CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR; NMUR2;
Small molecule receptor (family A GPCR)	ADRA2C; ADRA2A;
Protein Phosphatase	PTPN1;
Hydrolase	GAA; ACHE;
Enzyme_unclassified	TDP1; HKDC1; HPGD; AKR1B1; GFER; HSD17B10; ALOX15; AKR1B10; ALDH1A1; USP2; POLB;
Protein Kinase	MAPK1;
Lyase	CA2; CA1; CA12; CA9; CA13; CA7; CA3; CA14; CA5B; CA5A; CA6;
Cysteine protease	CASP1; CASP7;
Metallo protease	MMP9; MMP1; MMP2;
Transcription Factor	HIF1A; NFKB1;
Unclassified	LMNA; MAPT;
Oxidoreductase	XDH;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cysteine protease	CASP1	Caspase-1	P29466	CHEMBL4801
Cysteine protease	CASP7	Caspase-7	P55210	CHEMBL3468
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	HKDC1	Putative hexokinase HKDC1	Q2TB90	CHEMBL1741200
Enzyme_unclassified	HPGD	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428	CHEMBL1293255
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Enzyme_unclassified	GFER	FAD-linked sulfhydryl oxidase ALR	P55789	CHEMBL1741189
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903

Showing 1 to 10 of 41 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0033554; cellular response to stress	9.845E-06	7.499E-03	AKR1B1, ALOX15, CA2, CA9, HIF1A, LMNA, MAPK1, MAPT, MMP9, NFKB1, POLB, PTPN1, TDP1
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	1.317E-05	8.399E-03	CA2, CA7
BP	GO:0008283; cell proliferation	GO:1904707; positive regulation of vascular smooth muscle cell proliferation	1.329E-05	8.399E-03	HPGD, MMP2, MMP9
BP	GO:0008152; metabolic process	GO:0055114; oxidation-reduction process	1.350E-05	8.399E-03	AKR1B1, AKR1B10, ALDH1A1, ALOX15, CYP1A2, GAA, GFER, HPGD, HSD17B10, XDH
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	6.626E-21	7.214E-17	CA1, CA12, CA13, CA14, CA2, CA3, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.380E-19	6.010E-16	CA1, CA12, CA13, CA2, CA3, CA5A, CA5B, CA6, CA7, CA9
CC	GO:0044464; cell part	GO:0032838; plasma membrane bounded cell projection cytoplasm	1.215E-05	8.399E-03	AKR1B1, HIF1A, MAPK1, MAPT
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	4.438E-05	1.823E-02	ADRA2A, CA2, CA9, HPGD, TSHR
MF	GO:0005488; binding	GO:0008270; zinc ion binding	5.990E-10	1.186E-06	CA1, CA12, CA13, CA2, CA3, CA5A, CA5B, CA6, CA7, CA9, MMP1, MMP2, MMP9, PTPN1
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	1.229E-27	2.676E-23	CA1, CA12, CA13, CA14, CA2, CA3, CA5A, CA5B, CA6, CA7, CA9

Showing 1 to 10 of 13 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	7.579E-27	1.122E-24	CA12, CA1, CA3, CA5B, CA2, CA5A, CA7, CA6, CA9, CA14, CA13
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	4.007E-07	2.965E-05	AKR1B10, GAA, HKDC1, AKR1B1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	3.806E-05	1.007E-03	AKR1B10, HKDC1, AKR1B1
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	4.084E-05	1.007E-03	CYP1A2, XDH
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	5.803E-05	1.227E-03	HKDC1, MAPK1, HIF1A, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04668	TNF signaling pathway	7.499E-05	1.387E-03	CASP7, MAPK1, MMP9, NFKB1
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	1.905E-04	2.621E-03	CASP7, LMNA, MAPK1, NFKB1
09150 Organismal Systems	09151 Immune system	hsa04621	NOD-like receptor signaling pathway	2.167E-04	2.672E-03	CASP1, MAPK1, NFKB1
09150 Organismal Systems	09152 Endocrine system	hsa04915	Estrogen signaling pathway	1.094E-03	8.996E-03	MMP2, MAPK1, MMP9
09160 Human Diseases	09161 Cancers	hsa05219	Bladder cancer	1.457E-06	7.187E-05	MMP1, MMP2, MAPK1, MMP9

Showing 1 to 10 of 19 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
C00-D49: Neoplasms	Renal cancer	C64	CA9;
C00-D49: Neoplasms	Renal cell carcinoma	NA	MMP2;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	MMP2;
C00-D49: Neoplasms	Pancreatic cancer	C25	MMP2;
C00-D49: Neoplasms	Cancer	C00-C96	NFKB1; ACHE; MMP9; MMP2; CA9;
C00-D49: Neoplasms	Solid tumours	C00-D48	MMP9; MMP2; CA9;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9;

Showing 1 to 10 of 44 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Fraxinus szaboana

Taxonomic Information:

Plant External Links:

Used in Medicines:

Country/Region:

Traditional Medicine System:

Geographical Distribution:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities