CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Nuclear hormone receptor subfamily 1 group C	PPARA; PPARD;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Toll-like and Il-1 receptors	TLR2;
Unclassified	HTT; FABP3; FABP2; FABP4; FABP5;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Nuclear hormone receptor subfamily 1 group C	PPARD	Peroxisome proliferator-activated receptor delta	Q03181	CHEMBL3979
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Toll-like and Il-1 receptors	TLR2	Toll-like receptor 2	O60603	CHEMBL4163
Unclassified	HTT	Huntingtin	P42858	CHEMBL5514
Unclassified	FABP3	Fatty acid binding protein muscle	P05413	CHEMBL3344
Unclassified	FABP2	Fatty acid binding protein intestinal	P12104	CHEMBL4879
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083
Unclassified	FABP5	Fatty acid binding protein epidermal	Q01469	CHEMBL3674

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0019433; triglyceride catabolic process	4.557E-10	1.654E-06	FABP2, FABP3, FABP4, FABP5
BP	GO:0051179; localization	GO:0015908; fatty acid transport	4.704E-06	4.268E-03	FABP3, PPARA, PPARD
BP	GO:0050896; response to stimulus	GO:0070542; response to fatty acid	8.039E-06	6.405E-03	FABP3, NR1H4, TLR2
BP	GO:0008152; metabolic process	GO:0071073; positive regulation of phospholipid biosynthetic process	8.667E-06	6.508E-03	FABP3, NR1H4
BP	GO:0008152; metabolic process	GO:1902894; negative regulation of pri-miRNA transcription from RNA polymerase II promoter	1.323E-05	9.006E-03	PPARA, PPARD
MF	GO:0140110; transcription regulator activity	GO:0004879; nuclear receptor activity	1.818E-06	1.885E-03	NR1H4, PPARA, PPARD
MF	GO:0060089; molecular transducer activity	GO:0003707; steroid hormone receptor activity	3.199E-06	3.029E-03	NR1H4, PPARA, PPARD
MF	GO:0005488; binding	GO:0036041; long-chain fatty acid binding	1.323E-05	9.006E-03	FABP3, PPARD

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	4.206E-03	4.627E-02	PPARA, TSHR
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	2.804E-13	9.252E-12	FABP2, FABP3, FABP4, FABP5, PPARA, PPARD
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	3.416E-04	5.636E-03	FABP4, TSHR
09150 Organismal Systems	09154 Digestive system	hsa04975	Fat digestion and absorption	2.032E-02	9.117E-02	FABP2
09150 Organismal Systems	09152 Endocrine system	hsa04918	Thyroid hormone synthesis	3.495E-02	9.117E-02	TSHR
09160 Human Diseases	09167 Infectious diseases	hsa05144	Malaria	2.424E-02	9.117E-02	TLR2
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	2.814E-02	9.117E-02	PPARD
09160 Human Diseases	09162 Immune diseases	hsa05320	Autoimmune thyroid disease	2.619E-02	9.117E-02	TSHR
09160 Human Diseases	09167 Infectious diseases	hsa05134	Legionellosis	2.717E-02	9.117E-02	TLR2
09160 Human Diseases	09167 Infectious diseases	hsa05140	Leishmaniasis	3.591E-02	9.117E-02	TLR2

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
No data available in table

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Clematis manshurica

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities