Plant Name: Mortonia palmeri
Taxonomic Information:
Plant ID: NPO9769
Plant Latin Name: Mortonia palmeri
Taxonomy Genus: Mortonia
Taxonomy Family: Celastraceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| TSHR; | |
| BLM; RECQL; | |
| CDK2; AURKB; AURKA; CDK1; CDK4; | |
| MAPT; | |
| L3MBTL1; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 2 | CYP2C19 | Cytochrome P450 2C19 | P33261 | CHEMBL3622 |
| Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Enzyme_unclassified | BLM | Bloom syndrome protein | P54132 | CHEMBL1293237 |
| Enzyme_unclassified | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Methyl-lysine/arginine binding protein | L3MBTL1 | Lethal(3)malignant brain tumor-like protein 1 | Q9Y468 | CHEMBL1287622 |
| Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
| Protein Kinase | CDK2 | Cyclin-dependent kinase 2 | P24941 | CHEMBL301 |
| Protein Kinase | AURKB | Serine/threonine-protein kinase Aurora-B | Q96GD4 | CHEMBL2185 |
| Protein Kinase | AURKA | Serine/threonine-protein kinase Aurora-A | O14965 | CHEMBL4722 |
| Protein Kinase | CDK1 | Cyclin-dependent kinase 1 | P06493 | CHEMBL308 |
| Protein Kinase | CDK4 | Cyclin-dependent kinase 4 | P11802 | CHEMBL331 |
| Unclassified | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0009987; cellular process | GO:1901796; regulation of signal transduction by p53 class mediator | 4.462E-08 | 1.388E-04 | AURKA, AURKB, BLM, CDK2, L3MBTL1 |
| MF | GO:0005488; binding | GO:0030332; cyclin binding | 8.154E-07 | 7.720E-04 | CDK1, CDK2, CDK4 |
| MF | GO:0003824; catalytic activity | GO:0004693; cyclin-dependent protein serine/threonine kinase activity | 1.186E-06 | 9.220E-04 | CDK1, CDK2, CDK4 |
| CC | GO:0044464; cell part | GO:0000307; cyclin-dependent protein kinase holoenzyme complex | 1.927E-06 | 1.311E-03 | CDK1, CDK2, CDK4 |
| MF | GO:0003824; catalytic activity | GO:0009378; four-way junction helicase activity | 3.534E-06 | 2.025E-03 | BLM, RECQL |
| CC | GO:0032991; macromolecular complex | GO:0032133; chromosome passenger complex | 3.534E-06 | 2.025E-03 | AURKA, AURKB |
| CC | GO:0043226; organelle | GO:0005876; spindle microtubule | 4.217E-06 | 2.296E-03 | AURKA, AURKB, CDK1 |
| BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 5.300E-06 | 2.684E-03 | CYP2C19, CYP3A4 |
| MF | GO:0003824; catalytic activity | GO:0035174; histone serine kinase activity | 5.300E-06 | 2.684E-03 | AURKA, AURKB |
| BP | GO:0009987; cellular process | GO:0006977; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | 6.787E-06 | 3.102E-03 | AURKA, CDK1, CDK2 |
| MF | GO:0003824; catalytic activity | GO:0043140; ATP-dependent 3'-5' DNA helicase activity | 7.417E-06 | 3.167E-03 | BLM, RECQL |
| MF | GO:0005488; binding | GO:0005524; ATP binding | 8.470E-06 | 3.480E-03 | AURKA, AURKB, BLM, CDK1, CDK2, CDK4, RECQL |
| MF | GO:0005488; binding | GO:0036310; annealing helicase activity | 9.886E-06 | 3.883E-03 | BLM, RECQL |
| BP | GO:0032502; developmental process | GO:0031100; animal organ regeneration | 1.255E-05 | 4.392E-03 | AURKA, CDK1, CDK4 |
| BP | GO:0009987; cellular process | GO:0000733; DNA strand renaturation | 1.271E-05 | 4.392E-03 | BLM, RECQL |
| BP | GO:0008152; metabolic process | GO:0031145; anaphase-promoting complex-dependent catabolic process | 1.465E-05 | 4.748E-03 | AURKA, AURKB, CDK1 |
| BP | GO:0009987; cellular process | GO:0035690; cellular response to drug | 2.007E-05 | 5.987E-03 | BLM, CDK1, CDK2, CDK4 |
| BP | GO:0050896; response to stimulus | GO:0042738; exogenous drug catabolic process | 2.327E-05 | 6.581E-03 | CYP2C19, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0035404; histone-serine phosphorylation | 2.327E-05 | 6.581E-03 | AURKA, AURKB |
| CC | GO:0043226; organelle | GO:0000780; condensed nuclear chromosome, centromeric region | 2.327E-05 | 6.581E-03 | AURKA, AURKB |
| CC | GO:0043226; organelle | GO:0031616; spindle pole centrosome | 2.327E-05 | 6.581E-03 | AURKA, AURKB |
| BP | GO:0051179; localization | GO:0034501; protein localization to kinetochore | 2.749E-05 | 7.469E-03 | AURKB, CDK1 |
| BP | GO:0009987; cellular process | GO:0000226; microtubule cytoskeleton organization | 2.873E-05 | 7.537E-03 | AURKA, AURKB, CDK1, MAPT |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04115 | p53 signaling pathway | 8.456E-06 | 3.805E-04 | CDK4, CDK2, CDK1 |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04114 | Oocyte meiosis | 4.796E-05 | 7.369E-04 | CDK2, CDK1, AURKA |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04110 | Cell cycle | 4.913E-05 | 7.369E-04 | CDK4, CDK2, CDK1 |
| 09160 Human Diseases | 09161 Cancers | hsa05203 | Viral carcinogenesis | 2.181E-04 | 1.963E-03 | CDK4, CDK2, CDK1 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 1.328E-04 | 1.494E-03 | CYP3A4, CYP2C19 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00982 | Drug metabolism - cytochrome P450 | 7.571E-04 | 5.678E-03 | CYP3A4, CYP2C19 |
| 09160 Human Diseases | 09161 Cancers | hsa05222 | Small cell lung cancer | 1.173E-03 | 6.598E-03 | CDK4, CDK2 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04914 | Progesterone-mediated oocyte maturation | 1.519E-03 | 7.596E-03 | CDK2, CDK1 |
| 09160 Human Diseases | 09161 Cancers | hsa05204 | Chemical carcinogenesis | 1.067E-03 | 6.598E-03 | CYP3A4, CYP2C19 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05162 | Measles | 2.897E-03 | 1.304E-02 | CDK4, CDK2 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| C00-D49: Neoplasms | Cancer | C00-C96 | CDK2; CDK1; |
| C00-D49: Neoplasms | Thymoma | C37, D15.0 | CDK2; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Anxiety disorder | F32, F40-F42 | CYP3A4; |
| G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | CDK1; |
| C00-D49: Neoplasms | Acute lymphoblastic leukemia | C91.0 | CDK2; |
| C00-D49: Neoplasms | Non-small cell lung cancer | C33-C34 | CDK2; |
| C00-D49: Neoplasms | Breast cancer | C50 | CDK1; |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | CDK2; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
