Plant Name: Asclepias curassavica
Taxonomic Information:
Plant ID: NPO9165
Plant Latin Name: Asclepias curassavica
Taxonomy Genus: Asclepias
Taxonomy Family: Apocynaceae
Plant External Links:
NCBI TaxonomyDB:
52823
Plant-of-the-World-Online:
94213-1
Used in Medicines:
Country/Region:
Thailand; Indonesia; India; China; MexicoTraditional Medicine System:
TCM; Ayurveda; SiddhaGeographical Distribution:
Brazil; Bangladesh; Kenya; Guinea; Nepal; Costa Rica; Bahamas; Rwanda; Tanzania; Sri Lanka; Peru; Laos; Argentina; Bolivia; Vanuatu; Burkina Faso; Ecuador; Ghana; Vietnam; Australia; Cuba; El Salvador; Venezuela; Japan; Cape Verde; Papua New Guinea; Malawi; Suriname; Guatemala; Zimbabwe; China; Chile; Thailand; Dominican Republic; Belize; United States; Sierra Leone; Spain; Nigeria; Netherlands; Uganda; Trinidad and Tobago; Philippines; Indonesia; New Caledonia; Mauritius; Morocco; Seychelles; Gabon; Guyana; Haiti; Jamaica; Iraq; Honduras; Myanmar; Mexico; Nicaragua; Cyprus; South Africa; India; Senegal; Congo; Mozambique; Colombia; Greece; Paraguay; French Guiana; Taiwan; Fiji
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| ATP12A; | |
| MAPT; PAX8; RAB9A; NPC1; | |
| SMN1;SMN2; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Hydrolase | ATP12A | Potassium-transporting ATPase alpha chain 2 | P54707 | CHEMBL2933 |
| Methyl-lysine/arginine binding protein | SMN1;SMN2 | Survival motor neuron protein | Q16637 | CHEMBL1293232 |
| Unclassified | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
| Unclassified | PAX8 | Paired box protein Pax-8 | Q06710 | CHEMBL2362980 |
| Unclassified | RAB9A | Ras-related protein Rab-9A | P51151 | CHEMBL1293294 |
| Unclassified | NPC1 | Niemann-Pick C1 protein | O15118 | CHEMBL1293277 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0060089; molecular transducer activity | GO:0004996; thyroid-stimulating hormone receptor activity | 6.212E-04 | 7.119E-01 | PAX8 |
| CC | GO:0044464; cell part | GO:0005764; lysosome | 2.896E-03 | 8.445E-01 | NPC1, RAB9A |
| MF | GO:0005488; binding | GO:0034452; dynactin binding | 3.412E-03 | 8.846E-01 | MAPT |
| MF | GO:0005488; binding | GO:0001046; core promoter sequence-specific DNA binding | 3.429E-02 | 1.000E+00 | PAX8 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09160 Human Diseases | 09161 Cancers | hsa05216 | Thyroid cancer | 8.670E-03 | 6.789E-02 | PAX8 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04918 | Thyroid hormone synthesis | 2.111E-02 | 6.789E-02 | PAX8 |
| 09140 Cellular Processes | 09141 Transport and catabolism | hsa04142 | Lysosome | 3.634E-02 | 6.789E-02 | NPC1 |
| 09100 Metabolism | 09102 Energy metabolism | hsa00190 | Oxidative phosphorylation | 3.925E-02 | 6.789E-02 | ATP12A |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05162 | Measles | 4.012E-02 | 6.789E-02 | RAB9A |
| 09160 Human Diseases | 09163 Neurodegenerative diseases | hsa05010 | Alzheimer's disease | 4.936E-02 | 6.789E-02 | MAPT |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04010 | MAPK signaling pathway | 7.411E-02 | 8.338E-02 | MAPT |
| 09160 Human Diseases | 09161 Cancers | hsa05202 | Transcriptional misregulation in cancer | 5.281E-02 | 6.789E-02 | PAX8 |
| 09160 Human Diseases | 09161 Cancers | hsa05200 | Pathways in cancer | 1.134E-01 | 1.134E-01 | PAX8 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Cognitive disorders | F01-F07, F04, F05, R41.3 | MAPT; |
| G00-G99: Diseases of the nervous system G00-G99 | Central nervous system disease | G00-G99 | MAPT; |
| G00-G99: Diseases of the nervous system G00-G99 | Alzheimer disease | G30 | MAPT; |
| G00-G99: Diseases of the nervous system G00-G99 | Neurodegenerative disease | G30-G32 | MAPT; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
