CMAUP Plant Collective Molecular Activities

Plant Name: Bauhinia racemosa

Taxonomic Information:

Plant ID: NPO9537
Plant Latin Name: Bauhinia racemosa
Taxonomy Genus: Bauhinia
Taxonomy Family: Fabaceae

Plant External Links:

NCBI TaxonomyDB: 1227988
Plant-of-the-World-Online: 481612-1

Used in Medicines:

Country/Region:

China; India

Traditional Medicine System:

TCM; Unani; Ayurveda; Siddha

Geographical Distribution:

Mauritania; Bangladesh; Myanmar; Pakistan; Tanzania; India; Cambodia; Vietnam; China; Uganda; Sri Lanka; Thailand; Iraq; Sierra Leone

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	ALPL; HSD17B10; ALDH1A1;
Hydrolase	GAA;
Protein Kinase	MAPK1;
Lyase	CA2; CA13; CA1; CA7; CA4; CA6; CA12; CA9; CA14;
Transcription Factor	NFKB1;
Unclassified	MAPT; RAB9A; NPC1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P05186	CHEMBL5979
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA13	Carbonic anhydrase XIII	Q8N1Q1	CHEMBL3912
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0008270; zinc ion binding	2.860E-07	4.449E-04	CA1, CA12, CA13, CA2, CA4, CA6, CA7, CA9
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	2.357E-25	5.133E-21	CA1, CA12, CA13, CA14, CA2, CA4, CA6, CA7, CA9
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	2.459E-06	3.150E-03	CA2, CA7
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	3.299E-20	3.592E-16	CA1, CA12, CA13, CA14, CA2, CA4, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	2.724E-18	1.483E-14	CA1, CA12, CA13, CA2, CA4, CA6, CA7, CA9
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	1.228E-05	1.337E-02	CA1, CA2
BP	GO:0050896; response to stimulus	GO:0014070; response to organic cyclic compound	3.506E-05	3.636E-02	ALPL, CA2, CA9, MAPK1, NFKB1, NPC1
BP	GO:0051179; localization	GO:2001225; regulation of chloride transport	3.675E-05	3.637E-02	CA2, CA7

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	8.365E-25	9.787E-23	CA12, CA1, CA2, CA4, CA7, CA6, CA9, CA14, CA13
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05010	Alzheimer's disease	4.330E-04	1.689E-02	MAPK1, MAPT, HSD17B10
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1.914E-04	1.120E-02	CA2, CA4
09160 Human Diseases	09161 Cancers	hsa05212	Pancreatic cancer	1.586E-03	1.838E-02	MAPK1, NFKB1
09150 Organismal Systems	09152 Endocrine system	hsa04917	Prolactin signaling pathway	1.884E-03	1.838E-02	MAPK1, NFKB1
09150 Organismal Systems	09151 Immune system	hsa04662	B cell receptor signaling pathway	1.936E-03	1.838E-02	MAPK1, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05131	Shigellosis	1.539E-03	1.838E-02	MAPK1, NFKB1
09160 Human Diseases	09161 Cancers	hsa05220	Chronic myeloid leukemia	1.936E-03	1.838E-02	MAPK1, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05140	Leishmaniasis	1.936E-03	1.838E-02	MAPK1, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05133	Pertussis	2.042E-03	1.838E-02	MAPK1, NFKB1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities	Genetic disease	Q00-Q99	ALPL;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2;
A00-B99: Certain infectious and parasitic diseases	Anthelmintic	B89	ALPL;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1;
NA: NA	Edema	NA	CA2;
C00-D49: Neoplasms	Colon cancer	C50	ALPL;
C00-D49: Neoplasms	Cancer	C00-C96	NFKB1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases