Plant Name: Dioscorea panthaica
Taxonomic Information:
Plant ID: NPO9089
Plant Latin Name: Dioscorea panthaica
Taxonomy Genus: Dioscorea
Taxonomy Family: Dioscoreaceae
Plant External Links:
NCBI TaxonomyDB:
336258
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| HKDC1; ALOX15; USP2; | |
| KDM4E; | |
| SLCO1B3; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: | CYP1A2; |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Enzyme_unclassified | HKDC1 | Putative hexokinase HKDC1 | Q2TB90 | CHEMBL1741200 |
| Enzyme_unclassified | ALOX15 | Arachidonate 15-lipoxygenase | P16050 | CHEMBL2903 |
| Enzyme_unclassified | USP2 | Ubiquitin carboxyl-terminal hydrolase 2 | O75604 | CHEMBL1293227 |
| Lysine demethylase | KDM4E | Lysine-specific demethylase 4D-like | B2RXH2 | CHEMBL1293226 |
| SLC superfamily of solute carriers | SLCO1B3 | Solute carrier organic anion transporter family member 1B3 | Q9NPD5 | CHEMBL1743121 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0019369; arachidonic acid metabolic process | 1.142E-04 | 8.454E-01 | ALOX15, CYP1A2 |
| BP | GO:0008152; metabolic process | GO:0070988; demethylation | 1.365E-04 | 8.454E-01 | CYP1A2, KDM4E |
| BP | GO:0008152; metabolic process | GO:0032787; monocarboxylic acid metabolic process | 2.866E-04 | 8.454E-01 | ALOX15, CYP1A2, HKDC1 |
| MF | GO:0003824; catalytic activity | GO:0032451; demethylase activity | 5.928E-05 | 8.454E-01 | CYP1A2, KDM4E |
| MF | GO:0003824; catalytic activity | GO:0051213; dioxygenase activity | 3.181E-04 | 8.454E-01 | ALOX15, KDM4E |
| MF | GO:0003824; catalytic activity | GO:0047977; hepoxilin-epoxide hydrolase activity | 6.212E-04 | 8.454E-01 | ALOX15 |
| MF | GO:0003824; catalytic activity | GO:0050473; arachidonate 15-lipoxygenase activity | 9.316E-04 | 9.079E-01 | ALOX15 |
| MF | GO:0003824; catalytic activity | GO:0004052; arachidonate 12-lipoxygenase activity | 9.316E-04 | 9.079E-01 | ALOX15 |
| MF | GO:0003824; catalytic activity | GO:0051120; hepoxilin A3 synthase activity | 9.316E-04 | 9.079E-01 | ALOX15 |
| MF | GO:0005488; binding | GO:0005506; iron ion binding | 1.001E-03 | 9.079E-01 | ALOX15, CYP1A2 |
| MF | GO:0003824; catalytic activity | GO:0034875; caffeine oxidase activity | 1.242E-03 | 9.326E-01 | CYP1A2 |
| CC | GO:0044464; cell part | GO:0031234; extrinsic component of cytoplasmic side of plasma membrane | 2.216E-02 | 1.000E+00 | ALOX15 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 3.034E-05 | 7.282E-04 | CYP1A2, ALOX15 |
| Unclassified | Unclassified | hsa01100 | Metabolic pathways | 4.116E-03 | 2.470E-02 | HKDC1, CYP1A2, ALOX15 |
| 09100 Metabolism | 09105 Amino acid metabolism | hsa00380 | Tryptophan metabolism | 1.194E-02 | 2.742E-02 | CYP1A2 |
| 09100 Metabolism | 09110 Biosynthesis of other secondary metabolites | hsa00524 | Butirosin and neomycin biosynthesis | 1.499E-03 | 1.199E-02 | HKDC1 |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00052 | Galactose metabolism | 8.967E-03 | 2.742E-02 | HKDC1 |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00500 | Starch and sucrose metabolism | 1.668E-02 | 2.742E-02 | HKDC1 |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04930 | Type II diabetes mellitus | 1.432E-02 | 2.742E-02 | HKDC1 |
| 09100 Metabolism | 09110 Biosynthesis of other secondary metabolites | hsa00232 | Caffeine metabolism | 1.499E-03 | 1.199E-02 | CYP1A2 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 2.170E-02 | 2.742E-02 | CYP1A2 |
| 09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 2.111E-02 | 2.742E-02 | SLCO1B3 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
