CMAUP Plant Collective Molecular Activities

Plant Name: Persicaria tinctoria

Taxonomic Information:

Plant ID: NPO9069
Plant Latin Name: Persicaria tinctoria
Taxonomy Genus: Persicaria
Taxonomy Family: Polygonaceae

Plant External Links:

NCBI TaxonomyDB: 96455
Plant-of-the-World-Online: 60455325-2

Used in Medicines:

Country/Region:

South Korea

Traditional Medicine System:

Geographical Distribution:

Ukraine; South Korea; China; South Africa

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	ADORA3; ADORA2A; ADORA1; ADRA2B;
Peptide receptor (family A GPCR)	TSHR; NPSR1;
Enzyme_unclassified	CDA; ADK; ALOX12; HSD17B2; HSD17B10; NOX4; ALOX15; POLB;
Protein Kinase	MET; AXL; FLT3; CDK1; PIM1; KDR; IGF1R; AURKB;
Lyase	CA2; CA12; CA7; CA4;
Nuclear hormone receptor subfamily 1 group C	PPARA; PPARD;
Oxidoreductase	ALOX5; TYR; PTGS2;
Metallo protease	MMP9; MMP1; MMP2;
Transcription Factor	AHR; NFKB1;
Unclassified	LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2; CYP1B1; CYP1A1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Enzyme_unclassified	CDA	Cytidine deaminase	P32320	CHEMBL4502
Enzyme_unclassified	ADK	Adenosine kinase	P55263	CHEMBL3589
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	HSD17B2	Estradiol 17-beta-dehydrogenase 2	P37059	CHEMBL2789
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Metallo protease	MMP9	Matrix metalloproteinase 9	P14780	CHEMBL321
Metallo protease	MMP1	Matrix metalloproteinase-1	P03956	CHEMBL332
Metallo protease	MMP2	Matrix metalloproteinase-2	P08253	CHEMBL333
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Nuclear hormone receptor subfamily 1 group C	PPARD	Peroxisome proliferator-activated receptor delta	Q03181	CHEMBL3979
Oxidoreductase	ALOX5	Arachidonate 5-lipoxygenase	P09917	CHEMBL215
Oxidoreductase	TYR	Tyrosinase	P14679	CHEMBL1973
Oxidoreductase	PTGS2	Cyclooxygenase-2	P35354	CHEMBL230
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Protein Kinase	MET	Hepatocyte growth factor receptor	P08581	CHEMBL3717
Protein Kinase	AXL	Tyrosine-protein kinase receptor UFO	P30530	CHEMBL4895
Protein Kinase	FLT3	Tyrosine-protein kinase receptor FLT3	P36888	CHEMBL1974
Protein Kinase	CDK1	Cyclin-dependent kinase 1	P06493	CHEMBL308
Protein Kinase	PIM1	Serine/threonine-protein kinase PIM1	P11309	CHEMBL2147
Protein Kinase	KDR	Vascular endothelial growth factor receptor 2	P35968	CHEMBL279
Protein Kinase	IGF1R	Insulin-like growth factor I receptor	P08069	CHEMBL1957
Protein Kinase	AURKB	Serine/threonine-protein kinase Aurora-B	Q96GD4	CHEMBL2185
Small molecule receptor (family A GPCR)	ADORA3	Adenosine A3 receptor	P0DMS8	CHEMBL256
Small molecule receptor (family A GPCR)	ADORA2A	Adenosine A2a receptor	P29274	CHEMBL251
Small molecule receptor (family A GPCR)	ADORA1	Adenosine A1 receptor	P30542	CHEMBL226
Small molecule receptor (family A GPCR)	ADRA2B	Alpha-2b adrenergic receptor	P18089	CHEMBL1942
Transcription Factor	AHR	Aryl hydrocarbon receptor	P35869	CHEMBL3201
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0043066; negative regulation of apoptotic process	8.150E-10	1.471E-06	ADORA1, ADORA2A, ALOX12, AURKB, AXL, CDK1, IGF1R, KDR, LMNA, MMP9, NFKB1, PIM1, PPARD, PTGS2
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	2.116E-08	1.646E-05	CA12, CA2, CA4, CA7
BP	GO:0008152; metabolic process	GO:0019372; lipoxygenase pathway	2.818E-08	1.979E-05	ALOX12, ALOX15, ALOX5, PTGS2
BP	GO:0050896; response to stimulus	GO:0001666; response to hypoxia	4.977E-08	2.929E-05	ADORA1, CYP1A1, LMNA, MMP2, NOX4, PPARA, PPARD, PTGS2
BP	GO:0008152; metabolic process	GO:0055114; oxidation-reduction process	1.585E-07	7.345E-05	ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, HSD17B10, HSD17B2, NOX4, PPARD, PTGS2, TYR
MF	GO:0060089; molecular transducer activity	GO:0001609; G-protein coupled adenosine receptor activity	2.863E-07	1.075E-04	ADORA1, ADORA2A, ADORA3
BP	GO:0009987; cellular process	GO:0001973; adenosine receptor signaling pathway	6.851E-07	2.162E-04	ADORA1, ADORA2A, ADORA3
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	8.851E-07	2.667E-04	CA12, CA2, CA4, CA7
MF	GO:0005488; binding	GO:0005506; iron ion binding	8.941E-07	2.667E-04	ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	9.773E-07	2.876E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0022414; reproductive process	GO:0007566; embryo implantation	1.106E-06	3.168E-04	MMP2, MMP9, PPARD, PTGS2
MF	Unclassified;	GO:0004872; receptor activity	1.422E-06	3.971E-04	ADORA1, ADORA2A, ADORA3, ADRA2B, AHR, AXL, FLT3, IGF1R, KDR, MET, NPSR1, PPARA, PPARD, TSHR
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	2.016E-06	5.225E-04	CA12, CA2, CA4, CA7
MF	GO:0005488; binding	GO:0019825; oxygen binding	2.209E-06	5.593E-04	CYP1A1, CYP1A2, CYP1B1, NOX4
BP	GO:0023052; signaling	GO:0032230; positive regulation of synaptic transmission, GABAergic	2.319E-06	5.805E-04	ADORA2A, CA2, CA7
BP	GO:0050896; response to stimulus	GO:0050728; negative regulation of inflammatory response	3.818E-06	8.484E-04	ADORA1, ADORA2A, NFKB1, PPARA, PPARD
BP	Unclassified;	GO:2000021; regulation of ion homeostasis	4.103E-06	8.755E-04	ADORA1, ADORA2A, CA2, CA7, KDR, NPSR1
BP	GO:0008152; metabolic process	GO:2001303; lipoxin A4 biosynthetic process	4.181E-06	8.755E-04	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0047977; hepoxilin-epoxide hydrolase activity	4.181E-06	8.755E-04	ALOX12, ALOX15
MF	GO:0005488; binding	GO:0008270; zinc ion binding	4.435E-06	9.196E-04	CA12, CA2, CA4, CA7, CDA, MMP1, MMP2, MMP9, PPARA, PPARD
BP	GO:0032501; multicellular organismal process	GO:0097746; regulation of blood vessel diameter	5.526E-06	1.056E-03	ADORA1, ADORA2A, ADRA2B, PPARD, PTGS2
MF	GO:0005488; binding	GO:0020037; heme binding	6.454E-06	1.201E-03	CYP1A1, CYP1A2, CYP1B1, NOX4, PTGS2
BP	GO:0032502; developmental process	GO:0007568; aging	7.489E-06	1.328E-03	AURKB, CDK1, CYP1A1, NOX4, POLB, PTGS2
BP	GO:0065007; biological regulation	GO:0010817; regulation of hormone levels	8.054E-06	1.392E-03	ADORA1, ADORA2A, ADRA2B, CYP1A1, CYP1B1, HSD17B2, NFKB1, PPARD
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	1.066E-05	1.772E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	1.253E-05	1.948E-03	CA2, CA7
MF	GO:0003824; catalytic activity	GO:0050473; arachidonate 15-lipoxygenase activity	1.253E-05	1.948E-03	ALOX15, PTGS2
MF	GO:0003824; catalytic activity	GO:0004052; arachidonate 12-lipoxygenase activity	1.253E-05	1.948E-03	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0051120; hepoxilin A3 synthase activity	1.253E-05	1.948E-03	ALOX12, ALOX15
CC	GO:0044464; cell part	GO:0099056; integral component of presynaptic membrane	1.253E-05	1.948E-03	ADORA1, ADORA2A
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	1.416E-05	2.156E-03	CYP1A1, CYP1A2, CYP1B1
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	1.416E-05	2.156E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0050896; response to stimulus	GO:0032496; response to lipopolysaccharide	2.100E-05	2.950E-03	AXL, CYP1A1, CYP1A2, NFKB1, PPARD, PTGS2
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	2.502E-05	3.322E-03	CYP1A1, CYP1A2
BP	GO:0008152; metabolic process	GO:0006691; leukotriene metabolic process	3.552E-05	4.227E-03	ALOX12, ALOX15, ALOX5
BP	GO:0008152; metabolic process	GO:0018108; peptidyl-tyrosine phosphorylation	3.927E-05	4.598E-03	AXL, FLT3, IGF1R, KDR, MET
BP	GO:0008152; metabolic process	GO:0051122; hepoxilin biosynthetic process	4.165E-05	4.773E-03	ALOX12, ALOX15
BP	GO:0008152; metabolic process	GO:0046777; protein autophosphorylation	5.040E-05	5.543E-03	AURKB, FLT3, IGF1R, KDR, PIM1
MF	GO:0005488; binding	GO:0046982; protein heterodimerization activity	6.391E-05	6.821E-03	ADORA1, ADORA2A, AHR, AXL, NFKB1, PPARD, TYR
MF	GO:0005488; binding	GO:0031072; heat shock protein binding	6.481E-05	6.884E-03	ADORA1, AHR, CDK1, KDR
BP	GO:0065007; biological regulation	GO:0042592; homeostatic process	7.161E-05	7.377E-03	ADORA1, ALOX12, AXL, CA12, CA2, CA7, FLT3, MET, NOX4, NPSR1, POLB
BP	GO:0009987; cellular process	GO:0071407; cellular response to organic cyclic compound	7.859E-05	7.960E-03	CYP1A1, CYP1B1, FLT3, NFKB1, NOX4, PTGS2
BP	GO:0008283; cell proliferation	GO:0008285; negative regulation of cell proliferation	8.179E-05	8.207E-03	ADORA1, ADORA2A, ADORA3, CYP1B1, LMNA, NOX4, PPARD, PTGS2
MF	GO:0060089; molecular transducer activity	GO:0005021; vascular endothelial growth factor-activated receptor activity	8.723E-05	8.674E-03	FLT3, KDR
BP	GO:0008152; metabolic process	GO:0019216; regulation of lipid metabolic process	9.456E-05	9.251E-03	ADORA1, CYP1A1, FLT3, NFKB1, PPARA, PTGS2
CC	GO:0044425; membrane part	GO:0005887; integral component of plasma membrane	9.599E-05	9.331E-03	ADORA1, ADORA2A, ADORA3, ADRA2B, AXL, FLT3, IGF1R, KDR, MET, NPSR1, TSHR

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	6.440E-10	8.308E-08	ALOX5, HSD17B2, CYP1A1, CYP1B1, PTGS2, IGF1R
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	6.935E-08	2.982E-06	FLT3, MMP1, MMP2, PTGS2, MET, MMP9, NFKB1, PPARD, IGF1R
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	3.203E-08	2.066E-06	CA12, CA2, CA4, CA7
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	5.018E-06	1.389E-04	FLT3, PIM1, NFKB1, PPARD
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	7.036E-06	1.513E-04	ALOX5, ALOX15, ALOX12, PTGS2
Unclassified	Unclassified	hsa01100	Metabolic pathways	2.150E-05	3.467E-04	CDA, ALOX5, HSD17B2, CYP1A2, ALOX15, CYP1A1, ADK, ALOX12, PTGS2, TYR, HSD17B10
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	5.382E-06	1.389E-04	CYP1A2, HSD17B2, CYP1A1, CYP1B1
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	2.559E-05	3.668E-04	PIM1, CYP1B1, PTGS2, MMP9, MET, NFKB1
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	5.055E-05	5.434E-04	MMP2, KDR, MMP9, MET, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	4.598E-05	5.392E-04	ADORA2A, ADORA1, PPARA, NFKB1, TSHR
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	2.144E-05	3.467E-04	CYP1A2, CYP1A1, CYP1B1, PTGS2
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	2.847E-05	3.673E-04	FLT3, MMP9, MET, NFKB1, IGF1R
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	7.290E-05	6.445E-04	ALOX5, ALOX15, ALOX12, PTGS2
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	2.175E-04	1.651E-03	ADORA2A, ADORA3, ADORA1, ADRA2B, TSHR
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	6.956E-05	6.445E-04	CYP1A2, CYP1A1, CYP1B1
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1.909E-04	1.539E-03	ADORA1, PTGS2, TSHR
09160 Human Diseases	09161 Cancers	hsa05219	Bladder cancer	7.495E-05	6.445E-04	MMP1, MMP2, MMP9
09130 Environmental Information Processing	09132 Signal transduction	hsa04015	Rap1 signaling pathway	8.172E-04	5.271E-03	ADORA2A, KDR, MET, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04014	Ras signaling pathway	1.072E-03	6.048E-03	KDR, MET, NFKB1, IGF1R
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04933	AGE-RAGE signaling pathway in diabetic complications	1.078E-03	6.048E-03	MMP2, PIM1, NFKB1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	4.183E-04	2.840E-03	CYP1A2, CYP1A1, CYP1B1
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	3.543E-04	2.539E-03	MMP1, PPARA, PPARD
09130 Environmental Information Processing	09132 Signal transduction	hsa04668	TNF signaling pathway	1.379E-03	7.413E-03	PTGS2, MMP9, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04071	Sphingolipid signaling pathway	1.770E-03	8.783E-03	ADORA3, ADORA1, NFKB1
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.530E-03	7.896E-03	CYP1A2, ALOX15
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	9.609E-04	5.902E-03	CA2, CA4

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	ADORA1; ADORA2A; ADRA2B; PTGS2;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	KDR;
NA: NA	Joint and muscular pain	NA	PTGS2;
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	ADORA1;
L00-L99: Diseases of the skin and subcutaneous tissue	Atopic dermatitis	L00-L99	ALOX5;
E00-E89: Endocrine, nutritional and metabolic diseases	Atrial fibrillation	E78, I48	ADORA1;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	PPARD; NFKB1; PTGS2;
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 1 diabetes	E10	PPARD;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Ankylosing spondylitis	M08.1, M45	PTGS2;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR;
L00-L99: Diseases of the skin and subcutaneous tissue	Diabetic foot ulcer	L88-L89	ADORA2A;
E00-E89: Endocrine, nutritional and metabolic diseases	Hypertriglyceridemia	E78.1, E78.2, E78.3, I47-I49	ADORA1;
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	PPARD;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	MET; IGF1R; KDR; AXL; PTGS2;
K00-K95: Diseases of the digestive system	Non-alcoholic fatty liver disease	K76.0	PPARD;
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	ADORA3; PTGS2; ALOX5;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	PTGS2; ALOX5;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	PPARD; ALOX5;
J00-J99: Diseases of the respiratory system	Asthma	J45	ADORA1; ADORA2A; PTGS2; ALOX5;
I00-I99: Diseases of the circulatory system	Arteriosclerosis	I70	ADORA2A;
K00-K95: Diseases of the digestive system	Ulcerative colitis	K51	MMP9;
C00-D49: Neoplasms	Metastatic breast cancer	C50	KDR;
I00-I99: Diseases of the circulatory system	Cardiac arrhythmias	I47-I49	ADORA1;
L00-L99: Diseases of the skin and subcutaneous tissue	Dermatitis	L20-L30	ALOX5;
C00-D49: Neoplasms	Myelofibrosis	C94.4, D47.4	FLT3;
C00-D49: Neoplasms	Lung cancer	C33-C34	MMP2;
A00-B99: Certain infectious and parasitic diseases	Lymphatic filariasis	B74	ALOX5;
L00-L99: Diseases of the skin and subcutaneous tissue	Acne vulgaris	L70.0	MMP2;
C00-D49: Neoplasms	Liver cancer	C22	IGF1R; KDR;
C00-D49: Neoplasms	Leukemia	C90-C95	FLT3;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Knee osteoarthritis	M15-M19, M47	PTGS2;
L00-L99: Diseases of the skin and subcutaneous tissue	Vitiligo	L80	TYR;
C00-D49: Neoplasms	Gastrointestinal cancers	C15-C26	KDR;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA4; CA2;
C00-D49: Neoplasms	Melanoma	C43	KDR; TYR;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	MET; IGF1R; KDR; ADORA3;
NA: NA	GIST	NA	FLT3;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ADORA1; ADORA2A; ADORA3;
C00-D49: Neoplasms	Glioblastoma	NA	FLT3;
C00-D49: Neoplasms	Glioma	C71	KDR;
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	ADK;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ADK;
K00-K95: Diseases of the digestive system	Colon polyps	K63.5	PTGS2;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	IGF1R; KDR; FLT3; MMP9;
I00-I99: Diseases of the circulatory system	Coronary disorder diagnosis	I20-I25	ADORA2A;
C00-D49: Neoplasms	Medullary thyroid cancer	C73	KDR;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	ADORA3;
C00-D49: Neoplasms	Malignant adrenal gland cancer	C74.0	IGF1R;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	KDR; MMP2;
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	PTGS2;
NA: NA	Edema	NA	CA2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	PTGS2;
C00-D49: Neoplasms	Metastatic HER2-negative gastric cancer	NA	MET;
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	KDR;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriatic disorder	L40	IGF1R;
I00-I99: Diseases of the circulatory system	Heart disease	I00-I52	MET;
I00-I99: Diseases of the circulatory system	Heart failure	I50	ADORA1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	ADRA2B;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	NPSR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Dyslipidaemias	E78	PPARD;
NA: NA	Dyslipidemia	NA	PPARD;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
N00-N99: Diseases of the genitourinary system	Dysmenorrhea	N94.4-N94.6	PTGS2;
C00-D49: Neoplasms	Metastasis	C00-C97	AXL;
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	PPARD;
C00-D49: Neoplasms	Metastatic castration-resistant prostate cancer	C61	KDR;
I00-I99: Diseases of the circulatory system	Cardiac disease	I00-I99	ADORA1;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	AURKB;
NA: NA	Hepatitis C virus infection	NA	ADORA3;
NA: NA	Hematopoietic stem cell transplantation	NA	FLT3;
C00-D49: Neoplasms	Colon cancer	C50	FLT3;
C00-D49: Neoplasms	Gliosarcoma	NA	FLT3;
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	FLT3;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	AURKB; FLT3;
E00-E89: Endocrine, nutritional and metabolic diseases	Hormone deficiency	E00-E90	IGF1R;
NA: NA	HIV infections	NA	AHR;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Convulsions	R56.0	ADK;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	PTGS2; ALOX5; MMP1;
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
C00-D49: Neoplasms	Ovarian cancer	C56	KDR; MMP2;
C00-D49: Neoplasms	Gastric cancer	C16	KDR;
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	MET;
C00-D49: Neoplasms	Peritoneal cavity cancer	NA	KDR;
C00-D49: Neoplasms	Advanced renal cell carcinoma	C64	KDR;
C00-D49: Neoplasms	Advanced malignancies	C00-C96	KDR;
S00-T88: Injury, poisoning and certain other consequences of external causes	Hyperthermia	T68	PTGS2;
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	ADORA1; ADORA2A;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Fatigue	R53	ADORA1;
C00-D49: Neoplasms	Fallopian tube cancer	C57.0, D28.2	KDR;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic nephropathy	E11.21	MMP1;
C00-D49: Neoplasms	Thyroid cancer	C73	KDR; TSHR;
I00-I99: Diseases of the circulatory system	Thrombosis	I80-I82	ALOX5;
C00-D49: Neoplasms	AML	NA	KDR; FLT3;
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	ADORA2A;
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	ADORA1; ALOX5;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	PTGS2;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	ADORA1;
I00-I99: Diseases of the circulatory system	Ischemia	I99.8	ADORA3;
I00-I99: Diseases of the circulatory system	Stroke	I61-I63, I80-I82	MMP9;
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	KDR;
C00-D49: Neoplasms	Myeloid leukemia	C92	FLT3;
J00-J99: Diseases of the respiratory system	Airway inflammation	J00-J99	FLT3;
C00-D49: Neoplasms	Advanced solid tumor	C00-C75, C7A, C7B	MET;
L00-L99: Diseases of the skin and subcutaneous tissue	Melasma	L81.1	TYR;
C00-D49: Neoplasms	Cancer	C00-C96	PIM1; MET; CDK1; IGF1R; KDR; NFKB1; FLT3; ADORA3; MMP9; PTGS2; MMP2;
G00-G99: Diseases of the nervous system G00-G99	Multiple scierosis	G35	ADORA1;
C00-D49: Neoplasms	Multiple myeloma	C90	IGF1R; AHR;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Growth failure	R62.8	IGF1R;
H00-H59: Diseases of the eye and adnexa	Graves' ophthalmopathy	H06.2	IGF1R;
C00-D49: Neoplasms	Solid tumours	C00-D48	MET; AURKB; IGF1R; KDR; FLT3; MMP9; CDA; MMP2;
C00-D49: Neoplasms	Squamous cell cancer of head and neck	NA	KDR;
I00-I99: Diseases of the circulatory system	Angiogenesis disorder	I00-I99	KDR;
G00-G99: Diseases of the nervous system G00-G99	Motor neurone disease	G12.2	IGF1R;
K00-K95: Diseases of the digestive system	Liver disease	K70-K77	MET;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	KDR;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Moderate to severe rheumatoid arthritis	M05-M06	PTGS2;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
NA: NA	Anaplastic mixed oligoastrocytoma	NA	FLT3;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	PPARD; ADORA1;
I00-I99: Diseases of the circulatory system	Acute and chronic heart failure	I50	ADORA1;
C00-D49: Neoplasms	Biliary cancer	C22, C24	KDR;
A00-B99: Certain infectious and parasitic diseases	Sepsis	A40, A41	ADORA1;
C00-D49: Neoplasms	Breast cancer	C50	CDK1; IGF1R; KDR; FLT3;
A00-B99: Certain infectious and parasitic diseases	Fungal infections	B35-B49	ALOX5;
NA: NA	Rheumatold arthritis	NA	PTGS2;
J00-J99: Diseases of the respiratory system	Rhinitis	J00, J30, J31.0	ALOX5;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	PTGS2; ALOX5; MMP1; TYR;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Chronic pain	R52.1-R52.2, G89	PTGS2;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	ADORA2A; ALOX5;
J00-J99: Diseases of the respiratory system	Respiratory disease	J00-J99	ALOX5;
C00-D49: Neoplasms	Renal cell carcinoma	NA	KDR; MMP2;
C00-D49: Neoplasms	Renal cancer	C64	KDR;
N00-N99: Diseases of the genitourinary system	Renal failure	N17, N18, N19	ADORA1;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	CDK1; IGF1R; ADORA2A; ADK; PTGS2;
C00-D49: Neoplasms	Pancreatic cancer	C25	KDR; FLT3; PTGS2; MMP2;
C00-D49: Neoplasms	Cutaneous Melanoma	C43-C44	KDR;
C00-D49: Neoplasms	CLL	NA	FLT3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ADORA1;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Radionuclide imaging	W88	ADORA2A;
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	PPARD;
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	ADORA3;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ADORA1; ADORA2A;
I00-I99: Diseases of the circulatory system	Orthostatic hypotension	I95.1	ADORA1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	PTGS2; MMP2; ALOX5;
K00-K95: Diseases of the digestive system	Inflammatory bowel disease	K50, K51	PTGS2;
K00-K95: Diseases of the digestive system	Chemotherapy-induced mucositis	K12.3	MET;
L00-L99: Diseases of the skin and subcutaneous tissue	Pruritus	L29	ALOX5;
C00-D49: Neoplasms	Prostate cancer	C61	FLT3;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	FLT3; ALOX5;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases