CMAUP Plant Collective Molecular Activities

Plant Name: Daphne genkwa

Taxonomic Information:

Plant ID: NPO9756
Plant Latin Name: Daphne genkwa
Taxonomy Genus: Daphne
Taxonomy Family: Thymelaeaceae

Plant External Links:

NCBI TaxonomyDB: 1477590
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Medicinal Functions:

Abortifacient; Anticoagulant; Antiseptic; Antitussive; Antiviral; Diuretic; Purgative; Stomachic; Vesicant

Geographical Distribution:

China

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Hydrolase	ACHE;
Protein Kinase	FLT3; MAP2K1; CSNK2A1;
Lyase	CA12; CA7; CA4;
Nuclear hormone receptor subfamily 3 group A	ESR2;
Oxidoreductase	TYR;
Enzyme_unclassified	HSD17B1; HSD17B2; NOX4;
Metallo protease	MMP12;
Transcription Factor	AHR; HIF1A;
Unclassified	THPO;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP19A1; CYP2C19; CYP3A4; CYP1A2; CYP1B1; CYP1A1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	HSD17B1	Estradiol 17-beta-dehydrogenase 1	P14061	CHEMBL3181
Enzyme_unclassified	HSD17B2	Estradiol 17-beta-dehydrogenase 2	P37059	CHEMBL2789
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Metallo protease	MMP12	Matrix metalloproteinase 12	P39900	CHEMBL4393
Nuclear hormone receptor subfamily 3 group A	ESR2	Estrogen receptor beta	Q92731	CHEMBL242
Oxidoreductase	TYR	Tyrosinase	P14679	CHEMBL1973
Protein Kinase	FLT3	Tyrosine-protein kinase receptor FLT3	P36888	CHEMBL1974
Protein Kinase	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Q02750	CHEMBL3587
Protein Kinase	CSNK2A1	Casein kinase II alpha	P68400	CHEMBL3629
Transcription Factor	AHR	Aryl hydrocarbon receptor	P35869	CHEMBL3201
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Unclassified	THPO	Thrombopoietin	P40225	CHEMBL1293256

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0019825; oxygen binding	3.793E-14	8.259E-10	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, NOX4
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	3.905E-11	2.834E-07	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4
MF	GO:0005488; binding	GO:0020037; heme binding	7.466E-11	3.317E-07	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, NOX4
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	2.637E-10	6.673E-07	CYP1A1, CYP1A2, CYP1B1, CYP2C19
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	7.455E-09	1.082E-05	CYP1A1, CYP1A2, CYP1B1, CYP2C19
MF	GO:0005488; binding	GO:0005506; iron ion binding	1.966E-08	2.378E-05	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	2.559E-08	2.933E-05	CYP1A2, CYP2C19, CYP3A4
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	2.802E-07	2.252E-04	CYP1A2, CYP2C19, CYP3A4
BP	GO:0008152; metabolic process	GO:0006703; estrogen biosynthetic process	3.640E-07	2.642E-04	CYP19A1, HSD17B1, HSD17B2
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	5.783E-07	3.935E-04	CA12, CA4, CA7
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	2.238E-06	1.282E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0006706; steroid catabolic process	3.278E-06	1.784E-03	CYP19A1, CYP1A2, CYP3A4
MF	GO:0003824; catalytic activity	GO:0070576; vitamin D 24-hydroxylase activity	3.712E-06	1.972E-03	CYP1A1, CYP3A4
CC	GO:0016020; membrane	GO:0005789; endoplasmic reticulum membrane	4.558E-06	2.279E-03	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, HSD17B2, NOX4
MF	GO:0005488; binding	GO:0051879; Hsp90 protein binding	6.226E-06	2.658E-03	AHR, CSNK2A1, HIF1A
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	7.420E-06	2.992E-03	CYP1A1, CYP1A2
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	7.420E-06	2.992E-03	CYP1A2, CYP3A4
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	8.935E-06	3.413E-03	CA12, CA4, CA7
BP	GO:0050896; response to stimulus	GO:0014070; response to organic cyclic compound	1.081E-05	4.058E-03	CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FLT3, NOX4, TYR
MF	GO:0003824; catalytic activity	GO:0101020; estrogen 16-alpha-hydroxylase activity	1.236E-05	4.411E-03	CYP1A1, CYP3A4
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.648E-05	5.695E-03	CA12, CA4, CA7
BP	GO:0008152; metabolic process	GO:0002933; lipid hydroxylation	1.852E-05	6.302E-03	CYP1A1, CYP3A4
BP	GO:0008152; metabolic process	GO:0009820; alkaloid metabolic process	2.591E-05	8.472E-03	CYP1A2, CYP3A4

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1.955E-13	1.818E-11	HSD17B1, CYP1A2, HSD17B2, CYP1A1, CYP1B1, CYP3A4, CYP19A1
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	2.028E-09	9.428E-08	HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	2.553E-08	7.913E-07	CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.137E-06	2.114E-05	CYP1A2, CYP1A1, CYP1B1, CYP3A4
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	1.112E-05	1.477E-04	CYP1A2, CYP1A1, CYP1B1
Unclassified	Unclassified	hsa01100	Metabolic pathways	3.100E-05	3.603E-04	HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP2C19, CYP3A4, TYR, CYP19A1
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	4.143E-06	6.422E-05	CYP1A2, CYP3A4, CYP2C19
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	7.777E-07	1.808E-05	CA12, CA4, CA7
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	5.287E-05	4.882E-04	MAP2K1, FLT3, HIF1A
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	4.828E-05	4.882E-04	CYP1A2, CYP1A1, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	5.774E-05	4.882E-04	CYP1A2, CYP3A4, CYP2C19

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
J00-J99: Diseases of the respiratory system	Airway inflammation	J00-J99	FLT3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE;
I00-I99: Diseases of the circulatory system	Aortic aneurysm	I71	MMP12;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE;
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE;
C00-D49: Neoplasms	Multiple myeloma	C90	AHR;
C00-D49: Neoplasms	AML	NA	FLT3;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ACHE;
J00-J99: Diseases of the respiratory system	Asthma	J45	MMP12;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	FLT3;
C00-D49: Neoplasms	Advanced breast cancer	C50	CYP19A1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE;
C00-D49: Neoplasms	Leukemia	C90-C95	FLT3;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	MMP12;
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE;
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE;
C00-D49: Neoplasms	Melanoma	C43	TYR;
L00-L99: Diseases of the skin and subcutaneous tissue	Melasma	L81.1	TYR;
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	FLT3;
C00-D49: Neoplasms	Colon cancer	C50	FLT3;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	FLT3;
N00-N99: Diseases of the genitourinary system	Prostate disease	N42.9	CYP19A1;
C00-D49: Neoplasms	Prostate cancer	C61	FLT3;
L00-L99: Diseases of the skin and subcutaneous tissue	Vitiligo	L80	TYR;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	FLT3;
I00-I99: Diseases of the circulatory system	Pulmonary arterial hypertension	I27.0, I27.2	HIF1A;
C00-D49: Neoplasms	Hormonally-responsive breast cancer	C50	CYP19A1;
NA: NA	Anaplastic mixed oligoastrocytoma	NA	FLT3;
C00-D49: Neoplasms	Cancer	C00-C96	CSNK2A1; FLT3; ACHE; HIF1A;
C00-D49: Neoplasms	Breast cancer	C50	FLT3; CYP19A1;
C00-D49: Neoplasms	Solid tumours	C00-D48	FLT3; HIF1A;
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	CYP19A1;
C00-D49: Neoplasms	Bladder cancer	C67	CYP19A1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	TYR;
C00-D49: Neoplasms	Gliosarcoma	NA	FLT3;
C00-D49: Neoplasms	Glioblastoma	NA	FLT3;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ACHE;
NA: NA	GIST	NA	FLT3;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE;
C00-D49: Neoplasms	CLL	NA	FLT3;
C00-D49: Neoplasms	Myeloid leukemia	C92	FLT3;
C00-D49: Neoplasms	Myelofibrosis	C94.4, D47.4	FLT3;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE;
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CYP3A4; ACHE;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	MMP12;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE;
C00-D49: Neoplasms	Pancreatic cancer	C25	FLT3;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ACHE;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
NA: NA	Upper abdominal bloating	NA	ACHE;
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE;
NA: NA	Hematopoietic stem cell transplantation	NA	FLT3;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE;
C00-D49: Neoplasms	Lymphoma	C81-C86	HIF1A;
NA: NA	HIV infections	NA	AHR;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA4; ACHE;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE;
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	MMP12;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases