CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	CNR1; CNR2;
Peptide receptor (family A GPCR)	TSHR;
Transient receptor potential channel	TRPV1; TRPA1;
Nuclear hormone receptor subfamily 1 group C	PPARD; PPARA;
Enzyme_unclassified	ALOX15;
Toll-like and Il-1 receptors	TLR2;
Unclassified	FABP3; FABP2; LMNA; FABP4; FABP5;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2; CYP2C19;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Nuclear hormone receptor subfamily 1 group C	PPARD	Peroxisome proliferator-activated receptor delta	Q03181	CHEMBL3979
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Small molecule receptor (family A GPCR)	CNR1	Cannabinoid CB1 receptor	P21554	CHEMBL218
Small molecule receptor (family A GPCR)	CNR2	Cannabinoid CB2 receptor	P34972	CHEMBL253
Toll-like and Il-1 receptors	TLR2	Toll-like receptor 2	O60603	CHEMBL4163

Showing 1 to 10 of 17 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0019433; triglyceride catabolic process	6.595E-09	3.590E-05	FABP2, FABP3, FABP4, FABP5
BP	GO:0032501; multicellular organismal process	GO:0050968; detection of chemical stimulus involved in sensory perception of pain	2.459E-06	1.983E-03	TRPA1, TRPV1
BP	GO:0032501; multicellular organismal process	GO:0050955; thermoception	2.459E-06	1.983E-03	TRPA1, TRPV1
BP	GO:0050896; response to stimulus	GO:0043434; response to peptide hormone	4.378E-06	3.178E-03	FABP3, PPARA, TLR2, TRPV1, TSHR
BP	GO:0009987; cellular process	GO:0038171; cannabinoid signaling pathway	4.916E-06	3.453E-03	CNR1, CNR2
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	1.228E-05	7.425E-03	CYP1A2, CYP2C19
BP	GO:0008152; metabolic process	GO:0051001; negative regulation of nitric-oxide synthase activity	1.718E-05	8.698E-03	CNR1, CNR2
CC	GO:0043226; organelle	GO:0097504; Gemini of coiled bodies	5.383E-05	1.980E-02	SMN1, SMN2
CC	GO:0032991; macromolecular complex	GO:0032797; SMN complex	6.359E-05	2.198E-02	SMN1, SMN2
CC	GO:0044464; cell part	GO:0034719; SMN-Sm protein complex	1.244E-04	3.564E-02	SMN1, SMN2

Showing 1 to 10 of 16 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	2.204E-06	5.510E-05	CYP1A2, ALOX15, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	1.401E-03	1.401E-02	ALOX15, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.732E-03	1.443E-02	CYP1A2, CYP2C19
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	4.492E-03	2.246E-02	CYP1A2
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	9.454E-05	1.576E-03	CNR2, CNR1, TRPV1, TSHR
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	2.425E-11	1.213E-09	FABP2, FABP3, FABP4, FABP5, PPARA, PPARD
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1.145E-03	1.401E-02	FABP4, TSHR
09150 Organismal Systems	09157 Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	3.455E-03	2.159E-02	TRPA1, TRPV1
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	4.485E-03	2.246E-02	ALOX15, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	2.435E-03	1.739E-02	CYP1A2, CYP2C19

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Postherpetic neuralgia	B02.2, G44.847, G53.0	CNR1;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	CNR2;
C00-D49: Neoplasms	Ovarian cancer	C56	CNR1;
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Immune disorder	D80-D89	CNR2;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	CNR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Lipid metabolism disorder	E75-E78	CNR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	CNR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	CNR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	CNR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Endocrine disease	E00-E35	CNR1;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Cotylelobium scabriusculum

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities