CMAUP Plant Collective Molecular Activities

Plant Name: Zanthoxylum nitidum

Taxonomic Information:

Plant ID: NPO9650
Plant Latin Name: Zanthoxylum nitidum
Taxonomy Genus: Zanthoxylum
Taxonomy Family: Rutaceae

Plant External Links:

NCBI TaxonomyDB: 354528
Plant-of-the-World-Online: 775896-1

Used in Medicines:

Country/Region:

Thailand; China; India

Traditional Medicine System:

Indian Folk; TCM

Medicinal Functions:

Anodyne; Antiphlogistic; Antirheumatic; Carminative; Depurative; Stimulant; Tonic

Geographical Distribution:

Australia; Bangladesh; Myanmar; India; Cambodia; Vietnam; China; Laos; Thailand; Taiwan

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Lyase	CA12; CA9;
Nuclear hormone receptor subfamily 1 group C	PPARA;
Enzyme_unclassified	GFER;
Unclassified	FABP4; THPO; LMNA; FABP5;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1; CYP1A1; CYP1A2; CYP2D6; CYP3A4;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	GFER	FAD-linked sulfhydryl oxidase ALR	P55789	CHEMBL1741189
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083
Unclassified	THPO	Thrombopoietin	P40225	CHEMBL1293256
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	FABP5	Fatty acid binding protein epidermal	Q01469	CHEMBL3674

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	1.922E-12	4.086E-08	CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4
MF	GO:0005488; binding	GO:0019825; oxygen binding	6.924E-11	5.026E-07	CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	4.757E-09	2.072E-05	CYP1A2, CYP2D6, CYP3A4
MF	GO:0005488; binding	GO:0020037; heme binding	1.457E-08	3.173E-05	CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	2.850E-08	5.072E-05	CYP1A1, CYP1A2, CYP1B1
MF	GO:0005488; binding	GO:0005506; iron ion binding	4.468E-08	5.723E-05	CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	5.221E-08	6.301E-05	CYP1A2, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	3.145E-07	3.113E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	4.185E-07	3.505E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0009822; alkaloid catabolic process	1.254E-06	8.274E-04	CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0070576; vitamin D 24-hydroxylase activity	1.254E-06	8.274E-04	CYP1A1, CYP3A4
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	2.507E-06	1.475E-03	CYP1A1, CYP1A2
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	2.507E-06	1.475E-03	CYP1A2, CYP3A4
MF	GO:0003824; catalytic activity	GO:0101020; estrogen 16-alpha-hydroxylase activity	4.177E-06	2.218E-03	CYP1A1, CYP3A4
BP	GO:0008152; metabolic process	GO:0002933; lipid hydroxylation	6.262E-06	3.247E-03	CYP1A1, CYP3A4
BP	GO:0008152; metabolic process	GO:0009804; coumarin metabolic process	8.764E-06	4.337E-03	CYP1A1, CYP2D6
BP	GO:0008152; metabolic process	GO:0050665; hydrogen peroxide biosynthetic process	1.168E-05	5.529E-03	CYP1A1, CYP1A2

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	7.090E-10	2.127E-08	CYP2D6, CYP1A2, CYP1A1, CYP1B1, CYP3A4
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	4.464E-08	6.696E-07	CYP1A2, CYP1A1, CYP1B1, CYP3A4
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.824E-07	1.824E-06	CYP1A2, CYP1A1, CYP1B1, CYP3A4
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	2.090E-06	1.568E-05	CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	9.155E-06	4.699E-05	CYP1A2, CYP1A1, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.097E-05	4.699E-05	CYP2D6, CYP1A2, CYP3A4
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	1.097E-05	4.699E-05	FABP4, FABP5, PPARA
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	4.694E-04	1.408E-03	CYP1A1, CYP1B1
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.568E-04	5.226E-04	CYP1A2, CYP3A4
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	5.275E-05	1.978E-04	CA12, CA9
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	3.246E-03	8.853E-03	CYP1A2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CYP3A4;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	CYP2D6;
C00-D49: Neoplasms	Solid tumours	C00-D48	CA9;
C00-D49: Neoplasms	Breast cancer	C50	CA9;
C00-D49: Neoplasms	Renal cancer	C64	CA9;
C00-D49: Neoplasms	Cancer	C00-C96	CA9;
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CYP2D6;
G00-G99: Diseases of the nervous system G00-G99	Migraine	G43	CYP2D6;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases