CMAUP Plant Collective Molecular Activities

Plant Name: Rhododendron latoucheae

Taxonomic Information:

Plant ID: NPO9925
Plant Latin Name: Rhododendron latoucheae
Taxonomy Genus: Rhododendron
Taxonomy Family: Ericaceae

Plant External Links:

NCBI TaxonomyDB: 184576
Plant-of-the-World-Online: n.a.

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Protein Kinase	MAPK9;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Protein Kinase	MAPK9	c-Jun N-terminal kinase 2	P45984	CHEMBL4179

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0071276; cellular response to cadmium ion	1.605E-03	1.000E+00	MAPK9
BP	GO:0048511; rhythmic process	GO:0042752; regulation of circadian rhythm	5.074E-03	1.000E+00	MAPK9
BP	GO:0050896; response to stimulus	GO:0034614; cellular response to reactive oxygen species	5.591E-03	1.000E+00	MAPK9
BP	GO:0008152; metabolic process	GO:0018105; peptidyl-serine phosphorylation	8.542E-03	1.000E+00	MAPK9
BP	GO:0009987; cellular process	GO:2001235; positive regulation of apoptotic signaling pathway	9.112E-03	1.000E+00	MAPK9
BP	GO:0050896; response to stimulus	GO:0009612; response to mechanical stimulus	1.010E-02	1.000E+00	MAPK9
BP	GO:0048511; rhythmic process	GO:0048511; rhythmic process	1.470E-02	1.000E+00	MAPK9
BP	GO:0065007; biological regulation	GO:0051090; regulation of DNA binding transcription factor activity	2.009E-02	1.000E+00	MAPK9
CC	GO:0044464; cell part	GO:0043005; neuron projection	4.116E-02	1.000E+00	MAPK9
MF	GO:0005488; binding	GO:0008134; transcription factor binding	3.054E-02	1.000E+00	MAPK9

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04930	Type II diabetes mellitus	2.400E-03	9.594E-03	MAPK9
09160 Human Diseases	09161 Cancers	hsa05210	Colorectal cancer	3.100E-03	9.594E-03	MAPK9
09160 Human Diseases	09161 Cancers	hsa05212	Pancreatic cancer	3.300E-03	9.594E-03	MAPK9
09150 Organismal Systems	09151 Immune system	hsa04664	Fc epsilon RI signaling pathway	3.400E-03	9.594E-03	MAPK9
09150 Organismal Systems	09151 Immune system	hsa04621	NOD-like receptor signaling pathway	2.850E-03	9.594E-03	MAPK9
09160 Human Diseases	09167 Infectious diseases	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	3.400E-03	9.594E-03	MAPK9
09150 Organismal Systems	09152 Endocrine system	hsa04917	Prolactin signaling pathway	3.600E-03	9.594E-03	MAPK9
09160 Human Diseases	09167 Infectious diseases	hsa05131	Shigellosis	3.250E-03	9.594E-03	MAPK9
09150 Organismal Systems	09152 Endocrine system	hsa04920	Adipocytokine signaling pathway	3.500E-03	9.594E-03	MAPK9
09150 Organismal Systems	09157 Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	4.900E-03	9.594E-03	MAPK9
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04933	AGE-RAGE signaling pathway in diabetic complications	5.050E-03	9.594E-03	MAPK9
09150 Organismal Systems	09152 Endocrine system	hsa04912	GnRH signaling pathway	4.550E-03	9.594E-03	MAPK9
09130 Environmental Information Processing	09132 Signal transduction	hsa04012	ErbB signaling pathway	4.350E-03	9.594E-03	MAPK9
09150 Organismal Systems	09151 Immune system	hsa04622	RIG-I-like receptor signaling pathway	3.500E-03	9.594E-03	MAPK9
09150 Organismal Systems	09152 Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	4.900E-03	9.594E-03	MAPK9
09160 Human Diseases	09167 Infectious diseases	hsa05133	Pertussis	3.750E-03	9.594E-03	MAPK9
09160 Human Diseases	09161 Cancers	hsa05231	Choline metabolism in cancer	5.050E-03	9.594E-03	MAPK9
09160 Human Diseases	09167 Infectious diseases	hsa05132	Salmonella infection	4.300E-03	9.594E-03	MAPK9
09150 Organismal Systems	09156 Nervous system	hsa04723	Retrograde endocannabinoid signaling	5.050E-03	9.594E-03	MAPK9
09150 Organismal Systems	09151 Immune system	hsa04660	T cell receptor signaling pathway	5.200E-03	9.594E-03	MAPK9
09150 Organismal Systems	09151 Immune system	hsa04620	Toll-like receptor signaling pathway	5.300E-03	9.594E-03	MAPK9
09160 Human Diseases	09167 Infectious diseases	hsa05142	Chagas disease (American trypanosomiasis)	5.200E-03	9.594E-03	MAPK9
09130 Environmental Information Processing	09132 Signal transduction	hsa04668	TNF signaling pathway	5.500E-03	9.594E-03	MAPK9
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04931	Insulin resistance	5.450E-03	9.594E-03	MAPK9
09160 Human Diseases	09167 Infectious diseases	hsa05145	Toxoplasmosis	5.900E-03	9.594E-03	MAPK9
09150 Organismal Systems	09156 Nervous system	hsa04722	Neurotrophin signaling pathway	6.000E-03	9.594E-03	MAPK9
09150 Organismal Systems	09156 Nervous system	hsa04728	Dopaminergic synapse	6.450E-03	9.594E-03	MAPK9
09150 Organismal Systems	09158 Development	hsa04380	Osteoclast differentiation	6.600E-03	9.594E-03	MAPK9
09130 Environmental Information Processing	09132 Signal transduction	hsa04071	Sphingolipid signaling pathway	6.000E-03	9.594E-03	MAPK9
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	7.000E-03	9.594E-03	MAPK9
09130 Environmental Information Processing	09132 Signal transduction	hsa04068	FoxO signaling pathway	6.650E-03	9.594E-03	MAPK9
09160 Human Diseases	09167 Infectious diseases	hsa05160	Hepatitis C	6.650E-03	9.594E-03	MAPK9
09160 Human Diseases	09167 Infectious diseases	hsa05161	Hepatitis B	7.300E-03	9.594E-03	MAPK9
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04932	Non-alcoholic fatty liver disease (NAFLD)	7.550E-03	9.647E-03	MAPK9
09130 Environmental Information Processing	09132 Signal transduction	hsa04310	Wnt signaling pathway	7.100E-03	9.594E-03	MAPK9
09150 Organismal Systems	09152 Endocrine system	hsa04910	Insulin signaling pathway	6.950E-03	9.594E-03	MAPK9

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases