Plant Name: Kadsura coccinea
Taxonomic Information:
Plant ID: NPO912
Plant Latin Name: Kadsura coccinea
Taxonomy Genus: Kadsura
Taxonomy Family: Schisandraceae
Plant External Links:
NCBI TaxonomyDB:
124780
Plant-of-the-World-Online:
554572-1
Used in Medicines:
Unknown.
Geographical Distribution:
Thailand; Vietnam; China; Myanmar; Laos
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Unclassified | NPC1 | Niemann-Pick C1 protein | O15118 | CHEMBL1293277 |
| Unclassified | RAB9A | Ras-related protein Rab-9A | P51151 | CHEMBL1293294 |
| Unclassified | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0051179; localization | GO:0032880; regulation of protein localization | 5.824E-04 | 8.277E-01 | LMNA, MAPT, RAB9A |
| BP | GO:0009987; cellular process | GO:1990000; amyloid fibril formation | 1.656E-03 | 8.277E-01 | MAPT |
| CC | GO:0044464; cell part | GO:0005635; nuclear envelope | 4.200E-04 | 8.277E-01 | LMNA, NPC1 |
| CC | GO:0044464; cell part | GO:0005764; lysosome | 1.180E-03 | 8.277E-01 | NPC1, RAB9A |
| MF | GO:0005488; binding | GO:0034452; dynactin binding | 2.276E-03 | 8.790E-01 | MAPT |
| MF | GO:0005488; binding | GO:0005496; steroid binding | 1.769E-02 | 1.000E+00 | NPC1 |
| MF | GO:0005488; binding | GO:0031072; heat shock protein binding | 2.157E-02 | 1.000E+00 | MAPT |
| MF | GO:0005488; binding | GO:0019903; protein phosphatase binding | 2.421E-02 | 1.000E+00 | MAPT |
| MF | GO:0005215; transporter activity | GO:0005319; lipid transporter activity | 2.949E-02 | 1.000E+00 | NPC1 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 1.472E-02 | 3.695E-02 | LMNA |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05410 | Hypertrophic cardiomyopathy (HCM) | 1.650E-02 | 3.695E-02 | LMNA |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05414 | Dilated cardiomyopathy | 1.788E-02 | 3.695E-02 | LMNA |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04210 | Apoptosis | 2.771E-02 | 3.695E-02 | LMNA |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05162 | Measles | 2.693E-02 | 3.695E-02 | RAB9A |
| 09140 Cellular Processes | 09141 Transport and catabolism | hsa04142 | Lysosome | 2.438E-02 | 3.695E-02 | NPC1 |
| 09160 Human Diseases | 09163 Neurodegenerative diseases | hsa05010 | Alzheimer's disease | 3.318E-02 | 3.792E-02 | MAPT |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04010 | MAPK signaling pathway | 5.004E-02 | 5.004E-02 | MAPT |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
