Plant Name: Senna obtusifolia
Taxonomic Information:
Plant ID: NPO8921
Plant Latin Name: Senna obtusifolia
Taxonomy Genus: Senna
Taxonomy Family: Fabaceae
Plant External Links:
NCBI TaxonomyDB:
346985
Plant-of-the-World-Online:
234560-2
Used in Medicines:
Country/Region:
Kenya; Tanzania; Rwanda; India; ThailandTraditional Medicine System:
Ayurveda; KampoGeographical Distribution:
Brazil; Madagascar; Bangladesh; Kenya; Sudan; Guinea; Mali; Costa Rica; Bahamas; Ethiopia; Rwanda; Somalia; Peru; Suriname; Argentina; Bolivia; Cameroon; Burkina Faso; Ecuador; Benin; Ghana; Saudi Arabia; Australia; Libya; Togo; Thailand; Venezuela; Cape Verde; Cote d'Ivoire; Sri Lanka; Trinidad and Tobago; Zimbabwe; Oman; Senegal; Dominican Republic; Belize; Sierra Leone; Nigeria; Eritrea; Netherlands; Uganda; Liberia; Pakistan; Gambia; Tanzania; Zambia; United States; Paraguay; Mauritania; French Guiana; Guinea-Bissau; Guyana; Namibia; Honduras; Malawi; Yemen; Haiti; Jamaica; Iraq; Angola; Chad; Mexico; India; Botswana; Djibouti; Congo; Mozambique; Colombia; Burundi; Gabon; Niger; Nicaragua; Comoros
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| TSHR; | |
| TDP1; BLM; RECQL; ALOX15; HSD17B10; HPGD; | |
| CDC25B; | |
| PIM1; CSNK2A1; MAPK1; | |
| ESR1; ESR2; | |
| ELANE; | |
| HIF1A; TP53; | |
| MAPT; LMNA; | |
| SMN1;SMN2; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 2 | CYP2C9 | Cytochrome P450 2C9 | P11712 | CHEMBL3397 |
| Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Enzyme_unclassified | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
| Enzyme_unclassified | BLM | Bloom syndrome protein | P54132 | CHEMBL1293237 |
| Enzyme_unclassified | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Enzyme_unclassified | ALOX15 | Arachidonate 15-lipoxygenase | P16050 | CHEMBL2903 |
| Enzyme_unclassified | HSD17B10 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Q99714 | CHEMBL4159 |
| Enzyme_unclassified | HPGD | 15-hydroxyprostaglandin dehydrogenase [NAD+] | P15428 | CHEMBL1293255 |
| Methyl-lysine/arginine binding protein | SMN1;SMN2 | Survival motor neuron protein | Q16637 | CHEMBL1293232 |
| Nuclear hormone receptor subfamily 3 group A | ESR1 | Estrogen receptor alpha | P03372 | CHEMBL206 |
| Nuclear hormone receptor subfamily 3 group A | ESR2 | Estrogen receptor beta | Q92731 | CHEMBL242 |
| Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
| Protein Kinase | PIM1 | Serine/threonine-protein kinase PIM1 | P11309 | CHEMBL2147 |
| Protein Kinase | CSNK2A1 | Casein kinase II alpha | P68400 | CHEMBL3629 |
| Protein Kinase | MAPK1 | MAP kinase ERK2 | P28482 | CHEMBL4040 |
| Protein Phosphatase | CDC25B | Dual specificity phosphatase Cdc25B | P30305 | CHEMBL4804 |
| Serine protease | ELANE | Leukocyte elastase | P08246 | CHEMBL248 |
| Transcription Factor | HIF1A | Hypoxia-inducible factor 1 alpha | Q16665 | CHEMBL4261 |
| Transcription Factor | TP53 | Cellular tumor antigen p53 | P04637 | CHEMBL4096 |
| Unclassified | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0009987; cellular process | GO:0000733; DNA strand renaturation | 1.072E-07 | 2.335E-03 | BLM, RECQL, TP53 |
| BP | GO:0008283; cell proliferation | GO:0008284; positive regulation of cell proliferation | 2.527E-07 | 2.517E-03 | CDC25B, CSNK2A1, ELANE, ESR1, HIF1A, HPGD, MAPK1, PIM1, TSHR |
| MF | GO:0060089; molecular transducer activity | GO:0038052; RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding | 1.238E-06 | 5.393E-03 | ESR1, ESR2 |
| MF | GO:0005488; binding | GO:0042802; identical protein binding | 4.471E-06 | 1.346E-02 | BLM, CSNK2A1, ESR1, ESR2, HPGD, MAPK1, MAPT, SMN1, SMN2, TP53 |
| MF | GO:0005488; binding | GO:0051879; Hsp90 protein binding | 6.226E-06 | 1.346E-02 | CSNK2A1, HIF1A, MAPT |
| MF | GO:0005488; binding | GO:0034056; estrogen response element binding | 7.420E-06 | 1.346E-02 | ESR1, ESR2 |
| MF | GO:0003824; catalytic activity | GO:0034875; caffeine oxidase activity | 7.420E-06 | 1.346E-02 | CYP2C9, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:2001300; lipoxin metabolic process | 1.852E-05 | 1.681E-02 | ALOX15, HPGD |
| BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 1.852E-05 | 1.681E-02 | CYP2C9, CYP3A4 |
| CC | GO:0044464; cell part | GO:0005737; cytoplasm | 2.422E-05 | 1.953E-02 | BLM, CYP3A4, ELANE, ESR1, HIF1A, HSD17B10, MAPK1, MAPT, PIM1, RECQL, SMN1, SMN2, TDP1, TP53 |
| CC | GO:0044464; cell part | GO:0032838; plasma membrane bounded cell projection cytoplasm | 5.859E-05 | 3.112E-02 | HIF1A, MAPK1, MAPT |
| CC | GO:0043226; organelle | GO:0097504; Gemini of coiled bodies | 8.117E-05 | 3.399E-02 | SMN1, SMN2 |
| CC | GO:0032991; macromolecular complex | GO:0032797; SMN complex | 9.586E-05 | 3.662E-02 | SMN1, SMN2 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 4.143E-06 | 4.888E-04 | CYP2C9, ALOX15, CYP3A4 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04919 | Thyroid hormone signaling pathway | 7.758E-06 | 4.888E-04 | MAPK1, TP53, ESR1, HIF1A |
| 09160 Human Diseases | 09161 Cancers | hsa05205 | Proteoglycans in cancer | 6.531E-05 | 1.653E-03 | MAPK1, TP53, HIF1A, ESR1 |
| 09160 Human Diseases | 09161 Cancers | hsa05230 | Central carbon metabolism in cancer | 5.287E-05 | 1.653E-03 | MAPK1, TP53, HIF1A |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04917 | Prolactin signaling pathway | 6.559E-05 | 1.653E-03 | MAPK1, ESR1, ESR2 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04010 | MAPK signaling pathway | 1.576E-04 | 3.046E-03 | MAPK1, MAPT, TP53, CDC25B |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04915 | Estrogen signaling pathway | 1.692E-04 | 3.046E-03 | MAPK1, ESR1, ESR2 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04726 | Serotonergic synapse | 2.436E-04 | 3.837E-03 | CYP2C9, ALOX15, MAPK1 |
| 09160 Human Diseases | 09161 Cancers | hsa05206 | MicroRNAs in cancer | 2.822E-04 | 3.951E-03 | PIM1, MAPK1, TP53, CDC25B |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04210 | Apoptosis | 4.690E-04 | 5.372E-03 | LMNA, MAPK1, TP53 |
| 09160 Human Diseases | 09163 Neurodegenerative diseases | hsa05010 | Alzheimer's disease | 7.972E-04 | 8.371E-03 | MAPK1, MAPT, HSD17B10 |
| 09160 Human Diseases | 09161 Cancers | hsa05202 | Transcriptional misregulation in cancer | 9.734E-04 | 8.760E-03 | HPGD, TP53, ELANE |
| 09160 Human Diseases | 09161 Cancers | hsa05216 | Thyroid cancer | 4.606E-04 | 5.372E-03 | MAPK1, TP53 |
| 09160 Human Diseases | 09161 Cancers | hsa05219 | Bladder cancer | 9.228E-04 | 8.760E-03 | MAPK1, TP53 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
