Plant Name: Polanisia dodecandra
Taxonomic Information:
Plant ID: NPO9839
Plant Latin Name: Polanisia dodecandra
Taxonomy Genus: Polanisia
Taxonomy Family: Cleomaceae
Plant External Links:
NCBI TaxonomyDB:
72660
Plant-of-the-World-Online:
n.a.
Used in Medicines:
Country/Region:
MexicoTraditional Medicine System:
Geographical Distribution:
Mexico
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| NR1H3; | |
| ABCB1; | |
| NPC1L1; LMNA; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| ATP-binding cassette | ABCB1 | P-glycoprotein 1 | P08183 | CHEMBL4302 |
| Nuclear hormone receptor subfamily 1 group H | NR1H3 | LXR-alpha | Q13133 | CHEMBL2808 |
| Unclassified | NPC1L1 | Niemann-Pick C1-like protein 1 | Q9UHC9 | CHEMBL2027 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0050896; response to stimulus | GO:0042493; response to drug | 2.150E-04 | 8.502E-01 | ABCB1, NPC1L1, NR1H3 |
| BP | GO:0051179; localization | GO:0042908; xenobiotic transport | 2.069E-03 | 8.502E-01 | ABCB1 |
| MF | GO:0005215; transporter activity | GO:0008559; xenobiotic transmembrane transporting ATPase activity | 1.449E-03 | 8.502E-01 | ABCB1 |
| CC | GO:0032991; macromolecular complex | GO:0090575; RNA polymerase II transcription factor complex | 2.686E-02 | 1.000E+00 | NR1H3 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09150 Organismal Systems | 09154 Digestive system | hsa04975 | Fat digestion and absorption | 8.175E-03 | 3.065E-02 | NPC1L1 |
| 09130 Environmental Information Processing | 09131 Membrane transport | hsa02010 | ABC transporters | 8.772E-03 | 3.065E-02 | ABCB1 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa03320 | PPAR signaling pathway | 1.373E-02 | 3.065E-02 | NR1H3 |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 1.472E-02 | 3.065E-02 | LMNA |
| 09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 1.413E-02 | 3.065E-02 | ABCB1 |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05410 | Hypertrophic cardiomyopathy (HCM) | 1.650E-02 | 3.065E-02 | LMNA |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05414 | Dilated cardiomyopathy | 1.788E-02 | 3.065E-02 | LMNA |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04931 | Insulin resistance | 2.162E-02 | 3.244E-02 | NR1H3 |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04210 | Apoptosis | 2.771E-02 | 3.258E-02 | LMNA |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04932 | Non-alcoholic fatty liver disease (NAFLD) | 2.986E-02 | 3.258E-02 | NR1H3 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
