CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Transient receptor potential channel	TRPV1;
Enzyme_unclassified	ALDH1A1;
Unclassified	MAPT; MITF; NPC1; RAB9A;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4; CYP2C19; CYP2C9;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Transient receptor potential channel	TRPV1	Vanilloid receptor	Q8NER1	CHEMBL4794
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	MITF	Microphthalmia-associated transcription factor	O75030	CHEMBL1741165
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294

Showing 1 to 9 of 9 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	1.398E-09	3.044E-05	CYP2C19, CYP2C9, CYP3A4
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	1.536E-08	1.672E-04	CYP2C19, CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	3.127E-06	7.565E-03	CYP2C19, CYP2C9, CYP3A4, NPC1
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	8.667E-06	1.573E-02	CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	1.271E-05	1.976E-02	CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0006805; xenobiotic metabolic process	1.639E-05	2.230E-02	CYP2C19, CYP2C9, CYP3A4
CC	GO:0016020; membrane	GO:0005789; endoplasmic reticulum membrane	5.336E-04	2.421E-01	CYP2C19, CYP2C9, CYP3A4, RAB9A
CC	GO:0016020; membrane	GO:0031090; organelle membrane	4.210E-03	6.997E-01	CYP2C19, CYP2C9, CYP3A4, NPC1, RAB9A
CC	GO:0044464; cell part	GO:0005764; lysosome	6.758E-03	9.544E-01	NPC1, RAB9A
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	4.155E-07	1.810E-03	CYP2C19, CYP2C9, CYP3A4

Showing 1 to 10 of 14 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	2.289E-07	4.807E-06	CYP2C9, CYP3A4, CYP2C19
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2.714E-06	2.277E-05	CYP2C9, ALDH1A1, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	3.253E-06	2.277E-05	CYP2C9, CYP3A4, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	3.357E-04	1.410E-03	CYP2C9, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	4.653E-04	1.629E-03	CYP2C9, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	2.051E-02	4.787E-02	CYP3A4
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2.580E-02	5.419E-02	CYP3A4
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	1.091E-03	3.272E-03	CYP2C9, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	5.482E-06	2.878E-05	CYP2C9, CYP3A4, CYP2C19
Unclassified	Unclassified	hsa01100	Metabolic pathways	1.436E-03	3.768E-03	CYP2C9, ALDH1A1, CYP2C19, CYP3A4

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Postherpetic neuralgia	B02.2, G44.847, G53.0	TRPV1;
C00-D49: Neoplasms	Overactive bladder disorder	C67, N32.81	TRPV1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	TRPV1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CYP3A4;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	TRPV1;
G00-G99: Diseases of the nervous system G00-G99	Acute migraine	G43	TRPV1;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	TRPV1;
J00-J99: Diseases of the respiratory system	Asthma	J45	TRPV1;
K00-K95: Diseases of the digestive system	Gastroesophageal reflux disease	K21	TRPV1;
L00-L99: Diseases of the skin and subcutaneous tissue	Atopic dermatitis	L00-L99	TRPV1;

Showing 1 to 10 of 16 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Hippocrepis emerus

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities