients in Total

35 Ingredients with Acceptable Bioavailablity

18 Ingredients with experimental-derived Activity

Ingredient Structrual Cards

Classification of Human Proteins Collectively Targeted by the Plant

Detailed Information of Target Proteins

❱❱❱ Associated Human Diseases and Detailed Association Evidence

Associated Disease of the Plant

Association Type & Detailed Evidence

Diffuse large B-cell lymphomas

Other specified malignant neoplasms of kidney, except renal pelvis

Hepatoblastoma

Mesothelioma of pleura

Hepatocellular carcinoma of liver

Malignant neoplasms of biliary tract, distal bile duct

Germ cell tumour of testis

Pain, unspecified

Muscular atrophy

Inborn lipid metabolism error

Insomnia

Serous cystadenoma,borderline malignancy of ovary

Pheochromocytoma

Adenocarcinoma of pancreas

Cytomegaloviral disease

Adenocarcinoma of prostate

Malignant neoplasms of stomach

Malignant neoplasms of thymus

Human immunodeficiency virus disease without mention of tuberculosis or malaria

Renal cell carcinoma, chromophobe type

Malignant neoplasms of adrenal gland

Type 2 diabetes mellitus

Chronic kidney disease

Urinary tract infection

Metabolic disorder

Acute diabete complication

Atopic eczema

Anorexia nervosa

Obesity

General pain disorder

Nausea/vomiting

Nicotine use disorder

Attention deficit hyperactivity disorder

Colorectal cancer

Crohn disease

Cannabis use disorder

Xerostomia

Other specified non-alcoholic fatty liver disease

Freckles

Carcinosarcoma of uterus

Psoriasis

Leishmaniasis

Malignant neoplasm metastasis in lymph nodes of head, face or neck

Non-alcoholic fatty liver disease

Malignant neoplasms of bladder

Squamous cell carcinoma of bronchus or lung

Urothelial carcinoma of bladder

Systemic sclerosis

Invasive carcinoma of breast

Glioblastoma of brain

Carpal tunnel syndrome

Malignant neoplasm of pancreas

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

>> Targets derived from weak experimental activities