CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	ALPL; HSD17B10;
Hydrolase	GAA;
Lyase	CA2; CA7; CA4; CA6; CA12; CA9; CA1; CA14;
Transcription Factor	NFKB1; TP53;
Unclassified	MAPT; PFKFB3; RAB9A;
Oxidoreductase	XDH;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2D6; CYP2C19; CYP2C9;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Enzyme_unclassified	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P05186	CHEMBL5979
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	1.895E-08	4.126E-05	CYP2C19, CYP2C9, CYP2D6
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	3.054E-06	4.750E-03	CA2, CA7
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	4.560E-17	4.965E-13	CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	3.199E-15	1.742E-11	CA1, CA12, CA2, CA4, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	4.561E-05	3.310E-02	CYP2C19, CYP2C9
MF	GO:0005488; binding	GO:0008270; zinc ion binding	7.638E-07	1.288E-03	CA1, CA12, CA2, CA4, CA6, CA7, CA9, TP53
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	5.565E-06	7.128E-03	CYP2C19, CYP2C9, CYP2D6
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	1.682E-21	3.664E-17	CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9
MF	GO:0005488; binding	GO:0019825; oxygen binding	1.310E-05	1.426E-02	CYP2C19, CYP2C9, CYP2D6
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	1.524E-05	1.580E-02	CA1, CA2

Showing 1 to 10 of 10 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	4.807E-21	4.518E-19	CA12, CA1, CA2, CA4, CA7, CA6, CA9, CA14
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	4.296E-05	2.019E-03	CYP2C9, CYP2D6, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	3.795E-04	5.946E-03	CYP2C9, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	1.733E-03	1.870E-02	CYP2C9, CYP2C19
09130 Environmental Information Processing	09132 Signal transduction	hsa04010	MAPK signaling pathway	1.989E-03	1.870E-02	MAPT, TP53, NFKB1
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	1.818E-04	5.578E-03	CYP2C9, CYP2D6, CYP2C19
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2.374E-04	5.578E-03	CA2, CA4
09160 Human Diseases	09167 Infectious diseases	hsa05162	Measles	3.221E-04	5.946E-03	RAB9A, TP53, NFKB1
09160 Human Diseases	09161 Cancers	hsa05212	Pancreatic cancer	1.961E-03	1.870E-02	TP53, NFKB1
Unclassified	Unclassified	hsa01100	Metabolic pathways	1.019E-03	1.368E-02	CYP2C9, GAA, ALPL, CYP2C19, HSD17B10, XDH

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Anthelmintic	B89	ALPL;
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	CYP2C9;
C00-D49: Neoplasms	Solid tumours	C00-D48	PFKFB3;
C00-D49: Neoplasms	Cancer	C00-C96	NFKB1;
C00-D49: Neoplasms	Colon cancer	C50	ALPL;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;

Showing 1 to 10 of 13 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Haemanthus amarylloides

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities