CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	CNR2;
Oxidoreductase	HMGCR;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1; CYP1A1; CYP1A2; CYP19A1;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Oxidoreductase	HMGCR	HMG-CoA reductase	P04035	CHEMBL402
Small molecule receptor (family A GPCR)	CNR2	Cannabinoid CB2 receptor	P34972	CHEMBL253

Showing 1 to 6 of 6 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	1.997E-09	8.696E-06	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	2.210E-08	6.407E-05	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	2.942E-08	6.407E-05	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	4.823E-07	5.528E-04	CYP1A1, CYP1A2
BP	GO:0008152; metabolic process	GO:0055114; oxidation-reduction process	1.240E-06	1.350E-03	CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR
BP	GO:0008152; metabolic process	GO:0050665; hydrogen peroxide biosynthetic process	2.250E-06	2.227E-03	CYP1A1, CYP1A2
BP	GO:0050896; response to stimulus	GO:0009636; response to toxic substance	2.682E-06	2.336E-03	CNR2, CYP1A1, CYP1B1, HMGCR
BP	GO:0008152; metabolic process	GO:0016125; sterol metabolic process	5.603E-06	3.697E-03	CYP19A1, CYP1B1, HMGCR
BP	GO:0009987; cellular process	GO:0071280; cellular response to copper ion	6.262E-06	4.011E-03	CYP1A1, CYP1A2
CC	GO:0016020; membrane	GO:0005789; endoplasmic reticulum membrane	1.406E-06	1.457E-03	CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR

Showing 1 to 10 of 16 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	9.508E-10	1.426E-08	CYP1A2, CYP1A1, CYP1B1, CYP19A1
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	1.476E-07	1.107E-06	CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	9.258E-07	3.472E-06	CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.547E-04	3.868E-04	CYP1A2, CYP1A1
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	8.670E-03	1.300E-02	CYP1A2
09100 Metabolism	09109 Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	6.583E-03	1.097E-02	HMGCR
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	1.499E-03	2.811E-03	CYP1A2
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	2.925E-07	1.462E-06	CYP1A1, CYP1B1, CYP19A1
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.317E-06	3.950E-06	CYP1A2, CYP1A1, CYP1B1
Unclassified	Unclassified	hsa01100	Metabolic pathways	1.988E-04	4.259E-04	CYP1A2, CYP1A1, HMGCR, CYP19A1

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Hormonally-responsive breast cancer	C50	CYP19A1;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	CNR2;
C00-D49: Neoplasms	Bladder cancer	C67	CYP19A1;
C00-D49: Neoplasms	Breast cancer	C50	CYP19A1;
C00-D49: Neoplasms	Advanced breast cancer	C50	CYP19A1;
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Immune disorder	D80-D89	CNR2;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	CNR2;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	CNR2;
K00-K95: Diseases of the digestive system	Inflammatory bowel disease	K50, K51	CNR2;
L00-L99: Diseases of the skin and subcutaneous tissue	Atopic dermatitis	L00-L99	CNR2;

Showing 1 to 10 of 14 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Betula alnoides

Taxonomic Information:

Plant External Links:

Used in Medicines:

Country/Region:

Traditional Medicine System:

Medicinal Functions:

Geographical Distribution:

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Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities