CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	GPBAR1;
Protein Phosphatase	PTPN1; PTPN2; CDC25B;
Enzyme_unclassified	PLA2G1B; AKR1B10; POLB;
Nuclear hormone receptor subfamily 1 group H	NR1H4;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	PLA2G1B	Phospholipase A2 group 1B	P04054	CHEMBL4426
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Protein Phosphatase	PTPN1	Protein-tyrosine phosphatase 1B	P18031	CHEMBL335
Protein Phosphatase	PTPN2	T-cell protein-tyrosine phosphatase	P17706	CHEMBL3807
Protein Phosphatase	CDC25B	Dual specificity phosphatase Cdc25B	P30305	CHEMBL4804
Small molecule receptor (family A GPCR)	GPBAR1	G-protein coupled bile acid receptor 1	Q8TDU6	CHEMBL5409

Showing 1 to 8 of 8 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	4.502E-07	4.901E-03	GPBAR1, NR1H4
BP	GO:0050896; response to stimulus	GO:0046626; regulation of insulin receptor signaling pathway	8.514E-07	4.901E-03	NR1H4, PTPN1, PTPN2
BP	GO:0009987; cellular process	GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway	9.002E-07	4.901E-03	PTPN1, PTPN2
BP	GO:0008152; metabolic process	GO:0016311; dephosphorylation	3.058E-06	1.110E-02	CDC25B, POLB, PTPN1, PTPN2
BP	GO:0009987; cellular process	GO:1903897; regulation of PERK-mediated unfolded protein response	6.743E-06	1.710E-02	PTPN1, PTPN2
BP	GO:0008152; metabolic process	GO:0035335; peptidyl-tyrosine dephosphorylation	7.178E-06	1.710E-02	CDC25B, PTPN1, PTPN2
BP	GO:0009987; cellular process	GO:1900103; positive regulation of endoplasmic reticulum unfolded protein response	1.168E-05	2.312E-02	PTPN1, PTPN2
BP	GO:0009987; cellular process	GO:0010804; negative regulation of tumor necrosis factor-mediated signaling pathway	2.841E-05	5.156E-02	NR1H4, PTPN2
BP	GO:0009987; cellular process	GO:0001959; regulation of cytokine-mediated signaling pathway	3.443E-05	5.747E-02	NR1H4, PTPN1, PTPN2
CC	GO:0044464; cell part	GO:0097443; sorting endosome	2.483E-03	3.888E-01	PTPN1

Showing 1 to 10 of 17 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	9.958E-03	5.805E-02	PLA2G1B
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.154E-02	5.805E-02	PLA2G1B
09100 Metabolism	09101 Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1.431E-02	5.805E-02	AKR1B10
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	1.194E-02	5.805E-02	AKR1B10
09100 Metabolism	09101 Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1.273E-02	5.805E-02	AKR1B10
09100 Metabolism	09103 Lipid metabolism	hsa00561	Glycerolipid metabolism	2.336E-02	6.332E-02	AKR1B10
09100 Metabolism	09103 Lipid metabolism	hsa00565	Ether lipid metabolism	1.786E-02	5.805E-02	PLA2G1B
09120 Genetic Information Processing	09124 Replication and repair	hsa03410	Base excision repair	1.313E-02	5.805E-02	POLB
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	2.922E-02	6.332E-02	PTPN1
09150 Organismal Systems	09154 Digestive system	hsa04975	Fat digestion and absorption	1.629E-02	5.805E-02	PLA2G1B

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Cancer	C00-C96	CDC25B;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Gentiana macrophylla pall

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities