CMAUP Plant Collective Molecular Activities

Plant Name: Morus mongolica

Taxonomic Information:

Plant ID: NPO9402
Plant Latin Name: Morus mongolica
Taxonomy Genus: Morus
Taxonomy Family: Moraceae

Plant External Links:

NCBI TaxonomyDB: 229049
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Medicinal Functions:

Miscellany

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Protein Phosphatase	PTPN1;
Hydrolase	BCHE; ACHE;
Enzyme_unclassified	RECQL; GFER; HSD17B10; ALDH1A1;
Protein Kinase	MAPK1;
Lyase	CA7; CA12; CA9;
Oxidoreductase	PTGS1;
Cysteine protease	CASP7; CASP1;
Aspartic protease	BACE1;
Unclassified	MAPT;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Aspartic protease	BACE1	Beta-secretase 1	P56817	CHEMBL4822
Cysteine protease	CASP7	Caspase-7	P55210	CHEMBL3468
Cysteine protease	CASP1	Caspase-1	P29466	CHEMBL4801
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	GFER	FAD-linked sulfhydryl oxidase ALR	P55789	CHEMBL1741189
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Hydrolase	BCHE	Butyrylcholinesterase	P06276	CHEMBL1914
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Oxidoreductase	PTGS1	Cyclooxygenase-1	P23219	CHEMBL221
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Protein Phosphatase	PTPN1	Protein-tyrosine phosphatase 1B	P18031	CHEMBL335
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0003824; catalytic activity	7.407E-08	1.613E-03	ACHE, ALDH1A1, BACE1, BCHE, CA12, CA7, CA9, CASP1, CASP7, CYP1A2, GFER, HSD17B10, MAPK1, PTGS1, PTPN1, RECQL
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	2.559E-07	2.787E-03	CA12, CA7, CA9
MF	GO:0003824; catalytic activity	GO:0003990; acetylcholinesterase activity	7.290E-07	5.292E-03	ACHE, BCHE
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	3.971E-06	1.467E-02	CA12, CA7, CA9
BP	GO:0023052; signaling	GO:0050804; modulation of chemical synaptic transmission	4.717E-06	1.467E-02	ACHE, BACE1, BCHE, CA7, MAPK1
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	7.333E-06	1.996E-02	CA12, CA7, CA9
BP	GO:0008152; metabolic process	GO:0009820; alkaloid metabolic process	1.527E-05	3.067E-02	BCHE, CYP1A2
BP	GO:0008152; metabolic process	GO:0008152; metabolic process	1.549E-05	3.067E-02	ACHE, ALDH1A1, BACE1, BCHE, CA12, CA7, CA9, CASP1, CASP7, CYP1A2, GFER, HSD17B10, MAPK1, MAPT, PTGS1, PTPN1, RECQL
MF	GO:0005488; binding	GO:0001540; amyloid-beta binding	1.878E-05	3.409E-02	ACHE, BACE1, BCHE

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05010	Alzheimer's disease	2.247E-07	1.808E-05	BACE1, CASP7, MAPK1, MAPT, HSD17B10
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	3.443E-07	1.808E-05	CA12, CA7, CA9
09160 Human Diseases	09167 Infectious diseases	hsa05133	Pertussis	3.316E-05	1.161E-03	CASP7, CASP1, MAPK1
09160 Human Diseases	09167 Infectious diseases	hsa05134	Legionellosis	9.834E-04	2.217E-02	CASP7, CASP1
09150 Organismal Systems	09151 Immune system	hsa04621	NOD-like receptor signaling pathway	1.056E-03	2.217E-02	CASP1, MAPK1
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.371E-03	2.399E-02	CYP1A2, ALDH1A1
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	1.772E-03	2.658E-02	PTPN1, MAPK1
09150 Organismal Systems	09156 Nervous system	hsa04725	Cholinergic synapse	3.932E-03	3.713E-02	ACHE, MAPK1
09160 Human Diseases	09167 Infectious diseases	hsa05132	Salmonella infection	2.383E-03	3.128E-02	CASP1, MAPK1
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	4.001E-03	3.713E-02	MAPK1, PTGS1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Solid tumours	C00-D48	CA9;
C00-D49: Neoplasms	Cancer	C00-C96	CA9;
C00-D49: Neoplasms	Renal cancer	C64	CA9;
C00-D49: Neoplasms	Breast cancer	C50	CA9;
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases