CMAUP Plant Collective Molecular Activities

Plant Name: Carissa spinarum

Taxonomic Information:

Plant ID: NPO9099
Plant Latin Name: Carissa spinarum
Taxonomy Genus: Carissa
Taxonomy Family: Apocynaceae

Plant External Links:

NCBI TaxonomyDB: 429256
Plant-of-the-World-Online: 77756-1

Used in Medicines:

Country/Region:

India

Traditional Medicine System:

Geographical Distribution:

Madagascar; Bangladesh; Sudan; Guinea; Nepal; Cambodia; Malawi; Ethiopia; Rwanda; Somalia; Laos; Nigeria; Cameroon; Cote d'Ivoire; Benin; Ghana; Saudi Arabia; Australia; Thailand; Zambia; Cape Verde; Burkina Faso; Togo; Zimbabwe; China; Germany; Eritrea; Oman; Tanzania; New Caledonia; Mauritius; Sri Lanka; Vietnam; Namibia; Guinea-Bissau; Mali; Senegal; Yemen; Pakistan; Seychelles; Angola; Myanmar; Chad; Egypt; India; Botswana; Djibouti; Congo; Mozambique; Uganda; Burundi; Kenya; Comoros

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
SLC superfamily of solute carriers	SLCO1B3;
Unclassified	GLI1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
SLC superfamily of solute carriers	SLCO1B3	Solute carrier organic anion transporter family member 1B3	Q9NPD5	CHEMBL1743121
Unclassified	GLI1	Zinc finger protein GLI1	P08151	CHEMBL5461

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0032502; developmental process	GO:0060032; notochord regression	2.071E-04	1.000E+00	GLI1
BP	GO:0032502; developmental process	GO:0007418; ventral midline development	3.106E-04	1.000E+00	GLI1
BP	GO:0023052; signaling	GO:0021938; smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation	4.141E-04	1.000E+00	GLI1
BP	GO:0032502; developmental process	GO:0021696; cerebellar cortex morphogenesis	5.177E-04	1.000E+00	GLI1
BP	GO:0032501; multicellular organismal process	GO:0048546; digestive tract morphogenesis	1.656E-03	1.000E+00	GLI1
BP	GO:0032501; multicellular organismal process	GO:0009954; proximal/distal pattern formation	2.690E-03	1.000E+00	GLI1
BP	GO:0032501; multicellular organismal process	GO:0021983; pituitary gland development	2.794E-03	1.000E+00	GLI1
BP	GO:0051179; localization	GO:0043252; sodium-independent organic anion transport	2.897E-03	1.000E+00	SLCO1B3
BP	GO:0051179; localization	GO:0015721; bile acid and bile salt transport	3.104E-03	1.000E+00	SLCO1B3
BP	GO:0008152; metabolic process	GO:0045740; positive regulation of DNA replication	5.687E-03	1.000E+00	GLI1
BP	GO:0032501; multicellular organismal process	GO:0030324; lung development	7.854E-03	1.000E+00	GLI1
BP	GO:0050896; response to stimulus	GO:0009611; response to wounding	1.845E-02	1.000E+00	GLI1
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	1.917E-02	1.000E+00	SLCO1B3
MF	GO:0005215; transporter activity	GO:0015125; bile acid transmembrane transporter activity	1.863E-03	1.000E+00	SLCO1B3
MF	GO:0005215; transporter activity	GO:0015347; sodium-independent organic anion transmembrane transporter activity	2.484E-03	1.000E+00	SLCO1B3
MF	GO:0140110; transcription regulator activity	GO:0003705; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	1.022E-02	1.000E+00	GLI1
MF	GO:0005488; binding	GO:0000978; RNA polymerase II proximal promoter sequence-specific DNA binding	4.038E-02	1.000E+00	GLI1

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09160 Human Diseases	09161 Cancers	hsa05217	Basal cell carcinoma	5.493E-03	1.181E-02	GLI1
09130 Environmental Information Processing	09132 Signal transduction	hsa04340	Hedgehog signaling pathway	4.994E-03	1.181E-02	GLI1
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	7.088E-03	1.181E-02	SLCO1B3
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	1.980E-02	2.475E-02	GLI1
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	3.931E-02	3.931E-02	GLI1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases