CMAUP Plant Collective Molecular Activities

Collective Molecular Activities of the Plant: Mesembryanthemum Tortuosum

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PLANiTS DNA barcode

Click for details-----ITS2

Taxonomic Information

Plant ID: NPO12693
Plant Latin Name: Mesembryanthemum Tortuosum
Taxonomy Genus: Mesembryanthemum
Taxonomy Family: Aizoaceae

Plant External Links:

NCBI TaxonomyDB: 216016
Plant-of-the-World-Online: n.a.

Used in Medicines

Country/Region:

Madagascar; Angola; South Africa; Zimbabwe; China; Swaziland

Traditional Medicine System:

TCM

Geographical Distribution

Madagascar; Angola; South Africa; Zimbabwe; China; Swaziland

Geographical Distribution

−

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Compounds Summary

Overview of Ingredients

81 All known Ingredients in Total

Unique ingredients have been isolated from this plant.
Plant-Ingredients Associations were manually curated from publications or collected from other databases.

63 Ingredients with Acceptable Bioavailablity

Unique ingredients exhibit acceptable human oral bioavailablity, according to the criteria of SwissADME [PMID: 28256516] and HobPre [PMID: 34991690]. The criteria details:

SwissADME: six descriptors are used by SwissADME to evaluate the oral bioavailability of a natural product:
  ☑ LIPO(Lipophility): -0.7 < XLOGP3 < +5.0
  ☑ SIZE: 150g/mol < MW < 500g/mol
  ☑ POLAR(Polarity): 20Å² < TPSA < 130Å²
  ☑ INSOLU(Insolubility): -6 < Log S (ESOL) < 0
  ☑ INSATU(Insaturation): 0.25 < Fraction Csp3 < 1
  ☑ FLEX(Flexibility): 0 < Num. rotatable bonds < 9

If 6 descriptors of a natural plant satisfy the above rules, it will be labeled high HOB.
HobPre: A natural plant ingredient with HobPre score >0.5 is labeled high human oral availability (HOB)

24 Ingredients with experimental-derived Activity

Unique ingredients have activity data available.

Ingredient Structrual Cards

Ingredient ID: NPC99886

Ingredient ID: NPC99847

Ingredient ID: NPC9014

Ingredient ID: NPC89798

Ingredient ID: NPC87232

Ingredient ID: NPC85423

Ingredient ID: NPC83832

Ingredient ID: NPC83028

Ingredient ID: NPC79913

Ingredient ID: NPC71853

Ingredient ID: NPC71327

Ingredient ID: NPC6984

Ingredient ID: NPC65517

Ingredient ID: NPC61779

Ingredient ID: NPC57879

Ingredient ID: NPC51114

Ingredient ID: NPC47844

Ingredient ID: NPC4718

Ingredient ID: NPC44489

Ingredient ID: NPC38209

Ingredient ID: NPC36650

Ingredient ID: NPC34406

Ingredient ID: NPC32163

Ingredient ID: NPC315

Ingredient ID: NPC31279

Ingredient ID: NPC307095

Ingredient ID: NPC306988

Ingredient ID: NPC306720

Ingredient ID: NPC306647

Ingredient ID: NPC305205

Ingredient ID: NPC303740

Ingredient ID: NPC303621

Ingredient ID: NPC300017

Ingredient ID: NPC298834

Ingredient ID: NPC298817

Ingredient ID: NPC289475

Ingredient ID: NPC283843

Ingredient ID: NPC281387

Ingredient ID: NPC276222

Ingredient ID: NPC271527

Ingredient ID: NPC269919

Ingredient ID: NPC268862

Ingredient ID: NPC264288

Ingredient ID: NPC263222

Ingredient ID: NPC258171

Ingredient ID: NPC257451

Ingredient ID: NPC257190

Ingredient ID: NPC251306

Ingredient ID: NPC249624

Ingredient ID: NPC243475

Ingredient ID: NPC240163

Ingredient ID: NPC232881

Ingredient ID: NPC232375

Ingredient ID: NPC215990

Ingredient ID: NPC209705

Ingredient ID: NPC194155

Ingredient ID: NPC193812

Ingredient ID: NPC188501

Ingredient ID: NPC182797

Ingredient ID: NPC176326

Ingredient ID: NPC16737

Ingredient ID: NPC16525

Ingredient ID: NPC164958

Ingredient ID: NPC161617

Ingredient ID: NPC159312

Ingredient ID: NPC156654

Ingredient ID: NPC151775

Ingredient ID: NPC147800

Ingredient ID: NPC140805

Ingredient ID: NPC139576

Ingredient ID: NPC13755

Ingredient ID: NPC130849

Ingredient ID: NPC126825

Ingredient ID: NPC125793

Ingredient ID: NPC125564

Ingredient ID: NPC119039

Ingredient ID: NPC118636

Ingredient ID: NPC110634

Ingredient ID: NPC109875

Ingredient ID: NPC108441

Ingredient ID: NPC103531

Classification of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM Target Type: Individual Protein of Homo sapiens

*The classification criteria of Drug Transporter (DTP), CYP450 are referred to DrugMap. Other molecular targets in CMAUP are classified as therapeutic targets.

Detailed Information of Target Proteins

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Search:

Target Type	Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Drug Transporter	SLC superfamily of solute carriers	SLC6A4	Serotonin transporter	P31645	CHEMBL228
Therapeutic Target	Enzyme	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Therapeutic Target	Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Therapeutic Target	Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Therapeutic Target	Other cytosolic protein	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Therapeutic Target	Phosphodiesterase 4	PDE4B	Phosphodiesterase 4B	Q07343	CHEMBL275
Therapeutic Target	Transcription factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096

Showing 1 to 7 of 7 entries

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Clinical Trials Summary

Overview

Clinical trials associated with plant from natural product (NP) & plant level:

Clinical trials type	Number of clinical trials
NP level	43
Plant level	1

Clinical trial details

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Search:

NCT ID	Title	Condition	Form in clinical use	Associated by plant or compound
NCT00000541	Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS)	myocardial infarction;Myocardial Ischemia	Pyridoxine (NPC269919)	NP level
NCT00004758	Phase II Randomized Study of Early Surgery Vs Multiple Sequential Antiepileptic Drug Therapy for Infantile Spasms Refractory to Standard Treatment	epilepsy	Pyridoxine (NPC269919)	NP level
NCT00056225	VITAL - VITamins to Slow ALzheimer's Disease (Homocysteine Study)	Alzheimer disease	Pyridoxine (NPC269919)	NP level
NCT00070434	S0304 Induct Chemo Then Chemo-RT in Pts w/Locally Advanced Adenocarcinoma of the Rectum	colorectal carcinoma	Pyridoxine (NPC269919)	NP level
NCT00114400	BVAIT: B-Vitamin Atherosclerosis Intervention Trial	atherosclerosis	Pyridoxine (NPC269919)	NP level
NCT00202280	Efficacy of Treating First Episode Psychosis With Folic Acid,B12 and B6 in Addition to Antipsychotic Medication	psychosis	Pyridoxine (NPC269919)	NP level
NCT00446147	Study of Pyridoxine for Hand-Foot Syndrome	Hand-foot syndrome	Pyridoxine (NPC269919)	NP level
NCT00469183	Assessment of Atrophogenic Potential of Triple Combination Cream for Treatment of Melasma	freckles	Hydroquinone (NPC65517)	NP level
NCT00472966	Efficacy and Safety of Therapy With Tri-Luma® Cream in Sequence With Glycolic Acid Peels for Melasma	freckles	Hydroquinone (NPC65517)	NP level
NCT00669071	Treatment w/ Tri-Luma® Cream & Intense Pulsed Light (IPL) vs a Mild Inactive Control Cream & Intense Pulsed Light (IPL) in Melasma	freckles	Hydroquinone (NPC65517)	NP level

Showing 1 to 10 of 44 entries

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❱❱❱ Associated Human Diseases and Detailed Association Evidence

How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.

Show entries

Search:

Associated Disease of the Plant	Association Type & Detailed Evidence
Acute myeloid leukaemia Disease Category: 02.Neoplasms Disease ICD-11 Code: 2A60	MAPT,TP53
Adenocarcinoma of bronchus or lung Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C25.0	BLM
Adenocarcinoma of pancreas Disease Category: 02.Neoplasms Disease ICD-11 Code: 2C10.0	CA14,PDE4B,CA2,BLM
Adenocarcinoma of stomach Disease Category: 02.Neoplasms Disease ICD-11 Code: 2B72.0	BLM
Alzheimer disease Disease Category: 08.Diseases of the nervous system Disease ICD-11 Code: 8A20	SLC6A4,MAPT NCT00056225
Anxiety Disease Category: 21.Symptoms, signs or clinical findings, not elsewhere classified Disease ICD-11 Code: MB24.3	CYP3A4,SLC6A4
Asthma Disease Category: 12.Diseases of the respiratory system Disease ICD-11 Code: CA23	PDE4B NCT00992667
Atopic eczema Disease Category: 14.Diseases of the skin Disease ICD-11 Code: EA80	PDE4B,CYP3A4
Attention deficit hyperactivity disorder Disease Category: 06.Mental, behavioural or neurodevelopmental disorders Disease ICD-11 Code: 6A05	SLC6A4 NCT02189772,NCT01685281,NCT00995085,NCT01243242
Bacterial infection Disease Category: 01.Certain infectious or parasitic diseases Disease ICD-11 Code: 1A00-1C4Z	CA2,CA14

Showing 1 to 10 of 117 entries

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❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

Plant-Targeted Human Disease Network

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Plant Ingredients
3. Collective Molecular Proteins
4. Collective Enriched Activities
5. Plant molecular targets overlapping with DEGs
6. Associated clinical trials
7. Associated Human Diseases

Collective Molecular Activities of the Plant: Mesembryanthemum Tortuosum

Click for details-----ITS

Click for details-----ITS1

Click for details-----ITS2

Plant External Links:

Country/Region:

Traditional Medicine System:

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Overview of Ingredients

81 All known Ingredients in Total

63 Ingredients with Acceptable Bioavailablity

24 Ingredients with experimental-derived Activity

Ingredient Structrual Cards

Classification of Human Proteins Collectively Targeted by the Plant

Detailed Information of Target Proteins

❱❱❱ Associated Human Diseases and Detailed Association Evidence

Associated Disease of the Plant

Association Type & Detailed Evidence

Acute myeloid leukaemia

Adenocarcinoma of bronchus or lung

Adenocarcinoma of pancreas

Adenocarcinoma of stomach

Alzheimer disease

Anxiety

Asthma

Atopic eczema

Attention deficit hyperactivity disorder

Bacterial infection

❱❱❱ Network Visualization of Plant-Targeted Human Disease Associations

>> Targets derived from weak experimental activities