Plant ID: NPO9947
Plant Latin Name: Teucrium scorodonia
Taxonomy Genus: Teucrium
Taxonomy Family: Lamiaceae
NCBI TaxonomyDB:
53178
Plant-of-the-World-Online:
n.a.
Alterative; Appetizer; Astringent; Carminative; Diaphoretic; Diuretic; Emmenagogue; Skin; Tonic; Vulnerary
China
TDP1; RECQL; PKM; AKR1B1; POLB; APEX1; | |
GAA; | |
MMP1; | |
TP53; | |
SLCO1B3; SLCO1B1; | |
MCL1; LMNA; TTR; | |
SMN1;SMN2; |
Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|
Cytochrome P450 family 2 | CYP2C19 | Cytochrome P450 2C19 | P33261 | CHEMBL3622 |
Cytochrome P450 family 2 | CYP2C9 | Cytochrome P450 2C9 | P11712 | CHEMBL3397 |
Enzyme_unclassified | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
Enzyme_unclassified | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
Enzyme_unclassified | PKM | Pyruvate kinase isozymes M1/M2 | P14618 | CHEMBL1075189 |
Enzyme_unclassified | AKR1B1 | Aldose reductase | P15121 | CHEMBL1900 |
Enzyme_unclassified | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
Enzyme_unclassified | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | P27695 | CHEMBL5619 |
Hydrolase | GAA | Lysosomal alpha-glucosidase | P10253 | CHEMBL2608 |
Metallo protease | MMP1 | Matrix metalloproteinase-1 | P03956 | CHEMBL332 |
Methyl-lysine/arginine binding protein | SMN1;SMN2 | Survival motor neuron protein | Q16637 | CHEMBL1293232 |
SLC superfamily of solute carriers | SLCO1B3 | Solute carrier organic anion transporter family member 1B3 | Q9NPD5 | CHEMBL1743121 |
SLC superfamily of solute carriers | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Q9Y6L6 | CHEMBL1697668 |
Transcription Factor | TP53 | Cellular tumor antigen p53 | P04637 | CHEMBL4096 |
Unclassified | MCL1 | Induced myeloid leukemia cell differentiation protein Mcl-1 | Q07820 | CHEMBL4361 |
Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Unclassified | TTR | Transthyretin | P02766 | CHEMBL3194 |
GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|
BP | GO:0009987; cellular process | GO:0006286; base-excision repair, base-free sugar-phosphate removal | 8.202E-07 | 1.786E-02 | APEX1, POLB |
Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|---|
09140 Cellular Processes | 09143 Cell growth and death | hsa04210 | Apoptosis | 2.536E-04 | 6.556E-03 | LMNA, TP53, MCL1 |
09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 3.062E-04 | 6.556E-03 | CYP2C9, CYP2C19 |
09160 Human Diseases | 09161 Cancers | hsa05203 | Viral carcinogenesis | 7.730E-04 | 8.503E-03 | POLB, PKM, TP53 |
09160 Human Diseases | 09161 Cancers | hsa05219 | Bladder cancer | 6.144E-04 | 8.110E-03 | MMP1, TP53 |
09100 Metabolism | 09101 Carbohydrate metabolism | hsa00052 | Galactose metabolism | 3.279E-04 | 6.556E-03 | GAA, AKR1B1 |
09120 Genetic Information Processing | 09124 Replication and repair | hsa03410 | Base excision repair | 3.973E-04 | 6.556E-03 | POLB, APEX1 |
09100 Metabolism | 09103 Lipid metabolism | hsa00590 | Arachidonic acid metabolism | 1.401E-03 | 1.209E-02 | CYP2C9, CYP2C19 |
09160 Human Diseases | 09161 Cancers | hsa05230 | Central carbon metabolism in cancer | 1.634E-03 | 1.209E-02 | PKM, TP53 |
09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00982 | Drug metabolism - cytochrome P450 | 1.732E-03 | 1.209E-02 | CYP2C9, CYP2C19 |
09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 1.832E-03 | 1.209E-02 | SLCO1B1, SLCO1B3 |
ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
---|---|---|---|
C00-D49: Neoplasms | Refractory renal cell carcinoma | C64 | PKM; |
S00-T88: Injury, poisoning and certain other consequences of external causes | Toxicity | T36-T50, T51-T65 | TP53; |
C00-D49: Neoplasms | Late-stage solid tumors | C00-C75, C7A, C7B, D10-D36, D3A | TP53; |
C00-D49: Neoplasms | Oral cavity cancer | C00-C08 | TP53; |
C00-D49: Neoplasms | Colorectal cancer | C18-C21 | TP53; |
C00-D49: Neoplasms | Acute myeloid leukemia | C92.0 | TP53; |
C00-D49: Neoplasms | Cancer | C00-C96 | TP53; |
C00-D49: Neoplasms | Ocular cancer | C69 | APEX1; |
C00-D49: Neoplasms | Solid tumours | C00-D48 | PKM; TP53; |
H60-H95: Diseases of the ear and mastoid process | Hearing disorder | H90.5 | TP53; |
C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | TP53; |
C00-D49: Neoplasms | Hematological malignancies | C81-C86 | TP53; |
I00-I99: Diseases of the circulatory system | Renal artery disease | I70.1 | TP53; |
G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | PKM; |