Plant Name: Clematis manshurica
Taxonomic Information:
Plant ID: NPO9693
Plant Latin Name: Clematis manshurica
Taxonomy Genus: Clematis
Taxonomy Family: Ranunculaceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| TSHR; | |
| PPARA; PPARD; | |
| NR1H4; | |
| TLR2; | |
| HTT; FABP3; FABP2; FABP4; FABP5; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Nuclear hormone receptor subfamily 1 group C | PPARA | Peroxisome proliferator-activated receptor alpha | Q07869 | CHEMBL239 |
| Nuclear hormone receptor subfamily 1 group C | PPARD | Peroxisome proliferator-activated receptor delta | Q03181 | CHEMBL3979 |
| Nuclear hormone receptor subfamily 1 group H | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
| Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
| Toll-like and Il-1 receptors | TLR2 | Toll-like receptor 2 | O60603 | CHEMBL4163 |
| Unclassified | HTT | Huntingtin | P42858 | CHEMBL5514 |
| Unclassified | FABP3 | Fatty acid binding protein muscle | P05413 | CHEMBL3344 |
| Unclassified | FABP2 | Fatty acid binding protein intestinal | P12104 | CHEMBL4879 |
| Unclassified | FABP4 | Fatty acid binding protein adipocyte | P15090 | CHEMBL2083 |
| Unclassified | FABP5 | Fatty acid binding protein epidermal | Q01469 | CHEMBL3674 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0019433; triglyceride catabolic process | 4.557E-10 | 1.654E-06 | FABP2, FABP3, FABP4, FABP5 |
| MF | GO:0140110; transcription regulator activity | GO:0004879; nuclear receptor activity | 1.818E-06 | 1.885E-03 | NR1H4, PPARA, PPARD |
| MF | GO:0060089; molecular transducer activity | GO:0003707; steroid hormone receptor activity | 3.199E-06 | 3.029E-03 | NR1H4, PPARA, PPARD |
| BP | GO:0051179; localization | GO:0015908; fatty acid transport | 4.704E-06 | 4.268E-03 | FABP3, PPARA, PPARD |
| BP | GO:0050896; response to stimulus | GO:0070542; response to fatty acid | 8.039E-06 | 6.405E-03 | FABP3, NR1H4, TLR2 |
| BP | GO:0008152; metabolic process | GO:0071073; positive regulation of phospholipid biosynthetic process | 8.667E-06 | 6.508E-03 | FABP3, NR1H4 |
| BP | GO:0008152; metabolic process | GO:1902894; negative regulation of pri-miRNA transcription from RNA polymerase II promoter | 1.323E-05 | 9.006E-03 | PPARA, PPARD |
| MF | GO:0005488; binding | GO:0036041; long-chain fatty acid binding | 1.323E-05 | 9.006E-03 | FABP3, PPARD |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09150 Organismal Systems | 09152 Endocrine system | hsa03320 | PPAR signaling pathway | 2.804E-13 | 9.252E-12 | FABP2, FABP3, FABP4, FABP5, PPARA, PPARD |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04923 | Regulation of lipolysis in adipocytes | 3.416E-04 | 5.636E-03 | FABP4, TSHR |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04024 | cAMP signaling pathway | 4.206E-03 | 4.627E-02 | PPARA, TSHR |
| 09150 Organismal Systems | 09154 Digestive system | hsa04975 | Fat digestion and absorption | 2.032E-02 | 9.117E-02 | FABP2 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05144 | Malaria | 2.424E-02 | 9.117E-02 | TLR2 |
| 09160 Human Diseases | 09161 Cancers | hsa05221 | Acute myeloid leukemia | 2.814E-02 | 9.117E-02 | PPARD |
| 09160 Human Diseases | 09162 Immune diseases | hsa05320 | Autoimmune thyroid disease | 2.619E-02 | 9.117E-02 | TSHR |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05134 | Legionellosis | 2.717E-02 | 9.117E-02 | TLR2 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04918 | Thyroid hormone synthesis | 3.495E-02 | 9.117E-02 | TSHR |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05140 | Leishmaniasis | 3.591E-02 | 9.117E-02 | TLR2 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
