CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	ADORA3; ADORA2A; ADORA1; ADRA2B;
Peptide receptor (family A GPCR)	TSHR; NPSR1;
Enzyme_unclassified	CDA; ADK; ALOX12; HSD17B2; HSD17B10; NOX4; ALOX15; POLB;
Protein Kinase	MET; AXL; FLT3; CDK1; PIM1; KDR; IGF1R; AURKB;
Lyase	CA2; CA12; CA7; CA4;
Nuclear hormone receptor subfamily 1 group C	PPARA; PPARD;
Oxidoreductase	ALOX5; TYR; PTGS2;
Metallo protease	MMP9; MMP1; MMP2;
Transcription Factor	AHR; NFKB1;
Unclassified	LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2; CYP1B1; CYP1A1;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	HSD17B2	Estradiol 17-beta-dehydrogenase 2	P37059	CHEMBL2789
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Enzyme_unclassified	CDA	Cytidine deaminase	P32320	CHEMBL4502

Showing 1 to 10 of 40 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0043066; negative regulation of apoptotic process	8.150E-10	1.471E-06	ADORA1, ADORA2A, ALOX12, AURKB, AXL, CDK1, IGF1R, KDR, LMNA, MMP9, NFKB1, PIM1, PPARD, PTGS2
BP	GO:0008152; metabolic process	GO:0019372; lipoxygenase pathway	2.818E-08	1.979E-05	ALOX12, ALOX15, ALOX5, PTGS2
BP	GO:0050896; response to stimulus	GO:0001666; response to hypoxia	4.977E-08	2.929E-05	ADORA1, CYP1A1, LMNA, MMP2, NOX4, PPARA, PPARD, PTGS2
BP	GO:0008152; metabolic process	GO:0055114; oxidation-reduction process	1.585E-07	7.345E-05	ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, HSD17B10, HSD17B2, NOX4, PPARD, PTGS2, TYR
BP	GO:0009987; cellular process	GO:0001973; adenosine receptor signaling pathway	6.851E-07	2.162E-04	ADORA1, ADORA2A, ADORA3
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	8.851E-07	2.667E-04	CA12, CA2, CA4, CA7
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	9.773E-07	2.876E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0022414; reproductive process	GO:0007566; embryo implantation	1.106E-06	3.168E-04	MMP2, MMP9, PPARD, PTGS2
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	2.016E-06	5.225E-04	CA12, CA2, CA4, CA7
BP	GO:0023052; signaling	GO:0032230; positive regulation of synaptic transmission, GABAergic	2.319E-06	5.805E-04	ADORA2A, CA2, CA7

Showing 1 to 10 of 46 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	3.203E-08	2.066E-06	CA12, CA2, CA4, CA7
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	7.036E-06	1.513E-04	ALOX5, ALOX15, ALOX12, PTGS2
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	5.382E-06	1.389E-04	CYP1A2, HSD17B2, CYP1A1, CYP1B1
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	6.956E-05	6.445E-04	CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	4.183E-04	2.840E-03	CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.530E-03	7.896E-03	CYP1A2, ALOX15
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	4.598E-05	5.392E-04	ADORA2A, ADORA1, PPARA, NFKB1, TSHR
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	2.175E-04	1.651E-03	ADORA2A, ADORA3, ADORA1, ADRA2B, TSHR
09130 Environmental Information Processing	09132 Signal transduction	hsa04015	Rap1 signaling pathway	8.172E-04	5.271E-03	ADORA2A, KDR, MET, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04014	Ras signaling pathway	1.072E-03	6.048E-03	KDR, MET, NFKB1, IGF1R

Showing 1 to 10 of 26 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Lymphatic filariasis	B74	ALOX5;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	ADORA3;
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
A00-B99: Certain infectious and parasitic diseases	Sepsis	A40, A41	ADORA1;
A00-B99: Certain infectious and parasitic diseases	Fungal infections	B35-B49	ALOX5;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	KDR;
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	MET; IGF1R; KDR; AXL; PTGS2;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	PTGS2; ALOX5;
C00-D49: Neoplasms	Metastatic breast cancer	C50	KDR;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Persicaria tinctoria

Taxonomic Information:

Plant External Links:

Used in Medicines:

Country/Region:

Traditional Medicine System:

Geographical Distribution:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities