CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	NPSR1;
Protein Phosphatase	CDC25B;
Protein Kinase	MET; AXL; FLT3; CDK1; PIM1; KDR; IGF1R; AURKB;
Lyase	CA12; CA7; CA4;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Oxidoreductase	TYR; XDH;
Enzyme_unclassified	ALOX12; CBR1; HSD17B2; HSD17B10; NOX4; POLB;
Metallo protease	PEPD;
Transcription Factor	AHR;
Unclassified	LMNA; FABP4;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP19A1; CYP2C19; CYP1A2; CYP1B1; CYP1A1;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	CBR1	Carbonyl reductase [NADPH] 1	P16152	CHEMBL5586

Showing 1 to 10 of 31 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	1.132E-09	4.103E-06	CYP1A1, CYP1A2, CYP1B1, CYP2C19
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	3.186E-08	3.652E-05	CYP1A1, CYP1A2, CYP1B1, CYP2C19
BP	GO:0008283; cell proliferation	GO:0042127; regulation of cell proliferation	4.069E-06	1.846E-03	AHR, ALOX12, CDC25B, CDK1, CYP1B1, FLT3, IGF1R, KDR, LMNA, NOX4, PIM1, XDH
BP	GO:0009987; cellular process	GO:0043066; negative regulation of apoptotic process	5.331E-06	2.322E-03	ALOX12, AURKB, AXL, CDK1, IGF1R, KDR, LMNA, NR1H4, PIM1
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	6.486E-06	2.647E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0050896; response to stimulus	GO:0010035; response to inorganic substance	6.842E-06	2.661E-03	AXL, CDK1, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR
BP	GO:0008152; metabolic process	GO:0018108; peptidyl-tyrosine phosphorylation	1.088E-05	3.644E-03	AXL, FLT3, IGF1R, KDR, MET
BP	GO:0008152; metabolic process	GO:0046777; protein autophosphorylation	1.401E-05	4.488E-03	AURKB, FLT3, IGF1R, KDR, PIM1
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	1.493E-05	4.710E-03	CYP1A1, CYP1A2
BP	GO:0040011; locomotion	GO:0030334; regulation of cell migration	2.226E-05	6.551E-03	ALOX12, CYP19A1, CYP1B1, IGF1R, KDR, LMNA, MET, NOX4

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Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2.758E-08	9.928E-07	CYP1A2, HSD17B2, CYP1A1, CYP1B1, CYP19A1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	4.769E-06	6.868E-05	CBR1, CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	3.204E-05	2.884E-04	CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	2.259E-06	4.067E-05	CA12, CA4, CA7
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	1.199E-04	9.589E-04	CBR1, ALOX12, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	9.197E-04	6.020E-03	CYP1A2, CYP2C19
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	2.318E-05	2.385E-04	CYP1A2, XDH
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	1.286E-08	9.262E-07	HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R
09150 Organismal Systems	09152 Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	4.642E-04	3.342E-03	CDK1, CDC25B, IGF1R
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.600E-07	3.840E-06	CBR1, CYP1A2, CYP1A1, CYP1B1, CYP2C19

Showing 1 to 10 of 12 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
C00-D49: Neoplasms	Fallopian tube cancer	C57.0, D28.2	KDR;
C00-D49: Neoplasms	Metastatic breast cancer	C50	KDR;
C00-D49: Neoplasms	Metastasis	C00-C97	AXL;
C00-D49: Neoplasms	Metastatic castration-resistant prostate cancer	C61	KDR;
C00-D49: Neoplasms	Gastrointestinal cancers	C15-C26	KDR;
C00-D49: Neoplasms	Gastric cancer	C16	KDR;
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	KDR;
C00-D49: Neoplasms	Metastatic HER2-negative gastric cancer	NA	MET;
C00-D49: Neoplasms	Peritoneal cavity cancer	NA	KDR;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Notholaena aschenborniana

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities