CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	NPSR1;
Hydrolase	ACHE;
Enzyme_unclassified	TDP1; PIK3CA; PIK3CB; ALOX12; HSD17B1; HSD17B10; NOX4; NQO2; POLB;
Protein Kinase	MET; AXL; FLT3; CDK1; PIM1; KDR; IGF1R; AURKB; CSNK2A1;
Lyase	CA2; CA12; CA9; CA14; CA7; CA4;
Nuclear hormone receptor subfamily 3 group A	ESR1; ESR2;
Lysine demethylase	KDM4E;
Oxidoreductase	PTGS2;
Transferase	FUT7;
Unclassified	LMNA; THPO;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP19A1; CYP3A4; CYP1A2; CYP1B1; CYP1A1;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	HSD17B1	Estradiol 17-beta-dehydrogenase 1	P14061	CHEMBL3181
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Enzyme_unclassified	NQO2	Quinone reductase 2	P16083	CHEMBL3959

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Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	2.561E-10	8.303E-07	CA12, CA14, CA2, CA4, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	8.084E-09	9.310E-06	CA12, CA2, CA4, CA7, CA9
BP	GO:0008152; metabolic process	GO:0008610; lipid biosynthetic process	7.834E-08	6.092E-05	ACHE, ALOX12, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD17B1, PIK3CA, PIK3CB, PTGS2
BP	GO:0009987; cellular process	GO:0051897; positive regulation of protein kinase B signaling	4.823E-07	2.188E-04	AXL, MET, NOX4, PIK3CA, PIK3CB, THPO
BP	GO:0009987; cellular process	GO:0043066; negative regulation of apoptotic process	4.923E-07	2.188E-04	ALOX12, AURKB, AXL, CDK1, CSNK2A1, IGF1R, KDR, LMNA, PIK3CA, PIM1, PTGS2
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	8.349E-07	3.135E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0046777; protein autophosphorylation	2.130E-06	6.821E-04	AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1
BP	GO:0032502; developmental process	GO:0007568; aging	5.495E-06	1.496E-03	AURKB, CDK1, CYP1A1, NOX4, POLB, PTGS2
BP	GO:0008283; cell proliferation	GO:0008284; positive regulation of cell proliferation	5.795E-06	1.558E-03	ALOX12, CDK1, CSNK2A1, ESR1, FLT3, IGF1R, KDR, PIM1, PTGS2, THPO
BP	GO:0050896; response to stimulus	GO:0033993; response to lipid	8.338E-06	2.136E-03	AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, ESR1, FLT3, PTGS2

Showing 1 to 10 of 39 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	3.789E-13	4.774E-11	CA12, CA2, CA4, CA7, CA9, CA14
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1.171E-09	4.919E-08	HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.097E-05	1.257E-04	CYP1A2, CYP1A1, CYP1B1, CYP3A4
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	5.956E-05	4.690E-04	CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2.548E-04	1.338E-03	CYP1A2, CYP1A1, CYP3A4
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.382E-03	4.246E-03	CYP1A2, CYP3A4
09130 Environmental Information Processing	09132 Signal transduction	hsa04370	VEGF signaling pathway	5.349E-06	9.627E-05	PIK3CA, KDR, PIK3CB, PTGS2
09130 Environmental Information Processing	09132 Signal transduction	hsa04015	Rap1 signaling pathway	4.712E-05	3.958E-04	PIK3CA, KDR, PIK3CB, MET, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04014	Ras signaling pathway	6.666E-05	4.941E-04	PIK3CA, KDR, PIK3CB, MET, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04630	Jak-STAT signaling pathway	2.245E-04	1.338E-03	PIK3CA, THPO, PIM1, PIK3CB

Showing 1 to 10 of 52 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Trematode infection	B66.9	ESR1;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	KDR;
C00-D49: Neoplasms	Malignant adrenal gland cancer	C74.0	IGF1R;
C00-D49: Neoplasms	Advanced prostate cancer	C61	ESR1;
C00-D49: Neoplasms	Squamous cell cancer of head and neck	NA	KDR;
C00-D49: Neoplasms	Solid tumours	C00-D48	MET; AURKB; IGF1R; PIK3CA; KDR; FLT3; PIK3CB; CA9;
C00-D49: Neoplasms	Medullary thyroid cancer	C73	KDR;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Miliusa velutina

Taxonomic Information:

Plant External Links:

Used in Medicines:

Country/Region:

Traditional Medicine System:

Geographical Distribution:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities