CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	FFAR1; FFAR4; GPBAR1;
Nuclear hormone receptor subfamily 1 group C	PPARA; PPARD; PPARG;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Enzyme_unclassified	ALOX15; HPGD; AKR1B10;
Unclassified	FABP3; LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	HPGD	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428	CHEMBL1293255
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Nuclear hormone receptor subfamily 1 group C	PPARD	Peroxisome proliferator-activated receptor delta	Q03181	CHEMBL3979
Nuclear hormone receptor subfamily 1 group C	PPARG	Peroxisome proliferator-activated receptor gamma	P37231	CHEMBL235
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Small molecule receptor (family A GPCR)	FFAR1	Free fatty acid receptor 1	O14842	CHEMBL4422
Small molecule receptor (family A GPCR)	FFAR4	G-protein coupled receptor 120	Q5NUL3	CHEMBL5339
Small molecule receptor (family A GPCR)	GPBAR1	G-protein coupled bile acid receptor 1	Q8TDU6	CHEMBL5409

Showing 1 to 10 of 12 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0050896; response to stimulus	GO:0050728; negative regulation of inflammatory response	5.250E-09	2.286E-05	FFAR4, NR1H4, PPARA, PPARD, PPARG
BP	GO:0051179; localization	GO:0015908; fatty acid transport	6.408E-08	9.966E-05	FABP3, PPARA, PPARD, PPARG
BP	GO:0050896; response to stimulus	GO:0070542; response to fatty acid	1.317E-07	1.593E-04	FABP3, FFAR1, NR1H4, PPARG
BP	GO:0009987; cellular process	GO:0043401; steroid hormone mediated signaling pathway	9.299E-07	5.956E-04	NR1H4, PPARA, PPARD, PPARG
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	1.061E-06	6.418E-04	GPBAR1, NR1H4
BP	GO:0008152; metabolic process	GO:0006367; transcription initiation from RNA polymerase II promoter	2.131E-06	1.160E-03	NR1H4, PPARA, PPARD, PPARG
BP	GO:0009987; cellular process	GO:0030522; intracellular receptor signaling pathway	3.045E-06	1.507E-03	NR1H4, PPARA, PPARD, PPARG
BP	GO:0051179; localization	GO:0010891; negative regulation of sequestering of triglyceride	3.534E-06	1.673E-03	PPARA, PPARG
BP	GO:0051179; localization	GO:0010887; negative regulation of cholesterol storage	5.300E-06	2.308E-03	PPARA, PPARG
BP	GO:0008152; metabolic process	GO:0010871; negative regulation of receptor biosynthetic process	5.300E-06	2.308E-03	PPARA, PPARG

Showing 1 to 10 of 25 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.727E-02	8.529E-02	ALOX15
09100 Metabolism	09101 Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	2.139E-02	8.529E-02	AKR1B10
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	1.786E-02	8.529E-02	AKR1B10
09100 Metabolism	09101 Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1.904E-02	8.529E-02	AKR1B10
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	6.289E-08	1.887E-06	FABP3, PPARG, PPARA, PPARD
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	5.010E-03	7.516E-02	HPGD, PPARG
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	2.274E-02	8.529E-02	PPARG, PPARD
09160 Human Diseases	09161 Cancers	hsa05216	Thyroid cancer	1.727E-02	8.529E-02	PPARG
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	3.368E-02	9.163E-02	PPARD
09160 Human Diseases	09165 Cardiovascular diseases	hsa05414	Dilated cardiomyopathy	5.270E-02	9.163E-02	LMNA

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	FFAR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	FFAR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	FFAR1;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Cuphea infundibulum

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities