CMAUP Plant Collective Molecular Activities

Plant Name: Stephania delavayi

Taxonomic Information:

Plant ID: NPO9266
Plant Latin Name: Stephania delavayi
Taxonomy Genus: Stephania
Taxonomy Family: Menispermaceae

Plant External Links:

NCBI TaxonomyDB: 216145
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	DRD5; DRD3; DRD4; DRD1; DRD2;
Enzyme_unclassified	TDP1; USP2;
Unclassified	MAPT; F3; NPC1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	USP2	Ubiquitin carboxyl-terminal hydrolase 2	O75604	CHEMBL1293227
Small molecule receptor (family A GPCR)	DRD5	Dopamine D5 receptor	P21918	CHEMBL1850
Small molecule receptor (family A GPCR)	DRD3	Dopamine D3 receptor	P35462	CHEMBL234
Small molecule receptor (family A GPCR)	DRD4	Dopamine D4 receptor	P21917	CHEMBL219
Small molecule receptor (family A GPCR)	DRD1	Dopamine D1 receptor	P21728	CHEMBL2056
Small molecule receptor (family A GPCR)	DRD2	Dopamine D2 receptor	P14416	CHEMBL217
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	F3	Coagulation factor III	P13726	CHEMBL4081
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0035240; dopamine binding	1.446E-14	1.574E-10	DRD1, DRD2, DRD3, DRD4, DRD5
BP	GO:0050896; response to stimulus	GO:0001975; response to amphetamine	7.368E-13	4.011E-09	DRD1, DRD2, DRD3, DRD4, DRD5
BP	GO:0007610; behavior	GO:0048148; behavioral response to cocaine	1.748E-10	2.378E-07	DRD1, DRD2, DRD3, DRD4
MF	GO:0060089; molecular transducer activity	GO:0001591; dopamine neurotransmitter receptor activity, coupled via Gi/Go	5.588E-09	3.955E-06	DRD2, DRD3, DRD4
BP	GO:0009987; cellular process	GO:0007191; adenylate cyclase-activating dopamine receptor signaling pathway	1.197E-08	7.664E-06	DRD1, DRD3, DRD5
BP	GO:0009987; cellular process	GO:0007195; adenylate cyclase-inhibiting dopamine receptor signaling pathway	1.197E-08	7.664E-06	DRD2, DRD3, DRD4
BP	GO:0050896; response to stimulus	GO:0034776; response to histamine	1.645E-08	1.023E-05	DRD2, DRD3, DRD4
BP	GO:0050896; response to stimulus	GO:0060134; prepulse inhibition	2.850E-08	1.551E-05	DRD1, DRD2, DRD3
BP	GO:0009987; cellular process	GO:0060158; phospholipase C-activating dopamine receptor signaling pathway	2.850E-08	1.551E-05	DRD1, DRD2, DRD5
BP	GO:0051179; localization	GO:0050482; arachidonic acid secretion	1.760E-07	6.843E-05	DRD2, DRD3, DRD4
BP	GO:0007610; behavior	GO:0046960; sensitization	2.412E-07	8.903E-05	DRD1, DRD5
BP	GO:0007610; behavior	GO:0007628; adult walking behavior	2.904E-07	1.036E-04	DRD1, DRD2, NPC1
BP	GO:0065007; biological regulation	GO:0007194; negative regulation of adenylate cyclase activity	4.917E-07	1.530E-04	DRD2, DRD3, DRD4
CC	GO:0043226; organelle	GO:0097730; non-motile cilium	4.917E-07	1.530E-04	DRD1, DRD2, DRD5
BP	GO:0065007; biological regulation	GO:0006874; cellular calcium ion homeostasis	6.757E-07	1.967E-04	DRD1, DRD2, DRD3, DRD4, DRD5
BP	GO:0009987; cellular process	GO:0060160; negative regulation of dopamine receptor signaling pathway	7.235E-07	1.994E-04	DRD2, DRD3
BP	GO:0023052; signaling	GO:0051586; positive regulation of dopamine uptake involved in synaptic transmission	7.235E-07	1.994E-04	DRD2, DRD4
BP	GO:0065007; biological regulation	GO:0045776; negative regulation of blood pressure	1.135E-06	2.841E-04	DRD2, DRD3, DRD5
MF	GO:0060089; molecular transducer activity	GO:0001588; dopamine neurotransmitter receptor activity, coupled via Gs	1.447E-06	3.424E-04	DRD1, DRD5
BP	GO:0007610; behavior	GO:0008542; visual learning	1.707E-06	3.832E-04	DRD1, DRD2, DRD3
MF	Unclassified;	GO:0004872; receptor activity	2.088E-06	4.503E-04	DRD1, DRD2, DRD3, DRD4, DRD5, F3, NPC1
BP	Unclassified;	GO:0021853; cerebral cortex GABAergic interneuron migration	2.410E-06	4.884E-04	DRD1, DRD2
BP	GO:0040011; locomotion	GO:0090325; regulation of locomotion involved in locomotory behavior	2.410E-06	4.884E-04	DRD2, DRD3
BP	GO:0032501; multicellular organismal process	GO:0032922; circadian regulation of gene expression	2.585E-06	5.124E-04	DRD2, DRD3, USP2
BP	Unclassified;	GO:0032415; regulation of sodium:proton antiporter activity	3.614E-06	6.636E-04	DRD3, DRD4
CC	GO:0044422; organelle part	GO:0060170; ciliary membrane	8.983E-06	1.377E-03	DRD1, DRD2, DRD5
BP	GO:0032501; multicellular organismal process	GO:0030432; peristalsis	1.083E-05	1.562E-03	DRD1, DRD2
BP	GO:0009987; cellular process	GO:0002031; G-protein coupled receptor internalization	1.323E-05	1.836E-03	DRD2, DRD3
BP	GO:0032502; developmental process	GO:0021756; striatum development	1.323E-05	1.836E-03	DRD1, DRD2
BP	GO:0007610; behavior	GO:0007625; grooming behavior	1.588E-05	2.161E-03	DRD1, DRD2
BP	GO:0007610; behavior	GO:0007613; memory	1.822E-05	2.464E-03	DRD1, DRD2, MAPT
BP	GO:0032501; multicellular organismal process	GO:0035815; positive regulation of renal sodium excretion	1.876E-05	2.521E-03	DRD2, DRD3
BP	GO:0007610; behavior	GO:0048149; behavioral response to ethanol	2.188E-05	2.887E-03	DRD2, DRD4
CC	GO:0044425; membrane part	GO:0005887; integral component of plasma membrane	2.423E-05	3.160E-03	DRD1, DRD2, DRD3, DRD4, DRD5, NPC1
BP	GO:0009987; cellular process	GO:0050709; negative regulation of protein secretion	2.787E-05	3.590E-03	DRD2, DRD3, DRD4
BP	GO:0023052; signaling	GO:0060292; long term synaptic depression	2.884E-05	3.672E-03	DRD1, DRD5
BP	GO:0051179; localization	GO:1901386; negative regulation of voltage-gated calcium channel activity	3.267E-05	4.089E-03	DRD2, DRD4
BP	GO:0009987; cellular process	GO:0019226; transmission of nerve impulse	3.675E-05	4.521E-03	DRD1, DRD5
BP	GO:0008152; metabolic process	GO:0042053; regulation of dopamine metabolic process	4.106E-05	4.885E-03	DRD1, DRD4
BP	GO:0032501; multicellular organismal process	GO:0045187; regulation of circadian sleep/wake cycle, sleep	4.106E-05	4.885E-03	DRD2, DRD3
BP	GO:0007610; behavior	GO:0007617; mating behavior	4.106E-05	4.885E-03	DRD1, DRD5
BP	GO:0009987; cellular process	GO:0014059; regulation of dopamine secretion	9.053E-05	9.523E-03	DRD2, DRD3
CC	GO:0044464; cell part	GO:0042995; cell projection	3.530E-04	2.787E-02	DRD1, DRD2, DRD3, DRD5, MAPT

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09156 Nervous system	hsa04728	Dopaminergic synapse	2.536E-09	4.057E-08	DRD1, DRD2, DRD3, DRD4, DRD5
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	1.170E-07	9.364E-07	DRD1, DRD2, DRD3, DRD4, DRD5
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	1.106E-04	5.898E-04	DRD1, DRD2, DRD5
09160 Human Diseases	09164 Substance dependence	hsa05030	Cocaine addiction	2.613E-04	1.045E-03	DRD1, DRD2
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04540	Gap junction	8.418E-04	2.694E-03	DRD1, DRD2
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05012	Parkinson's disease	2.170E-03	5.787E-03	DRD1, DRD2
09130 Environmental Information Processing	09132 Signal transduction	hsa04020	Calcium signaling pathway	3.457E-03	6.914E-03	DRD1, DRD5
09160 Human Diseases	09164 Substance dependence	hsa05034	Alcoholism	3.419E-03	6.914E-03	DRD1, DRD2
09160 Human Diseases	09164 Substance dependence	hsa05031	Amphetamine addiction	3.301E-02	5.868E-02	DRD1
09150 Organismal Systems	09151 Immune system	hsa04610	Complement and coagulation cascades	3.881E-02	6.210E-02	F3

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	DRD1;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT;
J00-J99: Diseases of the respiratory system	Adult respiratory distress syndrome	J80	F3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Female sexual dysfunction	F52	DRD3;
K00-K95: Diseases of the digestive system	Gastric motility disorder	K22.4	DRD3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cocaine addiction	F14.2	DRD1; DRD3;
C00-D49: Neoplasms	Solid tumours	C00-D48	DRD5;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	DRD5; DRD1; DRD3;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAPT;
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	DRD1;
I00-I99: Diseases of the circulatory system	Bleeding	I74, I80-I82	F3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychiatric disorder	F01-F99	DRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychotic disorders	F20-F29	DRD1; DRD3;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	DRD1;
C00-D49: Neoplasms	Pancreatic cancer	C25	F3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	DRD1; MAPT;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Drug abuse	F10-F19	DRD3;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	DRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Dementia	F01-F07	DRD1;
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Male sexual disorders	F52	DRD3;
O00-O9A: Pregnancy, childbirth and the puerperium	Excessive bleeding following childbirth and spontaneous or elective abortion	O04	DRD1;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Emesis	R11	DRD3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Substance dependence	F10-F19	DRD1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases