CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	NPSR1;
Hydrolase	ACHE;
Enzyme_unclassified	RECQL; TDP1; BLM; GLO1; ALOX12; HSD17B1; CBR1; AKR1B1; HSD17B2; HSD17B10; NOX4; APEX1; POLB;
Isomerase	TOP2A;
Protein Kinase	AURKB; AXL; MET; FLT3; CDK1; PIM1; KDR; IGF1R; CSNK2A1;
Lyase	CA2; CA12; CA7; CA4;
Nuclear hormone receptor subfamily 3 group A	ESR2;
Oxidoreductase	TYR; XDH;
Metallo protease	MMP12;
Transcription Factor	AHR; HIF1A;
Unclassified	LMNA; THPO;
Methyl-lysine/arginine binding protein	L3MBTL1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP19A1; CYP2C19; CYP2C9; CYP1A2; CYP1B1; CYP1A1;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Enzyme_unclassified	APEX1	DNA-(apurinic or apyrimidinic site) lyase	P27695	CHEMBL5619
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138

Showing 1 to 10 of 44 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	1.212E-11	5.277E-08	CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	9.605E-10	1.494E-06	CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	2.195E-07	9.559E-05	CYP1A2, CYP2C19, CYP2C9
BP	GO:0009987; cellular process	GO:0070301; cellular response to hydrogen peroxide	2.625E-07	1.079E-04	AKR1B1, APEX1, AXL, CDK1, CYP1B1
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.308E-06	3.747E-04	CA12, CA2, CA4, CA7
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	2.392E-06	6.351E-04	CYP1A2, CYP2C19, CYP2C9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	2.974E-06	7.803E-04	CA12, CA2, CA4, CA7
BP	GO:0008152; metabolic process	GO:0006703; estrogen biosynthetic process	3.104E-06	7.995E-04	CYP19A1, HSD17B1, HSD17B2
BP	GO:0008283; cell proliferation	GO:0008284; positive regulation of cell proliferation	3.427E-06	8.488E-04	AKR1B1, ALOX12, CDK1, CSNK2A1, FLT3, HIF1A, IGF1R, KDR, MMP12, PIM1, THPO
BP	GO:0009987; cellular process	GO:0006286; base-excision repair, base-free sugar-phosphate removal	5.071E-06	1.104E-03	APEX1, POLB

Showing 1 to 10 of 31 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2.955E-09	1.345E-07	HSD17B1, CYP1A2, HSD17B2, CYP1A1, CYP1B1, CYP19A1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	5.479E-07	9.972E-06	CYP2C9, CBR1, CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	1.036E-05	1.346E-04	CYP2C9, CBR1, ALOX12, CYP2C19
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	4.748E-08	1.080E-06	CA12, CA2, CA4, CA7
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	9.273E-05	8.438E-04	CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	3.488E-05	3.967E-04	CYP2C9, CYP1A2, CYP2C19
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	3.945E-04	3.264E-03	CYP2C9, CYP1A2, CYP1A1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	4.703E-04	3.292E-03	CYP2C9, CYP1A2, CYP2C19
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	4.710E-05	4.763E-04	CYP1A2, XDH
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	5.775E-04	3.754E-03	CSNK2A1, MET, IGF1R

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	CYP2C9;
C00-D49: Neoplasms	Fallopian tube cancer	C57.0, D28.2	KDR;
C00-D49: Neoplasms	AML	NA	KDR; FLT3;
C00-D49: Neoplasms	Gastric cancer	C16	KDR;
C00-D49: Neoplasms	Hormonally-responsive breast cancer	C50	CYP19A1;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	IGF1R; KDR; FLT3;
C00-D49: Neoplasms	Colon cancer	C50	FLT3;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Orthosiphon spicatus

Taxonomic Information:

Plant External Links:

Used in Medicines:

Country/Region:

Traditional Medicine System:

Geographical Distribution:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities