CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	DRD3; HTR2C;
Peptide receptor (family A GPCR)	OPRD1;
Protein Phosphatase	PTPN1;
Aspartic protease	BACE1;
Endoplasmic reticular retrotranslocon family	VCP;
Unclassified	MCL1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Aspartic protease	BACE1	Beta-secretase 1	P56817	CHEMBL4822
Endoplasmic reticular retrotranslocon family	VCP	Transitional endoplasmic reticulum ATPase	P55072	CHEMBL1075145
Peptide receptor (family A GPCR)	OPRD1	Delta opioid receptor	P41143	CHEMBL236
Protein Phosphatase	PTPN1	Protein-tyrosine phosphatase 1B	P18031	CHEMBL335
Small molecule receptor (family A GPCR)	DRD3	Dopamine D3 receptor	P35462	CHEMBL234
Small molecule receptor (family A GPCR)	HTR2C	Serotonin 2c (5-HT2c) receptor	P28335	CHEMBL225
Unclassified	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1	Q07820	CHEMBL4361

Showing 1 to 7 of 7 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0007610; behavior	GO:0007626; locomotory behavior	2.665E-05	3.430E-01	DRD3, HTR2C, OPRD1
BP	GO:0023052; signaling	GO:0007268; chemical synaptic transmission	1.144E-04	3.430E-01	DRD3, HTR2C, OPRD1
CC	GO:0044425; membrane part	GO:0005887; integral component of plasma membrane	8.249E-04	3.742E-01	BACE1, DRD3, HTR2C, OPRD1
CC	GO:0032991; macromolecular complex	GO:0097136; Bcl-2 family protein complex	2.173E-03	4.621E-01	MCL1
CC	GO:0044464; cell part	GO:0097443; sorting endosome	2.173E-03	4.621E-01	PTPN1
MF	GO:0060089; molecular transducer activity	GO:0030594; neurotransmitter receptor activity	6.505E-04	3.430E-01	DRD3, HTR2C
MF	GO:0005488; binding	GO:0071886; 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding	7.247E-04	3.430E-01	HTR2C
MF	GO:0005488; binding	GO:0019903; protein phosphatase binding	7.617E-04	3.529E-01	PTPN1, VCP
MF	GO:0005488; binding	GO:0019904; protein domain specific binding	1.456E-03	4.243E-01	DRD3, MCL1, VCP

Showing 1 to 9 of 9 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	8.828E-05	1.589E-03	OPRD1, HTR2C, DRD3
09130 Environmental Information Processing	09132 Signal transduction	hsa04630	Jak-STAT signaling pathway	5.401E-02	6.900E-02	MCL1
09130 Environmental Information Processing	09132 Signal transduction	hsa04022	cGMP-PKG signaling pathway	5.701E-02	6.900E-02	OPRD1
09130 Environmental Information Processing	09132 Signal transduction	hsa04020	Calcium signaling pathway	6.133E-02	6.900E-02	HTR2C
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	2.562E-02	6.900E-02	PTPN1
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04540	Gap junction	3.040E-02	6.900E-02	HTR2C
09150 Organismal Systems	09157 Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	3.380E-02	6.900E-02	HTR2C
09150 Organismal Systems	09152 Endocrine system	hsa04910	Insulin signaling pathway	4.765E-02	6.900E-02	PTPN1
09160 Human Diseases	09167 Infectious diseases	hsa05134	Legionellosis	1.909E-02	6.900E-02	VCP
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04931	Insulin resistance	3.754E-02	6.900E-02	PTPN1

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Overactive bladder disorder	C67, N32.81	OPRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	OPRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	OPRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	OPRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Premature ejaculation	F52.4	OPRD1;
G00-G99: Diseases of the nervous system G00-G99	Acute migraine	G43	OPRD1;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	OPRD1;
I00-I99: Diseases of the circulatory system	Ischemic heart diseases	I20-I25	OPRD1;
K00-K95: Diseases of the digestive system	Diarrhea-predominant IBS	K58.0	OPRD1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	OPRD1;

Showing 1 to 10 of 16 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Juniperus occidentalis

Taxonomic Information:

Plant External Links:

Used in Medicines:

Geographical Distribution:

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Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities