CMAUP Plant Collective Molecular Activities

Plant Name: Typha angustifolia

Taxonomic Information:

Plant ID: NPO9822
Plant Latin Name: Typha angustifolia
Taxonomy Genus: Typha
Taxonomy Family: Typhaceae

Plant External Links:

NCBI TaxonomyDB: 59011
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Turkey; China; New Zealand; India

Traditional Medicine System:

Sowa-Rigpa; TCM; Unani; Ayurveda

Medicinal Functions:

Anticoagulant; Diuretic; Emmenagogue; Haemostatic; Lithontripic; Miscellany

Geographical Distribution:

Turkey; India; New Zealand; China

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	ADORA3; ADORA2A; ADORA1;
Peptide receptor (family A GPCR)	NPSR1;
Enzyme_unclassified	CDA; ADK; TK1; ALOX12; HSD17B2; HSD17B10; NOX4; AOX1; POLB;
Protein Kinase	MET; FLT3; CDK1; PIM1; AXL; KDR; IGF1R; AURKB;
Lyase	CA2; CA12; CA7; CA4;
Oxidoreductase	TYR; MAOB;
Transcription Factor	AHR; TP53;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP19A1; CYP1A2; CYP1B1; CYP1A1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Enzyme_unclassified	CDA	Cytidine deaminase	P32320	CHEMBL4502
Enzyme_unclassified	ADK	Adenosine kinase	P55263	CHEMBL3589
Enzyme_unclassified	TK1	Thymidine kinase, cytosolic	P04183	CHEMBL2883
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	HSD17B2	Estradiol 17-beta-dehydrogenase 2	P37059	CHEMBL2789
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Enzyme_unclassified	AOX1	Aldehyde oxidase	Q06278	CHEMBL3257
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Oxidoreductase	TYR	Tyrosinase	P14679	CHEMBL1973
Oxidoreductase	MAOB	Monoamine oxidase B	P27338	CHEMBL2039
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Protein Kinase	MET	Hepatocyte growth factor receptor	P08581	CHEMBL3717
Protein Kinase	FLT3	Tyrosine-protein kinase receptor FLT3	P36888	CHEMBL1974
Protein Kinase	CDK1	Cyclin-dependent kinase 1	P06493	CHEMBL308
Protein Kinase	PIM1	Serine/threonine-protein kinase PIM1	P11309	CHEMBL2147
Protein Kinase	AXL	Tyrosine-protein kinase receptor UFO	P30530	CHEMBL4895
Protein Kinase	KDR	Vascular endothelial growth factor receptor 2	P35968	CHEMBL279
Protein Kinase	IGF1R	Insulin-like growth factor I receptor	P08069	CHEMBL1957
Protein Kinase	AURKB	Serine/threonine-protein kinase Aurora-B	Q96GD4	CHEMBL2185
Small molecule receptor (family A GPCR)	ADORA3	Adenosine A3 receptor	P0DMS8	CHEMBL256
Small molecule receptor (family A GPCR)	ADORA2A	Adenosine A2a receptor	P29274	CHEMBL251
Small molecule receptor (family A GPCR)	ADORA1	Adenosine A1 receptor	P30542	CHEMBL226
Transcription Factor	AHR	Aryl hydrocarbon receptor	P35869	CHEMBL3201
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	9.506E-09	3.450E-05	CA12, CA2, CA4, CA7
MF	GO:0005488; binding	GO:0019825; oxygen binding	1.234E-08	3.837E-05	CYP19A1, CYP1A1, CYP1A2, CYP1B1, NOX4
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	6.108E-08	8.550E-05	CYP19A1, CYP1A1, CYP1A2, CYP1B1
MF	GO:0060089; molecular transducer activity	GO:0001609; G-protein coupled adenosine receptor activity	1.583E-07	1.325E-04	ADORA1, ADORA2A, ADORA3
BP	GO:0008152; metabolic process	GO:0050665; hydrogen peroxide biosynthetic process	2.529E-07	1.721E-04	CYP1A1, CYP1A2, MAOB
MF	GO:0005488; binding	GO:0005506; iron ion binding	2.706E-07	1.786E-04	ALOX12, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1
BP	GO:0009987; cellular process	GO:0001973; adenosine receptor signaling pathway	3.790E-07	2.358E-04	ADORA1, ADORA2A, ADORA3
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	4.000E-07	2.373E-04	CA12, CA2, CA4, CA7
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	5.407E-07	2.855E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	9.130E-07	4.322E-04	CA12, CA2, CA4, CA7
BP	GO:0009987; cellular process	GO:0043066; negative regulation of apoptotic process	1.023E-06	4.646E-04	ADORA1, ADORA2A, ALOX12, AURKB, AXL, CDK1, IGF1R, KDR, PIM1, TP53
MF	GO:0003824; catalytic activity	GO:0009055; electron transfer activity	1.043E-06	4.646E-04	AOX1, CYP19A1, CYP1A2, MAOB, NOX4
BP	Unclassified;	GO:2000021; regulation of ion homeostasis	1.261E-06	5.294E-04	ADORA1, ADORA2A, CA2, CA7, KDR, NPSR1
BP	GO:0008283; cell proliferation	GO:0042127; regulation of cell proliferation	1.272E-06	5.294E-04	ADORA1, ADORA2A, ADORA3, AHR, ALOX12, CDK1, CYP1B1, FLT3, IGF1R, KDR, NOX4, PIM1, TP53
BP	GO:0023052; signaling	GO:0032230; positive regulation of synaptic transmission, GABAergic	1.284E-06	5.294E-04	ADORA2A, CA2, CA7
BP	GO:0050896; response to stimulus	GO:0033993; response to lipid	2.333E-06	8.192E-04	AXL, CA2, CYP1A1, CYP1A2, FLT3, HSD17B2, MAOB, TP53, TYR
MF	GO:0005488; binding	GO:0020037; heme binding	2.416E-06	8.351E-04	CYP19A1, CYP1A1, CYP1A2, CYP1B1, NOX4
BP	GO:0050896; response to stimulus	GO:0055093; response to hyperoxia	5.917E-06	1.673E-03	CYP1A1, POLB, TP53
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	5.917E-06	1.673E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0009987; cellular process	GO:0051289; protein homotetramerization	7.465E-06	2.058E-03	CDA, HSD17B10, TK1, TP53
BP	GO:0008152; metabolic process	GO:0022900; electron transport chain	7.656E-06	2.084E-03	AOX1, CYP19A1, CYP1A2, MAOB, NOX4
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	7.860E-06	2.113E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	8.482E-06	2.199E-03	CA2, CA7
CC	GO:0044464; cell part	GO:0099056; integral component of presynaptic membrane	8.482E-06	2.199E-03	ADORA1, ADORA2A
BP	GO:0008152; metabolic process	GO:0018108; peptidyl-tyrosine phosphorylation	1.496E-05	3.194E-03	AXL, FLT3, IGF1R, KDR, MET
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	1.695E-05	3.514E-03	CYP1A1, CYP1A2
BP	GO:0008152; metabolic process	GO:0046777; protein autophosphorylation	1.926E-05	3.883E-03	AURKB, FLT3, IGF1R, KDR, PIM1
MF	GO:0005488; binding	GO:0005524; ATP binding	2.015E-05	4.026E-03	ADK, AURKB, AXL, CDK1, FLT3, IGF1R, KDR, MET, PIM1, TK1, TP53
BP	GO:0009987; cellular process	GO:1902533; positive regulation of intracellular signal transduction	2.723E-05	5.202E-03	ADORA1, AXL, CDK1, CYP1B1, FLT3, KDR, MET, NOX4, TP53
MF	GO:0005488; binding	GO:0031072; heat shock protein binding	2.988E-05	5.467E-03	ADORA1, AHR, CDK1, KDR
BP	GO:0050896; response to stimulus	GO:0045471; response to ethanol	4.417E-05	7.514E-03	CDK1, MAOB, POLB, TP53
MF	GO:0005488; binding	GO:0042802; identical protein binding	5.045E-05	8.516E-03	ADORA2A, AOX1, CDA, FLT3, IGF1R, KDR, MAOB, MET, TK1, TP53, TYR
MF	GO:0060089; molecular transducer activity	GO:0005021; vascular endothelial growth factor-activated receptor activity	5.912E-05	9.607E-03	FLT3, KDR

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	5.625E-09	6.018E-07	MAOB, CYP1A2, CYP1A1, AOX1, CYP1B1
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	1.790E-08	6.385E-07	HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R
Unclassified	Unclassified	hsa01100	Metabolic pathways	3.181E-07	6.807E-06	CDA, MAOB, HSD17B2, CYP1A2, CYP1A1, ADK, AOX1, ALOX12, TK1, TYR, CYP19A1, HSD17B10
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3.835E-08	1.026E-06	CYP1A2, HSD17B2, CYP1A1, CYP1B1, CYP19A1
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.439E-08	6.385E-07	CA12, CA2, CA4, CA7
09100 Metabolism	09105 Amino acid metabolism	hsa00350	Tyrosine metabolism	2.584E-05	4.608E-04	MAOB, AOX1, TYR
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.667E-04	2.098E-03	CYP1A2, CYP1A1, AOX1
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	1.824E-04	2.098E-03	FLT3, TP53, MET
09160 Human Diseases	09161 Cancers	hsa05218	Melanoma	2.167E-04	2.098E-03	TP53, MET, IGF1R
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.991E-04	2.098E-03	MAOB, CYP1A2, AOX1
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	3.348E-04	2.559E-03	KDR, TP53, MET, IGF1R
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	2.117E-04	2.098E-03	FLT3, TP53, MET, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04015	Rap1 signaling pathway	3.876E-04	2.765E-03	ADORA2A, KDR, MET, IGF1R
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2.353E-04	2.098E-03	CYP1A2, CYP1A1, CYP1B1
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	3.316E-04	2.559E-03	CYP1A2, CYP1A1, CYP1B1
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	1.389E-03	8.255E-03	PIM1, CYP1B1, TP53, MET
09130 Environmental Information Processing	09132 Signal transduction	hsa04071	Sphingolipid signaling pathway	1.008E-03	6.343E-03	ADORA3, ADORA1, TP53
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	6.536E-04	4.371E-03	CA2, CA4

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	MET; IGF1R; KDR; ADORA3;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	AURKB; TP53;
NA: NA	Hematopoietic stem cell transplantation	NA	FLT3;
C00-D49: Neoplasms	Colon cancer	C50	FLT3;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	IGF1R; KDR; FLT3; TP53;
C00-D49: Neoplasms	Ovarian cancer	C56	KDR;
I00-I99: Diseases of the circulatory system	Ischemia	I99.8	ADORA3;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	ADORA1;
C00-D49: Neoplasms	Breast cancer	C50	CDK1; IGF1R; KDR; FLT3; CYP19A1;
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	CYP19A1;
NA: NA	Edema	NA	CA2;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
C00-D49: Neoplasms	Solid tumours	C00-D48	MET; AURKB; IGF1R; KDR; FLT3; TK1; CDA; TP53;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	AURKB; FLT3; TK1; TP53;
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	ADK;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Idiopathic parkinson's disease	F02.3, G20	MAOB;
K00-K95: Diseases of the digestive system	Chemotherapy-induced mucositis	K12.3	MET;
I00-I99: Diseases of the circulatory system	Moderate to severe hypertension	I10-I16	MAOB;
C00-D49: Neoplasms	Bladder cancer	C67	CYP19A1;
C00-D49: Neoplasms	Advanced breast cancer	C50	CYP19A1;
A00-B99: Certain infectious and parasitic diseases	Adult varicella zoster virus infection	B02	TK1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	TYR;
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAOB;
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	ADORA3;
NA: NA	Motor symptoms	NA	MAOB;
C00-D49: Neoplasms	Multiple myeloma	C90	IGF1R; AHR;
G00-G99: Diseases of the nervous system G00-G99	Multiple scierosis	G35	ADORA1;
C00-D49: Neoplasms	Advanced malignancies	C00-C96	KDR;
C00-D49: Neoplasms	Cutaneous Melanoma	C43-C44	KDR;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Fatigue	R53	ADORA1;
C00-D49: Neoplasms	Fallopian tube cancer	C57.0, D28.2	KDR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ADORA1; MAOB;
C00-D49: Neoplasms	Advanced solid tumor	C00-C75, C7A, C7B	MET;
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	MET;
C00-D49: Neoplasms	Gastric cancer	C16	KDR;
I00-I99: Diseases of the circulatory system	Arteriosclerosis	I70	ADORA2A;
J00-J99: Diseases of the respiratory system	Asthma	J45	ADORA1; ADORA2A;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	ADORA2A;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	FLT3;
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	ADORA1;
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	ADORA2A;
C00-D49: Neoplasms	AML	NA	KDR; FLT3;
C00-D49: Neoplasms	Peritoneal cavity cancer	NA	KDR;
C00-D49: Neoplasms	Brain cancer	C71, D33	TK1;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
C00-D49: Neoplasms	Biliary cancer	C22, C24	KDR;
C00-D49: Neoplasms	Thyroid cancer	C73	KDR;
I00-I99: Diseases of the circulatory system	Cardiac arrhythmias	I47-I49	ADORA1;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	KDR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	MAOB;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	MAOB;
C00-D49: Neoplasms	Metastatic castration-resistant prostate cancer	C61	KDR;
C00-D49: Neoplasms	Metastatic breast cancer	C50	KDR;
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53;
L00-L99: Diseases of the skin and subcutaneous tissue	Vitiligo	L80	TYR;
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	KDR;
C00-D49: Neoplasms	Advanced renal cell carcinoma	C64	KDR;
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	KDR;
C00-D49: Neoplasms	Metastatic HER2-negative gastric cancer	NA	MET;
A00-B99: Certain infectious and parasitic diseases	Sepsis	A40, A41	ADORA1;
NA: NA	Anaplastic mixed oligoastrocytoma	NA	FLT3;
NA: NA	Hepatitis C virus infection	NA	ADORA3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive episode without melancholia	F30-F39	MAOB;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	MAOB;
J00-J99: Diseases of the respiratory system	Airway inflammation	J00-J99	FLT3;
G00-G99: Diseases of the nervous system G00-G99	Motor neurone disease	G12.2	IGF1R;
L00-L99: Diseases of the skin and subcutaneous tissue	Melasma	L81.1	TYR;
C00-D49: Neoplasms	Medullary thyroid cancer	C73	KDR;
C00-D49: Neoplasms	Melanoma	C43	KDR; TYR;
C00-D49: Neoplasms	Malignant adrenal gland cancer	C74.0	IGF1R;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	ADORA3;
C00-D49: Neoplasms	Squamous cell cancer of head and neck	NA	KDR;
S00-T88: Injury, poisoning and certain other consequences of external causes	Toxicity	T36-T50, T51-T65	TP53;
I00-I99: Diseases of the circulatory system	Heart failure	I50	ADORA1;
I00-I99: Diseases of the circulatory system	Heart disease	I00-I52	MET;
H60-H95: Diseases of the ear and mastoid process	Hearing disorder	H90.5	TP53;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	KDR; TP53;
C00-D49: Neoplasms	Leukemia	C90-C95	FLT3;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53;
C00-D49: Neoplasms	Liver cancer	C22	IGF1R; KDR;
N00-N99: Diseases of the genitourinary system	Prostate disease	N42.9	CYP19A1;
C00-D49: Neoplasms	Prostate cancer	C61	FLT3; TK1;
S00-T88: Injury, poisoning and certain other consequences of external causes	Graft-versus-host disease	T86.0	TK1;
H00-H59: Diseases of the eye and adnexa	Graves' ophthalmopathy	H06.2	IGF1R;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Growth failure	R62.8	IGF1R;
K00-K95: Diseases of the digestive system	Liver disease	K70-K77	MET;
C00-D49: Neoplasms	Myelofibrosis	C94.4, D47.4	FLT3;
C00-D49: Neoplasms	Myeloid leukemia	C92	FLT3;
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	MAOB;
E00-E89: Endocrine, nutritional and metabolic diseases	Atrial fibrillation	E78, I48	ADORA1;
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	ADORA1;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriatic disorder	L40	IGF1R;
C00-D49: Neoplasms	CLL	NA	FLT3;
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	ADORA3;
C00-D49: Neoplasms	Glioblastoma	NA	FLT3;
C00-D49: Neoplasms	Gliosarcoma	NA	FLT3;
C00-D49: Neoplasms	Glioma	C71	KDR;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ADORA1; ADORA2A; ADORA3;
NA: NA	GIST	NA	FLT3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	FLT3;
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	MAOB;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	KDR;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Radionuclide imaging	W88	ADORA2A;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	MET; IGF1R; KDR; AXL;
C00-D49: Neoplasms	Gastrointestinal cancers	C15-C26	KDR;
C00-D49: Neoplasms	Hormonally-responsive breast cancer	C50	CYP19A1;
I00-I99: Diseases of the circulatory system	Acute and chronic heart failure	I50	ADORA1;
NA: NA	HIV infections	NA	AHR;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	NPSR1;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	ADORA1; ADORA2A;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAOB;
C00-D49: Neoplasms	Renal cancer	C64	KDR;
C00-D49: Neoplasms	Renal cell carcinoma	NA	KDR;
I00-I99: Diseases of the circulatory system	Renal artery disease	I70.1	TP53;
N00-N99: Diseases of the genitourinary system	Renal failure	N17, N18, N19	ADORA1;
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	ADORA1; ADORA2A;
E00-E89: Endocrine, nutritional and metabolic diseases	Hypertriglyceridemia	E78.1, E78.2, E78.3, I47-I49	ADORA1;
I00-I99: Diseases of the circulatory system	Orthostatic hypotension	I95.1	ADORA1;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ADK;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAOB;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	ADORA1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Dementia	F01-F07	MAOB;
C00-D49: Neoplasms	Cancer	C00-C96	PIM1; MET; CDK1; IGF1R; KDR; FLT3; TK1; ADORA3; TP53;
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA4; CA2;
C00-D49: Neoplasms	Metastasis	C00-C97	AXL;
I00-I99: Diseases of the circulatory system	Cardiac disease	I00-I99	ADORA1;
L00-L99: Diseases of the skin and subcutaneous tissue	Diabetic foot ulcer	L88-L89	ADORA2A;
E00-E89: Endocrine, nutritional and metabolic diseases	Hormone deficiency	E00-E90	IGF1R;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Convulsions	R56.0	ADK;
I00-I99: Diseases of the circulatory system	Coronary disorder diagnosis	I20-I25	ADORA2A;
C00-D49: Neoplasms	Pancreatic cancer	C25	KDR; FLT3; TK1;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	CDK1; IGF1R; ADORA2A; ADK;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ADORA1; ADORA2A; MAOB;
I00-I99: Diseases of the circulatory system	Angiogenesis disorder	I00-I99	KDR;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases