CMAUP Plant Collective Molecular Activities

Plant Name: Piper hancei

Taxonomic Information:

Plant ID: NPO9078
Plant Latin Name: Piper hancei
Taxonomy Genus: Piper
Taxonomy Family: Piperaceae

Plant External Links:

NCBI TaxonomyDB: 450286
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Protein Kinase	MAPK1;
Lyase	CA13; CA7; CA12; CA9;
Enzyme_unclassified	GFER; ALDH1A1; HSD17B10;
Metallo protease	MMP3;
Cysteine protease	CASP7; CASP1;
Unclassified	RAB9A; NPC1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4; CYP1A2; CYP2D6; CYP2A6; CYP2C19; CYP2A13;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cysteine protease	CASP7	Caspase-7	P55210	CHEMBL3468
Cysteine protease	CASP1	Caspase-1	P29466	CHEMBL4801
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Cytochrome P450 family 2	CYP2A6	Cytochrome P450 2A6	P11509	CHEMBL5282
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 2	CYP2A13	Cytochrome P450 2A13	Q16696	CHEMBL3542436
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	GFER	FAD-linked sulfhydryl oxidase ALR	P55789	CHEMBL1741189
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Lyase	CA13	Carbonic anhydrase XIII	Q8N1Q1	CHEMBL3912
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Metallo protease	MMP3	Matrix metalloproteinase 3	P08254	CHEMBL283
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	1.001E-11	1.534E-07	CYP1A2, CYP2C19, CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	1.420E-10	7.728E-07	CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	3.292E-10	1.195E-06	CYP1A2, CYP2A6, CYP2C19, CYP3A4
MF	GO:0005488; binding	GO:0019825; oxygen binding	6.192E-10	1.926E-06	CYP1A2, CYP2A13, CYP2C19, CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	9.062E-10	2.193E-06	CA12, CA13, CA7, CA9
MF	GO:0005488; binding	GO:0020037; heme binding	1.902E-09	3.766E-06	CYP1A2, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	3.959E-09	6.631E-06	CYP1A2, CYP2A13, CYP2A6, CYP2C19
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	5.850E-09	8.754E-06	CYP1A2, CYP2A13, CYP2D6, CYP3A4
MF	GO:0005488; binding	GO:0005506; iron ion binding	7.297E-09	9.926E-06	CYP1A2, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0009804; coumarin metabolic process	2.817E-08	2.788E-05	CYP2A13, CYP2A6, CYP2D6
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	3.860E-08	3.362E-05	CA12, CA13, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006805; xenobiotic metabolic process	7.135E-08	5.179E-05	CYP1A2, CYP2A13, CYP2C19, CYP2D6, CYP3A4
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	8.851E-08	6.217E-05	CA12, CA13, CA7, CA9
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	9.711E-08	6.608E-05	CYP1A2, CYP2A6, CYP2C19, CYP2D6, CYP3A4, NPC1
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	1.765E-07	1.098E-04	CYP1A2, CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0008392; arachidonic acid epoxygenase activity	5.439E-07	3.037E-04	CYP2A13, CYP2A6, CYP2C19
MF	GO:0003824; catalytic activity	GO:0008389; coumarin 7-hydroxylase activity	9.167E-07	4.753E-04	CYP2A13, CYP2A6
BP	GO:0008152; metabolic process	GO:0009822; alkaloid catabolic process	2.748E-06	1.392E-03	CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	5.494E-06	2.600E-03	CYP1A2, CYP3A4
CC	GO:0016020; membrane	GO:0005789; endoplasmic reticulum membrane	1.666E-05	7.255E-03	CYP1A2, CYP2A13, CYP2A6, CYP2C19, CYP2D6, CYP3A4, RAB9A
BP	GO:0050896; response to stimulus	GO:0046686; response to cadmium ion	2.164E-05	9.062E-03	CYP1A2, MAPK1, NPC1
BP	GO:0008152; metabolic process	GO:0009056; catabolic process	2.379E-05	9.420E-03	ALDH1A1, CYP1A2, CYP2A6, CYP2C19, CYP2D6, CYP3A4, HSD17B10, MMP3, NPC1

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	4.723E-09	2.267E-07	CYP2A6, CYP2D6, CYP1A2, CYP3A4, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	6.298E-09	2.267E-07	CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP3A4
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.373E-09	1.483E-07	CA12, CA7, CA9, CA13
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.138E-08	3.073E-07	CYP2A6, CYP2A13, CYP1A2, CYP3A4, CYP2C19
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	3.796E-07	8.199E-06	CYP2A6, CYP1A2, ALDH1A1, CYP3A4
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	2.615E-06	4.707E-05	CYP1A2, CYP3A4, CYP2C19
09160 Human Diseases	09167 Infectious diseases	hsa05133	Pertussis	4.701E-05	6.346E-04	CASP7, CASP1, MAPK1
09130 Environmental Information Processing	09132 Signal transduction	hsa04668	TNF signaling pathway	1.471E-04	1.676E-03	CASP7, MMP3, MAPK1
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	1.552E-04	1.676E-03	CYP2D6, MAPK1, CYP2C19
Unclassified	Unclassified	hsa01100	Metabolic pathways	7.523E-04	6.771E-03	CYP2A6, CYP1A2, ALDH1A1, CYP2C19, CYP3A4, HSD17B10
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05010	Alzheimer's disease	5.110E-04	5.017E-03	CASP7, MAPK1, HSD17B10
09160 Human Diseases	09167 Infectious diseases	hsa05134	Legionellosis	1.232E-03	9.243E-03	CASP7, CASP1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	8.632E-04	7.171E-03	CYP2A6, CYP3A4
09150 Organismal Systems	09151 Immune system	hsa04621	NOD-like receptor signaling pathway	1.323E-03	9.243E-03	CASP1, MAPK1
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1.369E-03	9.243E-03	CYP1A2, CYP3A4
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	8.536E-06	1.317E-04	CYP2A6, CYP1A2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
I00-I99: Diseases of the circulatory system	Ischemic stroke	I61-I63	MMP3;
C00-D49: Neoplasms	Cancer	C00-C96	CA9;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	MMP3;
I00-I99: Diseases of the circulatory system	Myocardial infarction	I21, I22	MMP3;
H00-H59: Diseases of the eye and adnexa	Corneal ulcers	H16.0	MMP3;
C00-D49: Neoplasms	Solid tumours	C00-D48	CA9;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	MMP3;
C00-D49: Neoplasms	Renal cancer	C64	CA9;
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
A00-B99: Certain infectious and parasitic diseases	HCV infection	B17.1, B18.2	MMP3;
C00-D49: Neoplasms	Breast cancer	C50	CA9;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases